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Development of Liver: Embryology
The liver, one of the largest and most vital organs, begins its development during the fourth week of embryogenesis from the endodermal outgrowth known as the hepatic diverticulum or liver bud, which arises from the ventral wall of the foregut. This liver bud rapidly proliferates into the septum transversum, a mass of mesoderm located between the developing heart and midgut. The hepatic cells, derived from the endoderm, intermingle with the mesenchyme of the septum transversum to form the hepatic cords and the hepatic sinusoids. The interaction between the growing liver bud and the septum transversum mesoderm also leads to the development of the connective tissue stroma, blood vessels, and the bile ducts. By the sixth week, the liver constitutes a significant portion of the abdominal cavity and plays a critical role in hematopoiesis, which is the formation of blood cells. As development proceeds, the liver's hematopoietic function diminishes, and it starts producing bile around the 12th week of gestation. The liver continues to grow and mature, becoming a major metabolic hub in the body. 🧬
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Негізгі бет 17. Development Of Liver : Embryology
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