I swear you'll get me through med school lol, thank you for such indepth videos
@himariyabelayneh1937
3 жыл бұрын
I hope you made it
@wyleybug
Жыл бұрын
Did you make it bro? lmao
@sophiemirza9435
2 ай бұрын
@@wyleybug I guess we will never know...
@wyleybug
2 ай бұрын
@@sophiemirza9435 real 😔
@lilitinoco8869
Ай бұрын
We need an update!
@vladimirtrump5637
3 жыл бұрын
2,3 BPG formation occurs only in erythrocytes, not in the exercising cells! The reason that the 2,3 BPG is higher at tissue level RBCs is that the enzyme responsible for breakdown of 2,3 BPG (phosphatase) is pH sensitive - less active at a lower pH!
@ellios5734
2 жыл бұрын
thats my question
@StudyBits3560
Жыл бұрын
Yes , I think when 2,3-BPG level increases during hypoxic conditions it binds to Hb and reduces its affinity for oxygen and may be this causes lowering of pH rendering phosphatase less effective .🤔
@TheRealChristianPress
6 жыл бұрын
Somebody give this man an award
@diogoccas
6 жыл бұрын
Your lectures are awesome, so much content condensed, and you speak very clearly and at the right speed. Thank you!
@aishavpmd
2 жыл бұрын
Rapaport-Luebering Pathway occurs in RBC as one of its mechanism to metabolize glucose since RBS has no organelles for that. Please read it on Rodak's Hematology 4th Edition.
@camillypinheiro3792
Жыл бұрын
You speak so clearly that me, as a non english native, could understand you perfectly!! Thank you so much for the amazing video.
@nursenataliya
3 жыл бұрын
Thank you for helping nurses everywhere understand concepts like this!!! "If you can't explain it simply, you don't understand it well enough"- A.E. Thank you so much for your videos!
@salmaalnajar220
9 жыл бұрын
My absolute favorite teacher !! brilliant as always :)
@AKLECTURES
9 жыл бұрын
Salma Al najar thanks! :-)
@Paramedic_Necromancer
3 жыл бұрын
I'm a critical care paramedic studying for my flight paramedic licensing exam, this video was very helpful in conceptualizing 2,3 BPG's physiological role in respiration. Thank you for the great content!
@yazeedalbeladi4286
6 жыл бұрын
Best tutor in the EVER .. He gives you everything that you should know❤️❤️. Thank you so much
@nikeshtravelvlog370
6 жыл бұрын
Sir, I'm Nike from India but i study MBBS in Russia. I often watch your videos for learning. thank you so much sir.
@yesuchristoba
6 жыл бұрын
I love this guy... And this is coming from someone preparing for his ACEM exams (John West is good but this guy's break down is just heaven) .Thank you sooo much
@volo7
9 жыл бұрын
my goodness you are a godsend... the way you explain this process with the help of your diagrams makes everything so coherent
@FantasticHermitCrab
8 жыл бұрын
Hot damn, this was satisfying to watch, man! You demonstrate amazing comprehension of the subject and manage to introduce and present it in such a great, understandable and digestible way. I was a littlelost on the subject when I looked up this video, but you cleared it up perfectly. Thanks for the help and keep up the good work!
@niko6743
5 жыл бұрын
@AK Lectures Dude why didn't I have you as my instructor when I was in college?!!! Your explanation was brilliantly explained and made so much more sense!!! You are freaking awesome! Doing an online class for my BSN and have to take Biochem and this by far is the greatest!!! Looking forward to view your other vids on DNA, etc!!! You have a new SUBSCRIBER!!!
@AKLECTURES
5 жыл бұрын
haha well glad to hear that my content is helping! best of luck with your course
@zorayanieves7055
9 жыл бұрын
This guy knows his shit!
@matildae882
8 жыл бұрын
Brilliant!!!! I'm gonna nail this exam because of your videos, thank you so much for posting!
@jaywilliam4296
9 жыл бұрын
This has really helped! Thanks for a very informative, thorough video
@AKLECTURES
9 жыл бұрын
Jay William Awesome to hear Jay, you're welcome!
@kawtheralidressi9558
Жыл бұрын
He is the best teacher ❤
@TRIUMPH413
10 ай бұрын
always enjoy your lectures, keep the great word
@user-pi9cc3xh4t
2 жыл бұрын
عاشت ايدك 😀😀 من طب الكوفة المرحلة الأولى 🙂🙂🙂🙂😭😭😭😭😭😭😭
@mohamedaminenahil5777
3 жыл бұрын
Man, you're our savior
@ceige131
6 жыл бұрын
medical intern here.. this guy nails it.. thanks for the video!!
@user-fz4bh6kf2t
2 ай бұрын
amazing explanation , thank you so much
@mayflower2904
3 жыл бұрын
You are doing more for us than the AAMC
@thefadorachampion7263
3 жыл бұрын
Great teacher! Very clear and concise explanation. Thank you for providing such high-quality content!
@oliviaalladaye6592
8 жыл бұрын
Thanks for this step by step explananations that makes everything so clear suddenly. You have such a way to explain, and repeat !! Thanks so much
@umasrivastava4142
4 жыл бұрын
Awesome explanation. Love from India. Best regards, Uma Srivastava
@dansap69
3 жыл бұрын
Thank you for explaining such a simple concept that textbooks seem to gloss over!
@stephengarramone6056
9 жыл бұрын
These were excellent lectures. Finally understood this physiologic principle.
@AKLECTURES
9 жыл бұрын
Stephen Garramone thanks! congrats ! :)
@kathyweeds
7 жыл бұрын
Excellent video. Was refreshing my memory of this from physiology for biochemistry, and wow- Refreshed in 10 min. Awesome. Thank you for this. I'm going to subscribe.
@myherpesitch7763
6 жыл бұрын
Very clear spoken guy. Great vids. Thanks
@kaymak4865
2 жыл бұрын
after all years ı found this video and appreciate it :)
@garciafortea97
8 жыл бұрын
Very explicatory and always clear. It has been great to expand on my notes. Keep up the good work!
@arianel-taher4553
3 жыл бұрын
This man is amazing. Enough said.
@marwaabuelezz9773
8 жыл бұрын
I would really like to thank you for the great video and explanation. I have gotten to understand this part thanks to you. Keep up the good work!!
@Full-stack1198
2 жыл бұрын
very well explained, thank's man
@AbdullahKhan-cd5mt
3 жыл бұрын
Thanks for your help and support ❤️
@AZSROSE
5 жыл бұрын
Thank you! Those clips are gold!
@carlarabe
5 жыл бұрын
you're a life saver to us medical students, in short you're a "MED SAVER" thank you! :D
@sirajkakar188
4 жыл бұрын
Its bisphosphoglycerate Not a biphosphate.....
@masterprocrastinatoryeah
Жыл бұрын
Wow! Thanks dude! Very clear and to the point
@chiragchandan9135
3 жыл бұрын
Thanks a lot!!!
@deae3831
2 жыл бұрын
thank you so much for you work sir👍
@Sohaib0O0
7 жыл бұрын
the most favourite lessons ever ❤ it's very helpful and provide the information that we need in such a perfect way 😍😍
@abdulwajidwani
Жыл бұрын
Very helpful.
@michaelaconnors4428
4 жыл бұрын
Thank you for your clear explanation.
@rollindy
7 жыл бұрын
Amazing video! I have an exam in 2 hours, thank you very much :')
@blightreign
8 жыл бұрын
great video and very to easy understand explanation!
@thatotlakedi5694
9 жыл бұрын
You're the best. Simply the best!!
@AKLECTURES
9 жыл бұрын
Thato Takedi Thank you very much! :)
@andreabraquet4869
Жыл бұрын
Not a nurse or Dr, just a concerned mother. I have a 5 year old girl with high hemocrit, high platelets, high hemoglobin, slightly high calcium, slightly elevated potassium, and slightly elevated iron saturation. I've recorded all she drank and she is not dehydrated. Please help
@nofarmarom1306
6 жыл бұрын
you never fail me.
@suphsris
Жыл бұрын
Thank you so much!!!
@luiseduardonavarroperalta297
4 жыл бұрын
I have read today that the Blood Units have the disadvantage that they don’t have 2,3 DPG( or too few) . That’s why they aren’t good when they have to deliver oxygen. I don’t understand that . Because the tissues make 2,3 DPD when they are in Stress, that means that it shouldn’t be a problem . Or does it mean , that die Units too few DesoxyHb hat, that’s why 2,3DPG from ours tissues don’t help .???? Please help
@taraann2409
3 жыл бұрын
Fabulous 👏🏻👏🏻👏🏻👏🏻👏🏻👏🏻👏🏻👏🏻
@andrewbergemann4878
7 жыл бұрын
AK, Most 2,3BPG is actually produced within the erythrocyte.
@shivanishastri4285
6 жыл бұрын
Very helpful. Thanks!
@hamayasin3084
5 жыл бұрын
Thanks teacher
@EdW4rdO1
6 жыл бұрын
Have I told you lately that I love you
@tikagurung3998
6 жыл бұрын
It's very very helpful..😊😊👌thank u
@raghadhammami5364
2 жыл бұрын
Thank you 🐐
@danyalahmed768
4 жыл бұрын
Amazing
@sufiasultana5071
6 жыл бұрын
sir thanks a lot 4 ur videos. u really teach us from the heart, plz sir send us a video on collagen, plzzzzzzz
@eunicetan5960
3 жыл бұрын
hi,in the absence of bpg,isnt the curve rectangular hyprbola?
@shreyashah9598
4 жыл бұрын
At 6:12 you said hhmg instead of mmHg. Lol!
@ronin18D
8 жыл бұрын
So, are you saying 2,3 DPG occupies a heme molecule not allowing O2 to bind thereby increasing the dissolved O2 concentration making it more available for tissue in need at lower pressures?
@oo-jii
3 жыл бұрын
8:20 OMG EVERYTHING MAKES SENSE
@jimhempe7247
5 жыл бұрын
I did an NCBI search and can't find any research to support the speakers contention that RBC import 2,3-BPG from plasma.
@vladimirtrump5637
3 жыл бұрын
2,3 BPG formation occurs only in erythrocytes, not in the exercising cells! The reason that the 2,3 BPG is higher at tissue level RBCs is that the enzyme responsible for breakdown of 2,3 BPG (phosphatase) is pH sensitive - less active at a lower pH.
@pascalHenrich
7 жыл бұрын
massive teaching but how do the erythrocytes get rid of the BPG ?
@amandatrutanich6037
6 жыл бұрын
You’re amazing! Thank you💕💕
@rmrmali8288
9 жыл бұрын
thank you ...you are great..and smart ...
@taaniasaeed8819
5 жыл бұрын
AK Lectures~=~Guyton.🙆
@vpriya1992
5 жыл бұрын
Amazing lecture ! thank you :)
@snehapadghan6007
5 жыл бұрын
Very helpful thank you so much
@oscarguzmancruz5990
9 жыл бұрын
This video is awesome
@irineandrona7948
6 жыл бұрын
Excellent video but I just don't get it, why will a measurable( high anyway quantity) of 2,3 BPG leave the cell in the first place and not became pyruvate? And the curve shouldn't stop in the region of the lungs as the BPG only binds to deoxyhemoglobin?
@anaherrera4805
4 жыл бұрын
I Love it!! Thank you!!! The best!!
@alvinjohnmasaku2198
9 жыл бұрын
Awesome work
@AKLECTURES
9 жыл бұрын
Alvinjohn Masaku thanks!
@DROCKJAMO
9 жыл бұрын
awesome vid!
@AKLECTURES
9 жыл бұрын
Derick Brown thanks Derick!
@faizanfayaz8978
7 жыл бұрын
Pretty helpful, thank you....
@cma44444444444444444
9 жыл бұрын
I believe RBC are the only cells that produce 2,3BPG. Exercising cells sounds like you are saying any cell can produce.
@aishavpmd
2 жыл бұрын
I agree
@nanobebe77
9 жыл бұрын
Really helped, thanks.
@AKLECTURES
9 жыл бұрын
Nadin Arabi you're welcome!
@drcgiri09
5 жыл бұрын
thank you so much
@evaafif7239
5 жыл бұрын
So, what's happen after that for 3-phosphoglycerate? Is there any product for pyruvate or no?
@zero450571
7 жыл бұрын
i wish you were my personal tutor, i would give you all my money. which is not much lol
@Ak-un6ed
11 ай бұрын
Im really torn here. Can someone say this is accurate? The fact that he calls is biphosphate and the 2nd comment is someone pointing out another discrepancy. I don’t know much about BPG and came here to learn-saw he has a few videos on it but don’t want to waste the time if there is general disagreement on the accuracy
@seddikib.m4850
7 жыл бұрын
Brilliant
@melogasm
8 жыл бұрын
You are awesome!
@AKLECTURES
8 жыл бұрын
+PMelograne thanks! :)
@zeanaalkudsi531
5 жыл бұрын
LIVE SAVIORRR , THANK YOU
@mintesinotdesalegn4726
5 жыл бұрын
i thank YOU!
@lopo1127
5 жыл бұрын
Deoxyhaemaglobin binds to O2 or co2
@NieceyWeesey
9 жыл бұрын
Woah! Talk about HD
@AKLECTURES
9 жыл бұрын
Niecey Weesey Thanks! glad you appreciate that! :-)
@prahladsahu4724
4 жыл бұрын
Awwwsm sir
@Mehu1997
4 жыл бұрын
One question: how is it 2,3-BPG formed in the excising tissue? Doesn't it need BPG-mutase and isn't it only found in the red blood cells and placental cells? Or am I wrong?
@DapaChrons
4 жыл бұрын
1,3-BPG is found on the pathway of glycolysis, so it should be found along any cell using that process. BPG-mutase changes it to 2,3-BPG and is unique to blood cells and placental cells, but because of circulation I suppose it would be easy for the body to create that 2,3-BPG from 1,3-BPG. What I mean is, BPG-mutase and 1,3-BPG will be in close proximity to one another
@NieceyWeesey
9 жыл бұрын
And one more thing, why are some haemoglobin molecules deoxygenated? Aren't they all supposed to be loaded with oxygen once they get to tissues so they can release their oxygen to the tissues that need it?
@NiranjanGyanchandani
9 жыл бұрын
nice work there..:)
@faisalalkoblan9906
4 жыл бұрын
my man!
@fungaimusangomunei3267
8 жыл бұрын
you the best!!!!
@ann8302
9 жыл бұрын
How would say this affects ETC? Are you increasing the final electron acceptor (O2) then because of this you require a higher metabolic rate of glycolysis and TCA?
@evaafif7239
5 жыл бұрын
No, this just happened in RBC, and at reason , no mitochondria init , they obtain their energy from anaerobic respiration by formation of lactic acid
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