I love your videos. It's going on 11 years since this process has taken place in my body. I woke up one morning in May 2012 and said, I'll never drink alcohol again, and I haven't, and never will.
@Musician-r5q
Жыл бұрын
Thanks for the ♥ What sparked my interest on Neuroscience is that a friend of mine I've known since high school,1979, his daughter is taking 2 Majors, Neuroscience, and Psychology and was told by the College Admin that they didn't know she wanted 2 Degrees and that she was 8 credits short for the Neuroscience degree so, 2 of her Professors have been helping her cram so she can get both degrees, and now I know what she's gotta go through, she'll make it I'm sure.
@595E
2 ай бұрын
I wish I was just as strong
@sherrygad5532
7 ай бұрын
Thanks so much. This really helped me in pharmacy school.
@jacobb8397
6 жыл бұрын
Very informative. I highly appreciate your work.
@neurochallenged
6 жыл бұрын
Thanks!
@jrgenchristensen7240
5 жыл бұрын
I do too. And i think my biologi teacher also highly appreciates it.
@salonipatankar8924
3 жыл бұрын
I'm convinced that the nine (9) people who disliked this video are alcoholics
@salonipatankar8924
3 жыл бұрын
@Erick Rowen i have always wanted to hack my friend's insta, we trust each other very much but the only thing we don't share is instagram password. i really needed to hear this today, will try it right away! it makes me feel so much better knowing that i can invade her privacy as much as i want without her having a single idea :))
@AVENTUS7777
3 ай бұрын
Damn I disliked and alcoholic
@celeb657
6 жыл бұрын
Really appreciate this! Was looking for some background info on effects of alcohol on sensory processing for my lab project, so this helps a bunch!!
@joshuafletcher3107
Ай бұрын
violent drunks etc, don't touch the stuff these days for, its more damaging to my brain then taking street drugs but don't touch those these days either
@evrencicekli7045
3 ай бұрын
im drunk and also taking neuroscience courses. it’s trippy to know what’s happening to my brain atm haha
@jasonlee6180
2 жыл бұрын
This is a great video! So clear and thought out. wow
@TobyFieldhouse
6 жыл бұрын
Please could someone explain how increasing GABA(A) receptor activity leads to increased dopamine release when GABAergic neurons typically inhibit DAergic neurons?
@neurochallenged
6 жыл бұрын
It's complicated and not fully understood. First, it's important to note (as I mentioned in the video) that alcohol affects more than just GABA receptors. and its influence on other neurotransmitter receptors and ion channel types may be responsible for its ability to stimulate dopamine release. Also, though, it's always important to realize that while GABA will inhibit the activity of the neuron whose receptors it stimulates, the overall/net effect doesn't have to be inhibitory. For example, one proposed way alcohol leads to stimulation of dopamine neurons is that it stimulates GABA neurons that inhibit other GABA neurons that were involved in continuous inhibition of dopamine neurons. So you have GABA neurons that are constantly inhibiting dopamine neurons, and that inhibition was stopped by GABA activity caused by alcohol. If you want a source that talks all about it, here are a couple (you'll need to access through a library): www.cell.com/neuron/comments/S0896-6273(17)31025-5 and this one goes into a lot of detail focusing just on alcohol & dopamine: www.ncbi.nlm.nih.gov/pubmed/20813245
@lightbeingpontifex
3 жыл бұрын
GABA blocks stimulation of dopamine activity but I think alcohol somehow increases dopamine activity,,, and possibly inhibits gaba,
@jasonlee6180
Жыл бұрын
Ethanol and benzos lessen endogenous GABA binding to dopaminergic neurons, (-) x (-) = +, contributing to a rewarding factor for both substances.
@dunragit9578
3 жыл бұрын
This would explain why it helps with my ataxia, cns damage from brainstem surgery?
@brokentombot
3 жыл бұрын
Yes. Ethanol is really weird. Good job covering the main things. As you said, it is an unknown effector in many ways. I think the dumb way of looking at it is that it will effect one area and then affect another. Ad infitum. It's a cascade phenomenon. And then when that cascade is going, the ethanol will do more effects for more affects. Why is this not an illegal drug?
@damianzachariah3645
3 жыл бұрын
you all prolly dont care at all but does anyone know a trick to log back into an instagram account? I stupidly lost my login password. I appreciate any tips you can give me
@dickschwanzstein1789
2 жыл бұрын
@@damianzachariah3645 What does that have to do with this video or the above reply?
@sais8681
3 жыл бұрын
Well, that's why Alcohol is the best relaxing drug out there. Thanks for the lecture.
@Trudon
3 жыл бұрын
I love it but the hangover not so much 😂
@lightbeingpontifex
3 жыл бұрын
@@Trudon you mean the waste products of the alcohol ie congeniers
@cornbread7710
3 жыл бұрын
Except for the part where it destroys you. 😟
@dickschwanzstein1789
2 жыл бұрын
Well, weed is a great relaxer too obviously and it’s much less detrimental to your body (although alcohol may be less bad for your career, to be fair). And there are things like gaba supplements, valerian and melatonin which work great in terms of relaxation and sedation, have much fewer side effects and are much cheaper as well. So I’m not sure I’d call alcohol the best relaxation drug. I like it, don’t get me wrong. But that’s also kind of like the problem with it.
@hello1943
Ай бұрын
Only while you’re drinking it. Once it wears off completely (ie the next day) you’re more likely to be anxious/stressed
@ethanboyd7843
2 жыл бұрын
Never tried 'em but watching that sure felt good.
@sergiosanchezpadilla1418
6 жыл бұрын
Thanks again :)
@neurochallenged
6 жыл бұрын
Thanks for being a regular viewer!
@Moonehz
6 жыл бұрын
thx
@kayaytz1502
2 жыл бұрын
I was the 1000th like
@vibrathor6974
4 жыл бұрын
hey soo it works similarly like benzos?
@neurochallenged
4 жыл бұрын
In terms of its action at GABA receptors, yes.
@Sevisstillalive
4 жыл бұрын
@@neurochallenged In what terms doesn't benzos and liquor work similarly ? like benzs hit gaba a and liquor is gaba b ?
@neurochallenged
4 жыл бұрын
@@Sevisstillalive One difference that comes to mind is that alcohol inhibits activity at glutamate receptors. I'm not aware of benzos having similar effects at the glutamate receptor. There are likely many other more poorly-defined differences.
@steelersrock4392
4 жыл бұрын
Similar mechanism of action, yes. Both are GABAergic drugs which is why the two are said to have a synergistic effect and can be catastrophic if taken in moderate to high doses together.
@Sevisstillalive
4 жыл бұрын
@@neurochallenged Oh I try to learn about these topics more, So Benzos don't hit the Gaba-B but isn't Glutamate the " go" receptor? Gaba being the stop?. Also Why do so little drugs touch the Gaba B? If that makes sense
@Sowrdfish8
2 жыл бұрын
Could you do one on what is known about GHB? Since I understand it works on similar receptors but in what way and how does the brain produce it?
@jasonlee6180
2 жыл бұрын
GHB hits two receptors: GABA-B, and the GHB receptor - GABA-B is generally a skeletal-muscular relaxant - GHB receptor releases dopamine and glutamate The effect is reduction of physical anxiety, and mental euphoria. GABA-B receptors are less present in your brain (compared to GABA-A receptors), so it doesn't "get in the way" for the large influx of dopamine (pleasure) released from the GHB receptor.
@obscurion5335
2 жыл бұрын
who using alcohol as nmda antagonist , i dont even feel the gaba agonism because of my xanax use i stopped eatin xans 1 month ago tho
@earthling1377
2 жыл бұрын
Benzos?
@joshuafletcher3107
4 ай бұрын
if you have depression its most likely going to stimulate cortisol
@mariannbalint1
2 жыл бұрын
Can anyone explain how drinking alcohol while taking anti epileptic drugs is bad?
@Svnfold
Күн бұрын
Yes
@johnnyboy6429
3 жыл бұрын
So pretty much this is like a weak benzo?
@neurochallenged
3 жыл бұрын
There are similarities with alcohol and benzodiazepines in how they interact with GABA receptors. But there is a lot about alcohol's other actions that make it unique from benzos. And in terms of effects, I wouldn't consider alcohol a weak benzo since it has a much greater risk of toxicity.
@dustinbailey9644
Жыл бұрын
I was almost sure alcohol increased negative Charges (chloride ions) So it was negative not positive allosteric. Same as benzos.
@cobalius
4 жыл бұрын
GABA? Could it be useful for autism and shizophrenia in some ways? ..despite the idea of getting those toddlers drunk, which is morally wrong and stuff
@lightbeingpontifex
3 жыл бұрын
I would only recommend it for hypertension and maybe adhd
@dickschwanzstein1789
2 жыл бұрын
@@lightbeingpontifex How would I help people who suffer from that?
@lightbeingpontifex
2 жыл бұрын
@@dickschwanzstein1789 diet and relaxation techniques,,,
@dickschwanzstein1789
2 жыл бұрын
@@lightbeingpontifex Haha I’m looking forward to meeting the first dietician who likes to prescribe people with hypertension and ad(h)d a high alcohol diet lol
@lightbeingpontifex
2 жыл бұрын
@@dickschwanzstein1789 I drink or take benadryl for hypertension and high blood pressure instead of seeing a doctor and taking prescribed medication,,,
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