During the 2024 MOGAD Together online event, Dr. GG deFiebre of SRNA was joined by Dr. Elias Sotirchos of Johns Hopkins Hospital in Baltimore, Maryland. Dr. Sotirchos answered the audience’s questions about myelin oligodendrocyte glycoprotein antibody disease (MOGAD) symptoms, diagnosis [00:00:05], and treatment options such as IVIG and subcutaneous IG [00:02:18]. Dr. Sotirchos emphasized the variability in disease manifestation, potential triggers for relapses like infections and stress, as well as the necessity for clinical trials to approve treatments [00:04:32].
He explored of the differences between MOGAD and NMOSD [00:07:39], predictors of relapse [00:13:45], the impact of MOGAD on children’s mental health [00:30:36], and the role of lifestyle factors like diet and exercise [00:40:14]. Dr. Sotirchos also touched on recent research developments [00:49:20] and encouraged patients to stay vigilant about symptoms while maintaining hope and seeking expert care [00:53:45]. Please note that the information shared during this session is for informational purposes only and is not medical advice.
Elias Sotirchos, MD is a neurologist at Johns Hopkins Hospital in Baltimore, Maryland. He specializes in the diagnosis, management, and treatment of neuroimmunological disorders that involve the central nervous system, including multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein-immunoglobulin G (MOG-IgG)-associated disorder (MOGAD). His research focuses on developing and validating novel imaging and blood-based biomarkers of these conditions, and clinical trials of experimental therapeutic agents.
00:00 Introduction and Overview of MOG Antibody Disease
01:22 Understanding MOG Antibody Disease Symptoms and Manifestations
02:20 Current Treatments and FDA Approval Process
04:38 Impact of Stress and Emotional Factors on MOGAD
07:39 Differences Between NMOSD and MOG
11:09 Challenges in Diagnosing and Treating MOGAD
13:45 Predictors of Relapse in MOGAD
30:36 Impact of MOGAD on Children's Behavior and Cognition
40:14 Natural and Alternative Therapies for MOGAD
49:20 Recent Research and Future Directions
53:45 Quality of Life and Mental Health in MOGAD Patients
58:04 Conclusion and Final Thoughts
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