I am at a loss for words. I can not express my gratitude. Thank you so much for sharing these videos. They are a wealth of information and so clear to understand. Again, Thank You!
@stahpitt8531
7 жыл бұрын
Very straight to the point, very well demonstrated with both visual and auditory learning for optimal memory retention.
@llkeeley
7 жыл бұрын
Thank you. That is exactly what I aim for. LK
@llkeeley
11 жыл бұрын
You are welcome. Thanks for writing. I am sure you saw that I do not discuss the role of potassium in the AP as there are no insecticides (we know, yet) that affect potassium channels. You might want to consider going to my playlists and view the video on Animal Neurobiology as it covers more on the role of the synapse in information transfer and interpretation. Some day I plan to do a video on the entire physiology of the AP, but unfortunately, it is still down the list. LK
@aglaia1111
11 жыл бұрын
This has helped me a lot! Thank your for your free Videos and explanations! Regards from Germany
@Caarve
7 жыл бұрын
Thank you for the great video. Helped a lot for my Biochemistry course!
@jamesbaldington1150
11 жыл бұрын
Clear, simple, precise, no waste of time. Excellent!
@Muuip
11 жыл бұрын
Great series of presentations! I have been looking for awhile now for a good presentation on Action potential and Synapse. Finally I have found was I was looking for. Thank you so much for posting.
@llkeeley
12 жыл бұрын
Thank you - happy to help
@SiddarthPratapneni
12 жыл бұрын
Your explanations are amazing!
@ajayghimire7393
5 жыл бұрын
Is this a similar method to treat Anti-depressants overdose patients?
@heathermattox496
7 жыл бұрын
this video was very clear and simple to understand with a great explanation
@llkeeley
7 жыл бұрын
Thank you. Happy it was helpful.
@SaadSaad-mb4py
4 жыл бұрын
Fantastic
@pottimurthyvenkatesh1965
2 жыл бұрын
At 1:23 you are saying that acetylcholine estare breaks acetyl choline to continue acetylcholine stimulate the sodium channel receptors and reopening the channel. How cum this is possible acetylcholine estare function is to degrade acetyl choline and not to stimulate sodium channel
@Apranik882
9 жыл бұрын
Thanks for sharing this! ;)
@llkeeley
9 жыл бұрын
+Natt F You are welcome. I am glad you found it useful. LK
@Apranik882
9 жыл бұрын
Very useful! :)
@beautytechniek8917
4 жыл бұрын
Thank you. How can humans get rid of this when they have this in their body?
@llkeeley
4 жыл бұрын
Depends on the chemical. Non-competitive pesticides like the organophospates require injection of a nontoxic chemical like atropine. The non-competitive pesticides block acetycholinesterase which causes accumulation of acetylchoine and hyperstimulation of acetylcholine receptors used for muscle contraction. Atropine blocks the receptors to lessen the hyperstimulation. Assuming the hyperstimulation is suppressed sufficiently for patient survival, you wait for natural enzymes that degrade the poison and excrete it from the patient and resynthesis of uninhibited acetylcholine molecules. For competitive toxins like carbamates, you can do the same, or if a subtoxic dose the still uninhibited acetylcholine will continue to work and the insecticide will be metabolized and excreted eventually. They are less toxic and more easily treated.
@MWALKLETT1
Жыл бұрын
What is the actual final cause of death? Ie "cardiac failure, respiratory failure, etc"? Or is it a systemic shut down? I understand the organophosphate mechanism (s.l.u.d.g.e.) I'm trying to understand the end result. Please help.
@llkeeley
Жыл бұрын
My reply is simply yes - all of those things. Since the nervous system is the main system affected it's likely that cardiac arrest and breathing ability are all affected in a general shutdown of the body as a result of a general stimulus overload and exhaustion.
@meghancarpenter5461
7 жыл бұрын
Any idea of how to cite this video for a paper?
@llkeeley
7 жыл бұрын
Depends on where you intend to put the article with this as a source reference. If this is to be published in an actual, published scientific journal, then all journals have specific rules for citing references. These rules can be found usually on the inside or back covers of each issue or by going to the journal website. If you are doing this for a classroom paper for college or high school, then your instructor may have a specific format you should use. If it is up to you, I would suggest the following: author (me) (year of copyright) Title of scene. In: Title of playlist. URL of the scene ( for example: www.youtube...). -- do this by copy/paste from the URL listed at the top of the page the scene is on. Here is what I think would be a format for this scene: Keeley, L.L. (2004) Scene 7. Acetylcholinesterase Inhibition. In Playlist: Neurotoxic Insecticides: Modes of Action. kzitem.info/news/bejne/jp1_145ugqqUp3o.
@meghancarpenter5461
7 жыл бұрын
Thank you so much! I'm using for a grant proposal for my developmental biology class! This video was incredibly helpful for my topic!
@TheONESsoldier777
11 жыл бұрын
makes me wonder how pesticides effect the human mind?
@markvest8578
5 жыл бұрын
I worked with dursban and lorsban for years , trust me it causes your brain and nervous system lots of issues
@regiodeurse6513
4 жыл бұрын
simlair because the system is the same... Only difference is the effective dose
@regiodeurse6513
4 жыл бұрын
organophosphates belong to the first generation of chemical warfare agents. They where so before they even used as insecticides. The same could be said about the majority of the pesticides.
@gemmeliusgrammaticus2509
3 жыл бұрын
Do insecticides cause insects pain? That is, is it a prolonged, painful death?
@llkeeley
3 жыл бұрын
I commonly get this question. It is hard to answer because it's very subjective from the insects' perspective. My answer has to be tempered by the fact that insects have a nervous system and nerves respond to nerve damage by what humans consider pain. Pain warns the animal that something unpleasant is happening somewhere to its body that endangers survival. The insect nervous system does not have a comparable regulatory center - like the vertebrate brain - that integrates all information, but the insect nervous system is scattered into ganglia that regulate each segment somewhat independently . Therefore, it is difficult to tell if the insect perceives pain with the same emotion that a vertebrate animal with a centralized brain would have. I would say that it is not a pleasant experience, but it is, also, probably not accompanied with the fear for survival that more highly developed nervous systems would provide. Our fear of pain is an emotional response to our knowledge regarding the fear of death; I doubt insects have a perception of death, and therefore, don't have the emotional fear-response that animals with a more developed nervous system and consciousness of personal survival possess. Hope this helps? .
@gemmeliusgrammaticus2509
3 жыл бұрын
Larry Keeley Thank you for responding. Yes, that’s very helpful!
@EDUARDO12348
11 жыл бұрын
poor little insects, but this is a classic survival of the fittest.
@NotMe35971
5 жыл бұрын
Eduardo This is what aliens told before destroying humans.
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