Since the ADHD diagnosis process is basically a obstacle course specifically designed to be difficult for ADHDers, I personally give very little importance to ADHD studies made with ADHDers who already had the diagnosis. It leaves out both those who are too ADHD to get the diagnosis and those who can somewhat manage with their ADHD, but probably get repeated depression periods due to it. Also, my blood pressure and RHR were all higher while I was doing a somewhat stressful office job from home than they were a year later when I was doing pretty much nothing at home and had a higher dosage of my meds. Since you get ADHD meds only when you need them, you could quite well argue that any increases in cardiovascular diseases correlate with the need of ADHD meds rather than exposure to ADHD meds. I don't really have a strong opinion one way or another on the heart safety of the meds, nor do I really care. Personally I consider my life to have been on borrowed time from before grade school age, since I managed to cheat death twice by that age already, so personally I really wouldn't consider dying at for example 70yo rather than 72yo even a loss, but having won 65 years 😅 Besides, without my meds I'm stressed, angry, and can barely get anything done, so even from that pointnof view if being medicated from 30yo to 70yo technically took off some years from the end, it still didn't. It gave me 40 years worth living 🤷♂️
@BS20-35
9 ай бұрын
Thank you so much for making a video on this! I’ve been super busy lately and as a result I haven’t had time to look at the data from the recent studies on this, but I’ve seen a bunch of headlines in articles like CNN and NYT that essentially make it sound like taking ADHD meds is a death sentence due to their cardiovascular risk so hearing your thoughts on the actual evidence is especially helpful. I know it’s a bit outside your usual area as it’s more of a GI topic, but I would be very interested to hear your thoughts on the recent studies that suggest a possible link between reflux medications like PPIs and dementia. As always, thank you for creating such amazing videos and for doing what you do!
@PsychiatrySimplified
9 ай бұрын
Thank you for your feedback. I'll take a look but causality but harm or etiology studies e.g ppi and dementia will have similar principles that are relevant.
@khaoticgrumpy
5 ай бұрын
Clonidine ER helps a lot with my high bp which I already had before taking stimulants(Vyvanse) with amlodipine
@PsychiatrySimplified
5 ай бұрын
Yes its very useful in a range of ways. Often beneficial as a co-prescription that can reduce the activating effects of stimulants
@fwps
8 ай бұрын
Dear Sir, I've had occasional exposure to amphetamine isomers and methylphenidate for around 40 years. Prior to any psychostimulant exposure, my first-ever BP reading at age 14 years was 140/90. I am now medicated with anti-hypertensives and I record my BP on a spreadsheet daily for my general practitioner. The averaged results and my ECGs are normal. I'm prescribed a small dose of dextroamphetamine sulphate in an immediate release formulation for professionally-related ADD symptoms. What does this all mean for me in a cardiovascular context, in relation to the outcomes of the clinical trial analyses you've discussed?
@ndcollective
9 ай бұрын
Thank you for your EXCELLENT discussion of this study!
@PsychiatrySimplified
9 ай бұрын
Glad it was helpful! Appreciate your generosity
@Liahs333
9 ай бұрын
Thanks! We need more channels like yours ❤
@PsychiatrySimplified
9 ай бұрын
Wow, thank you for your generosity🙏🏼. Your feedback motivates us.
@ashy107
8 ай бұрын
Very informative. I have a question related to people with ADHD and higher risk of cardiovascular disease because domaine plays a role in reducing inflammation. What if those with adhd engage in high levels of dopamine with hyper focus on activities that induce a lot of dopamine. Or is it specific dopamine release from say a neuro typical person that is required to maintain normal levels of inflammation. Hope that makes sense.
@PsychiatrySimplified
5 ай бұрын
We need optimal levels of DA. Both too much and too little can be harmful.
@semmanuellinus6339
9 ай бұрын
Can you talk about cognitive disengagement syndrome and treatment options?
@PsychiatrySimplified
9 ай бұрын
I’ll try to address this in a future video
@Liahs333
9 ай бұрын
Dr. Rege, I am a 51 F with a confounder of a history of poly substance use (10 yrs active, 5 yrs sober) with 5 yrs on Methodone maintenance therapy that now since returning to full time, computer work, I have either narcolepsy/sleep apnea affecting my daytime wakefulness. My doctor has tried me on Vyvanase 50mg which helps but I have noticed I’ve been getting chest pain lately. Then your video shows up. I would appreciate any thoughts but I really wanted to thank you for your always informative videos. I also have a side interest in psychiatry 🩵♥️🇨🇦
@PsychiatrySimplified
9 ай бұрын
Would be good to get a sleep study and a sleep physician opinion. When Vyvanse is prescribed and sleep difficulties are present this can increase arousal and hence HR and BP, agents like clonidine when used as a synergistic agent with the stimulant provides a good buffer. We have done a video on clonidine . “Clonidine should be used for cardioprotective prophylaxis in patients with a contraindication to β-blockers.” It is also cardioptiective and has anti-HT effects along with benefits in sleep and reducing hyperarousal. Ps not advice.
@Liahs333
9 ай бұрын
@@PsychiatrySimplified Awesome, so interesting as I was prescribed Clonidine for quite awhile when first going through withdrawal and stopped when I started to feel better. Perhaps, it’s time to check back in. Also, I was going to have a level 3 sleep study but they felt because of the medication I was on to refer me on to a level 1 sleep study. So now I wait for a referral to a Respirologist and in the meantime take the Vyvanase. Thank you again and please keep bringing these fascinating studies to the professionals and the lay people like me ❤️
@redsolaris1
9 ай бұрын
I'd have thought low birth weight would be the most obvious connection between ADHD and Cardiovascular Disease Risk. Did they make any attempt to control for this?
@PsychiatrySimplified
9 ай бұрын
No- these were confounders - matched on age, sex, and calendar time and adjusted for country of birth, educational level, somatic comorbidities (type 2 diabetes, obesity, dyslipidemia, and sleep disorders), and psychiatric comorbidities (anxiety disorders, autism spectrum disorder, bipolar disorder, conduct disorder, depressive disorder, eating disorders, intellectual disability, personality disorders, schizophrenia, and substance use disorders).
@ShadowMan66
8 ай бұрын
Hi Dr, A question slightly off base here. I was put on a dose of Quetiapine 25 mgs to aid with sleep and anxiety. After 8 months I want to come off it as it knocked me out at night and I was sleepy during the day.and my Dr sees no problem just stopping it. Can I just stop as she says or will it cause any nasty withdrawal effects over the short and/or long term?
@PsychiatrySimplified
8 ай бұрын
It's best to discuss this with your doctor as any comment here is general and not advice. Either way if insomnia occurs post stopping your doctor would need to know.
@Unknown-hr4wi
9 ай бұрын
I got exposed to second hand weed, will this get me psychotic, or no? Will it ruin my medication? It happened once. Hope you answer😊
@PsychiatrySimplified
9 ай бұрын
Sorry it’s not possible to answer this question.
@Unknown-hr4wi
9 ай бұрын
@@PsychiatrySimplified can you say why
@PsychiatrySimplified
9 ай бұрын
@@Unknown-hr4wi because 1. In order to make a probabilistic prediction one needs to have a very good understanding of characteristics , family history, illness history etc 2. History of use, etc 3. Predictions in itself are difficult 4. The above needs a thorough assessment in order to make an probabilistic predictions.
@Unknown-hr4wi
9 ай бұрын
@@PsychiatrySimplified my diagnosis is drug induced psychosis
@PsychiatrySimplified
7 ай бұрын
There is a risk of psychosis with exposure to substances like cannabis , speed etc. this however does not mean that it can’t be managed. ADHD can be managed with coexisting past history of psychosis . Studies also show that appropriate treatment reduces the risk of relapse
@mobillegenuiya4586
9 ай бұрын
Can antihistamine cause extra piramydal symptom.like tardive dyskinesia, tardive dystonia
@PsychiatrySimplified
9 ай бұрын
Rare but yes they can
@DennisBolanos
9 ай бұрын
Dr. Rege-do psychostimulants help people without ADHD?
@PsychiatrySimplified
9 ай бұрын
Yes they do . They are best thought of as dopaminergic and noradrenergic potentiators. They are evidence based in treatment resistant depression, cancer fatigue, POTS, chronic fatigue syndrome , narcolepsy and some others.
@DennisBolanos
9 ай бұрын
@@PsychiatrySimplified Great, thanks!
@PsychiatrySimplified
9 ай бұрын
I appreciate your generosity 🙏🏻
@mobillegenuiya4586
9 ай бұрын
Can antihistamine cause tardive dyskinesia, tardive dyskinesia
@PsychiatrySimplified
9 ай бұрын
Rare but yes
@curtiskarner2190
8 ай бұрын
Can antidepressants disinhibit an adhd patient ?
@PsychiatrySimplified
5 ай бұрын
Yes it’s possible .
@mobillegenuiya4586
9 ай бұрын
Sir please tell me, i won't take this as a medical advice. Tell me all the possible causes of vivid dream throughout the whole night
@PsychiatrySimplified
8 ай бұрын
Please read this article for a comprehensive understanding - psychscenehub.com/psychinsights/neurobiology-sleep/
@mobillegenuiya4586
8 ай бұрын
Sir, can antidepressant withdrawal cause slowing brain activity in focal left frontal area of the brain?
@PsychiatrySimplified
8 ай бұрын
Unlikely to lead to focal reductions.
@mobillegenuiya4586
8 ай бұрын
@@PsychiatrySimplifiedbut in my case, it does focal reduction. All i have is tardive dystonia and social phobia (cured with exposure therapy) and supporting evidence is that, it happened just after i gone cold Turkey the antidepressant. What could it be beside that.
@mobillegenuiya4586
8 ай бұрын
@@PsychiatrySimplifiedWhat do you think of probability that it is the cause?
@mobillegenuiya4586
8 ай бұрын
Sir what is it, can antidepressant withdrawal cause this : can't nap during day, it can, but, your eyes closed but you feeling like not sleep (it supported by the absent of sleep spindle activity i got EEG done ) and at night it is also like that. Ps not gonna take it as a medical advice
@mobillegenuiya4586
8 ай бұрын
Id like to know about slowing brain activity and all of that, where could i read that?
@PsychiatrySimplified
8 ай бұрын
For brain EEG a neurology resource .
@mobillegenuiya4586
8 ай бұрын
@@PsychiatrySimplified is that the title of it?
@PsychiatrySimplified
8 ай бұрын
@@mobillegenuiya4586 here is a resource neurology.med.wayne.edu/pdfs/how_to_interpret_and_eeg_and_its_report.pdf
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