Review the alpha-2 medications clonidine and guanfacine. Understanding the alpha-2 agonists mechanism sheds light on how these medications work and their potential therapeutic benefits💡Anti-depressant Course: www.psycho.far...
📖 PsychoFarm's Treating Depression Book: a.co/d/3M0uFui
================
Follow PsychoFarm:
🔴SUBSCRIBE ► www.youtube.co...
🧠Mental Health Resources: www.psycho.far...
➡️Instagram: / thepsychofarm
➡️Tiktok: / thepsychofarm
➡️Twitter: / thepsychofarm
================
The video explains the mechanism of action of clonidine and guanfacine, which are alpha-2 agonists used to treat ADHD. Clonidine acts on all three subtypes of alpha-2 receptors (A2A, A2B, and A2C), while guanfacine is more selective for the A2A subtype, contributing to its improved efficacy and reduced side effects. The mechanism is confusing because alpha-2 receptors have opposite effects depending on their location. Presynaptic alpha-2 receptors inhibit norepinephrine release, while postsynaptic A2A receptors in the prefrontal cortex enhance norepinephrine levels, improving attention and impulse control in ADHD. The A2B subtype in the thalamus has more sedative effects, and the A2C subtype in the locus coeruleus contributes to hypotensive and sedative actions. The video also discusses Stahl's paradigm, which suggests that ADHD involves finding the right balance of norepinephrine and dopamine signaling, with alpha-2 agonists optimizing norepinephrine levels to enhance signal and improve emotional control and hyperactivity, although they are not as effective for cognitive symptoms as stimulants.
#adhd #psychopharmacology #pmhnp
Негізгі бет Alpha-2 Medications Clonidine and Guanfacine Mechanisms (Alpha-2 Agonists Mechanism of Action)
No video
Пікірлер: 34