You are asking a Question that comes-up ALL the time! Let me try to address it as simply as I can: Any drug that works by blocking the "muscarinic" ACh Receptor sites will block the parasympathetic actions on the visceral organs. This allows the sympathetic autonomic motorneurons to exert the dominant effect ON THE VISCERAL ORGANS. IN ADDITION, any drug that works by blocking the "muscarinic" ACh Receptor sites will ALSO BLOCK THE ACTION OF ACh IN THE CNS (BRAIN). In the CNS, ACh is primarily EXCITATORY. This causes an overall decrease in electrical activity in the Brain, causing drowsiness & lethargy. YES; on the surface it looks a paradox: "Stress state" on the VISCERAL ORGANS (peripheral action), but drowsiness in the Brain (central action)! BUT it is all based on blocking the muscarinic ACh Receptor sites: (1) on the visceral organs and (2), in the Brain. Thus, drugs that block muscarinic ACh Receptor sites, like atropine, or many drugs with "atropine-like" actions (including Antihistamines) cause CENTRAL sedation (drowsiness) and are even used to slow-down electrical activity in the Vestibular (Balance) Reflex Center and Vomiting Reflex Center and are prescribed to reduce "motion sickness" (such as meclizine & cyclizine.) Good Question!
@lainaamadhila8114
4 жыл бұрын
What are the 5 common antihistamine drugs with sedatory properties?
@jsvlad
8 жыл бұрын
You are a true Champion! I think you have 5 dislikes from other professors who wish they could be doing what you are doing
@YLSESERRANO
11 жыл бұрын
Professor Fink your lectures are amazing! I watch them for fun, they are very informative.
@barbarabasia9804
10 жыл бұрын
Thank you Professor Fink, your lectures are helping me prepare for the provincial Nursing Exam (Canada). Youre a great teacher, and you explain concepts very well.
@professorfink
10 жыл бұрын
Thank you for your kind words. Best Wishes for your SUCCESS!
@heliosantos1193
11 жыл бұрын
I say: Professor Fink, you are the best. Professor Fink say: I don't know what you are talking about. I Said: In page A378, where I talk about "all the greatest teachers ever", your name is number one in that list.
@nellyhoffman6194
8 жыл бұрын
This is a great professor ! i learned so much from you than from my university god bless you
@dustrabosigo673
5 жыл бұрын
You helped me get through my pharmacology back in 2013, God bless!!
@aliceyang1185
2 жыл бұрын
Thanks for sharing your presentation with public, you are the best professor in my life ! !
@user-xp3cg6dz4h
9 ай бұрын
Ohh I love professor fink ❤God bless your heart 😊
@jatinsehgal8448
9 ай бұрын
Thank you very much professor FInk the lecture was very beautiful organized really helped me a lot to clear my concepts.
@TheHappySharer
11 жыл бұрын
Thank you very much from your neighborhood pharmacist. I appreciate your impressive presentation and passion in teaching...way better than many of pharmacy school professors...Please keep up the good work. You are the reason my explanations (to sick patients) are friendlier and easier to understand.
@hotpersiangal
9 жыл бұрын
You are inspiring, if all lecturers where like you then students will be willing to continue their education. I am currently revising for my preregistration Pharmacy exam :)
@SeeWhatISee3
11 ай бұрын
May god bless you. You have taught very well❤
@Taisho74
11 жыл бұрын
Captivated me for the whole video. Histamine/Antihistamine made easy.
@haroldplatypus2732
4 жыл бұрын
Professor Fink, you're the man! Your fine lecture is helping me out with a writing assignment and I sure ain't no scientist.
@ikbaliremalkan4315
3 жыл бұрын
I really enjoy pharmacology thanks to you
@4everanurse
11 жыл бұрын
Professor Fink is the Best.
@TheSarika81
9 жыл бұрын
love your lectures sir ! you are awesome !!! people live you raise the standard for teachers .. you are truly 'GURU"..
@ssempebwadaniel9513
3 жыл бұрын
Very nice lectures. Have benefited alot❤
@ZokieZol
11 жыл бұрын
i wish you were my teacher in every subject
@rcarmona76
10 жыл бұрын
Thank you for your lectures professor Fink, you are a very good professor. Is there a way that I could get your lecture notes. They are very helpful and very informative. Thank for your time and dedication.
@arianabdulkhaliq4703
7 жыл бұрын
Thank you Professor Fink.
@jumatron12
11 жыл бұрын
Great lecture you make reviewing so easy. THANK U
@niranjanpradhan1252
6 жыл бұрын
Fantastic lecture sir, you are a good teacher
@karenmoore2972
7 жыл бұрын
i really enjoyed this!!
@pianopera
9 жыл бұрын
About the so-called "Second-generation" H1-antihistamines such as Zyrtec: In the written out lecture you write that it *does not cross* the Blood-Brain-Barrier. But when you talk about it at around 18:40, you say that they are "less able to to cross the Blood-Brain-Barrier". That's a huge difference. Personally, I have bad experiences taking even half a pill of Zyrtec (for the purpose of reducing allergic rhinitis): even this small amount makes me sleepy, it slows me down both physically and mentally, so I stopped using it. It's simply not true that this "Second-generation" drugs does not produce anti-cholinergic side-effects.
@arielol89
8 жыл бұрын
great lesson
@aeew
10 жыл бұрын
When you say when you can take antihistamines for sleep, shouldn't you mention that this works only with 1st generation antihistamines because these cross the BBB?
@thepharmacistview2490
6 жыл бұрын
even with the second generation we could have somnolence (around 8%)
@Heylookaneagle
11 жыл бұрын
Great stuff! Thank you Professor.
@laylaann2011
6 жыл бұрын
Great professor!
@OJASVIVYAS
11 жыл бұрын
Awesome..Thank you sooooooooooooooo much !!
@AC-tn1cy
7 жыл бұрын
So for. whole body skin itch burning "crawly" and prickling and even numbness will a H1 and H2 (ranitidine and certrizine) taken help this?
@teressazaglin3631
4 жыл бұрын
its 2020...Are you still monitoring the communication during user viewing of your video lectures?
@professorfink
4 жыл бұрын
YES, I am! -- professor fink
@weatherphobia
4 жыл бұрын
Which Anti-histamine, or combinations of, can be or are known to enhance or potentiate the effects or longevity of Opioids for drugs like Oxycodone? And is their a min MG threshold of the Anti-histamine one must take for this enhancement to be achieved ?? Thanks.
@sid31663
6 жыл бұрын
tk u sir for the video lecture helped alot
@kingwls
10 жыл бұрын
i have a question professor. i have almost watched all of your lectures... and you said that parasympathoLYTIC drugs causes the brain to go to a SYMPATHETIC response by DEFAULT... and in a sympathetic response there is CNS STIMULATION... i hope you could answer this. have you just made a small error in explanation or is my analyzation wrong?
@professorfink
10 жыл бұрын
You are asking a Question that comes-up ALL the time! Let me try to address it as simply as I can: Any drug that works by blocking the "muscarinic" ACh Receptor sites will block the parasympathetic actions on the visceral organs. This allows the sympathetic autonomic motorneurons to exert the dominant effect ON THE VISCERAL ORGANS. IN ADDITION, any drug that works by blocking the "muscarinic" ACh Receptor sites will ALSO BLOCK THE ACTION OF ACh IN THE CNS (BRAIN). In the CNS, ACh is primarily EXCITATORY. This causes an overall decrease in electrical activity in the Brain, causing drowsiness & lethargy. YES; on the surface it looks a paradox: "Stress state" on the VISCERAL ORGANS (peripheral action), but drowsiness in the Brain (central action)! BUT it is all based on blocking the muscarinic ACh Receptor sites: (1) on the visceral organs and (2), in the Brain. Thus, drugs that block muscarinic ACh Receptor sites, like atropine, or many drugs with "atropine-like" actions (including Antihistamines) cause CENTRAL sedation (drowsiness) and are even used to slow-down electrical activity in the Vestibular (Balance) Reflex Center and Vomiting Reflex Center and are prescribed to reduce "motion sickness" (such as meclizine & cyclizine.) Good Question!
@kingwls
10 жыл бұрын
thank you very much professor. This made my day
@ezatullahakbari6199
6 жыл бұрын
Tnx Doctor👍❤️
@adiblue100
9 жыл бұрын
Professor,which university do you taught during this lecture ?
@nigelhoward1729
7 жыл бұрын
is it possible to get the handouts you have to make notes on while we watch your videos?
@professorfink
7 жыл бұрын
Check-out professor fink's web-site for additional resources in Biology, Anatomy, Physiology & Pharmacology: www.professorfink.comDown-loadable e-Books of the Lecture Outlines by Professor Fink can be purchased from the WLAC Bookstore at: wlac.redshelf.com/“Hard Copy” Lecture Outlines can be purchased from the WLAC Bookstore at: onlinestore.wlac.edu/fink.asp
@jkidd3383
11 жыл бұрын
can benadryl destroys the liver if taken once a day in one week.. thanks
@cu99460
7 жыл бұрын
Professor Fink where are your based? In Canada or America?
@wwfww
9 жыл бұрын
what a great lesson, you know here in my country (portugal) teachers are always telling us how worthless we are, how we can't compare to british and american med students and etc, but honestly most of the british and american teachers also give much better lessons and have a great attitude too!
@plasmamembrane5118
8 жыл бұрын
What are the use of Anti-Histamin in normal patients? :( How could i make it about 5/6 page for an assignment ? Thank You :)
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