Have been aware of this for decades. Thanks for the detailed review. Surprised any antibiotics work anymore. Isn't this also a problem with antifungals? Any evidence (and this assumes new classes of antibiotics are developed) that treating with two or more antibiotics at same time reduces chances of resistance developing? It seems just using one antibiotic at a time is a recipe for resistance to develop.
@WhiteboardMedicine
2 жыл бұрын
Some are proposing this much like antiviral therapies for HIV that require combination treatments to prevent resistance, which use to be a big problem
@cynthiacole6140
2 жыл бұрын
Yes and glad you mentioned antifungal. There are only 2 or 3. As someone who got a systemic fungal infection, this was frightening news.
@marklemont3735
2 жыл бұрын
Is there a typical infection which happens in the lungs with COVID, in older or high risk people, and if so what is/are the antibiotics which help fight it?
@therevolutionwill23
2 жыл бұрын
I saw time lapse video produced by mycologist Trad Cotter of South Carolina of strep he cultivated from his son's throat put next to oyster mushroom culture (pleurotus) in a petri dish and the oyster mushroom culture encircled and completely killed the strep in about a day. According to Cotter, the pleurotus produces a unique and extremely specific( to that particular strep) metabolite that would need to be diluted many fold in order to be used safely in humans. Fascinating stuff.
@phillee2814
2 жыл бұрын
It is a regular feature in mainstream media here in the UK, and people are routinely tested for the most common strains of multiresistant bacteria on admission to any NHS hospital. I know of research being conducted here, funded by various bodies, like the Wellcome Trust, the NHS, and several universities. The most common one here is MRSA (Multi-Resistant Staphylococcus Aureus is how they use that acronym here in the UK), which I have been tested for several times. Almost every doctors' surgery has posters warning of antibiotic overuse and particularly the need to always complete a course if prescribed - many people stop taking the antibiotic as soon as they feel better and have no symptoms, and leave the bacteria most resistant to the antibiotic still alive. A month or so later, they return for further treatment and a stronger antibiotic needs to be used, and a new resistant strain has been created. "Precautionary" use of antibiotics is heavily discouraged. I hate being given antibiotics, as it takes months to rebuild my GI biome, which is necessary for the absorbance of many nutrients - every antibiotic I've ever had causes major GI effects as it kills the lot, including the good bacteria we rely on.
@janeolinger8038
2 жыл бұрын
Although with reluctance, I do have to admit my great respect for and appreciation of bacteria! Powerful little creatures they are!
@janborkowski6659
2 жыл бұрын
Thank you! Very clear presentation to help us understand the perils we face with antibiotics.
@WhiteboardMedicine
2 жыл бұрын
Always our pleasure! Thanks for checking it out!
@sheryl3268
2 жыл бұрын
Thanks for covering this important topic. Some of these details I was not aware of. I appreciate your details. Two things in the presentation weren't so clear to me, perhaps you can clarify here and/or include it if/when addressing the topic in the future. First, the easier one. How does antibiotic use in farm animals become abx resistance in humans? Is the danger to create abx resistance in humans because the abx resistant strains in the animals can infect humans directly or is it residual abx in the food produced from those animals affecting bacteria in humans to become resistant that way? Or is it a combo, or something else entirely? Now the other one. If abx resistance in bacteria can be transferred from one to the other via bateriophages, yet those phages destroy the bacterium, how does the abx resistance spread become an issue? Is it that the phages take longer to destroy the bacteria than the abx resistance is gained and longer than the abx resistant bacteria take to harm the human.. or do the bacteriophages that take abx resistance with them not really destroy the bacteria? How would developing bacteriophages that affect infectious bacteria be any better at killing the bacteria or any less likely to spread abx resistance? Thanks again for all you do!!
@annae9639
2 жыл бұрын
Oh man..more to worry about😣
@eelkeaptroot1393
2 жыл бұрын
Yeah, they've been complaining about this for decades now, the most notorious one is the one called MRSA, but I also heard about TBD at some point, a tuberculosis variant that's multi resistant, more common in parts of Eastern Europe.
@osmanfb1
2 жыл бұрын
thanks for the interesting video. I have been aware of this for some time. But I have a problem with that CDC chart of different pathways of transmitting the resistance information between the bacteria. If a phage injects its deadly load into a bacteria, then that will end of causing the bacteria to lyse. How is this a pathway for transmission of genetic material? seems like a dead end to me. unless when the cell dies its content is spilled over maybe including some genetic material??
@pattidean4811
2 жыл бұрын
Is there any financial gain in extensive research and production of new antibiotics for the future ? I’ve talked with many people (including those in the medical profession) who are seeing that maybe, just maybe , in the long term profits for the big guys are coming before the health of the little . I know there are amazing scientists out there working for the greater good of people’s health, but $ can squash their greatest intentions . Still hopeful good will win . Thank you for thorough information .
@WhiteboardMedicine
2 жыл бұрын
Absolutely!
@alainacarroll1234
2 жыл бұрын
I got to thinking about this more and started to wonder if antibiotics used in livestock have maybe even a small part of this.. I know the hormones used in all the animals aren't good for people; I can't imagine consuming antibiotics consistently would be healthy either.. I'm not a doctor, nor do I have much of any medical or farming background.. Just my random (literal) shower thoughts..
@NBT2469
2 жыл бұрын
Too much antibiotics do this. We need to be more careful about this, from now on.
@a.figueiraroxa9859
2 жыл бұрын
Colloidal silver?
@minerblake7494
2 жыл бұрын
Doc, I'm excited to see your focus on a new and important topic. (bored with SARS)
@WhiteboardMedicine
2 жыл бұрын
It is nice to veer away from COVID content, that’s for sure! Hoping you all find some other topics interesting and rewarding as well!
@minerblake7494
2 жыл бұрын
@@WhiteboardMedicine I haven't looked at the transplant vid yet.
@cynthiarosa217
2 жыл бұрын
Do you think mass vaccination will contribute to thus event, turning our immune system into a concocted by genetic therapy “army” against Covid, and less effective against other infections?
@austinauigbelle7467
2 жыл бұрын
What about bacteriophages? Aren't they used to kill superbugs?
@kaceeboxers3580
2 жыл бұрын
What about going back to nature to look for more answers? Oil of oregano, honey, lemons, aloe Vera, various root extracts, clays, charcoal, c silver, coconut oil. My cabinet contains all of this and more and while these natural or more natural items do not fix everything, they can fix a lot. My feelings on antibiotics are they should only be used as a last resort. Not natural, but also beneficial are hydrogen peroxide, iodine/betadine, and a nebulizer.
@DSonBlue
2 жыл бұрын
Playing devil’s advocate for a second: Could these (so-called) super bugs - that are able to adapt to ignore antibiotics - be explained by anti-biotic FAILURE? What I mean is, the figures mentioned for antimicrobial resistance are in fact (relative to patients treated globally) so small - and the bacteria being treated so common - could it just be that the drug manufacturers are just using this as an excuse for their product having a certain (expected) failure rate? In other words, if this were such a big problem, surely after 30 years we would have had a global pandemic (or three) resulting from these so-called super bugs? I postulate that we haven’t because the single source of truth in all of this is the immune system. Surely it stands to reason that a “super bug” would - if this were a genuine problem - go on to infect many more people as it passes on to other hosts? Please forgive the cynicism - happy to be educated here.. but right now I’m hyper-sensitive to the motives of big pharmaceutical right now!
@theoxfordrunner
2 жыл бұрын
Hi there I am studying immunology to a masters level atm so I will not clam to an expert. There is no link between antimicrobial resistance and the ability of the bacteria to evade to immune system. This is because antimicrobials work in a very different way to the immune system. Antimicrobials target structures that are common to large groups of bacteria therefore if a bacteria can change that structure (for example a cell wall) the antimicrobial no longer works. This does not work with the immune system as it can adapt and change. As of now most of the bacteria that have developed resistances to antimicrobials have not developed resistances to all of them and those that have are not very good at infecting healthy people. The worry is that as bacteria continue to develop antimicrobials resistance a bacteria that is good at infecting a humans will develop antimicrobial resistance. Just because something has not happened yet does not mean it will not happen and as more bacteria become resistance so do the chances of bacteria causing a pandemic/epidemic in the western world. The truth is bacteria have caused pandemics in the past (the black death) and if they become immune to the drugs we use will again. As for not trusting pharmaceutical company’s this is fair as in the US they are often out scam people for as must money as they can get for there produces (Im from to UK so this affects me less although still a bit). But try not to let Ur self-distrust science. People do not go into science partially biology for money or power as in truth is there is not must of that in the field. The people who study these things almost always do to for one or two reasons the first being to help people and the second being knowledge or knowledges sake. Either way they have no reason to lie to you. I hope this helps
@DSonBlue
2 жыл бұрын
@@theoxfordrunner Firstly Sam thanks for taking the time to explain anti microbiology to me - helps a lot! 👏🏻 Secondly, I don’t distrust science (completely the opposite), and one thing that has come from this pandemic is I have learned to massively respect scientists. I have nothing but respect for their passion and patience, for the more there is to know, the more both qualities are required! Finally, I do have a healthy distrust of those (inc. the talking heads of big pharma and the like) that push a narrative that doesn’t align with scientific reason. Hope that all makes sense and again, thanks for your time and good luck in your future career 👍🏻
@guapodesperado2822
2 жыл бұрын
Get on a healthy nutritional diet and stock up on colloidal silver, folks.
@dennisgarber
2 жыл бұрын
I do not argue any points in this video. However, the truth goes far deeper and has a few more factors. Before you close the "book" and cement your opinion (I could hear real conviction, emotion, in your voice), download the audio book called Bottle of Lies by someone named K. Eban. I do not think any medical professional should not thoroughly listen to this book. I am especially open to this book as I have watched in horror the quality and price drop of goods sold in the USA over the past 20 years. The lack of morality....(It failed to post due a banned book reference , trying again.)
@rogerscottcathey
2 жыл бұрын
His first discovery was lysozyme. Hydrolases are better than antibiotics.
@rogerscottcathey
2 жыл бұрын
Flemming had a cold a drop from his nose fell on a sample plate. He let it be rather restart the plate. Next day it showed that the subject growth stopped at the effluvium. Lysozyme is among the slower hydrolases. Hydrolase inhibitors are typical defense mechanisms used by microbes. Either physically incorporated into their surface and secreted into the milieu. Enzyme reactivaters are able to restore the digestive enzymes. Mendel and Blood discovered that Hydrocyanic acid was such an enzyme reactivater. In fact papain was practically inert without HCN and operated very slow. So HCN can be termed an accelerator as well. It is a co-catalyst or B I vitamin. The simplest. This I believe is actually the true front line of immunity, the free floating serum hydrolases in conjunction with HCN.
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