From Aaron Quinlan's course on Applied Computational Genomics at the University of Utah (github.com/qui.... This lecture covers the concepts of "genome arithmetic" behind bedtools. Collectively, the bedtools utilities are a swiss-army knife of tools for a wide-range of genomics analysis tasks. The most widely-used tools enable genome arithmetic: that is, set theory on the genome. For example, bedtools allows one to intersect, merge, count, complement, and shuffle genomic intervals from multiple files in widely-used genomic file formats such as BAM, BED, GFF/GTF, VCF. While each individual tool is designed to do a relatively simple task (e.g., intersect two interval files), quite sophisticated analyses can be conducted by combining multiple bedtools operations on the UNIX command line.
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Applied Computational Genomics - 13 - An introduction to bedtools.
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