At the end of the video would you consider zooming all the way out so that I can see the entire picture and make sure I can see/talk it out to myself?
@ruchita6801
5 жыл бұрын
@@louie188 thanks~~
@maxtonfletcher8436
3 жыл бұрын
Instablaster...
@sumeetha
10 жыл бұрын
You would be the reason I graduate from med school.Thank you so much for making this course so much easier. I wouldn't be able to do this if it wasn't for your tutorials.
@isaacalade6359
10 жыл бұрын
added to my pharmacy playlist! awesome vid
@TheLastVigil1
7 жыл бұрын
OMG, you are a savior! Thanks from the Vet student from Latvia!
@angelajohnson6908
10 жыл бұрын
Thank you! So straightforward when you explain it!
@maxfactorone
10 жыл бұрын
Brilliant ! thanks for making this subject clear and simple...
@FooCork20
12 жыл бұрын
Thank you, 6 weeks of hard to understand lectures condensed into 7 mins of easy to understand video. University lecturers should be afraid of these videos, they could easily take their jobs!
@Naseemzarin
9 жыл бұрын
how can these videos have unlike??? omgg ure amazing
@ismailchaudhary8901
3 жыл бұрын
Some Haters ...
@ticklemepurple86
10 жыл бұрын
Well done... So neat and organized! Thank you :-)
@buqbooQ
3 ай бұрын
wya rn
@sohamparikh3085
11 жыл бұрын
hey I am a post graduate and was still fumbling with that.. appreciate your efforts, it certainly did help.... Thanks !! :)
@buqbooQ
3 ай бұрын
defo post post graduate rn
@drabdullahameer5505
11 жыл бұрын
funtastically explained A.A acid...a great help thank you sir
@sajaal-khattab2183
10 жыл бұрын
one of the best videos .. great work !!
@danypetrix
12 жыл бұрын
AMAZING!!! I'll never forget it!!!
@madchen.roentgen
11 жыл бұрын
DUDE... YOU'RE A GENIUS !!!
@MrBearic
10 жыл бұрын
Thanks for the review! Just want to add a few things now that things are coming back to me: PGE2 --> uterine contraction; NSAIDs might be good for menstrual cramps. Prostaglandin also affects the kidneys; NSAIDs can cause kidney failure/damage.
@hasankuliyev4211
5 жыл бұрын
amazing explanation. Thank you a lot
@Canuck403
11 жыл бұрын
Very well described thanks!!!
@ChippyChoppyNagle
12 жыл бұрын
Fantastic, thankyou
@abedmohammad
12 жыл бұрын
thaaanx
@djurovukotic7655
11 жыл бұрын
AS i bodybuilder, i supplement with AA at 1000mg before every workout! Its a product called X-factor by molcular nutrition. Well the point is to cause inflammation in the muscles, which in results tells to body to send nutrients and blood into them, this then has a positive effect on muscle building. Any thought on this kind of use of AA ?
@Bindasjhakyass
9 жыл бұрын
I have one question but i am not sure whether its related and it is really confusing me . I want to know that if Arachidonic acid and the cyclooxygenas enzyme could be produced from the same cell . Does COX and AA could have same site of production ? Ok even i could include LOX.
@darrellng7617
8 жыл бұрын
+Black Mimosa I can't find those either..where does COX come from?
@eric-sunnynatangwekambonde1340
8 жыл бұрын
+Darrell Ng COX 2 is selectively produced by the enterocytes but COX 1 can be produced in any cell under inflammatory conditions.
@dochawk9449
11 жыл бұрын
Only if our lecturers explained things this clearly, they just assume that you know the basics and overload you information right from the start :(
@ericemericaful
8 жыл бұрын
Thank god 2011 is over and people dont still make writing videos!
@heidiblack-twist1541
6 жыл бұрын
Watch at 1.5x speed. You’re welcome
@مصطفىمحمدعبدالكريم-ب8ق
8 жыл бұрын
Amazing tutorial, the explanation was simple and informative. Keep up the good work
@bellalee3872
9 жыл бұрын
Hello. Can anyone tell me what's the sentence on 7:04 'this is because the protective ________ of the prostaglandin on the stomach......' Thank you in advance
@rhiannonbreezesturgess9870
9 жыл бұрын
protective effect
@106066
9 жыл бұрын
This video is amazing, just watched it for fun a year after I found it for physiology homework.
@Lazyweazer
9 жыл бұрын
Thank you so much you helped to find out what was actually the role of COX but i heard that painkillers may also have effect on the kidney. Can someone please explay me short why ? ( sorry for my bad english i'm actually french )
@euniceannedulatre1505
9 жыл бұрын
thanks alot! this vid helped me understand our eicosanoid lesson in my metabolism subject
@abelincolnparth
8 жыл бұрын
COX 1 and COX2, acylation by aspirin, time course of action compared between Aspirin and other NSAIDS ? What I understand is that when COX is inhibited, the AA is shunted to make more leukotrienes and that is the cause of the broncoconstriction. Where does the Phospholipase A2 come from? I know some comes from the pancreas but I assume that is not the source here.
@swashnaavneeta943
6 жыл бұрын
abelincolnparth hi, phospholipase A2 is released due to any stress to phospholipid layer (the cell membrane)..
@فلانالفلاني-و5ك4ه
7 жыл бұрын
Omg man I’m studying Pharma and I just got these point only from you
@user-ac.97
6 жыл бұрын
Very useful video. Keep uploading many more like this in medical physiology.
@Antitroll2011
11 жыл бұрын
I am doing a project on Aclovate, a topical corticosteroid. Now, you mentioned that non-steroidal anti inflammatory inhibit the production of COX. However, what do steroidal anti-inflammatory inhibit?
@Sam_1964
4 жыл бұрын
Phospholipase A2
@lebaneselearner
10 жыл бұрын
Very good. However, I do think that you are missing a step between the production of arachadonic acid and PGH2. The formation of PGG2.
@harpinmartin
11 жыл бұрын
Hi Leandra, I'm from Melbourne, Australia.
@pragadeeshwarisampathkumar7752
7 жыл бұрын
Was easy to understand n recall!! thank u 😊
@chinyere95
10 жыл бұрын
Thank you!! This saved my fine ass
@AliRaza-wg9pt
5 жыл бұрын
😂
@msthiramoti5855
9 жыл бұрын
Really helpful, simple and easy to understand. Thanks a lot.
@youngjay1574
10 жыл бұрын
Cox Blocking @ it's finest.
@geeberryphahla2502
10 жыл бұрын
thank you for this. brief, clear and simple..
@123qwe82
11 жыл бұрын
Finally! I understand this yessss
@ahmadziaahmadi7529
6 жыл бұрын
IT WAS REALLY HELPFUlLL .AHMAD AFGHA
@avinashpendhe6225
6 жыл бұрын
Very useful... Thank you
@vesselofpeace
10 жыл бұрын
This is gold! I finally get it thanks to u:)
@sid31663
11 жыл бұрын
From where do phospholipase A2 come from?
@Abhiqismat
11 жыл бұрын
Steroids inhibit the key enzyme Phospholipase A2, so the entire cascade is blocker, thereby Streroids can play a beneficial role both in Asthma and Inflammation. :)
@dr.allmight7810
5 жыл бұрын
watch at 1.5x
@Laraian2030
11 жыл бұрын
I don't understand how can arachidonic acid give thromboxane and prostaglycin which would work in opposite manner ?!
@kurdaware
10 жыл бұрын
Thank you .well done
@simsimx8911
6 жыл бұрын
Thank you
@jennygrant6162
3 жыл бұрын
This was an excellent video... thank you
@KatieFerraro1
10 жыл бұрын
super helpful, thank you!
@rebekkahportelli1210
5 жыл бұрын
very helpful video explained brilliantly and in a sequence thankyou :)
@loveleenishar799
8 жыл бұрын
thanks fr the video bt i have one question. i didnt get how aspirin was gud fr heart ?if it inhibits activity of cyclooxygenase so how could it possibly produce prostacyclins?plzz HELP !!
@syafiqkhairul1255
8 жыл бұрын
it inhibits Cox pathway in both platelts and endothelial cell..however endothelial cell has nucleus, thus able to regenerate the COX...soo aspirin will shift towards anti coagulant state..I think
@smileyhenke1
11 жыл бұрын
WOW! very good and educational video. Thanks alot!!
Fantastic explanations & easy to understand. Thank you sooo much & I'm hoping with enough practice these short vids will really help with my Pharmacology exam :-)
@trinamr7
12 жыл бұрын
this is a wonderful video do you have any videos on Glycolysis, ETC, Oxidative Phoshorlyation
@jadon12341
12 жыл бұрын
I have always found it easier to understand what I am reading with the aid of visuals , Thank you very much for making these videos.
@speedhuntergodhunter
11 жыл бұрын
the first pathway is 5-lipxygenase
@kategray4548
11 жыл бұрын
very educational, easy to understand
@doctoroberoi
12 жыл бұрын
Marvelous! very clear voice which makes it easy to understand the process.. thanks a bunch!
@jimmyhearne1
12 жыл бұрын
Far out...if only you were my lecturer...I'd be less confused during class! Thank you!
@ibrarmustafa
11 жыл бұрын
Very easy to understand like this!
@UmerSaeed-ch6mn
5 жыл бұрын
But PGE2 is for pain and fever not D2
@Ponine14
12 жыл бұрын
Wonderful overview. Amazing that weeks of lectures couldn't convey what you did in 7.5 minutes. Keep up the great work.
@leandrageyser6434
11 жыл бұрын
to answer my own question.... definitely Australian!!!! Thanks so much!!! ive watched it many times xx
@briam143_
5 жыл бұрын
Thank you this has really helped!!!
@gooddoctor6434
4 жыл бұрын
Thank you so much❤❤❤❤❤❤❤
@leandrageyser6434
11 жыл бұрын
THANK YOU!! where are you from I wonder? I cant place your accent for sure?
@LovingLife094
11 жыл бұрын
wow! the way you link everything together, makes everything just click!. thank you sooo much!
@VictorMikeLima
7 жыл бұрын
Excellent video, thank you!
@Maram379h
12 жыл бұрын
best video 👍 Thank you
@sholomlevitin8407
11 жыл бұрын
Amazing. You just saved me for my Cell and Molec test!! Keep on making these videos.
@wittynatty9820
8 жыл бұрын
Sir. Why does the body produce substances which is harmful to it ?
@rodjar13
8 жыл бұрын
To state that Thromboxane A2 is 'bad for the heart' and therefore harmful to the body is an oversimplification. Thromboxane A2 (TXA2) is released by platelets once they are activated- that is, once they have bound to damaged blood vessels and are in the process of creating a 'platelet plug' as the first step in repairing that damage. The released TXA2 recruits other platelets from circulating blood to assist in covering the site of damaged blood vessel. In this case, TXA2 is very GOOD for the cardiovascular system and the body as it allows for efficient blood vessel repair. However, individuals who have an increased risk of thrombus formation (blood clots) can reduce this risk by inhibiting the release of TXA2 and thus reducing platelet accumulation. Aspirin is given on a regular basis to people with this risk to reduce TXA2 production, not to reduce inflammation. Although aspirin and ibuprofen are both NSAIDs, they have very different pharmacokinetics as aspirin covalently binds to COX (disabling it entirely) whereas other NSAIDs only competitively bind to it. The covalent bond to COX allows for aspirin to effectively disable platelet aggregation (thus why it is known as an antiplatelet drug) whereas other NSAIDs only have a mild inhibitory effect on platelets. In general, any substance produced by the body isn't purely 'harmful', and if it is, it's because not creating that substance would have meant something much worse for the body. For example, harmful substances are created when you are starving as a byproduct of trying to produce energy, but if you didn't create these byproducts you would die much more quickly from lack of energy. The only exception to this rule is during a pathology when inappropriate amounts of something harmful, or production of something harmful at the wrong time, is occurring. Hope this helps :).
@tasneemsabir3632
5 жыл бұрын
this was golden. thank yoU!
@SR7_AMP2
9 жыл бұрын
Thnx....God bless u.
@crazypigs100
11 жыл бұрын
You are getting me through my MPHARM degree!!! thankyou so much.
@stikkle55
12 жыл бұрын
thank you sir
@fidahasan3132
5 жыл бұрын
thanks
@srinivaassunkara3700
5 жыл бұрын
Super
@jevmano9553
5 жыл бұрын
Easy
@sageerahamad6785
5 жыл бұрын
Good
@nurainisyakirahmohdshahidin
11 жыл бұрын
i love this explanation.. very useful.. thank you =)
@skyman2906
8 жыл бұрын
Best explanation, thanks
@amathews9
13 жыл бұрын
dude you are a genius!!! thank you!!!
@roshandeoghare3767
7 жыл бұрын
helped me a lot.....thanks
@madeleinestewart2216
12 жыл бұрын
Created an account just to say thank you so much for making this video. Was super helpful since I had no idea what my lecturer was on about. Really easy to understand and saved me listening to an hour long lecture. Thank you!
@buqbooQ
3 ай бұрын
u alive ?
@ashleybowers2775
7 жыл бұрын
Really helpful thank you
@DaSolJoung
9 жыл бұрын
thank you soooooo much (:
@traceyliddell3554
12 жыл бұрын
Awesome! Thanks heaps!
@WinterWonder932
10 жыл бұрын
thank you =]
@JA-zw6gr
11 жыл бұрын
amazing videos, I have seen a few and you make something that looks hard look so easy, thank you so much!
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