"Molecular fate-mapping of serum antibodies and 'Original Antigenic Sin'."
Ariën Schiepers’ doctoral research focused on antibody responses against repeated exposure to viruses and their surface proteins. He and colleagues developed a series of novel techniques that represented breakthroughs in our ability to dissect antibody responses with unprecedented precision. He engineered mice to track the antibody-producing B cells as they undergo training to make better antibodies during the first response, tagging their memory descendants and the actual antibody molecules the descendants of this cohort of B cells will secrete. He found that, upon repeated boosting, the antibody response strongly favours reuse of the first cohort of B cells. New B cells, trained during the second response, only meaningfully contribute to subsequent antibody responses when induced by boosting with sufficiently divergent protein variants.
Ariën Schiepers studied biomedical sciences with a focus on infection and immunity at Utrecht University before joining The Rockefeller University. His doctoral research was supported by a fellowship of the Boehringer Ingelheim Fonds. His master thesis was awarded a best Master’s thesis prize by the Royal Holland Society of Sciences.
More about the Birnstiel Award: www.imp.ac.at/...
Негізгі бет Ariën Schiepers | Birnstiel Award 2023
Пікірлер