Sir what is the treatment for this..my grandmother is suffering from this..plz guide me which specialist doctor I have to consult for this.
@ahmedabd3191
Жыл бұрын
Thx for this lecture, Corticosteroid, because it is the first line treatment of warm AIHA.
@kharboze_asmr
3 жыл бұрын
I have an exam for hematology Master's degree in 4 months and ur videos are really helpful to me even though i still need to read a lot of stuff i get the whole picture of every single topic with ur videos, i wish sth like this existed for other topics like immunology too!!. Anyway i really appreciate your work man. #respect
@MedicosisPerfectionalis
3 жыл бұрын
Thank you so much 😊 Good luck 🍀
@kunaljain197
2 жыл бұрын
I couldn't stop laughing when he said "idiopathic" becoz we are idiots not knowing the pathology!😂😂 Great vid man as always!
@MedicosisPerfectionalis
2 жыл бұрын
Thank you ☺️
@DrogbaPT454
4 жыл бұрын
In case people are wondering: The answer on the question in the end of video is Corticosteroids!; If it doesn't work then maybe splenectomy; In Children you can use Rituximab
@leojanuszewski1019
4 жыл бұрын
Rituximab is also used on adults. I have seen it be highly effective.
@user-fx7zs2kr6c
6 ай бұрын
@@leojanuszewski1019how many years are u okay after rituxan
@nourahaljuwaisri9183
4 жыл бұрын
I loved the video. Great job. Just wanted to correct one point (at 7:09) it is LEAST INCOMPATIBLE BLOOD, which means we cross match the available blood units and decide which one of them is least incompatible then we can transfuse, because we will never find a perfectly compatible unit in warm AIHA as the antibody is pan-agglutinin that react with all the reagents.
@nourahaljuwaisri9183
4 жыл бұрын
It is a Fatal mistake to intentionally give a patient an incompatible blood
@user-dl8ox4lt3k
Жыл бұрын
I was confused a lot, but thank you guys you saved my future patients and my license.
@thiskenyonslady
Жыл бұрын
THIS!!!
@ahmadal_shanqeety802
4 жыл бұрын
Your style of summarising is perfect, as will as the drawing explaining which is the best way of studying for me, I can't study without any sort of drawing
@MedicosisPerfectionalis
4 жыл бұрын
You’re very similar to me!
@Dr.Harini_Sakthivel
2 жыл бұрын
I am a AIHA Survivor
@cxramelty242
2 жыл бұрын
me too :)
@juliamicha
9 ай бұрын
❤❤❤❤❤
@professor9883
Ай бұрын
bless you
@mo7amed3babneh70
2 жыл бұрын
its clear that you are on a hurry in comparison of your other videos , and the mice is not the usual mice i can tell . plz stick to your other mice and try to explain and repeat as you did in your previous videos . very helpful channel and great work
@moomoo6277
4 ай бұрын
i would like to thank you for making these videos. it really is a great help. you make the topics so much easier to understand
@MedicosisPerfectionalis
4 ай бұрын
You're very welcome!
@rosh6369
5 жыл бұрын
Great video :) One issue ( that's not really an issue, just a visual error) I believe the IgG at 2:58 should be inverted as the IgG is recognising Rhesus antigens on the RBC, right? Not presenting the IgG itself (makes exposure of the Fc portion more understandable).
@MrSmejg
Ай бұрын
I love you video, the best at teaching for one to understand and retain info! Well done. By the way, did you speed up your presentation? As suggested by the comment in your previous video? I quite like the normal pace, made it easier to digest all the info.
Great video! I understood what happens to the erythrocyte when it arrives to the spleen: the spleen macrophage endocite the erythrocyte by recognicing IgG from the erythrocyte... But what is the role of the complement (specially C3)?
@MedicosisPerfectionalis
6 жыл бұрын
Thanks for the question...I have explained this issue in this video. kzitem.info/news/bejne/yJms346ErZ-IoYY
@katmeow95
4 жыл бұрын
Thank you! Your videos are absolutely BRILLIANT!!
@MedicosisPerfectionalis
4 жыл бұрын
Thanks a million for your encouraging words!
@mariamughal6697
2 ай бұрын
Ur voice is awesome
@deepvaishnav4506
3 жыл бұрын
Audio quality is very poor. Couldn't understand some parts as it could not be heard.
@luolulin5245
4 жыл бұрын
Thanx for the revisiion. As a mbbs graduate who just diagnosed with autoimmune hemolytic anemia. Wish me good luck : )
@MedicosisPerfectionalis
4 жыл бұрын
I am so sorry 😐 Best of luck to you!
@chanduz4658
3 жыл бұрын
😞😞😞😞😓
@user-fx7zs2kr6c
6 ай бұрын
What medicine did u take
@anishareddysingireddy1799
8 ай бұрын
Great job doctor awesome
@MedicosisPerfectionalis
8 ай бұрын
Many many thanks!
@juliennegrace4155
6 жыл бұрын
Corticoid then rituximab. ..
@MedicosisPerfectionalis
6 жыл бұрын
Perfect 👌
@sonalibhat5149
3 жыл бұрын
But if it is AIHA why are platelet count and wbc increased?
@salilkulkarniindia
3 жыл бұрын
@@sonalibhat5149 Immune response ----> WBC count is increased
@lonak1330
2 жыл бұрын
Great explanation🔥♥️..please can you give me the link of this question ..i searched but i didn't find😔
@shahabuddin6149
3 жыл бұрын
Really great lecture thanks unlimited
@MedicosisPerfectionalis
3 жыл бұрын
My pleasure 😇
@alihasanalrashid3137
3 жыл бұрын
Very nice video 👍🏻 thank u
@MedicosisPerfectionalis
3 жыл бұрын
My pleasure 😇
@VeerabadrenMylappan
3 жыл бұрын
Great video. Thank you! 😊 Just one thing though - hemoglobin levels unit is in grams/ dL- not mg/dL
@MedicosisPerfectionalis
3 жыл бұрын
Oops 😬 Sorry
@MAli-hd4sy
4 жыл бұрын
Very very good
@MedicosisPerfectionalis
4 жыл бұрын
Thanks 🙏
@Verbena_Vetiver
6 жыл бұрын
great video!
@MedicosisPerfectionalis
6 жыл бұрын
Thank you so much...Glad you liked it!
@mirabadrina3863
6 жыл бұрын
Keep up the great work!
@MedicosisPerfectionalis
6 жыл бұрын
Thanks a million!
@Darieee
6 жыл бұрын
Please fix your sound situation, on a proper set of speakers, this video is barely watchable. A quick fix would be to cut everything below 200Hz in your video editor ... and a better one would be improving the acoustics of the room :)
@MedicosisPerfectionalis
6 жыл бұрын
Hey, Thanks a lot for your feedback...This video was recorded in a library room and wasn’t so clear plus I increased its speed to 1.5X...Please take a look at my latest videos, I am sure the audio quality is much better, and if you have any suggestions, I am more than open to try...Thanks again!
@Majaschoice
3 жыл бұрын
For the transfusion part, isnt it best to then transfuse O RhD negative blood?
@noorhamed4690
5 жыл бұрын
Aswesome....Now I was fascinated autoimmune H.A🤗
@MedicosisPerfectionalis
5 жыл бұрын
Thanks :)
@ahmadaljazeeri9287
3 жыл бұрын
Thank you for making these videos 😄
@MedicosisPerfectionalis
3 жыл бұрын
My pleasure 😇
@Ibrahim-0433
3 ай бұрын
at 5:50 mins what will happen to the rest of 50% of the blood unit in the body they are incompatible to the body?
@Roxy__12
2 жыл бұрын
So good thank you!!!
@MedicosisPerfectionalis
2 жыл бұрын
My pleasure 😇
@neroetal
5 жыл бұрын
nice presentation
@MedicosisPerfectionalis
5 жыл бұрын
Thanks 🙏
@deepthimadabushi842
4 жыл бұрын
I Actually got diagnosed with Evan's Syndrome a month ago... Thanks for the information. Really helpful as I'm on prednisone..
@MedicosisPerfectionalis
4 жыл бұрын
My pleasure! I am so sorry to hear about what you’re going through. How is your health now?
@deepthimadabushi842
4 жыл бұрын
@@MedicosisPerfectionalis My blood reports seem normal except for my lymphocyte count very low say 1-2 cells out of 13-20%. and my neutrophil count is off the charts.. Apart from that, I have spells of depression and anxiety.
@MedicosisPerfectionalis
4 жыл бұрын
I am so sorry 😐. Make sure to follow up with your doctor! And don’t give up!
@deepthimadabushi842
4 жыл бұрын
@@MedicosisPerfectionalis Sometimes I do feel like giving up... I do know mine is not genetically related but it is due to somatic mutation. Trying to avoid radiation as much as possible but kinda addicted to them... Distracting myself by doing more research on my condition if they are any support group where i can join and share my experience. :)
@leojanuszewski1019
4 жыл бұрын
@@deepthimadabushi842 Diagnosed with Evans myself this past summer. White cells were fine but was anemic and had undetectable platelet levels. Hospital, IVIG, prednisone, etc. A potential game changer for me has been Rituximab---completed a course of that in September and all cell levels steadily normal since them. There are a couple of E.S. online support groups on Facebook. Hope you are doing better!
@mustafa-hd9625
3 жыл бұрын
Why you give rituximab since it is type 2 hypersensitivity ? And what mean not specific antibody?
@MAli-hd4sy
4 жыл бұрын
Great thanx
@MedicosisPerfectionalis
4 жыл бұрын
My pleasure 😇
@amirasaied5755
5 жыл бұрын
U talk rapidly here than ur usual, I like ur usual tone😢
@MedicosisPerfectionalis
5 жыл бұрын
Don’t worry...It’s only this video
@ilovebeinagirl
5 жыл бұрын
Slow it down to 0.75 speed
@yolyos15
3 жыл бұрын
sorry but i still dont understand what you mean by antibodies have 2 choices either they "fix a complement" or "complement activation is weak" what do you mean by fix a complement??? fix it where?? i feel like im missing the context. :(
@MedicosisPerfectionalis
3 жыл бұрын
The complement proteins are normally floating in the blood. We need to fix them (onto the target cell or tissue) in order for destruction to take place. Hope it helps!
@yolyos15
3 жыл бұрын
@@MedicosisPerfectionalis thank you.
@co-asst_ayubettyhutagaol4932
4 жыл бұрын
thanks you sir!
@MedicosisPerfectionalis
4 жыл бұрын
My pleasure 😇
@danthorngren1826
6 жыл бұрын
Corticosteroids? Your videos are excellent, thank you much!!
@MedicosisPerfectionalis
6 жыл бұрын
Dan Thorngren you’re correct, answer is corticosteroids...Thanks!
@nabilahnurulislami8292
3 жыл бұрын
is the answer corticosteroid?
@published.research6624
4 жыл бұрын
Thanks for the video. Out of curiosity, why is the haptoglobin low in extravascular hemolysis. Sounds like it would be low in 'intravascular' hemolysis
@MedicosisPerfectionalis
4 жыл бұрын
It can be low in either.
@argumentumadbaculum
5 жыл бұрын
Corticosteroids, will it not mask the diagnosis of underlying lymphoma
@jamshaidkhan2971
4 жыл бұрын
I have a question; If we see spherocytes on peripheral film, then why is MCV high because I was under the impression that spheres have less volume then biconcave RBCs?
@lebocarolinenkosi5533
3 жыл бұрын
I guess the macrocytes(due to increased bone marrow activity) are more than the spherocytes in number🤷♀️
@drpepper7801
3 жыл бұрын
Spherocytes are larger...
@bibimaryam7315
11 ай бұрын
Mcv is higher because reticulocyte count os higher which have larger volume thn the RBCs
@sofiaahmed3872
4 жыл бұрын
Great
@MedicosisPerfectionalis
4 жыл бұрын
Thank you so much 😊
@cindyhansen7681
3 жыл бұрын
What if you have both Warm and Cold?
@ELSEDEM
2 жыл бұрын
Great video..but didn't hear much because you were speaking too fast... Nice summary though
@ujjawalbhaidiya7991
4 жыл бұрын
Great sir...... thank you very much I have a question sir .... What is the source of the material I mean the reference...I you answered this it will be a great help sir
@MedicosisPerfectionalis
4 жыл бұрын
Harrison's, Davidson's, Goljan, and Medstudy
@lunaahmed8989
6 жыл бұрын
Q please :haptoglopin is low because there is too much free hemoglbin in the blood flow to bound up with? ..or because of phagocyts ..it is in RBC?? many thanks 🌹🌹
@MedicosisPerfectionalis
6 жыл бұрын
It’s not in that red blood cells. It was a mistake from me. I’ve made a separate video on haptoglobin to discuss that: kzitem.info/news/bejne/soiVzpeJqKllgn4
@lunaahmed8989
6 жыл бұрын
@@MedicosisPerfectionalis thanks alot ..I can't study hematology without your vedios ....you're great👌
@MedicosisPerfectionalis
6 жыл бұрын
My pleasure! Good luck with everything!
@neroetal
5 жыл бұрын
was equally confused about the same,,,, otherwise great progress bro
@andriqukamanahan3208
3 жыл бұрын
I would say corticosteroids is the next step
@ericac2355
6 жыл бұрын
Is Haptoglobin affected by extravascular hemolysis? I thought it would only be affected by intravascular? Thanks for the video!
@MedicosisPerfectionalis
6 жыл бұрын
Great question...Haptoglobin can be low in either type of hemolysis, especially with intravascular...I have explained this in my video: Intravascular Vs Extravascular Hemolytic Anemia kzitem.info/news/bejne/s393xapqiX6aoJg
@yinkus100
4 жыл бұрын
okay, let me try to answer a question today . This patient obviously has signs of anaemia, hemolysis and overworking of the reticuloendotilear system, hmm.. what is the diagnosis? I'm thinking in a 70year old man, possibly warm immume hemolytic disease, so I'll give corticosteriod. I have a question thou, why is the white blood cell count that elevated? Also, I'll rather do further tests. Please, medicosis, shed more light. Thanks.
@MedicosisPerfectionalis
3 жыл бұрын
Steroids is the correct answer. WBCs could be elevated due to many factors including stress.
@yinkus100
3 жыл бұрын
@@MedicosisPerfectionalis l know the answer to my question now, its leukemoid reaction
@hindhind466
4 жыл бұрын
9. What is an iatrogenic cause of AIHA?
@Fizz826
3 жыл бұрын
Last time I had aiha it was triggered by the MMR vaccine in 1996 when I was 22. Now that the COVID vaccine is coming out, can I take it?
@kyau124
3 жыл бұрын
I've tried Rituximab, it didn't work for me. I have been on and off Corticosteroids now as I'm reluctant to Splenectomy. What is EPO? Blood transfusion? Just trying to find an alternative way to get well.
@MedicosisPerfectionalis
3 жыл бұрын
EPO is a hormone that stimulates the bone marrow to secrete more RBCs.
@rubymusqan3792
4 жыл бұрын
wonderful lecture!! but i have one doubt on the treatment of patients with blood transfusion of incompatible type. if the antibodies are nonspecific, then they might as well react with the transfused blood. should i understand it more differently? can u explain?
@MedicosisPerfectionalis
4 жыл бұрын
Can you elaborate please?
@rubymusqan3792
4 жыл бұрын
@@MedicosisPerfectionalis why don't the antibodies react with the incompatible blood type completely? and what does it mean if you say that the antibodies are nonspecific?
@rogeryin5777
6 жыл бұрын
I think the clinical scenario look 2nd AIHA due to chronic lymphocytic leukemia, the Retic count is 8% indicate there is hemolysis, the CLL is mostly affected by B-cell. since Rituximab is specific for CD 20 of B-cell, therefore, I choose A. please tell us the correct answer.
@MedicosisPerfectionalis
6 жыл бұрын
Thanks for your answer...Although it’s not totally incorrect, I prefer “corticosteroids” as next step for the autoimmune hemolytic anemia...Then you can try Rituximab (for the hemolytic anemia as well as CLL)...Thanks!
@rogeryin5777
6 жыл бұрын
I agree, thanks for your reply, keep up the good stuff. your video is very informative.
@MedicosisPerfectionalis
6 жыл бұрын
Of course...and please try to share these videos with others...It really helps...thanks dear :)
@XXXDTVXX
3 жыл бұрын
The answer is corticosteroids
@arianks7668
3 жыл бұрын
Great video as always. I'm not sure if you've already addressed this: antibodies should "grab" the RBCs from the variable region, not the constant region (at 2:59, for example).
@swethagandikota6351
4 жыл бұрын
I have AIHA disorder and suffering with hypothyroidism in which tsh is fluctuating.what can be done.now my condition is normal
Can u tell me the DIAGNOSIS?type of hemolytic anaemia?
@MedicosisPerfectionalis
6 жыл бұрын
Regarding what?
@citlalie9791
4 жыл бұрын
I have sjogrens and I have this type of anemia
@MedicosisPerfectionalis
4 жыл бұрын
I am sorry to hear that!
@ganeshchidambar3299
4 жыл бұрын
this video slightly faster than others :) maybe u drank some strong coffee :)
@MedicosisPerfectionalis
4 жыл бұрын
Hehe 🙃
@Reemessi1
2 жыл бұрын
ههههههههههههههههههههههههههههه
@babariqbal413
Жыл бұрын
If we transfused blood in pateint, can we go for comb test or not ?
@rafaelvieira4267
2 ай бұрын
good question
@bhaveshgarg8142
3 жыл бұрын
how am i ever gonna find the answer to that qn on your facebook page . it has like a 1000s of post and this post will be 3 years before
@MedicosisPerfectionalis
3 жыл бұрын
I am sorry about that! Just email me your questions, and I will answer them for you: medicosisperfectionalis@gmail.com
@Sarah-fy2vf
4 жыл бұрын
Are you ok here ? I like your funny soul 💙 Thanks alot 🌹
@MedicosisPerfectionalis
4 жыл бұрын
I am doing great 👍
@lisahineslh
5 жыл бұрын
This is happening to me. They want me on Rituxan. No one ever did the stool guac test though? What is the purpose for that. Also, have you ever heard of way to attack this holistically?
@MedicosisPerfectionalis
5 жыл бұрын
The stool guaiac test is to rule out bleeding from the gastrointestinal tract...I don’t believe in holistic medicine, I only believe in evidence-based medicine; the one with the randomized clinical trials and meta-analyses. I wish you the best!
@lisahineslh
5 жыл бұрын
@@MedicosisPerfectionalis Oh, they did rule out gastrointestinal bleeding. Thank you for your response.
@MedicosisPerfectionalis
5 жыл бұрын
You’re welcome 😊
@sohailasghar8471
5 жыл бұрын
Splenectomy bcz infection is not going to settle even with antibiotics bcz of continuous extravascular haemolysis .
@MedicosisPerfectionalis
5 жыл бұрын
I will choose steroids first...Think cheap! The diagnosis is CLL causing autoimmune hemolytic anemia.
@sohailasghar8471
5 жыл бұрын
@@MedicosisPerfectionalis Thanks for correcting me .
@MedicosisPerfectionalis
5 жыл бұрын
No worries...You’re doing fine!
@leojanuszewski1019
4 жыл бұрын
Are you familiar with any books on Evans Syndrome? Or a textbook chapter on ES? Thank you!
@MedicosisPerfectionalis
4 жыл бұрын
No! Try UpToDate website (you might have to pay for subscription).
@leojanuszewski1019
4 жыл бұрын
@@MedicosisPerfectionalis Thanks for the tip. 👍
@MedicosisPerfectionalis
4 жыл бұрын
You’re welcome 😇
@cindyhansen7681
3 жыл бұрын
What’s your take on getting Covid vaccine with both Warm and Cold antibodies?
@user-pz9ti1ub8y
3 жыл бұрын
Incompatible blood may kill the patient
@MedicosisPerfectionalis
3 жыл бұрын
That's right.
@eghonghonomonbude4643
3 жыл бұрын
Please, what's the name of ur KZitem page?
@MedicosisPerfectionalis
3 жыл бұрын
Medicosis Perfectionalis
@eghonghonomonbude4643
3 жыл бұрын
@@MedicosisPerfectionalis thanks..... Ooopss, I meant Facebook page🙏
@sipofmedicine7407
3 жыл бұрын
@@MedicosisPerfectionalis LOL😂😂❤️
@nurfasihah1709
2 жыл бұрын
the video is so great. but the way you explain is not as good as other videos in your channel.
@alaaadammohammed2426
2 жыл бұрын
No 1 I guess am I right?!!
@DocAmikable
Жыл бұрын
Splenectomy
@Yaseen1051
Жыл бұрын
corticosteroid i guess
@drtonyissac9297
3 жыл бұрын
Bro what happened to your sound
@shikhavats7898
3 жыл бұрын
I feel like this either medicosis perfectionalis 😑isn't well 🙄r u well or someone else is here 🧐
@tahiransari3917
4 жыл бұрын
Corticosteroid
@rafalaliaseeb8553
2 жыл бұрын
corticosteroid but and i don't why 😂👌🏻
@MedicosisPerfectionalis
2 жыл бұрын
Haha 😂
@hardik7942
5 жыл бұрын
The primary - idiopathic thing. House MD anyone ?
@MedicosisPerfectionalis
5 жыл бұрын
I don’t understand.
@hardik7942
5 жыл бұрын
@@MedicosisPerfectionalis House MD is a drama series based on clinical cases and team of doctors working together. " Idiopathic - we are idiots because we don't know the cause " exact same dialogue in one of the episodes.
@MedicosisPerfectionalis
5 жыл бұрын
Hahahaha 😅
@holzeinn4834
4 жыл бұрын
It's never lupus!
@toufiqenam9516
5 жыл бұрын
Next time pls try to explain the lines by your own method.because we are here to clear the concept.im text book we all have this info.
@MedicosisPerfectionalis
5 жыл бұрын
I don’t quite understand...Can you explain more, please?
@A6Bnito
3 жыл бұрын
Corticosteroids
@1st.marvelvsdc
5 жыл бұрын
Video is fast
@MedicosisPerfectionalis
5 жыл бұрын
True...I made a mistake in that video that I never repeated again.
@BretHitman
3 жыл бұрын
Transfuse
@sabakhan2016
4 жыл бұрын
U speak very fast
@lifeandsciencecomicsfacthi1916
4 жыл бұрын
that is a great effort I really appreciate that may you send me your Facebook account
@dewiarianna
5 жыл бұрын
ur speaking is too fast :(
@mrstmx99
3 жыл бұрын
cause we are idiots :D
@MedicosisPerfectionalis
3 жыл бұрын
Haha 😂
@nurfasihah1709
2 жыл бұрын
next time please give your lecture with your heart. you seems so lazy to explain. anyway thank you for everything hope you improve
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