Genuinely super frustrating how the only thing people care about is my mispronunciation of Alzheimer's instead of the actual story. Yes I know my pronunciation is wrong, I'm sorry. It's how I've always said it and never got corrected in school or by friends so I never unlearnt it; I will ensure I never make that mistake again
@christiantran8454
2 жыл бұрын
its fine we all make mistakes
@DaxtheMilkMan
2 жыл бұрын
It’s ok :)
@Dsyelcix
2 жыл бұрын
Nah I’ve said it that way too.
@caddiebo742
2 жыл бұрын
It's ok, Jesus. We make mistakes.
@aaronngo7793
2 жыл бұрын
Sorry Jesus, forgive us
@zealous6832
2 жыл бұрын
"Science doesn't lie, but people do." I couldn't agree with that more.
@iFYMxDRKNSFALLS
2 жыл бұрын
i said that similar to my friend who says “religion is corrupt and lie” I respond with “science is by man, and man has a reason to make their theories to be fact” and i’ll list some old “scientific facts” and he goes quiet. everything can be manipulated and corrupted
@sefatsilverlake3816
2 жыл бұрын
Could you mention some of those old "scientific lies"?
@delayedcreator4783
2 жыл бұрын
@@iFYMxDRKNSFALLS are you a flat earther
@JoeMama-hf2if
2 жыл бұрын
@@delayedcreator4783 💀
@Unvaccinated69
2 жыл бұрын
@@sefatsilverlake3816 safe and effective
@mmmarisa
2 жыл бұрын
knowing that the paper is fabricated is so upsetting. my grandpa had alzheimer’s and it was difficult watching him struggle everyday until his passing. i hope there is a cure/treatment someday
@MbitaChizi
2 жыл бұрын
Ok dont read my name🙄,
@-whyquestion
2 жыл бұрын
Ratio + k-pop better + NCT outsold 🤳🏼🤳🏼🤳🏼🤳🏼🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓
@dontreadmyprofilepicture270
2 жыл бұрын
DONT READ MY USERNAME!!!
@martinpadilla5224
2 жыл бұрын
Dang bro I feel that one. I'm sure we will find a cure one day.
@savy473
2 жыл бұрын
my fucking god these bots im so sorry for your loss
@SaltyGamer41
2 жыл бұрын
This hits on a personal level. I lost a family member to this disease and have been donating towards its research for almost a decade.
@sonikblade
2 жыл бұрын
My condolences dude... I think that sums up the role thing actually, people are donating for this kind of researches cause there is not enough incentive for those to be able to maintain itselves alone, and in those scenarios of low incentives the scientists become more vulnerable to being corrupted or bought...
@icryglitterandfartrainbows
2 жыл бұрын
Same that's quite awful
@Crqnki
2 жыл бұрын
that sucks. sorry for your loss
@Princess_Aubrey
2 жыл бұрын
Aww.. sorry for you lost man.
@sareatonin
2 жыл бұрын
I know exactly how you feel, I lost my grandma years ago and my mom has never been the same. it’s such a heart breaking disease.
@yourfriend9251
2 жыл бұрын
“Science doesn’t lie but people do “- Charlie , love that quote
@WadeAlma
2 жыл бұрын
Science is what we believe of the world. It's how we explain phenomenon. Therefore it "lies" all the same. It's also capable of being incorrect.
@theneotrinity
2 жыл бұрын
i do be posting some pretty cool content tbh, check it out ?
@Humburbur
2 жыл бұрын
@@WadeAlma but at least science is almost always accurate
@zehsackett6132
2 жыл бұрын
"Bullshit comes in every flavor" -George Carlin
@killerplunger
2 жыл бұрын
"Wine from a chalice, for my blood. Bread by hand, for my flesh. Each, bussin respectfully." - Jesus Christ
@DrDubMemes
2 жыл бұрын
Everyone jokes about the way he pronounces Alzheimer’s, but this scandal is genuinely an issue and steps should be taken to punish those who put forth these false claims.
@dontreadmyprofilepicture270
2 жыл бұрын
DONT READ MY USERNAME!!!
@IceIsRick
2 жыл бұрын
@@dontreadmyprofilepicture270 shut
@mattgliottone2356
2 жыл бұрын
I agree, it’s still funny tho
@-whyquestion
2 жыл бұрын
Ratio + k-pop better + NCT outsold 🤳🏼🤳🏼🤳🏼🤳🏼🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓
@Tyburn109
2 жыл бұрын
Yeah, there is a growing issue with people sometimes deliberately falsifying data for personal gain, but I just find it funny that Charlie didn't correct himself on the word even once.
@davidci
2 жыл бұрын
As Charlie said, this title being "Biggest Scandal I've Ever Seen" is not a joke, this is genuinely one of the most awful things ever done. It regresssed so much progress in such an important discussion.
@Jacobmathews.
2 жыл бұрын
@Kavetion can't believe bot still replying
@prosysus
2 жыл бұрын
Tbh, we have such scandal every 3 months or so. I am actually suprised suddenly you normies care. Medical reaserch is a shitshow, despite EBM and such. Imagine psychology
@saveyabreath680
2 жыл бұрын
@@goldsnafu always making it about vaccinations huh?
@cameron7374
2 жыл бұрын
@@goldsnafu The difference there is that it's regular people as opposed to the scientists conducting the research. Once something is available to the public in the form of some medication or vaccine it should generally not be based on bullshit anymore. The average person shouldn't need to try and replicate any studies, especially since most people probably can't due to lack of know-how, equipment and money. And if it turns out that it's very possible to get deliberate bullshit into a peer reviewed study, that is a major issue and that is the main problem. Not that half the population just gets a vaccine without much apparent questioning.
@lezty
2 жыл бұрын
charlie is literally saying OLDTIMERS lmao
@d-_-b8558
2 жыл бұрын
Charlie truly has the most diverse content of anyone I've ever seen on KZitem. -reacting to goofy videos with funny commentary -rating various media like movies, games, and shows -tier lists of the most off-the-wall products like flavored condoms -storytelling videos -breaking news on scandals in the scientific community -gameplay stream clips -dildo competitions
@orion10x10
2 жыл бұрын
not competitions just competition, with one other person
@baconbeast3209
2 жыл бұрын
I somewhat Disagree, maybe most diverse today, but in the past, you had folks like nigahiga, smosh, tobuscus and so much more with plenty of diverse content. No disrespect to charlie though, or you.
@saintpena8800
2 жыл бұрын
@@baconbeast3209 while some of those KZitemrs you mentioned were great, they mostly did games and skits. Those were entertaining, but not necessarily diverse.
@baconbeast3209
2 жыл бұрын
@@saintpena8800 well in a way charlie is no different he mostly does commentary and gaming. He is amongst the greats no doubt. I guess they are very much the same but unique in their own way.
@saintpena8800
2 жыл бұрын
@@baconbeast3209 to be fair, KZitem itself changed a lot, so we can’t quite compare then the same way lol
@captainpjarker
2 жыл бұрын
For anyone who doesn’t know science, This scandal is exactly why peer-reviewing other peoples research is so fucking vital.
@caedesContained
2 жыл бұрын
@Kavetion Proof?
@l.a.freeman520
2 жыл бұрын
@@caedesContained its a bot dont waste your time bud
@kimbonice
2 жыл бұрын
People find ways to get around peer reviews either by self publishing or finding a group of "like minded," extremely biased people that'll just ok their research without even thinking about it. This fraudulent form of peer review is how we've had several toxic ideologies spread throughout the years even through they are barely based in reality.
@vez3834
2 жыл бұрын
@Kavetion Ratio
@Curiosity_R
2 жыл бұрын
@@l.a.freeman520 He's just asking for the peer review
@kearnschafer2733
2 жыл бұрын
My mother has Alzheimer's. I cannot truly describe to you how horrifying and painful this disease is. It slowly strips you of everything. Your independence, your memory, your thoughts. You slowly become a child again and then a baby and then your body can't perform basic functions and you die slowly and painfully. I don't care if this paper didn't slow down progress in the long run. If there's proof they falsified this paper then they should have their degrees and doctorates completely revoked and that should become the norm for anyone who falsifies any research. We need to make an example of these greedy pricks.
@OneBrokenEgg
2 жыл бұрын
I’m sorry about your mom. Prayers for both of you.
@alemswazzu
2 жыл бұрын
Very Sorry to hear that.
@xenomorphiia
2 жыл бұрын
My grandfather had it, I feel your pain & I'm sorry. I also agree, we're supposed to rely on these "experts" to find the cure so our loved ones don't suffer and the whole time it was a sham? It's infuriating and they shouldn't get away with it.
@tryme9740
2 жыл бұрын
I feel your pain because I saw my mother's aunt has it. She was push around in a wheelchair and her husband and children had to take care of her. I felt so bad for her, imagine loosing all your body function and becoming a child before dying while suffering from pain.
@legendarytomatobird2816
2 жыл бұрын
I agree, I've watched family members and family friends with alzheimers slowly get worse and worse. Hopefully your mother's still ok
@cobleen3982
2 жыл бұрын
As a melanoma survivor, I just want to suggest you get the mole on your bicep checked. The borders are abnormal and it doesn’t hurt to get it looked at. I had a tiny mole that started looking less circular and it turned out I had metastatic melanoma and had to do six months of immunotherapy and have four lymph nodes removed. Melanoma, once it spreads, is one of the most deadly cancers. Just get it looked at. Xoxo
@nandak965
2 жыл бұрын
Commenting on this to hopefully boost this
@websafe.
2 жыл бұрын
ayo charlie go look at this
@charlottegilmore5220
2 жыл бұрын
also commenting to boost
@monke210
2 жыл бұрын
^
@cobleen3982
2 жыл бұрын
Once a melanoma goes metastatic you have less than a 20% five year survival rate.
@elliewellie_YouTube
2 жыл бұрын
I've lost too many family members to this disease. I'm worried that my mom is already showing signs. This is absolutely mortifying.
@rigobertorosenbaum9838
2 жыл бұрын
The thought is honestly awful. I’m not sure how I would react if anybody this close to me caught it.
@gaydonaldtrump
7 ай бұрын
May they become all timers
@dollinterrupted
7 ай бұрын
@@rigobertorosenbaum9838you don’t ‘catch’ Alzheimer’s it’s not contagious
@Planktonamor
6 ай бұрын
My dad had dementia, my brother is showing signs. Our aunt passed from another similar dementia disease but I can't remember what it was called. It's horrible, you lose them twice. I'm so sorry for your losses.
@nsfwlemon
2 жыл бұрын
this is super worrying to me because my grandmother passed with alzheimer's and it's genuinely one of the most helpless experiences of my life. the disease runs in my family and to know that research has been going in the wrong direction for so long is really just horrid.
@GraceWhip
2 жыл бұрын
Mine as well, back in January. It's hard to describe how horrific it is. I hope that this coming to the surface puts a brighter spotlight with higher scrutiny on it now. My condolences to you and your loved ones.
@sapnupuas1475
2 жыл бұрын
@Kavetion nah
@neutrin0329
2 жыл бұрын
This is truly the plot of a dystopian existential horror story
@whoisanarnb
2 жыл бұрын
@Kavetion no
@whoisanarnb
2 жыл бұрын
Do you have Alzheimer’s as well?
@octinauti6037
2 жыл бұрын
I'm a molecular biologist and it is really nice to see how social media personalities like you discuss about these subjects. Just wanted to say it out loud :)
@leafy126.5
2 жыл бұрын
im an aspiring molecular biologist
@octinauti6037
2 жыл бұрын
@@leafy126.5 hi :D nice to meet someone from the field here!
@Ankan._.
2 жыл бұрын
Yeah I also find it really nice to have a non-scientist celebrity digging into the problem
@ImpostorGaming06
2 жыл бұрын
Yeah! Love to see people talking about scientific subjects!
@MrZixad
2 жыл бұрын
I'm a bolecular miologist and it is really nice to put this title before every comment for some reason and it's not like i can make it up. Just wanted to say it out loud :)
@HeyItsEmilyLove
2 жыл бұрын
Alzheimer’s is such a terrifying thing. I hope somebody makes some breakthrough research soon. I’m so sorry to anybody who’s had to see a loved one go through it
@blackcat6508
2 жыл бұрын
All-Timers*
@mrscalloper
2 жыл бұрын
@@blackcat6508 read the pinned comment man, nobodies laughing.
@swum95
2 жыл бұрын
The thing that scares me the most is that I learned about this protein and it’s significant importance in relation to Alzheimer’s. Meaning many many college students are learning the same thing. This is extremely detrimental on a ton of different levels.
@DunceTree93
2 жыл бұрын
This. Some people really have no idea. Some ppl have never put in the 2 seconds to adequately use critical thinking and/or use an ounce of empathy to try to begin to understand what alzheimers and demtia are, and what it does to you and family members. My best friends grandma was a very intelligient and, dare I say influential, medical doctor in our tri state area...and then one day, she forgot how to get to work. Then, she forgot her spouses name. Then, a few years later, she didnt even know who she was more then half the time. Then after that, she had to be hand fed and given water gel pills and have someone massage her throat cause her body couldnt remember how to swallow. They found some journals of hers when she was still more aware of herself. She had attempted to meticulously label pictures with people, pictures of places she visited with all their names and her favorite memories. Places and things she still wanted to visit and do. She even tried to write down important information like birthdays...and then it was just all gone. As if none it ever happened to begin with. Her entire life. Gone. It was gut wrenching and haunting. Her own brain and body trapped her. She was being tortured by her own body and there was close to nothing anyone could do to stop it. Only thing anyone could do was attempt to ease the pain, and hold on tight to ensure an ounce of quality of life. Words dont do any of it justice. Unfortunately, her spouse was diagnosed as well some few years later....and shortly after they found her in her bed holding onto a portrait from their wedding day. She had taken her own life with a note that simply said something along the lines of "I will always remember". No one faulted her or pretended to not understand. And it made me think long and hard about what I would do if i was in her shoes...and made me realise that, there is a high chance that I would contemplate the same if i was ever in that situation. I wish people would take these diseases more seriously. It is an absolute horrifying and terrible way to go. Edit to correct certian misspellings: cause god forbid I don't proof read my youtube comment before I'm reported to the highly intelligent "acedemics" of the internet school of trolls and incels.
@lordbanetheplayer8844
2 жыл бұрын
What's scariest is that by the time you're starting to exhibit any symptoms, it's already too late. It's too far gone at that point.
@kristiancazorlacahill3962
2 жыл бұрын
The fact he has to apologize for mispronunciation is a reflection of the world we live in rn
@gorillagodgaming
2 жыл бұрын
Yeah
@tedk.6420
2 жыл бұрын
Fuck those people. I say it the same and I will never change or apologize.
@masterferguson8703
2 жыл бұрын
No it’s just funny that he’s being so serious but mispronouncing In such a funny way.. also the sheer amount of times he said it.
@linnealager6146
2 жыл бұрын
@@masterferguson8703 exactly!, and we still love him
@Sneevilman
2 жыл бұрын
He had me thinking I was pronouncing it wrong lol
@BrickT2D
2 жыл бұрын
This is genuinely sad. My grandmother died with Alzheimer's, so she couldn't remember anything. I remember the time that i spent rereading the same books to her as if she was a mentally disabled child. Safe to say it was disheartening. The fact that all of this research, even from before she even got Alzheimer's, was from a fake study. In these 16 years, who knows what cures or preventatives could have been made. Thx for the story.
@solar9137
2 жыл бұрын
i agree
@ushiookazaki3728
2 жыл бұрын
My grandma died at 100 and I was glad she died because Alzheimer’s is no way to live im livid
@cutykate_5924
2 жыл бұрын
I know im just a random person on the Internet but I'm really sorry for ur loss, that sounds absolutely heartbreaking
@kianag6692
2 жыл бұрын
Not fake study, rather fixed study so that it fits in the narrative of said researcher...
@nothankyou
2 жыл бұрын
And this comment is a great example of why people are pointing out the impact of irresponsible science reporting. My friend, the scientists have made it clear that this research has likely had very little impact on Alzheimers research for quite some time - Charlie's scare-mongering, and 'whos to say' retoric is not helpful and I'm sorry that it's caused you this upset. He even glosses over the fact that experts have clarified this in his video, but STILL goes on to speculate unneccessarily. The original data and scientist definitely did a bad thing - but it likely had no impact on the passing of your grandmother. Seriously Charlie stick to video games mate.
@molly536
2 жыл бұрын
charlie sounding serious for 90% of this video is absolutely startling, it's all fun and games until serious charles makes an appearance
@chrisdawson1776
2 жыл бұрын
all timers
@vikzn1607
2 жыл бұрын
cringe
@AnimalLover101195
2 жыл бұрын
Charlie: normal Charles: listen up, this shit's serious
@guysumpthin2974
2 жыл бұрын
It was completely proven 40 years ago, consuming aluminum creates the spiderweb plaque inside of the blood brain barrier. Also Prime source of dementia/schizophrenia/Parkinson’s/depression/ cysts/miscarriage is toxoplasmosis. “Science “ that was “Swept under the rug” (is it still science)
@joejoejoe2233
4 ай бұрын
@@vikzn1607very cringe 😬
@Mimikinn
2 жыл бұрын
My dad has Alzheimer’s and watching him forget me and my mom and the rest of my family has been hard. And now knowing that all the drugs he’s taken that didn’t work are possibly due to this damn paper is just infuriating. I hope this fraudulent scientist loses his career and license and whatever else he values.
@tashthebean
2 жыл бұрын
My father has vascular dementia. It's an extremely tough road. I hope you have supportive people around you and that you are taking good care of yourself through this. Stay strong and never be afraid to ask for help. X
@marcus5900
2 жыл бұрын
@DONT READ PROFILE PIC this man post a serious fucking post this isn't some sort of thing to be joking about fuck off
@damjanp7920
2 жыл бұрын
he should go to prison for life imo
@lionstone4
2 жыл бұрын
I am very sorry for your loss. I wanted to reassure you that you don't need to be afraid of some drugs not working just because of 1 fraudulent research paper. Nowadays we are very careful in medicine and we learned from mistakes in the past and every new drug needs to pass a lot of various tests and also clearly show that it works, it helps and that it is beneficial for us compared to it's risks, cost and other consequences. This is true also for any older drugs which are already being used, they are being continuously reassessed and they can be withdrawn at any moment when benefits are no longer good enough. Stay strong and safe 😊
@DPSFSU
2 жыл бұрын
@@lionstone4 he said his father HAS Alzheimer's. Trusting your doctor nowadays is a very hard thing to do. Also, you saying that past and present drugs are constantly being reassessed, what the hell happened with oxycontin and many many other deadly meds doctors have pushed onto patients? A lot of doctors are just paid drug dealers.
@joaoalves-we6il
2 жыл бұрын
Imagine being a researcher and after all these years you find out you were literally basing your work on fraudulent fake information... Must feel bad
@thedecafe1
Жыл бұрын
Imagine being lol 😂
@machine4971
2 жыл бұрын
This is actually a huge problem in science in general, I’m working in the field right now. If you want to submit a paper to one of the ‘big’ journals you have to send in something that doesn’t go over the peer reviewers’ head, but also something good enough to seem worthwhile to publish. Lots of the time papers with falsified evidence are submitted and accepted as the scientists working on it are ‘trustworthy’ and the work is understandable to the peer reviewers, while a person who may actually have something entirely groundbreaking is turned away due to the lack of effort/ignorance on the peer reviewers part
@sheevinopalpatino4782
2 жыл бұрын
and experiments have become too bloody expensive to replicate :(
@frenchfryequeen
2 жыл бұрын
Exactly!!! I had that same conversation with one of my mentors a few weeks back about how half the time peer reviewers for grants and publications don't know nearly enough about the science to actually know if its worthwhile or good science. For example, my mentor was doing immunology and organic chemistry based research. The peer reviewers for his paper were a mix between a basic immunologists and an organic chemist. They all understood about one half of what he wanted to do and they denied him and said that in order to get the grant he'd have to create a knockout which was impossible for the kind of thing he was working on so it told him that they didn't even understand what they were reading. I went to a conference and a big named scientist submitted a paper for publication and deliberately started talking about Star Wars or something halfway through the paper and THEY PUBLISHED IT! They don't even bat an eye when a well known scientist submits papers for review its ludicrous. The other day some of my coworkers were saying how the big journals like Nature and Cell etc. etc. make tons of money from scientists submitting papers, I'm talking 8,000 ~ 10,000 a paper and none of the money goes back into the community or to tax payers who are the ones who fund research in the first place. I've said it before and I'll say it again the current state of reviewing and publishing papers is nonsense. Don't even get me started on the methods section in papers....
@RabidDisposition
2 жыл бұрын
@@frenchfryequeen I'm too stupid to work in science even though I'd love too. I love science more than anything, but I know I wouldnt be able to keep up. I decided to instead devote my life to getting scientists the proper funding and government support they deserve, because I want to see some badvss science before I die lol
@elizza8770
2 жыл бұрын
@@RabidDisposition can i ask what your job is?
@RabidDisposition
2 жыл бұрын
@@elizza8770 right now I'm a paralegal while I finish my poli sci undergrad, then it's off to law school for me.
@Dan70166
2 жыл бұрын
Wasn’t expecting a science oriented scandal, but good shit
Ratio + k-pop better + NCT outsold 🤳🏼🤳🏼🤳🏼🤳🏼🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓
@theluschmaster
2 жыл бұрын
that's where the biggest scandals are created
@mylegghh
2 жыл бұрын
these bots needa get a dayum life
@oinkgoespiggy7781
2 жыл бұрын
The guy that made the paper should be actually publicly prosecuted and held accountable for this because the fact they've been using this paper for many years makes me so angry
@RandoSando.
2 жыл бұрын
Misread your comment and thought it said that he needed to be executed. I agree either way. So many lives were lost due to this
@ivegonesickomode1610
2 жыл бұрын
@Kavetion you wish
@odious574
2 жыл бұрын
@@ivegonesickomode1610 don't respond to the bots, they work by getting a reaction from someone
@mage1439
2 жыл бұрын
Prosecuted? Publicly executed would be more appropriate. I can provide the stake if someone else wants to provide the matches.
@lepwood
2 жыл бұрын
@@ivegonesickomode1610 if you respond to bots youtube thinks they're real people.
@callalily0004
2 жыл бұрын
Honestly, this kind of thing is shockingly common in science, where people will fabricate data and yes, it sometimes gets published if it's done convincingly enough. But usually, when the data is determined to be fake, the researcher responsible is forever discredited and they will probably never be published again. Happens all the time. What it sounds like happened here is that since the results couldn't be replicated, as they say, the results were probably tossed out, and the inaccuracy tossed up to faulty methods. A lot of those citings on the paper are probably from papers saying it's wrong. And if there was no reason to suspect deliberate fabrication, then there's no reason to completely discredit someone for one wrong paper. But now that there's more proof that this might have been based on fabricated data, this 100% needs to be taking seriously, less because of the paper itself, but because of the researcher, because what else has he faked? Anyone who has faked data needs to have all of their work immediately scrutinized. And yes, this should have been caught sooner, if possible because of any further work he's done that might also be false. That's the biggest issue in my mind.
@falkwulf3842
2 жыл бұрын
What is sad is researchers like myself called this out years ago, we were labeled as conspiracy theorists and crackpots. We have been forever discredited for telling the truth, and even now after this scandal has broke proving us right. Instead we are still labeled and unpublished. The issue is there was just too much money at stake for US to be right. There are many of us who have had our whole careers ruined because we dared to challenge accepted science with fact patterns that did not align with the accepted narrative.
@jeremycash2953
2 жыл бұрын
In my community college class we were told that something like 90% of all scholarly articles are retracted for false information
@stephens3909
2 жыл бұрын
It's because there is no money to be made in fact checking and re-publishing old works, researchers get paid for new publications of new data, which is why data dredging or P-Hacking exists... It's a vicious cycle and research papers like the one mentioned above aren't really that serious in reality, the 2000+ citing it on the website, most are probably student papers or similar situations. The big players in research for Alzheimer's and the professionally trained nurses and doctors are not going by this paper but may have seen it for sure, so it's still bad, but not as bad as it seems because it's so commonplace.
@jackiep2042
2 жыл бұрын
@D W they really didn’t. there have been issues in the scientific community regarding the volume of papers published on Covid, yes, but if you think this comment is summarizing it, then you really aren’t aware of the actual problems in the modern scientific process.
@jackiep2042
2 жыл бұрын
@D W lmao what narrative? the fact you think there’s some malicious narrative driving the issues is pretty telling.
@Biggl
2 жыл бұрын
“The last 16 years of research has been based on a deliberate lie.” That makes me wanna cry. Alzheimers is going to be the biggest battle future generations have to deal with disease wise and some fucker spat on the situation.
@praneelbhagavatula7680
2 жыл бұрын
@Kavetion but not better than this ratio
@elite625
2 жыл бұрын
@@praneelbhagavatula7680 Got his ass
@me0101001000
2 жыл бұрын
@Ohsew no, they're right. It's a tragedy. You often have these revolutionary papers, inventions, and businesses that come to the limelight, and when it comes to light that it was all a farce, it sets everyone back. It happened in semiconductors with the Schön scandal. This guy cooked his books to show that he discovered many great materials for semiconducting devices, but it was discovered how fake it was. Screwed over the entire industry for a bit.
@hinglemingleberry253
2 жыл бұрын
What makes you think Alzheimer's is going to be the biggest disease we have to fight in the future?
@Fuphu
2 жыл бұрын
I’d say Cancer and Obesity are the biggest issues for future generations but sure
@obamahimself2885
2 жыл бұрын
My grandmother passed recently with Alzheimer’s and it just hits harder how all this research that could of helped save people was wasted.
@strangelove_music9385
2 жыл бұрын
I’m super sorry man, that’s hard to fucking hear. Hope you find peace somehow
@reagancunningham4439
2 жыл бұрын
Me too man
@radicaltsunami
2 жыл бұрын
Same here brother.
@jayzell3687
2 жыл бұрын
I'm really sorry to hear about your grandma. I hope you and your family can keep holding onto the memories you do have from when she was more present and find some solace in that. My uncle has been getting progressively worse in terms of fluid memory, and while I can't know what it's like to be in your situation, I can empathize with how scary it is to see some you love and have had amazing conversations with lose that coherence, and how infuriating it is that the research on the topic was falsified so some shithead could feel like he was a success.
@Icetastesgood
2 жыл бұрын
@@strangelove_music9385 you didn’t kill her
@bowserjrsoutsidestory7125
2 жыл бұрын
glad to see charlie flex his degree and talk about something more than twitter drama, very nice to see
@FuckFistingAss7osuFF7osu
2 жыл бұрын
@Kavetion bots like this are fucking horrible i saw a cat's head get stomped on
@spiko-ou3bp
2 жыл бұрын
@@Shan-rb5rl The nether
@arktrooperecho7241
2 жыл бұрын
@@FuckFistingAss7osuFF7osu wth
@cantthink3012
2 жыл бұрын
@@FuckFistingAss7osuFF7osu on there channel???
@Fuckoutubeihadthisnamefirst
2 жыл бұрын
An undergrad degree doesn’t mean shit for anything lol. It’s just extended high school. doesn’t make him the slightest bit smarter than anyone else. Don’t glorify it
@iROMine
2 жыл бұрын
It seriously makes me wonder how often this type of stuff happens. Financial manipulation is EVERYWHERE in science and by extension medicine.
@thedecafe1
Жыл бұрын
It seriously 😒 lol 😂
@jusbertmeza4424
Ай бұрын
Be careful with which how you word it because scientifically illiterate people when they hear that they hear “science is just as corrupt with money as any other industry and we shouldn’t believe them” its because i speak stupid so i can understand how stupid people misinterpret everything
@abraveteddybear7390
2 жыл бұрын
I’m a current biology student in college and a HUGE thing I’ve learned as a researcher and student is that because in order to get decent funding it benefits people to just do everything they can to put out papers and “results” as much as they can
@dontreadmyprofilepicture270
2 жыл бұрын
DONT READ MY USERNAME!!
@-whyquestion
2 жыл бұрын
Ratio + k-pop better + NCT outsold 🤳🏼🤳🏼🤳🏼🤳🏼🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓
@mylegghh
2 жыл бұрын
i make entertaining content. If its trash let me know
as someone who’s lost family members to Alzheimer’s… this is so upsetting. all these years we could’ve been working towards treatment or even a cure and just… wow
@trollingisasport
2 жыл бұрын
*All-timers
@False_Refracted
2 жыл бұрын
My grandfather developed and passed away due to Alzheimer's in this time span It's possible they could've saved him if this didn't happen
@swum95
2 жыл бұрын
The thing that scares me the most is that I learned about this protein and it’s significant importance in relation to Alzheimer’s. Meaning many many college students are learning the same thing. This is extremely detrimental on a ton of different levels :(
@Dragonk116
2 жыл бұрын
Why are you surprised? If humans tried, we would have already solved things like world hunger, diseases, innovations in technology that far surpasses what we have now, climate change, even space travel to planetary colonies.... Unfortunately humanity tends to hold itself back, which is typically why it takes significantly longer years these things... While greed for money is typically one of the leading causes of preventing humanity from being the best it can be, we live in the age of the internet where people are more concerned for feelings than factual truth considering a variety of topics... We can no longer have proper back and fourth conversations because someone is always going to be offended even if it's on the behalf of someone else who doesn't care about it at all like how Americans complain about using specific terms for latins like latinx.... Or how they complain about us wearing ponchos and Mexican style hats when in reality the Mexicans or the Latinos could care less about any of this. All these things are holding humanity back, even progressing some things backwards like this wasted research you have to go back to square one... Meaning those 15-16 years were all pointless, all because humanity keeps giving idiots a voice to speak and or make rules for the rest of us. I don't know what is going to happen with the future, but I do know if these idiots are still left in charge we aren't heading to a good place....
@GlowyWowy1
2 жыл бұрын
@@trollingisasport bro shut the hell up he lost a family member and you make fun of something from the video, grow up
@dylanium5755
2 жыл бұрын
It's heartbreaking seeing all the comments from people who have lost family to Alzheimer's. It's a hard thing to go through for everyone involved
@deathstrike
2 жыл бұрын
It is, my father was riddled with both dementia and Alzheimer's disease before he died. It's bad enough to see this person mentally falling apart in front of you. And the worst part? You silently wonder if this is your fate as well? Alzheimer's is genetic.
@aaronlandry3934
2 жыл бұрын
Problem is this isn’t even very shocking as a Scientist myself. I remember when my Biological Engineering professor taught us about all sorts of studies that were entirely illegitimate. They do it to get news stations attention, politicians’s attention, and to get a subsidy/paycheck to fund their “important” research
@thedecafe1
Жыл бұрын
Problem is lol 😂
@ronitschem5858
2 жыл бұрын
Charlie's pronunciation aside, if a paper's results are not replicate-able then it should be retracted. The fact it it has been cited so many times MEANS that people have read and followed this paper's results while conducting their own. That's why retraction of sussy papers is so important. Andrew Wakefield's paper was "forcibly" retracted as soon as evidence came out that the results were fabricated but you see the damage it has caused. Equating those two situations might be a hyperbole but it says something about people deliberately doing bad science and the long-term effects it can have.
@theneotrinity
2 жыл бұрын
i do be posting some pretty cool content tbh, check it out ??
@joepemberton9031
2 жыл бұрын
replicable
@greenbean4422
2 жыл бұрын
Ideally this is what we would do, but in practicality is impossible. There are so many machines that exist that are actually one-of-a-kind that we use all the time for science experiments. Sure, some random person could come by, use the same machine I did for my experiment and try and repeat my findings, but these machines usually take so much time and power to operate that spending time on cross-examinations of previously found data doesn't usually happen unless during the initial testing or experiments. I think of the space telescope or a particle accelerator, and how someone could just "cross-examine" another scientist's findings, but such things aren't really feasible.
@AliensAreNoobs
2 жыл бұрын
Did you just call them sussy papers?
@DerGrosTitan
2 жыл бұрын
Never seen the word 'sussy' used in a formal context
@Gaybertis
2 жыл бұрын
It’s heartbreaking to see that so soon after Wakefield’s scandal subsided, someone tried and actually succeeded for a much longer time to do what he did.
@KariIzumi1
2 жыл бұрын
I'd argue Wakefield has still done the worst damage. His shit reached Jenny McCarthy who was still a Big Name in the 2000s and Oprah was the biggest name in talk television at the time and the media ran with that.
@Kikithegreen
2 жыл бұрын
These bots are burning in hell because Penguinz0 makes banger content Wait a minuite-
@sithwolf8017
2 жыл бұрын
@@KariIzumi1 as someone who is studying microbial pathogenesis I definitely agree Wakefield has done far more damage. It's getting to the point that there are people who are actively against vaccines like rabies and more alarmingly some deny the existence of pathogens.
@ItzMalick
2 жыл бұрын
Yoo Fam I’m an upcoming KZitemr, and I make a range of entertaining reactions, vlogs, and a variety of other content and I’m still working on versatility, and quality but I guarantee you will find something you will enjoy🙏🏾🙏🏾‼
@smelly4498
2 жыл бұрын
@@KariIzumi1 i agree,as an autistic child to an anti vaccine parent i have a hard time finding the words to express how disgusted i am with wakefield. the “vaccines: a measured response” video made me angry cry i was so appalled.
@konjurist
2 жыл бұрын
This is genuinely so frustrating. My grandmother passed away from this disease when I was 11, and knowing she could have had a chance of living had this not happened makes me too angry to put into words. To watch the kindest person you know shrink into a shell of themselves, a completely different husk- a base of a human with no mold, is one of the worst pains a person can go through. To forget your family, to forget your lover, to forget your life, to forget how to eat, to forget how to breathe, and the research ‘helping your cause’ basically just letting you die on the table. Unbelievable.
@KonoGufo
2 жыл бұрын
Proper response
@Crashoutcertified
2 жыл бұрын
Even if I don't share it or suffered far less but I'll definitely sympathise your pain, king.
@SheluvBen10
2 жыл бұрын
King
@Hi-xz6rz
2 жыл бұрын
@DONT READ PROFILE PIC out of all comments you say that here?
@nameless_magic5940
2 жыл бұрын
@@Hi-xz6rz it’s a bot
@saturn4430
2 жыл бұрын
I can’t believe I haven’t heard about this anywhere else. Thank you for discussing this in a video and making the information accessible to viewers- more people should be talking about this for sure.
@thedecafe1
Жыл бұрын
I can’t lol 😂
@ohioella
2 жыл бұрын
i worked at a home for people with alzheimer's for a year and this is heartbreaking. the way it turns intelligent amazing people into shells of their former selves who can barely eat or speak or understand why they're not at home is one of the worst things imaginable. to knowingly fake results and prolong finding a cure for it just for prestige & money is beyond fucked up. and the thing you said about prices is true, it cost $10-20k per month to live at the place i worked. people who can afford it will do whatever they can for their parents/siblings with alzheimer's and those are the people being hurt the most by this fraud
@SpinoRexy733
2 жыл бұрын
Honestly If I'm ever diagnosed with the disease, I'm committing suicide, no if ands or butts about it. I'd rather throw myself into traffic then suffer with such a disease.
@t0rbias
2 жыл бұрын
@Kavetion who?
@jerichorosales5030
2 жыл бұрын
@@t0rbias penguiz0 a.k.a CHARLIE a.k.a MoistCritical
@roberto3939
2 жыл бұрын
Have you noticed less alzheimers diagnosis and more dementia?
@ohioella
2 жыл бұрын
@@roberto3939 i didn't know this until i got there but alzheimer's is a type of dementia. it wasn't alzheimer's specific (just a memory care facility) but the only person i can remember there who didn't have alzheimer's had lewy body dementia. i'm probably not the person to ask though, we had ~27 residents when i got there and probably 30 when i left (people passed away but over the course of a year i think i only met 8 new people, all at different stages) so someone working at a clinic seeing different people every day would probably see any patterns in diagnoses
@zar1102
2 жыл бұрын
As someone who is studying science, this is something scientists are broadly aware of. The 'ripple effect' from fraudulent and/or manipulated data can often be silent and sap at funding and effort that could have been better used elsewhere. Unfortunately, as you said, many scientists have a bias towards generating impactful (statistically significant) results. Landmark studies in emerging fields can mean grants and funding and recognition and more, after all, and this means manipulation of data can seem appealing to some less scrupulous academics. This is why the peer-review and editing process of published articles is so highly scrutinized in science -- without it, we would have thousands of papers like this.
@dontreadmyprofilepicture270
2 жыл бұрын
DONT READ MY USERNAME!!!?
@hafsa.90
2 жыл бұрын
Wow... just wow 😳
@lmaolmao2871
2 жыл бұрын
No one cares 😂😂😂😂😂😂😂
@johnmachenzie1613
2 жыл бұрын
You need to believe in science, you're making an anti-science comment!
@TouringWolf42
2 жыл бұрын
@@johnmachenzie1613 You should, not believing in science leads to people not understanding how to interpret it.
@35Cypher
2 жыл бұрын
I've been an EMT for over a decade. Ive seen thousands of patients with Alzheimers. I've run the same patients dozens, if not hundreds of times. I got to know them and care about them. I'd talk to their families and their spouses. I'd gradually see their decline, and on more than one occasion I was there for their final moments. These people deserve our best help, our strongest advocacy, and our most heartfelt compassion but so often then get overlooked and pushed aside. I wish I could say this surprises me, but honestly? This is par for the course in how we treat people with chronic conditions, especially those originating in the brain and mind. Medical now isnt about helping people, its about profits and it makes me sick to my stomach.
@unnameddelta38
2 жыл бұрын
That's exactly why I got off the job. Worked at MAAS (Metro Atlanta Ambulance Services) for a while and that was all they ever cared about was money. It's shameful.
@4ltrs573
2 жыл бұрын
@@unnameddelta38 shoot em
@exiledkenkaneki701
2 жыл бұрын
@@unnameddelta38 how convenient that others were there for thr money which is a literal incentive for working????
@solar9137
2 жыл бұрын
i really fucking agree
@borgegush379
2 жыл бұрын
i literally just got my certification and that’s rlly making me start questioning my choices
@arinhardie8340
2 жыл бұрын
I lost my Grandmother to Alzheimer’s, most heartbreaking thing I’ve gone through. I don’t have words for how devastating this is to me if it’s true. I don’t want anyone else to go through what my grandmother went through, and the pain my family and I went through watching her fade away. I hope this falsified report did not cause any far-reaching damage, and if it did, that we can course correct quickly.
@thedecafe1
Жыл бұрын
I lost lol 😂
@powerslaveiron49
2 жыл бұрын
Honesty, because of the potential repercussions, this sort of thing should have VERY severe legal consequences
@aryajpegasus
2 жыл бұрын
problem is how would you conclusively prove deliberate falsification over just making a mistake
@DavidJCobb
2 жыл бұрын
@@aryajpegasus i mean that Lesné guy didn't _accidentally_ photoshop tons of the supporting images in his papers in order to protect their careers and even have a chance of being listened to, scientists have to be super cagey when accusing big names in their field of outright fraud. they can't say, "this guy is an effing liar;" it has to be, "there are some concerning irregularities in this research, and i think it merits further review." there's a three-part series by another channel, bobbybroccoli, covering a similar fraud committed by Jan Hendrik Schön, diving into the ugly job politics behind all that
@reservationatdorsias3215
2 жыл бұрын
For who? Everyone that could do something is already paid off, large scale medical crimes are never punished. No one went to jail for oxycontin, except maybe 1-2 scape goats.
@stormruner9183
2 жыл бұрын
Well, Wakefield got into legal trouble because of his bullshit, so there's some hope
@Happyduderawr
2 жыл бұрын
@@aryajpegasus eye witnesses, (graduate students working in the lab). Incentivize snitching. There are scientists who lose their job over misconduct.
@themarimo3324
2 жыл бұрын
I’m glad Charlie has spread awareness of this serious issue. The deception of scientific research is not new and has created serious consequences like what happened in Theranos.
@void_eagle4577
2 жыл бұрын
@MaccioVelli She promised to make blood testing super easy, cutting down the amount of blood needed by half and getting better results from it. It ended up a huge bust as the ceo was lying out her ass, the machine she was using was actually a normal blood testing machine and all her tests were false.
@Kumquat_Lord
2 жыл бұрын
@MaccioVelli company that made bullshit blood test devices
@denisebishi5212
2 жыл бұрын
What happened?
@Mrmidknight-yx9pg
2 жыл бұрын
@MaccioVelli ya got an hour or six
@ElleCirano
2 жыл бұрын
@MaccioVelli company tried to make a blood testing machine which is small and can test for multiple diseases from a single drop of blood. Their demo wouldn't work so they frauded it and were basically a pseudo science company
@Fluttershiez
2 жыл бұрын
As someone who works in assisted living and sees Alzheimer's everyday, this new development is absolutely devastating.
@theneotrinity
2 жыл бұрын
i do be making some pretty cool videos honestly, check it out mate ?
@apolloandwarrior_3229
2 жыл бұрын
Reminds me of Micheal from Vsauce. He's been donating a lot of money to Alzhimers research and without even knowing the truth he used amyloid B as an explanation of Alzheimers in one of his videos.
@chumpylumpy8072
2 жыл бұрын
Sorry if this bothers you In any way but how does Alzheimers affect people?
@anyone6691
2 жыл бұрын
@@chumpylumpy8072 it degenerates your memory and some brain functions. Very sad, some people forget who their family members are.
@ech9817
2 жыл бұрын
At least researchers won't be looking into this dead end anymore. Maybe we could finally get some movement going
@weaslby9265
2 жыл бұрын
Hey, I'm actually training in a similar area of science, so I thought I'd put my two cents forward for those interested (TRAINING, not an expert lol so take this with a grain of salt please I don't know everything). Obviously this is a huge scandal and it's really disappointing to see research being forged like this. Honest people in the research industry work our butts off (and it's a super competitive field) to try and present honest results to help advance the world's scientific understanding that could lead to therapies for these kinds of disorders. UNFORTUNATELY you get one or two bad eggs that think they're above the rules, or they're desperate for the funding (money from the government is so hard bc you have to compete against so many other potential projects, and to get the funding you have to show promising results) or they're being funded by a company that want specific results. Could be some of the reasons but I want to make it abundantly clear that NOBODY in ANY scientific discipline thinks this is acceptable. Because it's these bad eggs who get the funding that the hard workers miss out on. BUT BUT BUT imo this article is poaching on fear mongering and in doing so puts a lot of unseen strain on the science field AND PISSES ME OFF. I asked some people who do work on neurodegenerative diseases like Alzheimer's for the following: FOR ANYONE WORRIED! No! 16 years of research has NOT been for waste! To even suggest this invalidates the countless honest hours of thousands of researchers who have discovered valid results!! THE PROTEIN THAT RESEARCH HAS BEEN BASED OFF FOR THE PAST 16 YEARS IS NOT THE SAME FORM AS THE ONE IN THE FAKE PAPER! The protein in question was ALREADY correlated to Alzheimer's disease (in the intro of the paper, they mention this!!) They're not pulling a protein out of their asses. That's not a thing that can happen in this field. The protein they worked on is a different form of the main one (soluble in water compared to insoluble) that has largely been ignored for a while! As Charlie mentioned, papers did try to replicate their results but couldn't. It's a common issue in science and one that is not taken lightly. As a result, people already suspected the paper had issues and haven't really used it (just bc a paper references this fake one does not mean their research is built on it solely. Most papers have hundreds of references. I had a look at a couple of the top papers citing this one, they use it to say stuff that's more generalised and usually in the introduction paragraphs. Also, papers are referenced when there are discrepancies [eg. "our paper couldn't replicate the results of the fake paper so we did not consider these/changed strategies] counts as a reference!). When a paper is faked, scientists in the field can usually pick up on it pretty quickly, and if they don't, they can't use those results for a conclusion in their papers anyway. Science never proves anything, it can only provide evidence for or against. It's the media that will sink their teeth into whatever they can for the most views and run around like a mad animal with it. That's how anti-vax blows out of proportion, people see the media focus on something stupid and go "oh, this is really important! It must be true!" (this applies for stuff from articles like this to ads for diet supplements). Unfortunately, a lot of people don't have access to original papers, and can only access info through these media sources (and this is where the access to science argument comes in but that's another can of worms) and that's how people are convinced that scientists have no idea what they've been doing for 16 years when obviously that's a lie. So, above all, if something like this comes up and you want to pass an honest judgement on how it's actually impacted research. Read the paper. Read papers citing it. Ask people who know more. And have faith in your own critical thinking skills! Don't rely on one random article that claims that almost two decades of research has been a waste. Don't read an article and believe it blindly. AGAIN: not condoning fraudulent results or the actions of the original authors!! (I'm glad they're getting their merit stripped, they deserve it). Fraudulent results are an insult AND so are these kinds of articles. TL:DR - Yeah, the paper is a major scam but so is the article. The authors of the paper should be ashamed, nobody in science condones their actions and what they've done can potentially damage the field bc it makes people lose faith in us and stops us form progressing and getting funding for real research. BUT the authors of the article are your classic doom scroller predators and if you're genuinely concerned about the direction of Alzheimer's disease, please don't be. Like Charlie said, science doesn't lie, but people do. But, vice versa, people can lie, but science never does!
@weaslby9265
2 жыл бұрын
Just a reminder that my words should not be taken as law. I'm still only training in this field, and I highly recommend people go ask more experienced researchers about this. I just wanted to reassure people that 16 years of Alzheimer's research has not been based on a lie and to stop the article from putting unnecessary fear in people.
@Dogflamingo
2 жыл бұрын
One thing I was wondering was don't all science papers get peer reviewed? If so, wouldn't people have just said the paper can't be replicated and just ignore it. I haven't read much of the article either, but wouldn't that just mean the new information about the paper is just that it was purposely false, because they already knew it likely doesn't work? Not trynna downplay the situation, just wondering how peer reviewing works
@ChangedMan2.0
2 жыл бұрын
Bro you typed way too much
@ashleythekittymaster4907
2 жыл бұрын
Cant believe I read that whole thing but I think it was worth it :)
@aaronlandry3934
2 жыл бұрын
“one or two bad eggs” kinda underselling it there
@oracleofdelphiii
2 жыл бұрын
My grandmother had Alzheimer's ... she raised me and was the only reason I wasn't a latchkey kid, and we (my parents and I) took care of her in our home for as long as we could until she needed 24/7 care and was placed in hospice. I'll never forget those years; I still think about it pretty often, years later. This disease is horrible and one of the worst things you can go through. My heart feels like it's sinking the more I listen to this video. Thank you Charles for bringing awareness to this; I really hope we find a cure one day.
@ZestiestZach
2 жыл бұрын
I’ve had the same exact experience, it isn’t easy, we both know this I’m sure. Hope that the hospice is treating her well, and some real research on Alzheimer’s gets done because it’s one of the scariest diseases that exist.
@ruinsfnbr776
2 жыл бұрын
I’m better than penguinz0
@jerichorosales5030
2 жыл бұрын
@@ruinsfnbr776 IM BETTER THAN YOU BOTS RUINING THIS VIDEO
@moonshineblues204
2 жыл бұрын
Kudos to you and your family for taking care of the elderly. My husband worked in a hotel when I met him and he (as the night manager) had to fill out paperwork more than once to turn over elderly people who had been abandoned by their families at the hotel. Horrible.
@kam2894
2 жыл бұрын
Both of my grandparents suffered from it. It’s not a fate I would wish on anyone
@danadakhil7688
2 жыл бұрын
this is just insane... as an aspiring neuroscientist, i have never heard anything that could make your heart sink all the way to your stomach so much as this. i studied this in my first year neuro class and the beta-amyloid research was by far the most talked about topic in class. it stuck with me for a very long time as well... imagine how many other areas of research could have been elevated and funded with well-needed money and efficient resources. i'm literally sick.
@Antarctide
2 жыл бұрын
You must be very young and gullible if that's the first time you heard about something like this happening.
@shreyas4858
2 жыл бұрын
@@Antarctide u dont necessarily need to If the whole of Alzheimer disease was just simplified to a single protein, that that wud actually one of the major breakthroughs in curing alzheimers and of course, u wud actually trust it as every other neuroscientist is
@z.olderautist2209
2 жыл бұрын
If you're interested in scams and bad science, you've chosen the right field!
@LANCEtheBOIL
2 жыл бұрын
Look into antidepressants, they did the same thing thanks to big pharma. I can't believe you haven't heard of kovid 19 " vaccines "
@AsianTaile
2 жыл бұрын
Please, I know it sucks to hear. Dont blame the field, blame this one person. Science isn't perfect, but it's the best we have. Peer review doesnt catch everything, and as alot of people have pointed out there are much needed reforms in it, and unfortunately even if we made them all I'm pretty sure there will never be a way to fully rule out studies like this. You should keep in mind that the protein identified did lead to further research about that protein which was as charlie said had been previously associated with alzheimer's before the study came out. Yes you can make the argument that it motivated alot of research in the wrong direction, but because were in science and not in KZitem comment section what happened next was most scientists discovered some association and learned why there might be. This bad research paper sparked many scientists to find something that could be important later on. And of course some scientists found no direct relationship, or no causal association and guess what they just moved to research why they found no association or look into some other cure for alzheimer's. I have read the research years before and currently still do before this came out and I'm telling you now that I am genuinely not surprised that this paper was fake. And yes I think you shouldn't be afraid, your standing on decades of research not this one paper.
@doodoothedishonored9093
2 жыл бұрын
As someone who lost his mother to Alzheimer’s 4 years ago, I wanna do horrible things to that man.
@lennonh.4173
2 жыл бұрын
you mean charlie or the guy who wrote the article?
@doodoothedishonored9093
2 жыл бұрын
@@lennonh.4173 the guy who wrote the article
@ioio5293
2 жыл бұрын
Its not like she would’ve survived anyway
@glen7137
2 жыл бұрын
@@ioio5293 yes she probably wouldn't have survived but this is still a horrible scandal
@YTNimbus
2 жыл бұрын
I lost both of grandmothers to alzemiers
@gabihagelstein515
2 жыл бұрын
I'm SO glad that you're talking about this! I was shocked when I heard this news and then shocked again when I didn't see anyone talking about it. I hope you post an update when there's more information.
@thedecafe1
Жыл бұрын
I’m so lol 😂
@tickersr8239
2 жыл бұрын
My Grandpa struggled with Alzheimer's in his late age. It brought him to forgetting basic human functions, forgetting who anyone was and my dad eventually couldn't handle looking after him anymore and put him in aged care. He didn't last much longer and eventually passed away, and the sight of his face showed he wasn't ready yet and it hurt to not get to spend more time with him. The fact there's so much wasted research, I have no words
@TecTitan
2 жыл бұрын
What about the fact that people in the field (charlie's quoted them in this video) are saying this wasn't a big deal? That's the part that really gets me
@Dockhead
2 жыл бұрын
@@TecTitan this is youtube, its a cesspit of idiocy and autism
@Shredmoreroy
2 жыл бұрын
My 2 cents as an Alzheimer's researcher: It's terrible that this was able to happen and highlights the importance of proper peer reviewing and scrutinous checks on the financial ties of researchers. However, I feel a common sentiment among people is that this has set Alzheimer's research back 16 years and I just want to highlight that this is simply not true. Like charlie pointed out in the video, Amyloid-beta is still one of the key focuses in Alzheimer's research, as backed up by many papers before and since this one, and our understanding of other factors contributing to the disease has improved greatly over the past 16 years.
@aceman0000099
2 жыл бұрын
So what was actually falsified? Edit- pictures of mice brains. Made to show that they had more of the protein than they really did. It doesn't seem so significant
@jjonesa
2 жыл бұрын
@@aceman0000099 its definitely significant, it lead to a conclusion that could not have been come to which mislead millons
@wr8196
2 жыл бұрын
@@jjonesa please enlighten us what those 2 different conclusions are. You probably have no idea what ba plaque buildup even is. I dont know why im wasting my time writing to someone talking out of their ass and spreading more misinformation in their free time
@joshbeck9761
2 жыл бұрын
I love how Charlie can talk about anything. And I'm glad he brought this up
@acoasting8200
2 жыл бұрын
@Kavetion no you ain’t
@tonybanks1148
2 жыл бұрын
@@acoasting8200 that's what Sandy said, "I'm ready, I'm ready", "no you ain't"
@joshuaherron2292
2 жыл бұрын
his best video of all timeERRRZ
@Fawn_underscore
2 жыл бұрын
As someone studying science and specifically medicine, with two family members suffering with Alzheimer's, one of them almost gone and the other still developing symptoms, and knowing it is genetic this just makes me furious. Thanks Charlie for bringing up this issue, not only this, but autism and other cases, one of the reasons why you are one of the people I really enjoy watching.
@thedecafe1
Жыл бұрын
As someone lol 😂
@0nceuponatime486
2 жыл бұрын
"It throws into question the actual Peer review process here" As a scientist, let me touch on this subject because it's something I've been passionate about for the last 8 years and something that has long been in question by actual scientists. Peer review these days is pretty much just a word for the layman to latch onto and large organisations to use as a way of conveying information they want to get to the public. The concept of peer review literally means reviewed by a peer, nothing more nothing less. So here's some of the issues: 1) Incompetent reviewers - Reviewers who don't spend enough time on the manuscript - Reviewers are not chosen because of their expertise in the methodologies used - Reviewers are all within the same field and have been taught the same way and so have no chance of seeing things from another perspective (See early Goodall work) - Reviewers can be requested, i.e. I could request someone I know that will go easy on my manuscript. - Reviewers who are simply incompetent and do not understand the manuscript, like those who have become hyper obsessed on the notion of a p-value (Another buzzword the mainstream latched onto) when in reality it can only be used in the context of the entire paper. 2) Corrupt reviewers - Bias (In either direction): Your reviewer could be a competitor of your product (Bias against) or potentially someone who is extremely loyal to the principle investigator (Bias for). - A field which is dominated by a research cartel which filters out papers that go against a consensus 3) A barrier to actual science As a result of latching onto some key words from science we're now doing really bad science because we're all hyper focused on producing results that please the mainstream media, on results that turn positive p-values, and are peer-reviewed and published in "credible" journals like Nature (Nature is corrupt fyi and filled with people who failed at doing actual science) instead of focusing on really good science. This is why we saw studies" showing cigarettes are fine to smoke, alcohol is great to consume, this toxic chemical is fine to spray all over your body, and so on and so on. 4) Over reliance on peer review and appeal to authority Think about science of the past, for those who say non-peer reviewed science is trash you better throw out the origin of the species because not only was that not peer reviewed (It was basically a pre-print by todays standards) but it wasn't even written by someone with a PhD. Most of science was done before the adoption of any formalised peer review by people with no formal training. This idea that because a paper is peer-reviewed it must be good is one that is extremely easily falsifiable and this idea that only people with degrees can do science or know what they're talking about is anti-science. So stop with the parroting of the talking points you heard on reddit like BuT iS iT a DoUbLe BlInDeD PeEr ReViEwEd StUdY and start to understand what science actually is. Yes, when peer review is done WELL it can be really useful, but the idea that it filters for the best science (Whatever that means) is not true. So when people go Is It PeEr ReViEwEd? They have no idea what they're talking about and you can probably ignore them. Anyone can do science, ANYONE. And it doesn't need to be peer reviewed to be good science.
@0nceuponatime486
2 жыл бұрын
@@SmellyHam Where did I say there is no way to validate a study?
@keelinmacken9552
2 жыл бұрын
That’s actually really interesting. I never knew what it meant by peer reviewed but I remember always hearing about it in my classes. I’m curious what you mean about they’re so hyperfocused on the p-value. Are they focused on getting a low enough p-value so it rejects the null hypothesis and helps (in some cases) further prove their data as significant?
@proxivirus
2 жыл бұрын
Thats- concerning. And something I’ll keep in mind. I hadn’t thought about it before
@randomdeliveryguy
2 жыл бұрын
Do you think this could change naturally as time passes or something needs to be changed drastically? Also, what do you think about all the studies that can't be replicated? Is it because of the current peer-review system or the ungodly amount of papers being released getting too much to handle?
@Junuman1
2 жыл бұрын
@@0nceuponatime486 I think he just couldn’t read between the lines that you were saying that the peer review system needs a hard update. Though I have his same sentiment. At a certain point, how do we truly know what to trust if we aren’t a specialist in whichever relevant subject?
@Thuperman788
2 жыл бұрын
I lost my grandmother due to Alzheimer’s and the disease is honestly one of the most horrifying and tragic things that a person could go through or deal with. Thank you for spreading awareness 🙏🙏
@Brandon6295
2 жыл бұрын
This is horrifying. They've been following this data for almost two decades and it's now coming out that the information was not only falsified but also possibly deliberately done so. How much damage could have or has been done in all those years?
@Brandon6295
2 жыл бұрын
@@shyjy6241 That is very true. I don't know how something like this was able to fly for so long. Hopefully people in the future will learn from this situation and we won't have to have any more issues on related subjects.
@yoisthatoliver
2 жыл бұрын
My great aunt, who was like a second mother to me when I was a child, is currently battling the final stages of Alzheimers. When visiting my great uncle once sat me down and told me all about this paper and how he has been doing a bunch of research about it, etc. I already knew this paper was a sham, but I was in the medical field at one point, and to people who dont know a lot or understand much about the medical field, etc. They dont know better. People trust scientists to always tell them the truth, it is always damaging if a paper like this turns out to be unethical.
@azulovesyou2
2 жыл бұрын
The way Charlie can make me care about the dumbest things on the internet, while simultaneously being able to talk about super serious topics that really do matter
Bruh KZitem gotta get their hands off their power polls and deal with these bots.
@zalseon4746
2 жыл бұрын
The fact a fraudulent paper was cited that heavily despite no one replicating the results kinda scares me when you consider this could be happening in psychology right now. You can't blame the patient in straight medical chemistry research. In psych research, you often can and the scientific community there often just accepts it or let's it slide.
@squaeman_2644
2 жыл бұрын
Just think about the ramafacations of this on the medical community as a whole...
@lostpanda1598
2 жыл бұрын
watch, what is a woman by matt walsh
@galaxyocicat5660
2 жыл бұрын
@@lostpanda1598 Shut up. We're talking about actual science here, not fake pdf file conspiracy theorists like you make to justify hurting people.
@TheVideoIsLongEnough
2 жыл бұрын
@@lostpanda1598 nobody wants to see that transphobic garbage. Matt Walsh is a intellectually dishonest grifter at best, and historically anti science
@parkerdavis7132
2 жыл бұрын
@Lost Panda What exactly does your statement mean in relation to the comment?
@philwath
2 жыл бұрын
In general, the research field has a big issue when it comes publications and funding. Everyone wants to get published and get more funding. So researchers try to find something ground breaking. However, most of the time when you do real research, you find something to be inconclusive or reconfirm something that’s already known. Neither of the two make money or are glamorous enough to get published, but are very important to the research process. Had more money and attention went to replicating studies the initial findings concerning that protein would have been disproven and a lot of time saved. More funding should be put towards testing and re-evaluating older studies findings rather than pressuring researchers to do something ground breaking. Mundane research is important to insure safety, practicality, and that data isn’t being manipulated.
@thedecafe1
Жыл бұрын
In general, lol 😂
@meme_boi1012
2 жыл бұрын
Thanks Charlie for bringing attention to this horrible disease. Honestly so upsetting that it was all a scam.
@MechWarrior894
2 жыл бұрын
I don’t think it was so much of a scam as it was doing something for the wrong reasons. It’s close to the breast cancer awareness group, where all they do is bring awareness. I can’t remember if they pocket the money but from what Charlie said, Alzheimer’s research would still be on the same path regardless. It’s frustrating and that money seems wasted, but we’d still be in the same spot.
@ItzMalick
2 жыл бұрын
Yoo Fam I’m an upcoming KZitemr, and I make a range of entertaining reactions, vlogs, and a variety of other content and I’m still working on versatility, and quality but I guarantee you will find something you will enjoy🙏🏾🙏🏾‼
@Linguineo
2 жыл бұрын
@@ItzMalick Little insensitive to promote yourself on something like this.
@MarcosGarcia-xg1rf
2 жыл бұрын
@@Linguineo eh, live and let live.
@_Sloppyham
2 жыл бұрын
@@MarcosGarcia-xg1rf eh, let people complain if they want. Live and let live
@Lonslo
2 жыл бұрын
I get a C- on a paper because I didn’t paraphrase enough , but this man deliberately falsified information and it was fine for 16 years. I’d rather follow the source more than make up random bullshit and pass it as fact.
@honeybeestims
2 жыл бұрын
I’m an undergrad neuroscience student, and I had no idea about this. i’m just not really following up with things right now, but this is really horrible. we talk about alzheimer’s research a lot in my classes and I wonder how much this scandal is gonna impact the information we are taught. i’m sure that this situation will be brought up a lot once the fall semester starts
@SilverMoonLite
2 жыл бұрын
I’d definitely ask your professors when given the chance
@AsianTaile
2 жыл бұрын
Please dont let this stop you from pursuing your degree. I'm sorry, I love charlie to, but he's overplaying this really hard. Every field, even science will have bad actors, and just like in every field (especially science) they will just move around the bad data and might never mention in ever in the future other than to criticize it further. If they do cite it as evidence it will almost always be used with other citations supporting that worldview. As someone who has looked into alzheimer's research, I dont think any researcher is going into meltdown mode, the only people are people that I am again sorry again to say, I am genuinely not trying to insult people, but they dont understand how science works and especially let alone how peer review works. And yes please ask your professor, but I am gonna prep you, he is likely to say something of similarly as what I said. The study didn't change much of where science headed. I guess we can sit around arguing to the extent but Its rather subjective, but even as charlie said the main link identified in the study was known before. Individual studies usually mean nothing, giant meta analyses with fantastic designs for testing for a relationship and large longitudinal studies carried over years are what matter. Not a poorly made study.
@honeybeestims
2 жыл бұрын
@@AsianTaile Yeah, that’s generally what I was thinking too. I don’t really agree w charlie at all that it has led to 15 years of research that means nothing or that scientists were completely led astray onto the wrong path based on this paper. I also am interested in how this situation is going to affect how we are taught about the ethics of science and if it’s gonna be enough of a deal that people keep talking about it. I don’t think it’s horrible as for the entirety of alzheimer’s research, I more so think that it’s just disappointing that scientists would choose to falsify data just for their own benefit. As you said, ever field will have bad actors, it just sucks to see it happening in your own field also, a big indicator that it’s not as huge of a deal as it seems on the surface is the fact that charlie mentioned that their results weren’t reproducible - which is obviously such a huge part of science. tbh that made me feel better bc, as i’m sure you know, a single study doesn’t make a big difference if it can’t be reproduced and it’s definitely not gonna stop me from pursuing my degree :) i love neuroscience so much and some drama like this won’t change that haha
@MACtube7299999
2 жыл бұрын
That points at the ultimate truth. The powers that be aren't trying to heal people. But, they make plenty of money pretending to.
@okay621
2 жыл бұрын
My dad was diagnosed with Alzheimer’s & dementia when I was 8. The disease robbed me of a normal childhood with my father. I’m 30 now and still am traumatized from watching his decline over the years.
@Tyler-cd6ov
2 жыл бұрын
My dad has early onset dementia so this definitely pissed me off when I first heard about it.
@iiballisticpanda
2 жыл бұрын
My mom works in this field and I’ve dipped my toes in there - she’s so hard working, stays in the lab, and stays up late sometimes to go over her papers, peer review others, and make sure her English is perfect - and the amount of times she’s expressed disappointment over seeing a fake paper because people are trying to be famous is actually really saddening. Like Charlie said, there really is no place for falsified information, and the fact people will do that for fame and a higher position and larger salary is frankly not what science is about. Especially when the results matter, and people care about doing it the right way.
@JediMasterBaiter
2 жыл бұрын
How often does this happen and how often do perpetrators lose their credentials?
@brettduncan15
5 ай бұрын
“All Timers” 😂😂😂
@lazra4321
2 жыл бұрын
As someone who lost a family member to Alzheimer’s this year and has done several memory walks in my life to attempt to fund research this is just saddening to hear. As the experts said, this may not have had a large affect on the research field but it still leaves us with the ‘what if?’ of what could’ve been had this false data not been created. Perhaps we would’ve had a breakthrough since 2006 in another area if many researchers were not looking at this protein said to help, perhaps my families lives could’ve been less painful in the end had we all not had to suffer with watching someone we love forget us. Sure it’s a huge leap but for those of us who have had experience with this horrible disease first hand we live and hope that anything could’ve been different.
@jessefriaz2175
2 жыл бұрын
From Alex Aloian in the comments section: "hello, med student here, and its been known for a while that we dont trust this paper. If anything it was pretty influential for amyloidosis studies (which itself we know a lot more about), and a small bit for alzheimers itself, but a lot of people I know that currently do alzheimers/dementia studies kinda just ignore this study itself because anyone that does any kind of case/lit review knew for a while how much of a sham that paper was" I'm so sorry about you and your family, and can't imagine how sickening it is to have watched the video knowing things had a chance of being different, but I hope Alex's words bring comfort
@lazra4321
2 жыл бұрын
@@jessefriaz2175 thank you for this, they do help. As I said above we’ll always be stuck with the ‘what if?’ of this paper as it clearly steered a few studies back in the day down a wrong path but I’m glad over the years people have found out it’s false and they’re not using it in future within the science community for the most part. I’m glad that research may hopefully be looked at further surrounding Alzheimer’s from this coming to light too though; hopefully more people will realise it’s an area that really needs some medical geniuses out there, the more the better. Even if this paper was false I still appreciate all the work done when it came out from people who thought it to be true; they’re all just people who want to bring people like myself some peace and I can’t fault them for it. Wouldn’t wish Alzheimer’s on my worst enemy or their families, it’s one of those diseases where I imagine watching them forget hurts just as much as the person forgetting; it is truly a sickening disease and my heart goes to those of us who have been through it, are going through it or will go through it in future. Have a lovely day, thank you.
@jellyfishprime1
2 жыл бұрын
Biggest crime of all: Charlie not saying the "Z" in Alzheimer's even once
I didn’t have any idea what he was talking about for the first half of the video
@saberwooah
2 жыл бұрын
@LakehuntistEpic didn’t ask. 😏
@l1l086
2 жыл бұрын
I appreciate charlie spreading awareness about this. A Scandal like this is an issue and it could've/can have consequenses depending on each scandal -This scandal is an issue and those involved should be punished for their actions. It's apalling how people actively choose to lie about stuff like this - Especially considering it's those people whom we are supposed to believe and put or trust in, people whose jobs are to put the best interest of the world forward.
@silphcolapras2573
2 жыл бұрын
4:26 critikal is hitting a real important point here. There was a similar situation of artifact forgeries in middle eastern archaeology that was decades long and done by one guy. His papers were always treated with grains of salt, but it doesn't change the fact that his forgeries were a massive issue. Fake or bad science should be called out regardless of the impact within the ivory tower of the field.
@whooopdeedo
2 жыл бұрын
5:12 the point you make here is how i feel: the magnitude of the misleading/red herring effect of this falsified study should NOT be underestimated. cures or treatment for diseases can be considered the "exit" of a maze, and all the research done to reach the exit are the steps we (as a group) taken in any given direction. this fabricated study was a deliberate direction towards a dead end in that maze, which a LOT of people followed. this wasted time, effort, and resources that all could have been going towards the true end goal, the exit we've been looking for. how someone could do that for their own person gain while millions of people and their families suffer from the effects of alzheimers is sickening
@ItzMalick
2 жыл бұрын
Yoo Fam I’m an upcoming KZitemr, and I make a range of entertaining reactions, vlogs, and a variety of other content and I’m still working on versatility, and quality but I guarantee you will find something you will enjoy🙏🏾🙏🏾‼
@soovie2019
2 жыл бұрын
We all understood what Charlie meant, and understood the meat of the discussion. What I can't understand is the amount of people who's takeaway is solely based on a mispronunciation. This is a serious topic, c'mon now.
@SHMEGAF
2 жыл бұрын
Some people don't have more than 1 and a half brain cells unfortunately.
@jjsparks_9025
2 жыл бұрын
And also the pronunciation is how a lot my professors in undergrad said it. It’s not “wrong” it’s just another way of pronouncing Alzheimer’s. It’s really funny honestly
@dellgary7539
2 жыл бұрын
@jjsparks_ no no… it’s wrong lol. That’s isn’t the right pronunciation. Let’s not 😭 but at the end of the day it’s a mistake.
@melosjaha8897
2 жыл бұрын
@@dellgary7539 "That's isn't" Good thing taking grammatic or linguistic tips from you seems like a good idea.
@Fj-OuterSans
2 жыл бұрын
Honestly I like Charlie saying all timer since it kinda reference the meme where a guy says he has all timer disease If you can’t find the image just search up boneappletea all timer
@nikis2987
2 жыл бұрын
I'm sure others have already mentioned this, but one huge issue in research right now is that papers with negative results, such as ones that would have tried to but been unable to replicate the falsified study, don't get published as often as they should. Replication is hugely important to research, but it's not something primary investigators or graduate students often publish because funding sources want innovation and prestige, and researchers just don't get paid enough without outside funding. Scientific journals too are usually biased towards exciting and positive results, and since the number of publications you have effects your career prospects, people learn to write for publication which can lead to misrepresenting results or just leaving out negative or inconclusive findings altogether. It's a huge issue and it all comes down to money. There have been some movements made to improve things, providing open access to data and pre-registering studies before analyzing your data (so you have to discuss your negative/inconclusive findings) are two things that I've been seeing more labs engaging in. But governments and universities need to start prioritizing rigorous practice over their own egos. Anyways, I loved hearing your thoughts on this. I think you're right that this will have more impact on the field than people expect.
@Thelostboots
2 жыл бұрын
That’s honestly frustrating! I learned about that falsified study in my cell biology class. At the time, it seemed legit!
@harrysmith6252
2 жыл бұрын
One of the most important things Charlie’s ever talked about. Props to him for that
@RantKid
2 жыл бұрын
He can't pronounce the most important thing he's ever talked about
@nunpho
2 жыл бұрын
@@RantKid so?
@ariat3381
2 жыл бұрын
@@RantKid lol at first I thought he was mocking Alzheimer patients by calling them 'oldtimers'
@samanthal9114
2 жыл бұрын
I'm a research scientist, I'm a postdoc working on Lupus and...this is heartbreaking, infuriating, and makes me want to smash shit up. The wasted money, all the wasted money, must be billions by now, that just....gone. All based on a lie, the amount of published papers now invalidated, the careers of people who came after him...all of it wasted. Yet, here I am, writing 10+ grants a year to maybe get 1. It is insane. All of the money spent trying to replicate this could have gone on other stuff. It's not hyperbole. The wasted fucking money is unreal. It had robbed studies that would have been beneficial from being funded. It goes beyond the field.
@zookaroo2132
2 жыл бұрын
Send the fraud to lifetime prison
@ItzMalick
2 жыл бұрын
Yoo Fam I’m an upcoming KZitemr, and I make a range of entertaining reactions, vlogs, and a variety of other content and I’m still working on versatility, and quality but I guarantee you will find something you will enjoy🙏🏾🙏🏾‼
@MercuryKurogane
2 жыл бұрын
Alzheimer's and dementia run in my family and this is both heartbreaking and terrifying. I hope that those who were involved with this studied get punished and have rewards and titles revoked, never to be allowed to be in a scientific field. I know that research will still continue with this awful diseases, and I can only hope that there has been many advancements that did not go off of this one study.
@carlsong6438
2 жыл бұрын
4:43 u hit the nail on the head Charlie. That's one of the biggest problems with the current peer review/publishing system. Replication studies are not punlished nearly as often because they are not as hyped. Veritasium has a great video that addresses this.
@TraeDavis623
2 жыл бұрын
Charlie I now challenge you to release your own paper on why it is actually “all-timers” and not “Alzheimer’s”.
@dontreadmyprofilepicture270
2 жыл бұрын
DONT READ MY USERNAME!!
@-whyquestion
2 жыл бұрын
Ratio + k-pop better + NCT outsold 🤳🏼🤳🏼🤳🏼🤳🏼🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓🤓
@ilcarnifex
2 жыл бұрын
Because the discoverers name is pronounced alt heimer but it's upto you
@alexcunningham1647
2 жыл бұрын
@卐-Lakehuntist-卐 lol
@martinpadilla5224
2 жыл бұрын
Yo these bots are getting out of hand. Literally on every video Charlie posts.
@pengmaeda9908
2 жыл бұрын
I just got second-hand existential dread for anyone who just spent the last 16 years doing research based on this study. Jesus Christ...
@drunkenhobo5039
2 жыл бұрын
Here's another one - in the days of BSE (mad cow disease) scientists spent five years experimenting on sheep brain tissue to see if they could be vulnerable to the disease just like cows were. Only problem is they had bovine tissue instead of ovine tissue. So they'd been using cow brains instead of sheep the entire time.
@thegoozahyt
2 жыл бұрын
This deeply upsets me as my grandmother died from Alzheimer’s and she died alone while her brain decayed while we could do nothing.
@andresandrew1483
2 жыл бұрын
@Kavetion dude wtf this man just said that his grandma had died and that what you say
@josephengle4546
2 жыл бұрын
My grandma died around 2020 and I never got to really know her because I never got to talk to any of my grandparents and the fact that she could've been saved.
@MaggieJean
2 жыл бұрын
That's how I say it. Now I guess I have to look up the pronunciation. Yeah, like you stated, billions of dollars are spent regarding research, but when a scientist deliberately falsies information it's a big setback.
@ValorGlory
2 жыл бұрын
So some information about this whole scandal, 1. The earliest paper in which people had stated they couldn't reproduce the results claimed by Sylvain Lesne are from 2008. (some of can be found on pubmed) 2. A vast majority of the papers that cite Lesne's study are either by Lesne himself or are people refuting him. (Also the number Charlie quoted in the video, 8.5k or so, is the total number of citations for all of Lesne's papers not just the ones on Alzheimer's) 3. While it was January of this year that evidence of potential tampering of Lesne's evidence was submitted the actual investigation had been on going for at least multiple years prior. To me it seems pretty clear the problem has been known about for awhile and they have been simply trying to find conclusive evidence that proves it was knowingly faked.
@DravenUrei
2 жыл бұрын
Here's the problem though: how many doctors and physicians have quoted this man? Scientists may have known the problem, but they were not loud enough to call it out.
@Taylorgreenbjj
2 жыл бұрын
Interesting, glad they told everyone out loud and put this to the public instead of letting people waste over 10 years of research.
@ValorGlory
2 жыл бұрын
@@Taylorgreenbjj are you serious right now? Do you not understand how many papers get proven false daily? I mean for fucks sake I am not even a person working in the field and I was able to find those three points in less then an 1 hour of looking for them. IT WAS MADE PUBLIC, it is just most of the public didn't care to pay attention to complex medical papers that weren't dumbed down into baby food for the general public. Seriously, the bigger question would be "should we consider a doctor that took a study that couldn't be reproduced seriously as a real doctor?"
@logansweeney7433
2 жыл бұрын
Mispronounced as it may be this man is spreading awareness. He has a huge audience and his heart is absolutely in the right place. I love this man. Well done
@nnnyel
2 жыл бұрын
Old timer's
@Butts666
2 жыл бұрын
yeah it only took me like halfway through the video to realise he was talking about Alzheimer's related research, not research done by a journal or society calling themselves All-Timers (which was already weird, that sounds more like a retro pop rock band or something)
@BH-ix7nq
2 жыл бұрын
If you watch it with captions, it pops up perfect. Charlie never gets it wrong. That is the correct pronunciation now
@TheRandomYoYo
2 жыл бұрын
@@Butts666 I was sure initially he was talking about a Research Group called All-Timers based on Alzhimer's research.
@ItzMalick
2 жыл бұрын
Yoo Fam I’m an upcoming KZitemr, and I make a range of entertaining reactions, vlogs, and a variety of other content and I’m still working on versatility, and quality but I guarantee you will find something you will enjoy🙏🏾🙏🏾‼
@bobsaget3841
2 жыл бұрын
Stuff like this happens ALOT in science. Like way more than the general public knows. The whole publishing system and academia is set up to encourage “fudging” results because of how important publishing is to scientists and researchers jobs. The more you publish the more prestige you gain, the easier it is to get grant money, the easier it is to get a job. Research in general is not where near as rock solid and a source of truth as the public seems to think it is. Since there is such a huge incentive to publish research and make big discoveries there will always be false results being published. The sheer number of papers sent for submission and the fallibility of humans make cases like these very common, scarily common. I know this because I am a published scientist and I worked for the CDC and I have seen a lot of things that made me lose faith in the scientific community. The reason I left the field is because of how much weight is put on just getting you name on a published paper. Good science takes time and it is very common for researchers to be pressured into publishing as many papers as they can per year, sometimes there are even quotas which makes the pressure even more intense. It’s not hard to imagine if your job hinges on publishing papers with good results that you would cherry pick data so the results come out the way you want. The pressure, the cut throat mentality of research and the emphasis on quantity over quality produces issues like what Charlie is talking about. If we want this to change the entire research system needs to change and not be driven by quantity, meaning jobs and funding need to not be tied to a researchers prestige or the number of publications their name is on. It’s the same thing with fking health insurance, a system that exists only to make profit doesn’t care about integrity. The American health insurance system and to an ever growing extent (thanks to health insurance lobbies etc) the American health care system exist to make as much money out human illness as possible. It’s not there to help you get better, it’s there to exploit you at your weakest, to keep you chained to a shitty job because you can only afford health insurance if your employer subsidizes it ( this is by design, the prices are all set behind closed doors and the only reason all but the most intensive and niche health care is unaffordable is because these huge industries make it that way). It’s fine to want to make money, but the main priority shouldn’t be to make as much profit as possible. Especially on things like illness and scientific research. Pursuit of profit is a cancer in the body of America and we are nearing a terminal diagnosis. There needs to be a huge restructure where resources are realigned to help us, the American citizens. All Americans not matter the political party or skin color or gender or anything, all human beings deserve to be treated with dignity and this country could truly be as close to a utopia as humanly possible if these huge industries stopped putting profit before everything.
@qwertyuiop3656
2 жыл бұрын
The problem is they have us fighting eachother. We are way more powerful than the elites when we all stand together. If we don't we have zero. They've created strong division via the news and media. It's essentially mind control over the populace. It's really sad many people are blind to this
@qwertyuiop3656
2 жыл бұрын
CNN and similar news outlets have the older crowd, and the younger generations are mind-controlled via Twitter, Tiktok and many other social media platforms. You have to get off those platforms that only serve the elites. I only use KZitem only on occasion
@SpinoRexy733
2 жыл бұрын
It's almost as if religiously latching onto capitalism as the end all be all of societal structure is a mistake or something. . .
@raylenemejia3170
2 жыл бұрын
👏👏👏👏👏
@camwhapshare2729
2 жыл бұрын
@@SpinoRexy733 -american socialist capitalism isnt the problem, its your shitty country. We have capitalism in europe and none of those problems
@Spanishgecko
2 жыл бұрын
Really love this type of content Charlie, thanks for showing this side of your passion!
@thedecafe1
Жыл бұрын
Really love ❤️ lol 😂
@eviltim3786
2 жыл бұрын
The thing that bothers me is the lack of repercussions for these people. Like to me that kind of scandal is an especially egregious form of malpractice that quite literally effects the lives of thousands that are suffering the erasure of their lives as they live and breathe. think about it, YOU ARE LITERALLY DISAPPEARING WHILE YOU CONTINUE LIVING. An absolutely horrid nightmare that no description could ever properly portray such a horrible way to go and these fucking researchers just walk. “Inconsequential” they’ve said huh? Their fucking job is inconsequential and they should lose everything.
@ultimatetacoparty
2 жыл бұрын
scientific literacy classes should be mandatory in highschool/university, so many misleading titles and assumptions that scientific studies are irrefutable edit: im getting my bachelors in science right now and the statistics on misleading media articles are insane, not to mention how many peer reviewed articles have obvious confounds that should be considered. Reading an abstract or even the conclusion is not enough to determine the legitimacy of an article, let alone a media piece that takes the study out of context
jesus christ the bots line up seconds before each other
@djmcneill7470
2 жыл бұрын
@@bevydulcet it's never ending man there everywhere
@daryanswanson8781
2 жыл бұрын
It warms my heart that Mr. White is going out of his way to point out a serious issue. Most people wouldn't do the same.
@stxcxv
2 жыл бұрын
@@theneotrinity not if you talk like that
@prollyoli
2 жыл бұрын
@@theneotrinity advertising in youtube comments does nothing. just make good content and keep at it for a while. it takes lots of patience to get bigger
@Cholincy
2 жыл бұрын
@@theneotrinity don't promote in a KZitem comment section, just get blessed by the algorithm
@aarepelaa1142
2 жыл бұрын
@@theneotrinity probably a better idea is to just do KZitem for a hobby, and if it goes somewhere i guess that's a good thing, but you'll probably get work and school to do anyways.
@cardboardclub
2 жыл бұрын
Thank you for talking about this. I'm so desperate for a cure for this disease but you bringing it up like it this, bringing awareness and also acknowledging how scary it is. I appreciate you.
@thedecafe1
Жыл бұрын
Thank you lol 😂
@veed1ary
2 жыл бұрын
As someone who's inspiring to be in neurology this is just sad. Neurologists, Psychologists, even neurosurgeons work every single day to figure out the brain to help us, and we don't even understand all of it yet. The fact that this happened is actually frustrating..its essentially "progress lost".
@veed1ary
2 жыл бұрын
@lois gages Hopefully we can make more progress then that.
@gaydonaldtrump
7 ай бұрын
Hope you learn how to spell than. And all-timers
@AriiAniaismyname
2 жыл бұрын
Thank you for touching on this! My grandfather got early-onset Alzheimer's and passed in 2013. It's a heartbreaking disease that strips the affected person of their memories, their lives, and eventually basic skills like swallowing.
@NightmareEclipse
2 жыл бұрын
The last science class I took actually covered something similar to this. The professor talked about how common it is for studies to have falsified information. The only way to catch it is for people to try and replicate the results, but unfortunately that didn’t appear to happen for this study. Thanks for making this video Charlie, hopefully it will bring more awareness to the problem and lead to better research around Alzheimer’s that isn’t tied to that study.
@aydenmartin5650
2 жыл бұрын
like charlie said, it did happen. People couldnt replicate it but the paper was still a decent direction with the falsified data. People understood its been false data for awhile just never formally debunked it.
@butterflygroundhog
2 жыл бұрын
Honestly, I like that this video steers away from the usual gaming and KZitemr/tiktok scandals. Feel free to do more videos in that kind any day
@beardsmcguiness8463
2 жыл бұрын
You think just because he's talking a out something other than gaming and tiktok that he should ignore the seriousness of this and simply NOT put out the information to people that otherwise wouldn't necessarily see it? If I misunderstood I apologize but if that is what you're saying, grow up this is important to so many.
@butterflygroundhog
2 жыл бұрын
@@beardsmcguiness8463 what the hell are you even talking about
@MiftySive
2 жыл бұрын
I'm a dementia researcher - this is one specific amyloid-beta protein that was being investigated (amyloid-beta 56). This specific oligomer is actually kind of counter to what most researchers currently believe drives the amyloid hypothesis of Alzheimer's disease. Amyloid-beta 42 is believed to be the oligomer driving the formation of amyloid plaques that are a typical marker of Alzheimer's disease in older adults. Inability to replicate data is often not published, because journals typically want to only publish significant results. This is known as the "file drawer effect". This is especially true for high impact journals like Science, Nature, etc. Also, cool that you're covering this.
@whatsaeuphonium9077
2 жыл бұрын
Science
@RewindRevival
2 жыл бұрын
@@balmy659 you can't control it. Its like cancer, some people are just more likely than others. Scientists don't understand enough about the disease to prevent or treat it effectively yet.
@lorenzomeulli750
2 жыл бұрын
I work in Rett research, but my thesis could have been about AD back 3 years ago. As soon as I heard the topic of the video I had almost a stroke. If beta42 turned about to be fake data early on It would have been absurd
@Geoffreyshadid
2 жыл бұрын
Wrong, that paper wasn’t covering amyloid-beta 56, it was actually covering AB 36, get a real science degree !!! 🤣🤣🤣
@benk42254
6 ай бұрын
Replying to this over a year later because I’m a neuroscience minor and I just had a unit on Alzheimer’s in my behavioral neuroscience class and I learned about everything u just said. Cool stuff
@spacegay6030
2 жыл бұрын
I was just reading this article yesterday, and I'm really glad Charlie is talking about it because I feel like a lot of the people on here wouldn't even know about the article, much less take the time to read it (it is an extremely long article to be fair). There should be no space for false information in science, it poisons societal knowledge, especially for those not well versed in science to begin with.
@butteredbuns3491
2 жыл бұрын
what the article and publisher called?
@justsomefox8910
2 жыл бұрын
I remember my highschool psychology class talked a fair bit about the paper that was just proven wrong, so I can confirm it did have somewhat of an impact on the educational system’s curriculum in the subject, even if a small one
@dontreadmyprofilepicture270
2 жыл бұрын
DONT READ MY USERNAME!!
@sugarsweet4339
2 жыл бұрын
Holy clip the bots
@lmaolmao2871
2 жыл бұрын
No one cares 😂😂😂😂😂
@justsomefox8910
2 жыл бұрын
This bot bullshit is why I don’t like commenting on large channels I regret wanting to contribute my experience
@firo729
2 жыл бұрын
@@justsomefox8910 fr man
@syntrodigital
2 жыл бұрын
As a scientist, thank you for covering this in your corner of the web. The academic publishing industry needs to change - badly. It's the best we've got, but we can do better.
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