I made my own "Auvelity", although not exactly the same doses. I've been taking bupropion with some improvement, but I wasn't sure it was placebo effect, or maybe coincidental improvement. My melancholic days went from DAILY (yes, crying every day, for hours sometimes) to 2-3 times a week at most. Then I added extended release dextromethorphan 60mg (with guaifenesin, but apparently that can work for fibromyalgia, so why not!) That made a HUGE difference. I haven't cried in months. I feel normal. I guess I'm a believer, cause after over a dozen of antidepressants for many years, I thought they were all a joke, placebo. My mom died end of Sept in our home (in the middle of a hurricane to add to the stress) after a decade of decline from dementia, so it was expected, but I never thought I would be the one in the family to keep it together, do the arrangements without breaking down. My family handled some of my affairs (appointments, medication refills and adherence, etc...) They couldn't believe it, the emotional wreck of the family was the one that took the lead, lol! Now they don't have to (and I'm sure they're happy with less responsibilities, lol!) I'm much more inclined to believe in meds now, at least the combo I'm at (bupropion, dextromethorphan, lamictal) although I still think lots of those other antidepressants are BS, sorry to put it so blunt. Anyhow, for all of you, don't give up, it might take a while but you'll get there. Hugs to you all 🤗
@X-FILESCHILE
Жыл бұрын
Going to give this a try … and you are right about the fact that most of these meds are useless.
@nirmanshrestha2038
19 күн бұрын
@@X-FILESCHILEdid it work ??
@whoopdeedoo876
Жыл бұрын
I have had a miraculous recovery from my depression after being on a generic combo of buproprion and dex for 3 months after suffering 30 years.
@atiqrahman6865
11 ай бұрын
@whoopeedoo876. Glad to know that combination of Bupropion and Dextromethorphan has worked for you. You have said that you have recovered ------you mean to say CURED, need no medication---------------or just recovered and continue to need combination of Bupropion and Dextromethorphan.
@nirmanshrestha2038
19 күн бұрын
What are the dose of each ?
@chrisdusty8134
Жыл бұрын
Anecdotally. I was in the Esketimine trial for 4 years and it worked wonderfully. After the trial, I couldn't afford the medication. Fast forward to a month ago and I saw an article about the approval of Auvelity. I started taking as close to the stated dose of the combination as I could, given that it is not yet available on the market. Just shy of 30 days in it's working great so far.
@ShrinksInSneakers
Жыл бұрын
Good to hear, I think this is an interesting new concept building off the NMDA antagonist MOA. I'm glad you are having success with treatment. if you haven't subscribed to the channel please do and spread the word about what we are doing here
@garysimone4977
Жыл бұрын
@@ShrinksInSneakers I understand the med is 500.90 a month...
@chasvonplatten1298
Жыл бұрын
@@garysimone4977try $1,200.00 per month for the twice daily dose! This, for a combination of low dose Wellbutrin < $30.00 per month and an OTC cough suppressant "DXM" $25.00 for a bottle. No wonder people are trying to figure out if they can compound it themselves! Got to love big pharmacy looking out for the less fortunate mentally ill in our society.
@garysimone4977
Жыл бұрын
@@chasvonplatten1298 in USA how juch health can you afford
@chasvonplatten1298
Жыл бұрын
@garysimone4977 Not a lot apparently.
@adntigger71015
2 жыл бұрын
You posted this only a few days before FDA approval. Crazy timing, lol. It's AUVELITY by Axsome.
@ShrinksInSneakers
Жыл бұрын
Lucky timing or maybe a know a few things about what's coming 😁
@marielle36
Жыл бұрын
I have struggled with MDD for 15 years. I've been on so many medications and combinations of medications over the years, along with therapy. I gave up on finding anything to help me have any type of a quality life a few years ago and stopped changing any medications 5 years ago. I've been mulling over what you said in this video and talked with my Psychiatrist and tomorrow I am going to give it another try and will be starting AUVELITY. I'm scared to taper off and start a new med but I need to give it one more try. I have Grandkids now and I want to enjoy them and them me.
@ShrinksInSneakers
Жыл бұрын
I'm glad I could at the very least instill some hope back into your life. I wish you the best and know you have the ability to get better. Keep working at it. All the best, Dr.G
@mariawalker8403
Жыл бұрын
Look into to detoxing and nutrition like juicing. I used to have chronic depression for YEARS and it wasn’t until I did the above, that I started to feel hopeful again. The myth of chemical imbalances is just that, a myth.
@ginzo666
Жыл бұрын
@@mariawalker8403 If there's no chemical imbalance, then what are you detoxing???
@martinlutherkingjr.5582
Жыл бұрын
@@ginzo666 She doesn’t realize that everything influences brain chemistry. She’s confusing the discredited theory of a lack of sufficient serotonin being the root cause of depression with all forms of brain chemistry imbalance. The idea is that depression is more complex than simply 1 neurotransmitter being low. “Chemical imbalances” themselves aren’t a myth. The balance of chemicals changes all the time.
@Justintime619
Жыл бұрын
I start taking this tomorrow. First thank you for making me aware of it I really hope it works for me!
@ShrinksInSneakers
Жыл бұрын
Best of luck let me know how it goes
@Justintime619
Жыл бұрын
@@ShrinksInSneakers it’s been a game changer!! Thank you for putting me onto it after 20 years of trying everything within two weeks I felt relief.
@johnmoore1495
Жыл бұрын
@@Justintime619 still going good? I’m looking into the new med, or potentially just adding dextro to my current bupropion.
@teamburyoutdoors6989
Жыл бұрын
@@Justintime619 how is it going for you today? Really wanting to get on this
@Justintime619
Жыл бұрын
@@teamburyoutdoors6989 it’s been life changing. Honestly.
@sexualsalt6016
11 ай бұрын
Auvelity has helped me more than any other antidepressant and anxiolytic.
@alli138
3 ай бұрын
I am about to start. Really nervous
@nirmanshrestha2038
19 күн бұрын
@@alli138did it work on u ?
@susanschlesinger4791
Жыл бұрын
Great content -- glad to see that treatment for mental illness is getting as much play as living better for mental wellness. I would have watched longer but was experiencing a bad reaction to the neon sign over your shoulder. Many folks have a problem looking at a bright light. It causes eye stress, headache, nausea, and a sense of unease. This is especially so for people who take certain medications including psych meds. Light sensitivity, as well as strobe rate, are both issues. Could you update your backdrop to accommodate those of us who are triggered by your neon sign? Go with the emo/goth theme if that's your thing, but be aware of your background. Much appreciated, Susan
@ShrinksInSneakers
Жыл бұрын
I appreciate the support, if you found it helpful please subscribe and spread the word about what we are doing here.
@mikeg1433
Жыл бұрын
Was it changed because I don’t see an issue?
@SteezyMcDude
Ай бұрын
Started Auvelity today after years upon years of antidepressants with little to no effect. Fingers crossed!
@denise76
Күн бұрын
I stumbled onto dextromethorphan by accident. I noticed that every time I took cough medicine, the next day, my depression was lifted. I saw it happen so often, that I Googled it and BINGO! WOW! If it hadn't happened to me personally, I would have said that it was a load of crap. Who knew?
@amyfox369
Жыл бұрын
I am diagnosed with bipolar 1 and take nuedexta and lamotragine, I have for a couple of years, the nuedexta off label of course. It has worked very well for the depressive part of my illness, which generally spends it's time in depression. I've been stable since taking it, no side effects with either medicine thank goodness. I am NOT a candidate for ssri's or snri's because of mania and I have had mania taking buproprion. So the new medicine that includes buproprion would definitely be something to be careful in prescribing, especially if bipolar has not been ruled out in a patient. although as I always said at NAMI, everyone is different, everyone will react differently to different medicines. still trial and error unfortunately. I do hope it works for people with unipolar depression.
@ShrinksInSneakers
Жыл бұрын
Any type of antidepressant medication should be used with caution in patients with bipolar disorder. Personally I very rarely use them and will more often than not take people off of them due to the mood destabilizing effects. Hope this helps and if you haven't subscribed to the channel please do and spread the word about what we are doing here.
@chasvonplatten1298
Жыл бұрын
@@ShrinksInSneakersNote: a very low dose of Wellbutrin in Auvelity used to facilitate and extend the effects of the DXM. With it being an NMDA antagonist it mitigates excitatitory effects of high glutamate levels which would guard against mania in my research.
@jeepbme
Ай бұрын
For those saying they made their own mix its impossible to get the same mgs. The buprioon is105 mgs extended release which is not available in that dose and dex us 45 mgs which is also not available in that does unless you measure out liquid. Its 10 copay if you have insurance with the prescriptiion card from auvelity website for a months worth
@gettingshitdone
Жыл бұрын
DXM will help you sleep, it's a good sleep aid, and unlike other sleep aids you won't wake up feeling drowsy, therefore it is a good tool to treat depression, when people are depressed it makes it tough for them to get a good night sleep, which further escalates their depression, other than that it don't do shit
@melodymacken9788
Жыл бұрын
Brilliant, brilliant and brilliant. Thankyou.
@ShrinksInSneakers
Жыл бұрын
Thank you appreciate the support, spread the word and help me keep this thing going
@avril.227
2 жыл бұрын
Thank you for breaking this all down. It seems very activating. Thoughts on AUVELITY for mixed anxiety with depression?
@duslanjeremy4770
Жыл бұрын
I always recommend psychedelic mushroom to anyone battling with depression because I won my with the aid of shrooms and it helped me see the truth in my pain and gave me the confidence to fight to live purposefully, I get it from an online vendor that specializes in the growth and sales of psychedelics products like ketamine, DMT, LSD, MDMA it’s the best experience
@duslanjeremy4770
Жыл бұрын
*Formulah11*
@ShrinksInSneakers
Жыл бұрын
At this point it's only approved for depression. We have to wait and see what the investigations for anxiety disorders show. Sorry I don't have a better answer at this time
@nghtylu
2 жыл бұрын
I hadn’t heard of this before. Thank you, it was very informative and interesting
@ShrinksInSneakers
2 жыл бұрын
It should be available soon, watching for the FDAs review
@BobSacamano666
Жыл бұрын
I would think DXM and ketamine are similar disassociatives.
@ashleyzeleznik5388
Жыл бұрын
Really wish I had invested in axsome…
@lisaalexander1824
4 ай бұрын
It makes me high/ manic...which gives me energy,,motivation and life...if I get to the anger stage, I stop taking it
@andrewshort3043
2 жыл бұрын
great video! Can you do a video on testosterone replacement therapy's efficacy in treating men with co-occurring depression and hypogonadism or sub optimal testosterone levels
@ShrinksInSneakers
2 жыл бұрын
This has come up in some of my cases, mens mental health is a really important topic for me and I want to cover more issues related to men specifically. I will add it to the list
@ralphsmith2683
2 жыл бұрын
you should never just inject testosterone - you should first try CLOMID - without doing this you don't know for sure if it's PRIMARY or SECONDARY - you should only inject testosterone if it is in fact PRIMARY - if Testosterone fails to increase in the serum after CLOMID therapy one can assume it's PRIMARY and THEN resort to testosterone
@andrewshort3043
2 жыл бұрын
@@ralphsmith2683 I agree. I should have been more specific in my question which was precluded by my inherent assumption that you've tried all means of improving testosterone and still having clinically low or sub optimal levels with co-occurring depression. Its similar scenario to taking antidepressant which "you shouldn't just take either" unless you have tried other appropriate means of improving your depression to no avail.
@ShrinksInSneakers
2 жыл бұрын
@@ralphsmith2683 I think this is all the more reason to see an endocrinologist and go through a proper work up for hypogonadism. Although there is a lot of variability in what is considered a "normal testosterone level"
@ginzo666
Жыл бұрын
@@ralphsmith2683 Clomid is a dirty drug. Most men don't feel great on it. It modulates estrogen receptors all over the body, not just in the hypothalamus. It crashes free T because it upregulates SHBG. Also, it causes blindness in rare cases.
@Cognitoman
5 ай бұрын
Dude I tripped on DXM (I was depressed for like 2 years) and for a few weeks after I took it I felt super happy and not thinking about my pass, I felt like I was living k. The present … very odd feeling
@JakeStehliChaser
Жыл бұрын
At one time in my 20's, I took Effexor for Depression/Anxiety. It didn't work so we stopped tapering it. Worst discontinuation symptoms ever. Since I was already struggling in college with social phobia, causing severe academic issues, I was desperate to stop feeling that way without having to go back on Effexor. Long story short, as a last resort (don't recommend anyone doing this obviously) I chugged only 1 bottle of cough syrup thinking for some reason it would help ( without not knowing what DXM was or trying to abuse or have any self-harm behavior). Discontinuation symptoms were halted pretty much at that instant. Forever.
@ShrinksInSneakers
Жыл бұрын
I would not recommend this to anyone reading the comment here, but yes dextromethorphen has been proven to be helpful in depression and may have less risk for withdrawal syndromes than SSRIs or SNRIs alt ought this hasn't been available long enough to fully evaluate the risk of withdrawal this will come in the post marketing period.
@JakeStehliChaser
Жыл бұрын
@@ShrinksInSneakers Yes, I would not either! Just a random thing I've experienced that was interesting. To your followers, The thing I got out of it was... ALWAYS check with your doctor first if you are experiencing discontinuation! We all do dumb things, and potentially risk things out of desperation, especially if struggling mentally. I just found you and the reason why I found this interesting was Ironically, I was just prescribed Auvelity. As you know DXM/Bupropion. Insurance covered it with a PA. I have already been on Welbutrin for several years (which *might work a little* which is why we thought to give it a shot. I kid you not, I actually "feel" something over any other antidepressant. Two symptoms that tell me it's no placebo this time! Depression truly does take away physical feelings of "goodness" as well The return of "butterflies in my stomach" for example when you see a woman you like or a passion you think about. I haven't felt that since I was 20. I am 43! Second. I FEEL it the next day long after your last dose. You can lay in your bed feeling just "right". Not the typical depression symptom of frustrated and restless irrational thinking Since it is so new, I thought you and your readers would find that interesting. Everyone is different of course. Don't self medicate. See your physician Of course, we have to see if this continues long-term. Does the brain, just become tolerant and down-regulate back to baseline (the disorder)? Or does this strengthen/repair your receptors for the long term combined with reinforcement through psychotherapy and positive thinking? The million-dollar question. With me anyways... Profound enough to share this publically with you guys. Says a lot in of itself (self-confidence improving?) 🤔 Thanks
@garysimone4977
Жыл бұрын
@@JakeStehliChaser good luck, hope this med is THE ONE.
@Joseph-vh5fh
Жыл бұрын
Auvelity is insanely expensive for a combination of 2 generics. I wonder if physicians will be prescribing DXM + Buproprion XL instead.
@SandfordSmythe
Жыл бұрын
They're prescribe it and complain how insurance companies and government doesn't let them practice medicine.
@flatlogicinheaven7291
9 ай бұрын
I figured out the antidepressant properties on my own. I have several different mental issues including depression so i have a dopamine seeking brain so i tend to try different substances out ( yes self medicating, because pharmacudicals have never been very effective for me) and everything hase negative side effects in the morning aka hangovers, but the hangover to this was a general sense of well being. Unfortunately its doesn't last forever but its the best thing ive found
@landgabriel
Жыл бұрын
All NMDA antagonists are synapto- and neuro-genic. For this reason, they can help with almost everything, from pain relief to depression and anxiety to potentiating other drugs, and with brain injury. This is the Soma from Huxley's Brave New World.
@andrewortiz5797
Жыл бұрын
The Soma of ancient Hindu text's is not dextromethorphan. Its an all natural plant or leaf or fungus etc... No one knows what it is but it probably grew from the ground most likely. Dextromethorphan is synthetic
@ShrinksInSneakers
Жыл бұрын
This is the basic idea with ketamine as well as most psychedelic medications. I think one of the possible mechanism of all these medications is increased neuroplasticity making it much easier to form new connections and alter aberrant circuits. This is still theoretical and has not been proven scientifically so we need to be careful assuming this is a panacea for depression or is disease modifying which I do not believe they are unfortunately
@andrewortiz5797
Жыл бұрын
@@ShrinksInSneakers I suffer with debilitating social anxiety. It's hard to connect to people and form meaningful relationships with people and I find that when I do get close to people, I erect a barrier for fears of getting to close so that I won't get hurt. I have no idea where this stems from plus my body is always in fight or flight mode and once in a while I may get a panic attack, especially at work because there are too many people and they are all staring at me because I work extremely fast. I think it's the anxiety that is making work super fast plus I was always a hard worker but they stare!! It's the social anxiety and the loneliness that causes me to fall into a sad state or depressive funk. That's why I was wondering if DXM or ketamine may benefit me. Ketamine is too expensive so I was looking into natural medicine, preferably San Pedro which is a cacti that contains Mescaline. I've researched it and heard testimonials on how it can help people to change their Lives and help restructure and change a person's perspective on Life and their struggles. San Pedro causes visions and meaningful Insights that help one to see the world afresh. Plus its great with neuralplasicity.
@jeffmcbride2365
Жыл бұрын
It's important to say don't go out and get bottles of cough medicine to try to treat depression!
@ShrinksInSneakers
Жыл бұрын
I figured that went without saying but this is good advice
@sharrose7594
Жыл бұрын
I have found Mucinex regular not with other ingredients, think spelling guafenisin helped my mood. Also, benadryl ingredient was used as an early antidepressant.
@ShrinksInSneakers
Жыл бұрын
Benadryl is still used in child psychiatry occasionally for anxiety. My concern usually is anticholinergic effects which can worsen cognition. With Guaifenesin I have not seen any studies indicating this improves mood but maybe in the future it will be studied, Hope this helps, if you haven't subscribed to channel please do and spread the word about what we are doing here
@darvinreed2314
Жыл бұрын
Yes it can
@margaretclitherow7313
Жыл бұрын
Thank you for this information.
@sniper1444
2 ай бұрын
Auvelity wored for me almost immediately. And then the sexual side effects hit after week 1 S&H
@philmachen6508
2 ай бұрын
Auvelity made me suicidal for the first time in 20 years. This was immediately after a totally failed ketamine treatment. I have seen a side of depression that makes me fearful for some people, and has definitely slowed my search for help for my TRD.
@Followthechariot
2 ай бұрын
I felt the same way even after 3 days. I stopped taking it on the 6th day because of it and I've been feeling weird for over a month like it's still in my system. Weird drug. Glad it's helping other people.
@garysimone4977
Жыл бұрын
Hey...I hate meds, the psych society / Dr's almost killed me and I suffered...but let's hope this works big time
@X-FILESCHILE
Жыл бұрын
Can you buy the 2 separately and just take them at the same time? I imagine the medication is going to be very costly
@drinkwalter9346
Жыл бұрын
I was recommended to use psychedelic to treat my depression 3 months ago, I have had a very peaceful experience ever since I micro dosed on shroom, back to work and helping my family, I get it from a mycologist the sells psychedelic products online like dmt, LSD , MDMA and a lot that helps
@mountaindesert34788
6 ай бұрын
Yeah, I'm in the US so your results may vary. But here, your doctor can prescribe the buproprion and you can buy the DXM. (It's OTC in the US and Amazon has cheaper options for DXM. To match Auvelity, you need to make sure you can get a 45mg dose aka 3 pills with 15mg and 105mg buproprion SR. The first 3 days you take one Avuelitypill in the morning and then on the 4th day and on, you take 2 Avuelity (is what I have seen.) If you do the "DIY Avuelity, idk if there is a significant difference using the 150mg buproprion XL vs the Avuelity pill which includes 105mg of buproprion SR, I believe. I'm not 100% sure but that logically makes sense you'd take the shorter acting one twice a day but taking 150mg of buproprion XL sounds like it could be different than 105mg buproprion SR twice a day, 8 hours apart. I'm not certain though if they pretty much do a similar thing. I heard the buproprion was mainly there to strengthen and extend DXM's effects through enzyme inhibition. The DXM gets broken down more slowly and higher levels stay in the blood. I think that means it makes DXM feel stronger and last longer but I'm not sure. Good luck, I hope your depression is better a year later :) It can be a struggle but I have heard good things about this medication! The DXM should be about 25 dollars a month I'm guessing if you get the larger containers online. I only know Amazon and Robocough but Robocough pills are 30mg which are tiny so you might not want to cut them up. 3 of them fit on a penny or something like that
@nickjohn2051
2 жыл бұрын
Hello Dr. Good video btw. What is your opinion with magnesium supplement? I read on science journal it is also a NMDA antagonist. Would it differ in MOA than dextromorphan? Would love to read your opinion on this.
@duslanjeremy4770
Жыл бұрын
I always recommend psychedelic mushroom to anyone battling with depression because I won my with the aid of shrooms and it helped me see the truth in my pain and gave me the confidence to fight to live purposefully, I get it from an online vendor that specializes in the growth and sales of psychedelics products like ketamine, DMT, LSD, it’s the best experience
@duslanjeremy4770
Жыл бұрын
*Formulah11*
@ShrinksInSneakers
Жыл бұрын
A magnesium supplement is something I'm usually fine with in my practice. I usually recommend magnesium l threonate you can go to consumer lab.com and check for a brand that is reputable. While there is some data suggesting neuroplasticity is affected by increasing NMDA receptor subunits, the data is limited and it will not function at the level of a pharmaceutical grade medication like ketamine for example. Hope this helps
@AcmePhoto
Жыл бұрын
agmatine sulfate is also a good NMDA antagonist. Search pubmed for agmatine & depression.
@EphesianRose
2 жыл бұрын
I was wondering if you could also do video on on-label and off-label uses of drugs. And how much stock to put on things being either.
@duslanjeremy4770
Жыл бұрын
I always recommend psychedelic mushroom to anyone battling with depression because I won my with the aid of shrooms and it helped me see the truth in my pain and gave me the confidence to fight to live purposefully, I get it from an online vendor that specializes in the growth and sales of psychedelics products like ketamine, DMT, LSD, it’s the best experience
@duslanjeremy4770
Жыл бұрын
Search on Instagram for the handle below for the vendor’s contact address
@duslanjeremy4770
Жыл бұрын
*Formulah11*
@ShrinksInSneakers
Жыл бұрын
This is too big of a topic for a single video. What i can say is on label prescribing is preferred but there is something I call off label but on evidence. What I mean is there are medications that are proven to work but the randomized controlled trials are small and the pharmaceutical company did not get FDA approval for the diagnosis. In sum it's best to prescribe on label but there are many treatment resistant or difficult cases when off label on evidence prescribing will be helpful
@notcrazy1750
6 ай бұрын
When it modulates glutamate in the brain, does that mean an overall decrease in available glutamate?
@AdamKing60
Жыл бұрын
I was put on a 30 day trial of Auvelity almost a month ago and I haven't noticed any difference in mood or motivation. I read that people were told to take 1 pill for 3 days and then take 2 per day, 8 hours apart. I have only been taking 1 per day for this whole time. I don't know if taking 2 would actually help. Nothing else has helped so far.
@jeepbme
Ай бұрын
why not follow the fkn instructions
@AdamKing60
Ай бұрын
@@jeepbme I followed the instructions of my Dr!
@andrewortiz5797
Жыл бұрын
Does Dextromethorphan work for extreme social anxiety? I remember one time I took 109 mg of DXM and time felt like it was sped up and the music sounded like it was on fast mode. Also music sounded awesome!! What dose would you recommend for social anxiety or what would be a microdose of DXM?
@ShrinksInSneakers
Жыл бұрын
I do not know of any studies on social anxiety and dextromethorphan so I cannot provide any guidance in this area. I would say if depressive symptoms are driving the anxiety and the depression is treated with this medication, anxiety will naturally improve. Maybe in the future we will see this studies. Sorry could be more help, if you haven't subscribed to the channel please do and spread the word about what we are doing here
@85priesty
Жыл бұрын
Yes. It can. It has been brilliant. But then it's being taken away....no other antidepressant has had the same effect...going overboard or mixing with SSRIs or MAOI's, but with Buprion, in the right dose... you stop. But then when the doctor says "No" and Robutissin starts go off the shelf, which sucks. Will...Will Propanalol work in any way of Quinidine? Will go with the side effects. Yeah, I probably nearly died...but it's better than any antidepressant I've ever come across...and my father was a pharmacist....so I've tried everything....
@lakhbinderjitsingh7795
Жыл бұрын
DXM real deal means it can wipe away depression anxiety of awakening of my life, about awakening means Third Eye life right
@CF-Warrior
Жыл бұрын
Do u think this new a/d would help anxiety?
@ShrinksInSneakers
Жыл бұрын
Theoretically the mechanism NMDA antagonism is studied and supported as a treatment for depression. Now, if the anxiety is driven by depression and depressive symptoms it's possible that anxiety will improve as the depression improves. I have a large three part series on anxiety recent posted on the channel check it out tells you the most up to data data. Hope this helps if you haven't subscribed to the channel please do and spread the word about what we are doing
@marcellasimone1998
Жыл бұрын
Hi doctor. I am interested in taking this medication because I have treatment resistant depression. I have been on 11 different psychiatric drugs over the last six years and none have helped me with depression. I also have ADHD and generalized anxiety disorder. Would I be able to take Adderall or an SSRI with this medication? I have done research online and it seems as though stimulants and SSRIs are not to be taken with this medication. What medication can I take for my ADHD and anxiety with Auvelity? I am running out of options and feel like this could be my only hope.
@NoirOp78
2 жыл бұрын
Thanks for this. Great video. Do you know about any psychiatric benefits of Tapentadol?
@ShrinksInSneakers
2 жыл бұрын
It's a central acting opioid agonist, I'm not aware of any clinical studies looking at its use in mental health and given the opioid epidemic I doubt it would considered. I have seen some data on buprenorphine in low doses for depression. Hope this helps, if you haven't subscribed to the channel please do and spread the word bout what we are doing here.
@roxyiconoclast
Жыл бұрын
Wikipedia says Tapentadol “is similar to tramadol in its dual mechanism of action; namely, its ability to activate the mu opioid receptor and inhibit the reuptake of norepinephrine. Unlike tramadol, it has only weak effects on the reuptake of serotonin…” I’ve been taking Tramadol for 20+ years for chronic pain, and find it is only somewhat activating and mood boosting. So if Tapendatol affects serotonin availability even less, it sounds like it wouldn’t be that effective for depression.
@woolfy02
Жыл бұрын
It's probably not known but, how much bupropion is in Auvelity? Last time I took it by itself, it felt like it made my anxiety worse.
@rileyvaughn2792
Жыл бұрын
The combination should be 45mg/105mg DXM/buproprion once daily for 3 days, so 105mg buproprion. Then it moves to twice daily on the 4th day.
@woolfy02
Жыл бұрын
@@rileyvaughn2792 thank you.
@rileyvaughn2792
Жыл бұрын
You're very welcome. 🙂
@burningbright34
2 ай бұрын
Would magnesium glycinate be a good nmda inhibitor? I have neuropathic pain and dxm seems to have a pretty good effect, just hard to get the dosage I need. I am looking into memantine as well for an option. Any thoughts?
@allisdar3999
Жыл бұрын
Can’t you just take dextromphan and Wellbutrin together 😩
@ShrinksInSneakers
Жыл бұрын
I would not, the ratios of medication are hard to dose based on the available dosages of each medication. Your doctor could request a compounding pharmacy make the medication in the correct ratios but it may cost just as much as the medication. If you haven't subscribed to the channel please do and spread the word about what we are doing here,
@johnmoore1495
Жыл бұрын
Hypothetically you could, I’m willing to bet some doctors will just prescribe them separately considering the “new” medication is over $1000/month, meanwhile you can get them separate for less than $100/month lol.
@miranda725
Жыл бұрын
@@johnmoore1495 it’s 10 dollars
@miranda725
Жыл бұрын
@@johnmoore1495 it’s 10 dollars
@miranda725
Жыл бұрын
@@johnmoore1495 it’s 10 dollars
@notcrazy1750
Жыл бұрын
Can someone who is already taking a higher dose (300mg) of bupropion have it mixed with detromethorphan (or switched Auvelity with an addition of a lower dose of Bupropion) safely and maybe also help depression in the same way?
@vintagebleachedblonde4322
Жыл бұрын
Love you ❤️
@ShrinksInSneakers
Жыл бұрын
I appreciate the support spread the word about what we are doing here
@aaronklein7730
Жыл бұрын
Wonder if it would help with ocd?
@ShrinksInSneakers
Жыл бұрын
As of right now it does not have any RCT data for that disorder. I would say it would be less likely as pathways involved in OCD are mostly serotonin based and primary mechanism of action is believed to be NMDA antagonism. We will have to wait and see what data comes out.
@aaronklein7730
Жыл бұрын
@@ShrinksInSneakers thanks for the reply! Everytime I've been put on ssris, or snris they make my ocd worse n I don't know why? Lexapro, prozac, paxil, cymbalta all made my ocd worse. I've been through hell trying these drugs... I also tried zoloft, and effexor, they mellowed me out but I was a zombie with no motivation. Effexor gave me horrible brain surges, zaps . I had pharmacological testing done and luvox which is prescribed for ocd showed as being bad for me. I've tried seroquel which wipes out anxiety and ocd but all I wanna do is sleep and have zero motivation. Benzos help but I'm not supposed to take em often for addictive purposes. It's very frustrating... I'm in therapy and it helps some but also just brings back old trauma. I'm diagnosed with depression, anxiety, ocd, and now ptsd thanks to the extra trauma I've been through. Interestingly I've also microdosed psilocybin, and after a few days my anxiety is worse. My psychiatrist says I'm probably getting too much serotonin? I don't know what do believe anymore. What started out as mostly anxiety has become much worse. This was all started by stress n trauma, that turned into chronic anxiety. I've lost 3 friends to suicide unfortunately and I was hospitalized for anxiety... and was put on 4 drugs. Lexapro, gabapentin, trazadone, and Ativan. I was bunked, and roomed with 3 guys who had just tried hanging themselves, which just fueled everything. Now I'm trying to recover from all this, and the drugs just made me worse. Sorry n thanks just wanted to share.🙏
@giuliana5888
Жыл бұрын
@@ShrinksInSneakers Is there anything else new for OCD, like anything off label?
@dianasimms1810
5 ай бұрын
So…can you take robitussen to feel better?
@jeepbme
Ай бұрын
and alcohol coincidentally
@JPSaintAug
2 жыл бұрын
Dex makes me irritable sometimes. What is that saying abt my neurochemical makeup?
@ArishiaMosely
Жыл бұрын
Well my mental health team know I buy DXM from Amazon bc it's freebase and has no other activated ingredients. It helps with the adhd and chronic ptsd. I do not abuse this bc it is addictive and can overdose so YEAH. Plus I hate medications. I use it when needed not every day honestly. I go outside and I allow myself to venture into strengthening my mindset so that I can prosper instead of being stagnant to meds. This is the only medication I use now bc everything else made me either extremely sluggish and or really irritated. My medical team were studying this amongst the supervisor bc I was one of very few who used DXM for the change of thought process bc I allowed my mind to build towards better while using and without using these medications. Facts. I ordered DXM RAW from Amazon and I am happy I am not abusive. Be very careful and never use this with alcohol.
@samsrandoms8437
Жыл бұрын
In the UK I cant find DXM in the cough medicine, only guaifenesin. Does that also work like DXM.
@ShrinksInSneakers
Жыл бұрын
Nope it's not the same. The dextromethophan is the medication that functions as an NMDA antagonist when combined with 2D6 inhibitor. The reason is probably because people can abuse dextromethophan. Hope this helps, if you haven't subscribed to the channel please do and spread the word about what we are doing here
@lisaalexander1824
4 ай бұрын
Iboprufun makes me high/ manic
@garysimone4977
Жыл бұрын
I hope this med is a consistent answer. MORE AND MORE studies are coming out that SSRI, psych meds are at best a tad better then placebo and only 1/3 of people respon d, and x the side effects and the horror to get off , like effexor makes one wonder And the constant trial and error approach at times is brutal.. YOUR THAUGHT Dr woukd be very interesting. WOULD YOU EVER CONSIDER doing a youtube on such topic, as more psych Dr like DrcWhitaker DrBrogtan, Dr Bragain have been telling all
@ShrinksInSneakers
Жыл бұрын
I think I give a fair representation of what psychiatry is and what the benefits and limitations of the medications are. To answer the question in my mind the way we come to middle ground between antipsychiaty people and psychiatrists is by carefully deciding who should get medication and who should try other interventions. For anyone with mild to moderate depression try everything before medication eat better, exercise, go to therapy, read, listen to music but there will still be a subset of the population with serious mental illness that will only only respond to medication or ECT. I see these individuals everyday in daily practice and I think knowing how to distinguish the differences in severity and not putting everyone on medication who says they are depressed is the way to move in the right direction
@garysimone4977
Жыл бұрын
@@ShrinksInSneakers I had a psych Dr who put me on ambien while I was weening off a bebzo, I educated myself Saw the Ashton Manual , showed her and said, that's just another manual.. Got off valium and was hooked on ambien, 12 months latter drug free, but went through hell to get off as mention sadly very very few Dr like yourself who listen Sadly Dr only 1/3 respond to meds as more studies have shown
@garysimone4977
Жыл бұрын
@Shrinks In Sneakers you give a good representation , what is your opinion om meds. WHAT DO say about the many studies now coming our that only 20% are helped by meds ? Or how about the thousands of people suffering due the Dr ignorance on how damaging and addictive these meds are yet still Rx them Dr what happen c to the Oath fo no harm ??
@melissareising6565
Жыл бұрын
I am just starting dextromethorphan 30ml -50ml suspension BID ..working on getting the right dosage for me. the pills upset my stomach with gastroparesis & gastritis So I’m hoping the suspension will work. I get ketamine infusions for CRPS & this is to help absorb the ketamine better. My concern is I have always had trouble with anything that affects serotonin & I am wondering about serotonin syndrome if I have to stop taking this suddenly due to stomach issues or cost issues while I suffer from depression due to my pain, previous depression meds caused allergic reactions or were not tolerated due to a genetic test I finally had done and not possessing the proper enzymes to metabolize depression medication’s. So should I be even taking this ? I feel like I might be going down the wrong path with this medicine..
@ShrinksInSneakers
Жыл бұрын
I really can't say anything about what to do, you need to talk with your doctor who is supplying these medications and bring the concerns up. For educational purposes I can say for educational purposes that serotonin syndrome from dextromethorphan is usually when someone is taking an excess amount of the medication or using another medication that would increase serotonin levels such as an SSRI. Personally I would not try and dose dextromethorphan separate from the FDA approved combination pill. The safe thing to do is use the actually medication which is dosed in the right proportions and is what the studies tested. Hope this helps. If you haven't subscribed to the channel please do and spread the word about what we are doing here
@scumcnt
Жыл бұрын
Look I know someone said don't combine bupropion and cough syrpe to treat depression but I really want to give it a go for my bipolar depression I got robotisin DXM hbr 30mg and in on 150mg bup xr how would I dose it would it even work? Tyty
@ShrinksInSneakers
Жыл бұрын
I would not recommend doing it on your own without the support of your doctor. What i can say is there are some doctors doing this because it's a significantly reduced cost to the patient. I would talk it over with your doctor and see if they are open to the idea, you never know.
@jeepbme
Ай бұрын
i tried this and it didnt work like auvelity Totally different
@colfaxschuyler3675
Жыл бұрын
We use the strongest placebos allowed by law. If you go higher, you will, undoubtedly, have side effects.
@duslanjeremy4770
Жыл бұрын
I always recommend psychedelic mushroom to anyone battling with depression because I won my with the aid of shrooms and it helped me see the truth in my pain and gave me the confidence to fight to live purposefully, I get it from an online vendor that specializes in the growth and sales of psychedelics products like ketamine, DMT, LSD, it’s the best experience
@duslanjeremy4770
Жыл бұрын
*Formulah11*
@colfaxschuyler3675
Жыл бұрын
@@duslanjeremy4770 We've switched from placebos to panacea sucrose tablets. Cures everything.
@ShrinksInSneakers
Жыл бұрын
Placebo is a beautiful thing and is used all over medicine. If it works and helps patients I'm all for leveraging as much placebo as I can get. All these medications when approved have to show in RCT studies that they exceed the benefits of placebo or they don't get approved and placebo is a high standard.
@colfaxschuyler3675
Жыл бұрын
@@ShrinksInSneakers My concern is that recreational users will be making their own placebos, without any quality control or registration. They could easily make much stronger placebos than they should, and there's no telling what the side effects might be.
@sandijohnson2216
Жыл бұрын
Isn’t dextromethorohan a narcotic - similar to opium? It’s also widely abused. Don’t think this is something I would want to take.
@ShrinksInSneakers
Жыл бұрын
This is not a narcotic and does not function like opium. Yes it can abused which is something you and your doctor should discuss.
@createdby3685
2 жыл бұрын
I'm watching from Turkey. Could you add Turkish subtitle, please?
@jsb3605
2 жыл бұрын
Yeni ilac çıkmış adı Auvelity. Içinde Dekstrometorfan var bu ilaçta. aynı madde bazı öksürük şurubunda da var. Bu yeni gelişmeden bahsediyor.
@createdby3685
2 жыл бұрын
@@jsb3605 Ben diğer içerikleri de anlamak istiyorum. Otomatik altyazı eklemesi çok da zor olmayacaktır.
@jsb3605
2 жыл бұрын
@@createdby3685 Chrome browser dan auto translate yap. cep telefonundan olmuyor
@createdby3685
2 жыл бұрын
@@jsb3605 iyi fikir.
@ShrinksInSneakers
Жыл бұрын
I will try, I'm still learning all this KZitem stuff. Thanks for watching and if you haven't subscribed please do and spread the word about what we are doing here
@SandDuneProperties
Жыл бұрын
My wife is just starting this new drug, now called AUVELITY. I'll try to get back with positive news.
@alli138
3 ай бұрын
Any news?
@KarolB244
11 ай бұрын
I wish i could take this but wellbutrin almost gave me a,psychotic break so have other antidepressants
@Theiliteritesbian
Жыл бұрын
Why are you wearing scrubs?
@ShrinksInSneakers
Жыл бұрын
I wear scrubs everyday
@bwhalen77
2 ай бұрын
sigma-1 receptor... not alpha-1... dextromethorphan is a sigma-1 receptor agonist.
@cxmxc
4 ай бұрын
It makes me hungry so I stopped - Wellbutrin alone forever
@alli138
3 ай бұрын
Wait, so you just on Wellbutrin?
@jaxsun72
Жыл бұрын
Can being struck by lightning help YOU lose weight?
@ShrinksInSneakers
Жыл бұрын
only at the right dose
@Svnfold
2 жыл бұрын
I got high off this before...it was trippy
@duslanjeremy4770
Жыл бұрын
I always recommend psychedelic mushroom to anyone battling with depression because I won my with the aid of shrooms and it helped me see the truth in my pain and gave me the confidence to fight to live purposefully, I get it from an online vendor that specializes in the growth and sales of psychedelics products like ketamine, DMT, LSD, it’s the best experience
@duslanjeremy4770
Жыл бұрын
Search on Instagram for the handle below it’s the contact address for the vendor
@duslanjeremy4770
Жыл бұрын
*Formulah11*
@Theiliteritesbian
Жыл бұрын
This is the best comment
@ShrinksInSneakers
Жыл бұрын
all drugs are poisons the benefit depends on the dosage. I guess my saying can be all medications can be abused and people will certainly try
@ZenHulk
Жыл бұрын
Considering the audience you're trying to reach, you need to watch some videos, maybe from the THINK MEDIA guys, lots of good ideas. You have got to work on the background and you're not looking at the camera while reading your script, so your drawing our eyes away from you, either you don't know the information you're trying to convey or really not into the you tube thing.
@ShrinksInSneakers
Жыл бұрын
Fair enough, but I'm not a professional youtube star and I have no one helping me with this project. It would be nice to have a media team. I'm working on it like all things in life its a work in progress. As far as knowing the information, what I'm covering here is highly detailed. No one remembers all those details, I could give you the basics like they do in Think Media if thats all you want but it's superficial coverage of the topic that does not offer any depth. My goals are a little different.
@robgee1974
2 ай бұрын
900 mgs of DXM will cure ur depression for a good while. definitely something weird about the NMDA ANTAGONIST
@Rapture_Ready_Rabbit
Жыл бұрын
# John 3:16 For God so loved the world, that he gave his only begotten Son, that whosoever believeth in him should not perish, but have everlasting life. 9th of AV... TIME HAS RUN OUT !! BERISHEET 2023-2030 !! Tribulation !
@rosameryrojas-delcerro1059
Жыл бұрын
I heard that it was addictive. I have no intention of becoming a junkie.
@ShrinksInSneakers
Жыл бұрын
Anything can be abused and many medications are. If you take excessive amounts or abuse the prescribed medication there may be some risk, but for someone who is using the medication appropriately it should not be an issue. We do not use the term Junkie it breeds stigma for people who are dealing with addiction. I thought you were a mental health advocate??
@chawtak3r39
Жыл бұрын
Bupropion. Mixed With Dextromethphan: seizurez
@ShrinksInSneakers
Жыл бұрын
This is a potential risk but generally in higher doses (450 mg and above) if we are talking about bupropion. When people take the medication as prescribed and talk with their doctor about other medications they may be on that might affect seizure threshold it's considered a readable risk as long as the person is informed
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