If ADHD was really all about dopamine deficits, and antipsychotics were just dopamine blockers, then the two would make an awful combination. But newer antipsychotics have multiple actions on multiple dopamine receptors, as well as on other neurotransmitters, and different effects on ongoing versus episodic dopamine release.
Although not first-choice options, two atypical antipsychotics, Abilify (aripiprazole) and Risperdal (risperidone) are being used extensively, in many countries, to treat ADHD. Numerous case control and open trial studies indicate that these medications can be safe and effective. But we lack sizable, randomized-controlled studies that show they really work.
Both medications can cause serious side effects, with most meta-analyses suggesting that aripiprazole is substantially less likely to cause problems.
In my clinical practice I have seen several adults with ADHD (and depression) with positive responses to aripiprazole.
References:
Head-to-Head Comparison of Aripiprazole to Risperidone in the Treatment of ADHD Symptoms in Children with Autism Spectrum Disorder and ADHD: A Pilot, Open-Label, Randomized Contolled Study (2016)
link.springer....
Aripiprazole/Methylphenidate Combination in Children and Adolescents with Disruptive Mood Dysregulation Disorder and Attention-Deficit/Hyperactivity Disorder: An Open-Label Study (2016)
pubmed.ncbi.nl...
Systematic review of clinical trials of aripiprazole for treating attention deficit hyperactivity disorder (2013)
pubmed.ncbi.nl...
Aripiprazole in children with attention-deficit/hyperactivity disorder (2008)
pubmed.ncbi.nl...
General:
Psychiatrist, neuroscientist, and author John Kruse, MD, PhD presents practical, actionable, well-researched information about treatment options that scientists and clinicians recommend for adult ADHD and other mental health conditions. Subscribe if you're curious about how neuro-atypical brains can optimize their functioning in our shared, and somewhat strange, world.
Dr. Kruse has posted talks in both the "live" and the "video" sections of this channel. Thumbnails on ADHD topics have a pink background, and those on more general mental health topics have a purple background. A small collection of ADHD-Trump videos have an orange background.
You're welcome to email him with topics you want discussed or people you think he should interview.
drjohnkruse@gmail.com
Негізгі бет Can Antipsychotics Improve ADHD?
Пікірлер: 32