In the 4th TimePie Longevity Forum, Dr. Charles Brenner shared insights on the topic “NAD Co-enzymes are Disturbed in Diseases and Conditions of Metabolic Stress: Prospects for Enhanced Resiliency with NAD Boosting”.
Dr. Charles Brenner holds the Alfred E. Mann Family Foundation Chair in Diabetes and Cancer Metabolism in the Department of Diabetes & Cancer Metabolism. His laboratory focuses on disturbances in nicotinamide adenine dinucleotide (NAD), the central catalyst of metabolism, in diseases and conditions of metabolic stress. Among his most significant discoveries, he identified nicotinamide riboside (NR) as an unanticipated vitamin precursor of NAD.
He also developed a quantitative metabolomic technology that allowed him to discover that the NAD system is disturbed by many diseases and conditions of metabolic stress, including diabetes and cancer.
00:05 Greetings
00:28 Flow of electrons in mechanical and electrical engineering
01:00 Flow of electrons in biological systems
03:11 NAD co-enzymes are the central catalysts of metabolism and carriers of high-energy electrons in living systems
06:30 NAD biosynthesis
08:04 NAD-consuming enzymes: monoADPribosylation
09:40 NAD-consuming enzymes: polyADPribosylation
10:24 NAD-consuming enzymes: cADPribose formation
12:30 Sirtuins are not conserved longevity genes
17:11 Bioenergetic crisis in heart failure induces NRK2
18:25 NR improves heart function in dilated myopathy
18:43 Postpartum recirculates NAD metabolites from the liver
19:50 Transgenerational benefit of NR
20:32 Conditions that challenge NAD
21:33 NR is a safety-tested new dietary ingredient and investigational new drug with 89 registered clinical trials
21:55 Indications for NR
24:07 Conclusions
25:30 Q&A session
#NAD #NR #longevity #aging #nmn #lifespan
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