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@djw9920
5 жыл бұрын
Explained to me in 4 minutes what my lecturers couldn't explain me to in 1 hour. Thank you
@Hypnobreast
5 жыл бұрын
LOL what are you studying?
@xufenghuang1634
4 жыл бұрын
Danny Williams It’s very limitedly informative but good for premed beginners tho (not even enough for premed)
@sword7584
3 жыл бұрын
@@xufenghuang1634 yeah ! But for example, i will be working on lipid metabolism disorders and I am here to get some info before that
@AbhishekVerma-qn1th
3 жыл бұрын
In harper it is given nicely....and after that you can see Lippincott for revision too
@VijayKumar-kt4bc
2 жыл бұрын
Very true
@Arukah_
5 жыл бұрын
Best video in 4 mins. Let's show some love here.
@Cass_i
4 жыл бұрын
The BEST explanation. All you gotta do is brush up on some notes if you haven't already and you're good. Or can also serve as a wonderful review to put everything together. Amazing!
@MrBilld75
3 жыл бұрын
It should be mentioned too, that LDL is not a cholesterol at all, but a cholesterol "transporter". We just call it LDL "cholesterol" for convenience but, it's not really correct.
@bahatijairus
Жыл бұрын
Absolutely.....
@nikoletavassova3927
Жыл бұрын
it is said in the beggining of the video, that cholesterol is transported in lipoprotein particles and she talks about “low density lipoprotein - LDL” and not LDL cholesterol
@MrBilld75
Жыл бұрын
@@nikoletavassova3927 Hmmm, I must have missed that part. Thank's for pointing that out.
@michaell132
Жыл бұрын
Also listen at 3:05 where it’s stated that LDL is known as bad cholesterol
@MrBilld75
11 ай бұрын
@@michaell132 Yeah, I've always hated that term "bad" cholesterol. No such thing as bad cholesterol, just two different kinds of cholesterol. LDL is not necessarily "bad". I much prefer the more descriptive term of "small dense particles" and large. The large ones are harmless and just bounce around in the bloodstrream. Those small ones though, are the bad ones that lodge on artery walls, Atherosclerosis.
@Shadow1986
3 жыл бұрын
Oh my god. This video just packed together an entire day of gibberish so it made sense. Its SO FUCKING GOOD.
@mattbraga4033
6 жыл бұрын
Learned something new about the difference between HDL and LDL. Thanks!
@ian9302328611251125
4 жыл бұрын
thank you for explaining this biochemistry and pharmacology stuff in such simple way!
@fejirotalks
4 жыл бұрын
content that is compact and easy to understand. I Stan
@Majaschoice
2 жыл бұрын
crazy how much you can learn in 4 minutes, while ive been reading for hours not getting it
@VR-oy3fu
3 ай бұрын
because school is meant to enslave and confuse you.
@pratikpradhan885
3 жыл бұрын
Great VDO! Highly knowledgable was that stuff! 🤩
@nancysamy73
4 жыл бұрын
The Video I've been looking for. Great job
@alptekinakturk4185
6 жыл бұрын
Amazing video. Thank you so much.
@Zara0_0___
Жыл бұрын
5 hours lectures in 3min you saved my semester!!
@sidrazafar4597
6 жыл бұрын
Good summary of all the processes involved in Lipid transport ...
@marcelino01892
4 жыл бұрын
You are missing the transition from VLDL to LDL ( IDL ). Still great job
@kmcveigh100
3 жыл бұрын
Jose Cordova, also the difference between liver derived LDL vs LDL derived from VLDL degradation.
@mikalaurastern7991
2 жыл бұрын
I love that the video that was the easiest and clearst to understand was narrated by a woman :) Thank you so much Vicky!!
Very good. It would be even more helpful if intracellular processing of LDL cholesterol was included. One point would be to explain how cholesterol is exported from lysosomes. How many pathways are there? One pathway is via the lysosomal membrane protein NPC1 that allows transport of cholesterol to the ER facilitating homeostasis . Defects in this pathwat result in Niemann-Pick type C disease, a severe and fatal condition.
@rajmohamed2400
Жыл бұрын
It gives a fundamental knowledge about lipid metabolism to comman men and students. Thankyou very much with appreciations.
@mihir4719
3 жыл бұрын
A huge love form India...🙏
@theritehouse2583
3 жыл бұрын
Kudos on an awesome informative video. Thanks!!
@اوقيدمو-و4خ
3 жыл бұрын
So helpful 🥺♥️ thank U to make the Arabic translateor
@srinivasaswamy7843
2 жыл бұрын
Thank you for explaining cholesterol metabolism
@TheEbuitrago
4 жыл бұрын
I learned in less than 5 minutes about Lipoproteins instead of 5 hours of biochemistry
@drblues56
4 жыл бұрын
At 1:40 the video states that chylomicrons go from the gut via blood to the liver. They do not. They are secreted by the intestinal cells into the lymphatic system, and drain via the thoracic duct into the venous circulation at the junction of the left subclavian and internal jugular veins, at the commencement of the brachiocephalic vein.
@Alilamedicalmedia
4 жыл бұрын
So now they are in the bloodstream and will go to the liver, right? We just skipped the details you mentioned to focus on the MAJOR steps of cholesterol metabolism. Sorry if the video gave the impression that they go directly from the intestine to the liver, they do not, but those steps are not essential for the scope of this video.
@tube.brasil
10 ай бұрын
@@Alilamedicalmedia First they visit fat cells.
@anyadarlingg
3 ай бұрын
Learning this a while back is what made me want to limit/stop my intake of animal products. Over time, i have now been vegan for a good few years. No bad cholesterol in my diet 🙏
@uditevukicanavanua1818
4 жыл бұрын
Informative and Straight forward
@amitcarbyne3635
3 жыл бұрын
Ldl is off two types - small dense ldl and large buoyant ldl
@junemercado
2 жыл бұрын
So what does it mean?
@Malcolm-Achtman
2 жыл бұрын
@@junemercado Cholesterol does not just float around freely in your bloodstream. Cholesterol is like a fat and your blood is like water. And we know fat and water don't mix. Therefore, the cholesterol we typically learn about in our blood work (i.e. LDL-C, HDL) is carried within LDL particles that transport cholesterol throughout your body. In simple terms, there are two types of particles, small dense particles and large buoyant particles. Many experts now believe it is the nature of the particles, not the cholesterol they are carrying, that really matters when it comes to things like heart disease. The particles themselves can be measured with advanced lipoprotein testing, typically NMR (nuclear magnetic resonance) testing. It sounds intimidating but can be done via a routine blood test that is sent to labs to do this sort of testing (which are becoming more commonplace as time goes on). Most often the particle numbers are reported in nmol/L (nanomoles per liter). Optimally, you want results showing a total LDL particle number of about 1000 nmol/L or less. And you want your small (dense) particle number to be 200 nmol/L or less (optimally). The large buoyant portion, which your NMR result will also provide, is not the number to focus on according to some experts, as they are not atherogenic. But the small dense particles (so the theory goes) can get into the endothelium of your coronary arteries and contribute to the heart disease process. Why is that? Well, large LDL particles have a relatively short time duration, say 24 hours, and are "dispensed" with fairly quickly, but small LDL particles are not easily recognized by the liver and hence float around in your circulation much longer (e.g. a week or so) giving them more time to do their damage. You can appreciate therefore why standard cholesterol measurements (like LDL-C) never seem to correlate well to the occurrence of heart disease. Cardiologist Dr. Stephen Sinatra, who operated on thousands of patients and actually saw their arteries with his own eyes, used to say many patients with very high LDL-C would have beautiful, pristine arteries, yet many with low LDL-C had prolific heart disease. We now know the nature of LDL particles can be very much in our control by lifestyle and diet. Diets high in carbohydrates, wheat, grains, sugar etc. provoke the occurrence of abundant, dangerous small LDL particles. But low-carb diets (even if high in fat), support metabolic health and most often will result in a healthy small LDL particle sub-fraction (along with increased HDL by the way), thereby lowering your cardiovascular disease risk. To sum up, heart disease is a metabolic disease. Cholesterol is not the problem. And the sooner less attention is paid to cholesterol and the focus gets changed to metabolic health, the sooner we will see some progress in reducing heart disease. C'mon, we've been doing it wrong for 50 years. Let's change the paradigm now so we can start making strides.
@rredding
Жыл бұрын
@@Malcolm-Achtman Beautifully explained!! A lot of useful information can be gained from videos from Ivor Cummins on this subject. As you explained, LDL in itself is not bad, and high values of measured LDL are not dangerous. The problem arises when these LDL particles become "coated" with "sugary" molecules or oxidized. This changes the appearance of LDL and it is not recognized by special receptors on the liver that control the re-absorption of LDL. It remains floating in the blood for extended periods, causing the discussed health issues. Metabolic disease is caused by sugar- and refined carb loaded products as you explained. Also vegetable or seed oils are abundantly used in the food industry, because very cheap. Think of canola, cottonseed, sunflower, safflouer, soy, peanut and other oils and margerines. These products are highly processed and have nothing in common with the seeds they were taken from. The oils are easily oxidized inside and outside the body (compare this with a sliced apple, parts are browning fast when exposed to air). This oxidized oil leads to chronic low grade inflation in the body and changing the surface of LDL particles, after which they are not recognized by the liver for reuptake. The often demonized natural occurring saturated oils and fats have absolutely no impact on health. They contain no unsaturated (double) carbon-carbon bonds and are more or less inert to oxygen on body temperature. Also in the kitchen their smoke point is high. Unsaturated fatty acids like the omega varieties (e.g. in fatty fish) are heart healthy. It is best to consume fish, as capsules with oil are more easily oxidized.
@TheVafa95
Ай бұрын
@@Malcolm-Achtmanthanks for your explanation. How would you measure metabolic health at low cost?
@Malcolm-Achtman
Ай бұрын
@@TheVafa95 If you obtain a routine lipid panel it will include your triglyceride and HDL values. A crude but potentially good way to establish your metabolic health would be to calculate your triglyceride/HDL ratio. Ideally, that ratio should be 1.5 or less. For example, if your trigs were 70 mg/dL and your HDL was 55 mg/dL, the ratio would be 70/55 = 1.27. That's pretty good. Another key blood test to get is fasting insulin. Also get fasting glucose. So, be sure to fast for about 12 hours before getting these tests. You can drink water, but no juice or coffee or food. A very good fasting insulin result would be about 3 uIU/mL. A good fasting glucose result would be 80 - 90 mg/dL. Try to get HbA1c tested as well. An optimal value is 5.0% or close to that.
@boredpotato2176
4 жыл бұрын
Thanks for the video it's very helpful ^^
@thameralamri5187
6 жыл бұрын
Chylomicron is not always transported to the liver , some times the chylomicrons move from small intestine to peripheral tissues
@mrmeach1967
5 жыл бұрын
Right. Here is a Wikipedia article on lacteals that better describes the route taken by chylomicrons: en.m.wikipedia.org/wiki/Lacteal Chylomicrons actually travel through the lymphatic system first before being released into the bloodstream at the thoracic ducts for transit back to the liver. While traveling back to the liver, some triglycerides are removed from the chylomicrons thereby creating a more dense chylomicron remnant that contains a higher concentration of lipoprotein. This remnant is what actually gets reabsorbed into the liver. More triglycerides are then added to this denser structure to form VLDL.
@sawairagul251
3 жыл бұрын
Very clearly explained...🥰
@kaybchung
6 жыл бұрын
The voice is so soothing!!
@funmibitofunmi2573
Жыл бұрын
What you're doing is excellent. Thank you 💕.
@leonardsugg241
3 жыл бұрын
It might be a bit late to ask, but Im curious whether dietary cholesterol generally is processed more into LDL, since there was a lot of controversy regarding dietary cholesterols.
@kazimisbah7929
3 жыл бұрын
Great explanation👍👍👍
@afiatasneem4802
4 жыл бұрын
Excellent video. It helped me a lot. Thank you. 🙂
@Pro0osh
4 жыл бұрын
Absolutely great!
@ShannaCarlos-nh2st
Жыл бұрын
je suis en 2e année de médecine en France et je comprenais rien grâce a toi j'ai compris la base de mon cours, MERCII
@leeshmaboban4186
Жыл бұрын
Short and excellent explanation... thanks for the video 😊
@mohammedal-hammadi5085
4 жыл бұрын
It's amazing video, thank you so much really
@courtneysim2172
3 жыл бұрын
Hi, just wondering what your thoughts are on the different types of LDL - pattern A and pattern B which are increased in different diets? Also, thank you simplifying all these processes. Very helpful.
@reuvenmeirherrera9580
11 ай бұрын
to the point, simple, clear. G-d sent! tysm!
@lostboi3974
5 жыл бұрын
Good explanation
@dahirudahiruanche5380
2 жыл бұрын
You guys are awesome!! Keep it up with the good work.
@samahmed3874
4 жыл бұрын
Thank you so much
@duocphamtruongtho4462
2 жыл бұрын
Its is so helpful, thanks!
@Elena-ht1ml
3 жыл бұрын
oh my gosh. Thank youuuuu!
@notepochh
3 жыл бұрын
Very helpful, thanks.
@supsuxkwii_
7 ай бұрын
this is amazing, this vid is SO GOOD
@qazizahor7080
4 жыл бұрын
Excellent
@mehrukhan828
6 жыл бұрын
Good work👍👍👍
@lubnaabuzarour917
4 жыл бұрын
Perfect thank you Guys for being here
@communityhealth5003
2 жыл бұрын
Amazing and easy revision
@sanjaisrao484
5 ай бұрын
WOW so good, it was so helpful
@patricknnoromele8864
3 ай бұрын
Great work!
@layalharb2472
5 жыл бұрын
Amazing video thanks very much
@rajk1427
3 жыл бұрын
Superb
@Iampharmacist17
24 күн бұрын
Best Vedio and its very helpful😊😊😊😊
@foz-xm4fv
4 жыл бұрын
thanks
@roufarrohim8130
Жыл бұрын
Class khubi sundor vaiya..but camera quality valo hoi nai..lekha bojha jassena sob..
@elliedarling5312
Жыл бұрын
Thank you for the lovely video, very helpful
@Alilamedicalmedia
Жыл бұрын
You are so welcome!
@naturespeaks9060
2 жыл бұрын
Nice video, great lecture, understand able.
@yadavratna
3 жыл бұрын
Wonderful. ,,... thx
@Gareeluh
Жыл бұрын
Fantastic explanations. Thanks!
@Alilamedicalmedia
Жыл бұрын
Glad you enjoyed it!
@nouredineelfounini1323
2 жыл бұрын
Welldone. Good job.Hat off
@محمدسعد-ق8ع7ض
5 жыл бұрын
Perfect thank you so much
@saimhasan89
Жыл бұрын
Best explanation so for.
@jameslavides8688
Жыл бұрын
Why would LDL be bad when it is transporting essential cholesterol the muscles for energy, to adipose tissue for storage for future use and for the production of vital hormones, vitamin D and bile.
@aishidey2463
3 жыл бұрын
Awesome 👍 saved me 🙏
@elemelons1085
Жыл бұрын
One addition/correction: Chylomikrones are not transported via the (portal) blood to the liver, but through the lypmh fluid in the ductus thorcicus, then into blood circulation, first reaching the periphery then the liver (remenants). Its important for pharmacokinetics.
@Alilamedicalmedia
Жыл бұрын
The term "blood circulation" is never meant to be the "portal vein". Although we skipped the "lymph" part here, for simplicity, the main point was made: chylomicrons go to blood circulation first before reaching the liver.
@elemelons1085
Жыл бұрын
@@Alilamedicalmedia @Alilamedicalmedia Sure Sure. However, i think if you talk about digestion people assume entering blood is Portal vein. Our Professor recommended us this Video, thats just why it was funny to spot an issue ^^
@Alilamedicalmedia
Жыл бұрын
Our bad, we could not foresee that some people may "assume" something then make an "issue" about their own assumption. Thankfully, from the overall reaction to this video, most people know that "blood circulation" should never be confused with (or assumed to be) the "portal vein".
@halharinfigar6039
5 жыл бұрын
Iife saver thank you so much!😘
@gul6471
4 жыл бұрын
So helpful. Thanks!
@scottwebber652
2 жыл бұрын
G even I can follow this. Great presentation
@koitheawesome
3 жыл бұрын
So LDL inevitably turns into HDL. So if this is true, how can LDL be bad and HDL be good? And how does an imbalance occur between the two?
@enockosuma3662
2 жыл бұрын
Hdl is good becoz it enables transport back to liver for more breakdown while ldl enables transport to organs which mostly become atherosclerotic due to excess cholesterol in them hence complications. Imbalance mostly occurs wen we take excess cholesterol on top of the good endogenous cholesterol thus making it difficult for the body to breakdown excessive cholesterol
@jameslavides8688
Жыл бұрын
Why does body increase circulating LDL in a Low Carb environment. Is it because of the body is releasing more fats to be used for energy in a low carb environment, in which case, this requires more LDL particles to transport the increase in circulating lipids.
@paidtroll1102
4 жыл бұрын
Just the stuff you want to build basis
@mandirajayasinghe5165
2 жыл бұрын
thank you ❤
@herbalcookingvlog7011
Жыл бұрын
Yes
@director2345
2 жыл бұрын
From my understanding---Inflammation or tears in the artery alert cholesterol to patch it....if there are no tears or inflammation of the artery, then cholesterol just slides through harmlessly in the bloodstream....if the amount of cholesterol is lowered by statins, it still patches the tears but just takes a little longer to build up the same amount of plaque....but if the body needs a certain amount of cholesterol for normal function, is it deprived because of statins, and causing other issues....
@samvandervelden8243
2 жыл бұрын
Anti oxidants lower inflammation yet they have no effect on cardiovascular dissease. When cholesterol enters the endothelial it causes in inflammatory reaction itself which then causes a chain of events that lead to calcification of the arteries
@director2345
2 жыл бұрын
I thougt that cholesterol needs a reason to patch the endothelium...like inflammation, or a tear- like damage....I read that ldl will not try to enter a healthy endothelium lining.
@dawarjarral
3 жыл бұрын
Hats off 🙌
@herbalcookingvlog7011
Жыл бұрын
Yes
@bayurezkipratama6247
Ай бұрын
In 1:33 LDL was mentioned from liver but in 2:04 it was mentioned that actually VLDL is originally from liver and muscle & adipose tissue convert VLDL to LDL. Which one is correct then??😢
@Alilamedicalmedia
Ай бұрын
The liver makes VLDL. The LDL mentioned at 1:30 was for the direction only, it's not made in the liver.
@tube.brasil
10 ай бұрын
There's a BIG controversy about LDL causing plaque.
@salmakhan11112
2 жыл бұрын
outstanding
@dioufshameer1511
2 жыл бұрын
Tysm
@vinayakgupta8150
2 жыл бұрын
Loved it awsmmmmmm💯
@goussiksiddhardhan8863
6 жыл бұрын
Awesome
@josephbivera1399
2 жыл бұрын
Thanks 🙏🙏🙏🙏
@hello-xs7sk
3 жыл бұрын
thank u so much bestie
@1aliveandwell
Жыл бұрын
Am curious if hi TC and LDL, but low hormones and bile , what is missing or if liver?
@kmcveigh100
3 жыл бұрын
Great video. Is there more information on conditions driving lipoprotein synthesis? As in why would the liver produce more or less VLDL, vs more or less LDL. Does it have to do with triglyceride requirements at peripheral tissue?
@maartenstevens7730
2 жыл бұрын
Exactly my question! Does somebody know this?
@Ravi_Qant
2 жыл бұрын
What happens when VLDL and LDL are lower in blood?
@HegelsOwl
8 ай бұрын
Seems everybody else has this all backwards, saying that HDL is the larger particle.
@biovivaforfoodadditives2858
2 жыл бұрын
Actually, cholesterol reduces the cell membrane fluidity 0:13. Thank you for your informative video.
@thegahd
2 жыл бұрын
They are not wrong. At low temperatures cholesterol increases membrane fluidity. In medical school you learn first year that it makes the membrane rigid, which is true, but only at higher temperatures. So cholesterol regulates membrane fluidity both ways:)
@biovivaforfoodadditives2858
2 жыл бұрын
@@thegahd You're right. Thank you for your comment.
@gordonc8335
Жыл бұрын
LDL "bad Cholesterol" IS NOT BAD at all. Its only bad when it has become glycated by sugar or oxidated by inflammation
@hiit-itxr-fitness1962
Жыл бұрын
It’s also “bad” bc it’s too ez to get lots of it
@philipdunn7538
7 ай бұрын
LDL is only bad when the molecule got glycated or oxidised (damaged) and has become unrecognisable to the liver for recycling. These sad LDL particles then clog up and slip through endothelial cells. Cholesterol is a life giving molecule. Just don’t damage is with the consumption of sugar, seed oils and nicotine.
@islamislife1780
3 жыл бұрын
Wow..
@alex99fever
2 жыл бұрын
Can someone please explain this to me? I have heart issues and a bad digestive system
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