Chronic recurrent multifocal osteomyelitis (CRMO), or chronic nonbacterial osteomyelitis (CNO), is a disorder that causes bone pain due to inflammation in the bones not caused by infection.
Chronic recurrent multifocal osteomyelitis (CRMO) can take months to years to diagnose. CRMO was previously thought to be rare, occurring in about 0.4 out of 100,000 people per year. As recognition of CRMO is increasing, it appears to be more common than that. In fact, CRMO may be nearly as common as bone infections. The average age that CRMO starts is 9 to 10 years. More girls are affected than boys.
CRMO is an auto-inflammatory disorder, meaning the immune system attacks the bones causing inflammation, even though there is no infection. A small fraction of people with CRMO have a genetic component. Some families have more than one person with CRMO.
Treatment of CRMO depends on how severe it is and which bones it affects. Some people respond to non-steroidal anti-inflammatory medications (NSAIDs), such as naproxen, meloxicam or indomethacin.
Additional treatment options include biologic medications, such as etanercept, adalimumab or anakinra, which are injectable medications, or infliximab, which is an IV infusion.
Bisphosphonates such as pamidronate and zoledronic acid are another type of treatment for CRMO. These medicines are IV infusions used to treat bone conditions such as osteoporosis. Bisphosphonates can cause flu-like symptoms for a few days after the infusion.
Dr Vivek Allahbadia
PD Hinduja Hospital
Khar Division
Mumbai, India.
Tel: 02261746660
email - orthopod4u@hotmail.com
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Негізгі бет CHRONIC RECURRENT MULTIFOCAL OSTEOMYELITIS IN CHILDREN - EPISODE 64
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