Construction of maize haplotype map, transition from single genome to pan-genome reference
Dr Qi Sun
Director
Computational Biology Service Unit
Life Sciences Core Laboratories Center
Cornell University
Ithaca
USA
The maize HapMap project is an international collaboration with genomic sequencing data contributed by research laboratories from US, China, France and Germany. The maize HapMap v3 was built with whole genome sequencing data from 1218 maize lines, covering pre-domestication and domesticated Zea mays varieties across the world. One of the limitation of HapMap v3 was that it uses B73 genome as its reference, which only represented a fraction of genetics diversities in maize. The ongoing work on 4th generation of maize Hapmap uses the maize pan-genome as its reference.
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