🎯 Key points for quick navigation: 00:00:15 *🧬 CRISPR technology is currently being used in the U.S. to treat blood diseases like sickle cell anemia and beta thalassemia.* 00:00:56 *🔬 Patient's stem cells are genetically modified with CRISPR to produce fetal hemoglobin, replacing defective adult hemoglobin.* 00:02:27 *💉 Patients undergo chemotherapy to make space for modified stem cells, aiming to produce healthy blood cells.* 00:08:18 *🌍 Sickle cell anemia prevalence is linked to malaria resistance, mostly seen in people of African descent.* 00:09:29 *🌄 A patient cured with CRISPR climbed Mount Kilimanjaro, showcasing the treatment's effectiveness.* 00:15:11 *🎯 CRISPR therapy shows promise for curing type 1 diabetes by reducing insulin dependency.* 00:18:31 *🧪 Potential future application of CRISPR in treating hair loss involves deleting a gene responsible for enzyme production in hair follicles.* 00:21:47 *💰 While CRISPR therapies are expensive, their potential to cure serious illnesses could extend to less severe conditions like hair loss.* 00:24:34 *🌟 Advances in CRISPR technology could lead to breakthrough treatments in various medical conditions, paving the way for potentially curing hair loss.* Made with HARPA AI
@tomgillbanks
21 күн бұрын
Great work Kyle
@Kyle_Bu
21 күн бұрын
@@tomgillbanks thanks Tom!
@michaeldro7317
21 күн бұрын
another banger! always thought that it would be impossible to cure due to the 100s of genes responsible for hairloss but just targeting 5ar in the scalp would be huge in itself, possibly all that really matters. I def think you should do a video exploring the possibility of using crispy to up-regulate Sulfotransferase as well. Seems like this would be far less consequential to overall health than crispr targeting 5ar bc it doesnt seem to matter much how much sult1a1 activity someone has since it various greatly in people anyway, and it could obv help minoxidil work insanely well in everyone. reminds me of the vid you posted in the discord about the guy who DIY cured lactose intolerance with gene editing and crispr by targeting a lactose enzyme. I dont see why the same thing couldn't be done with Sult1a1, hopefully even locally with maybe a topical crispr delivery, or at worse a systemic one. that would be sick. should try talking to that guy and get his perspective too lol.
@Kyle_Bu
21 күн бұрын
Well in this case the researchers are just removing the gene from the hair follicle cells that produce type 2 5AR. I like the SULT1A1 CRISPR idea, seems interesting 🤔 but tbh the best bet is liposomal minoxidil sulfate.
@michaeldro7317
20 күн бұрын
@@Kyle_Bu i agree. Esp if its already being done which i think it is. But damn no one knows anything min sulphate lol. Still trying to find it. If it does exist tho then no need to fuck with genes for that i Agree
@sonofsanto
21 күн бұрын
5 more years
@Kyle_Bu
7 күн бұрын
🕊️🕊️🕊️🕊️🕊️
@empoweredpenguin4036
20 күн бұрын
Hey man thank you for your videos! Hopefully hair loss will be stopped forever in the future! Can I ask a question, do you know how long it takes finasteride to build up i. The scalp/how long it takes for scalp DHT to be suppressed?
A guy in Korea tried to trial this stuff on humans but they were shut down by the Korean government pretty fast. Gene editing in any fashion is serious business and I think it’ll be a long time before any regulatory body allows it for cosmetic reason.
@Kyle_Bu
7 күн бұрын
One day
@ВладимирВ-р7ф
18 күн бұрын
Hi bro! Can you give me some advice? If I use this protocol for hair: finasteride 1 mg every day plus dutasteride 0.5 mg either together or just switch to dutasteride, also local progesterone and local minoxidil with spironolactone and plus another local blocker ru or something like that with a second dose of minoxidil, after I restore my hair, can I just go back to finasteride 1 mg a day and 1 or 2 times dutasteride a week and not lose the results I achieved? What do you think about the therapy described above? Not too much? Now I take fin every day plus dut 2 times a week and minoxidil locally with topical fin
@Kyle_Bu
7 күн бұрын
You'll have to do your own research on this and talk to a doctor.
@AdamBriar-v4g
20 күн бұрын
Hello kyle i know this might be a little off topic but do you know if taking finesteride during mid-late puberty can inhibit penile development. I am 16 and diffuse thining and need help.
@Kyle_Bu
20 күн бұрын
It depends. There are some teens that use topical and even oral finasteride under a doctor's supervision. You weren't born with a 5ARI deficiency so it's likely you won't **really** harm your development. Testosterone can still do the work of DHT (and you aren't even getting the same reduction of DHT as those pseudo hermaphrodites. At the end of the day, talk to your doctor
@AdamBriar-v4g
20 күн бұрын
@@Kyle_Bu Sorry for being annoying im sure you know the stress that hairloss causes especially at a young age. I will go and find a derm to talk to. Logically speaking the reduction in dht would slow down but not halt development correct?
@AdamBriar-v4g
20 күн бұрын
@@Kyle_Bu Also thank you for your reply
@Aman-gc3it
21 күн бұрын
Hi my doctor said u can take dutastride 0.5 mg 3 times a week but he lost credilbility to me after saying that finastride and dutastride does not cause shedding only minoxidil does. So i want a opinion from you which is better 0.5 mg daily or every other day and what would be the difference btwn dht suppresion
@Kyle_Bu
20 күн бұрын
Just do what your doctor says.
@christianrodriguez4434
6 күн бұрын
Just curious Kyle do you think only the mega rich will afford this cure if it did exist
@Kyle_Bu
6 күн бұрын
Maybe
@endiosconfio2656
21 күн бұрын
Crisper biotechnology has caused cancer in fish used in Australia the question really is what are the long term implications playing with someone's dna/genetics 🧬 your clearly asking for trouble im not saying it can't be used for good but this is GENE EDITING we're clearly talking about many of u if not all of u don't understand the seriousness of what we're trying to do here
@Kyle_Bu
21 күн бұрын
Yeah let's discourage it's use ? C'mon give me a break.
@endiosconfio2656
20 күн бұрын
@@Kyle_Bu lmao 😅 once u change the dna, genome off a living organism there's no going back the damage will be permanent this is genetic manipulation, mutation change the natural genetic code will have sever consequences in my opinion
@nian60
20 күн бұрын
If CRISPR can cause cancer then I wouldn't personally do it for something cosmetic. But that's a risk/benefit decision people will have to do on an individual basis.
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