About the Webinar:
Ependymoma is a childhood central nervous system tumor type occurring in the brain and spinal cord. Two particularly aggressive molecular groups associated with poor prognosis include the ZFTA-fusion driven group (ZFTA) and the posterior fossa ependymoma group A (PFA). Despite recent progress in understanding the underlying molecular mechanisms, effective targeting of these groups for treatment remains challenging, creating a great need for innovative therapeutic approaches.
In this webinar, learn how leading pediatric cancer researchers at KiTZ and UCSD uncovered tumor-dependency genes, structural variants, and pathways to better characterize the ependymoma 3D genomic landscape and provide new insights into potential therapeutic targets.
What you will learn:
- Discover how 3D genomics techniques uncover novel insights into the molecular properties of aggressive ependymoma brain tumor subgroups
- Explore the critical associations and distinct chromosomal features, including neo-TADs and loops, in ZFTA and PFA ependymoma subgroups
- Learn about the discovery of unique chromosomal loops that led to the identification of new candidate target genes
Негізгі бет Decoding Pediatric Cancers: 3D Genomics Reveals Promising Therapeutic Targets in Ependymoma
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