You rock man. Normally you go to class to help you understand your book. I'm finding when I'm in class I can't understand my teacher at all, then I end up going to the book to try and get some clarity, which hardly ever happens. All the money I'm paying my college, and basically KZitem is the one doing the teaching.
@g-mannG
4 жыл бұрын
Same here! At least in Biochemistry.
@Nitro0xide
8 жыл бұрын
You deserve a lot more attention, your knowledge and explanations are amazing. Thanks so much!
@Ala22223
6 жыл бұрын
14 minutes worth a 2 hrs lecture .THANK YOU 💗💗
@danielm3131
18 күн бұрын
I could never understand the rationale behind lagging strands, this helped a lot. Thank you
@hamedhosseini4938
8 жыл бұрын
This video deserved at least a mil views, really awesome presented!
@Ummagumma760
5 жыл бұрын
Been Studying Replication for the past 2 hours looking at notes/and lecture slides. I just need to watch this 14 minute video and a light turns on. This is why I've donated and will continue to.
@lovetoreade4954
9 жыл бұрын
I can always count on your lectures to understand any confusing topic in class. Thank you
@AKLECTURES
9 жыл бұрын
thats wonderful to hear! you're welcome :)
@nwaramm9580
2 жыл бұрын
Every thing I want involved in molecular biology I visit your channel because you have answer to all my questions Thanks alot
@ujjawalarora8355
7 жыл бұрын
Thank you so much AK lectures! You have actually helped me pass my semesters wonderfully well. Please keep posting more and more videos like these. Its been 2 years now that I can actually count on your videos instead of the text. Thanks a lot man!
@yp2975
6 жыл бұрын
Your explanations are so clear! I always come out of your lectures really feeling confident about the material!
@RiginaPhalange
2 жыл бұрын
I can't beleive we are blessed with free content like this thank you so much!
@sourajitdas6000
4 жыл бұрын
Just want to add some details. DNApolymerase has 3 subunits. One is reserved for leading while two is for lagging strand. Imagine a person upside down walking backwards towards replication fork where the head synthesise the leading strand while the two legs synthesise the lagging strand. Also the lagging parental strand is twisted inwards for ease of replication. Source : Watson’s Molecular Biology of Cell.
@jessicak2530
6 жыл бұрын
Finally understood the DNA replication thank you!
@user-qd1pn9dl3n
Жыл бұрын
Hi Andrey, I scrolled and scrolled to find your class because I couldn't remind your name. I like your lectures
@krysky8628
3 жыл бұрын
This was amazing. I dont really have basic knowledge on DNA but i undertood everthing and you speak very clearly. Thank you.
@Nokoli_
3 жыл бұрын
Amazing as usual. You are undoubtedly the best!
@tegibbs3
7 жыл бұрын
AK Lectures "On point", very detailed explanation and I understand it! Thank you!!
@fareedasaad7574
6 жыл бұрын
Thank you so much for demonstrating such hard topics and make it easier for us to understand, thank you from the bottom of my heart for your efforts,god bless you
@kamalaneupane9411
6 жыл бұрын
always clear always helpful... i prefer your lectures over hundreds of other...
@user-wu1cp6kq1r
4 жыл бұрын
Im very lucky to have found you, thank you
@newtonisaac5482
6 жыл бұрын
AK ...you are my teacher currently am a student in Kenyan university of mmust ....l love your work ...keep on moving this way ..I love you
@Miehairb777
5 жыл бұрын
I will donating money to this cause until I no longer exist on Earth. You are great and appreciated deeply. Thank for your knowledge!
@noorclark2226
7 жыл бұрын
thank you so much , you always make it easier .
@ayeshahameed2859
6 жыл бұрын
Your lectures are always awesome
@SmartinfoBEST
8 жыл бұрын
Excellent lecture !! Thank You so muuuuuuuuuuuuuch !
@Nasirhussain-vc8yp
4 жыл бұрын
Execellent work i understand more your lecture than any other
@saratariq7969
2 жыл бұрын
everything now make a perfect scence thank u so much u are a real star
@SoumilSahu
7 жыл бұрын
this is sooooo good!!
@poluxrodriguez4997
8 жыл бұрын
he is great sometimes speak to quick but keep the line, very well he enjoys, and sometime he enter in a kind of trance very delightful that makes people to understand,
@christine2689
3 жыл бұрын
you drawing the leading and lagging strands while explaining just made me realize why the lagging strand is called as it is. It's because the lagging strand/Okazaki fragments grow in the opposite direction of the moving replication fork. Therefore, there needs to be at least some space or room for the primosomes to attach itself first before the individual addition of nucleotides can occur. This need does not arise for the leading strand because there is always room/space made by the unzipping of the helicase. Could the lagging strand's mode of polymerization be the reason why it forms in fragments?
@christine2689
3 жыл бұрын
Just watched. Yes, it is the reason. So that the Okazaki fragments can grow at about the same time, there have to be multiple initial replication points in which the polymerization can then proceed. Does this mean that the lagging strand requires more RNA primers than the leading strand?
@christine2689
3 жыл бұрын
Just watched. Yes, the RNA primase creates more RNA primers for the lagging strand.
@GeneticsLessons
3 жыл бұрын
Yes because replication goes in two direction but DNA polymerase only can ad new nucleotides in 5'-3' direction only.
@simonb5199
9 жыл бұрын
Your videos are so good! I owe you at least 10% of my final degree classification :) thanks
@AKLECTURES
9 жыл бұрын
Simon B hah! thats pretty sweet! you're welcome, use your degree wisely!
@sheryld8862
6 жыл бұрын
thank you for this video!
@waleedkhan-rg8mf
7 жыл бұрын
Thank u . your way of teaching is very good. people easy know it
@samiasohail4846
8 жыл бұрын
thanks sir ur brilliant teacher
@zainabs4159
2 жыл бұрын
this is amazing 🔥
@CitraTheKrumZ
8 жыл бұрын
+aklectures awesome video, i"ve been watching a lot of your video to help me in my exam, so I owe you a loottt,,, thank you,,, however this in this video you didn't mention anything about proofreading and 3' -> 5' exonuclease nor any other exo/endonuclease. do you make a separate video to discuss this?
@denaearias4504
5 жыл бұрын
Honestly bless ur soul, I have a AP biology exam tmw and I thought I was gonna fail
@emmanueltusiimire5721
4 жыл бұрын
Thanks for the lesson
@OmarAli-py3pq
5 жыл бұрын
Truly, I love you man 🤩🤩🤩🤩
@happyheng5476
4 жыл бұрын
Thanks a lot !
@geigerchukwu5075
9 жыл бұрын
Thank you!!!
@TheGabriellegrand
7 жыл бұрын
I m french and i dont know lot of english but your videos are really better than my lessons
@diegoortz8932
6 жыл бұрын
The only thing that you missed here, is the removal of the primer before DNA ligase comes in and seals the DNA molecules together. Great Vide!
@noonoo97204
6 жыл бұрын
Diego I Ortiz Mendiguren Hi, do you know what enzyme removes the primers please?
@gunfighter3890
6 жыл бұрын
Nayla Nayab Flap Endonuclease 1 (FEN1)
@michaelolafitness9491
5 жыл бұрын
Nayla Nayab aren’t they called Okazaki fragments not primerse
@michaelolafitness9491
5 жыл бұрын
?
@shafiahmadtalukder3543
6 жыл бұрын
wonderful work
@diegorocha2940
7 жыл бұрын
amazing! Ty
@patient3841
6 жыл бұрын
I love your explination
@petermambwe9430
5 жыл бұрын
u make work simplier its even great that an average of lecture hours in university would tke weeks to complete a sub topic u good at it,,,,lov yah
@Prabhdhillon697
4 жыл бұрын
Thank you so much🙏🏻
@deepikarao3157
4 жыл бұрын
Very much informative and we'll narrated
@zzazu8905
6 жыл бұрын
thank u so much for ur lecture
@noorclark2226
7 жыл бұрын
you are truly amaziiiiinnnnnnnggggggg
@indixman_SZN
3 жыл бұрын
Very helpful..thanks alot
@georgiaosei7799
6 жыл бұрын
Hi, thank you very much for your helpful video. I got the impression from your video that the DNA helicase only moves in one direction but I thought that the replication forks move in opposite directions opening up the DNA on both sides of the replication origin. Could you please clarify this for me.
@victorfernandes469
3 жыл бұрын
Thanks!!
@adhamsaad8359
9 ай бұрын
you are the best
@5kyzthelimit
Жыл бұрын
great video. is there a video with Telomere function explanation?
@smsomaalzubaidy6771
7 жыл бұрын
thanks doctor ⚘☘
@vetm.kaleemullah
6 жыл бұрын
its very helpful thanks
@MsRomanthic
8 жыл бұрын
Thank you sir so much !!!!
@jollyjokress3852
Жыл бұрын
Hello, I have a remark: I guess there are two helicases per "opened bubble" at work. The point of origin is in the center of a strand that belongs to a bubble.
@gojames1239
Жыл бұрын
So good
@patriciabarkoci2833
6 жыл бұрын
You are amazing! It is so easy to understand when you explain it. Can I ask about your background? Are you a lecturer? Thank you so much for your lectures.
@khaalidmuktar8084
7 жыл бұрын
thanks for help me to uderstad this lesson
@henryche121212
7 жыл бұрын
Video content may need to be updated. I think from what I learned from B. subtilis experiment, the origin should start from the middle where the DNA primase is binded and then, half the opening on the 5' to 3' strand on top become the leading strand. And then, DNA polymerase start to make daughter strand, the on the right of the origin in middle, lagging strand start to fill in the gap. Furthermore, the bottom strand start to have okazaki fragments to fill in nucleotides for bottom lagging strands. The part I think this video might be wrong is the origin of where DNA primase should be in the middle of the gap and not the right side of the gap, which is made by helicase. Thank you for correcting me if I am wrong
@henryche121212
7 жыл бұрын
Here is one of my sources: biology.stackexchange.com/questions/31585/does-dna-polymerase-always-go-the-same-direction/31590
@maka55567
3 жыл бұрын
Bacteria have circular chromosomes which is why it’s that way. Ak explained a linear DNA replication so clear your misconceptions.
@BISHALGUPTA1999
8 жыл бұрын
cooool!!!!!!!!!..... thank yu.......
@peaceandlov
4 жыл бұрын
Super awesome
@lolipop92s51
9 жыл бұрын
thanks now i know what the difference between the lagging and the leading strand
@AKLECTURES
9 жыл бұрын
salma awesome! you're welcome :)
@neomcyfolau2126
5 жыл бұрын
this is cool thank you
@shanesavage484
8 жыл бұрын
+ak lectures i really love your lectures its helped me greatly premed student here
@AKLECTURES
8 жыл бұрын
+Shane Savage awesome, keep up the hard work! :)
@shanesavage484
8 жыл бұрын
what do you have your degree in if you dont mind me asking
@AKLECTURES
8 жыл бұрын
+Shane Savage Physics and mathematics and I am working on my MD.
@tabassumfatima424
5 жыл бұрын
Is DNA gyrase and topoisomerase same?
@rahulkiroriwal8779
3 жыл бұрын
u rock tnx a lot lot
@extracrispypp5473
4 жыл бұрын
Very nice
@khaalidmuktar8084
7 жыл бұрын
can you mention me feature of d n a replication
@massiveattackdrop
7 жыл бұрын
why should we use only T radiocatively labelled T? is it to measure only replication and not transcription?
@user-gt1sq7hh8z
5 жыл бұрын
HI! is this the DNA-replication that takes place in the human cells or in the bacterial cells?
@thereal7490
5 жыл бұрын
in the lagging strand, why don't we add the RNA primer to the 3' end and we continue adding DNA peacefully? since it is bidirectional synthesis. I think we will get 5'-3' DNA without those fragments. Isn't it?
@alvinlee2522
3 жыл бұрын
EXACTLY! I’VE BEEN WATCHING SO MANY VIDEOS AND READING SO MANY WEBSITES BUT NOTHING IS ANSWERING THIS QUESTION
@ahmedelgohary4426
7 жыл бұрын
thanks af
@gunfighter3890
6 жыл бұрын
Flap Endonuclease 1 (FEN 1)?
@saif6076
6 жыл бұрын
thank you so much, literally the best explainer😊
@nourtohamy143
5 жыл бұрын
YOURE AMAZING THANK YOU
@user-gt1sq7hh8z
5 жыл бұрын
Is it so that every Okazaki fragment consists of one RNA-primer (one RNA-nucleotid) and many DNA-nukleotides???
@GeneticsLessons
3 жыл бұрын
No this is not the only difference between DNA and RNA - in RNA sugar is ribose and in DNA deoxyribose - so A, G, C nucleotides in RNA and DNA are not the same.
@gbolahan6349
5 жыл бұрын
🙏
@richardshane2080
6 жыл бұрын
Beautiful lecture The supercoiling you allude to from the removal of the hydrogen bond the biochemical scaffolding as a phosphodiester call the call the double helix tracks Enabling nucleotides hydrogen bonded as complementary pairs to be separated with the helicase gyrase process I'm sure you agree the magic is in the DNA sequence you have the rail the scaffolding down really well but what I'm unsure of the helicase is supercoiling to compensate the removal of the hydrogen bond the lattice wants to wind you say i say spin, as a positive supercoiling, you say again negative supercoiling introduced by the gyrase enzyme Supercoiling that might be a descriptive but what reference point because the next word is negative supercoiling just as a curiosity looking at these molecules is it left or right hand spin? or spiral? anybody know when the DNA is intact with the phosphorus bond and the hydrogen bond? creating a structural lattice the scaffolding with a phosphorus backbone Does the double-stranded unit does it have a propensity to spin left-handed or right-handed using the electron flow physics terminology of Elementary particle electron spin? Left or right hand spin please?
@ross4452
3 жыл бұрын
damn, this guy is in the freakin' zone
@iceice9568
3 жыл бұрын
13:30 full-screen lecture
@discoveries5075
4 жыл бұрын
Supper star
@naveedshaheeruddin4686
3 жыл бұрын
So this is what dna replication actually looks like 🙃
@usmanalimanj6840
5 жыл бұрын
Mistake present in your description of lagging strand.
@discoveries5075
4 жыл бұрын
😍😍😍😍😍😍😍😘😘😘😘😘😘😘🤩🤩🤩🤩🤩🤩
@leonardunganai8589
4 жыл бұрын
Lmao same man same
@natalia9501
8 жыл бұрын
I should be paying you my 9K instead of university.
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