The nucleus of the oocyte travels to what will become the dorsal side of the embryo. The gurken genes of the oocyte synthesize mRNA that becomes localized between the oocyte nucleus and the cell membrane, where it is translated into Gurken protein. The Gurken signal is received by the Torpedo receptor protein made by the follicle cells Given the short diffusibility of the signal, only the follicle cells closest to the oocyte nucleus (i.e., the dorsal follicle cells) receive the Gurken signal, which causes the
follicle cells to take on a characteristic dorsal follicle morphology and inhibits the synthesis of Pipe protein. Therefore, Pipe protein
is made only by the ventral follicle cells. The ventral region, at a slightly later stage of development. Sulfated proteins on the ventral region of the vitelline envelope recruit Gastrulation-defective (GD), which in turn complexes with other proteins, initiating a cascade that results in the cleaved Spätzle protein binding to the Toll recep- tor. The resulting cascade ventralizes the cell.
Source : Gilbert Developmental Biology
Негізгі бет Dorsal Ventral Polarity Generation in Drosophila | Gurken-Torpedo Pathway
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