Download my free Cognitive Enhancement Blueprint - packed with my specific protocols for boosting BDNF with heat stress, omega-3s, and exercise: bdnfprotocols.com/ Dr. Attia's book "Outlive: The Art and Science of Longevity": www.amazon.com/Outlive-Longevity-Peter-Attia-MD/dp/0593236599 CHAPTERS: (00:00:00) In this episode (00:04:29) Defining cardiovascular disease (00:06:36) Coronary plaque and fatality risk (00:08:02) What is cholesterol? (00:10:27) How ApoB predicts heart disease (00:18:27) Factors elevating ApoB (00:22:17) ApoB reference range explained (00:24:16) Does high ApoB cause cardiovascular disease (00:33:54) ApoB thresholds for ASCVD prevention (00:37:20) Dietary factors raising ApoB (00:36:26) Genetics of ApoB and LDL (00:50:17) Does low LDL increase cancer? (00:53:12) Cholesterol-lowering drugs (00:56:52) Statins, uses, and side effects (01:00:05) Are statins toxic to mitochondria? (01:06:49) Ubiquinol for statin-induced muscle soreness (01:08:02) How to train in zone 2 (01:14:02) Statins and neurodegenerative disease risk (01:18:47) Cholesterol synthesis in the brain (desmosterol role) (01:22:51) Statin alternatives - pros and cons (01:24:23) Ezetimibe (01:27:54) Bempedoic acid (01:33:42) Berberine for CVD Risk Reduction? (01:36:29) Muscle as a glucose sink (01:42:51) Chronic glucose toxicity and vascular impact (01:48:31) Hemoglobin A1C Levels and Mortality Data (01:52:28) 80/20 Zone 2/VO2 Max Training Protocol (01:59:05) Insights from VO2 max testing data (02:09:10) How obesity increases cancer risk (02:11:56) Cancer screening benefits and risks (02:17:40) Dr. Attia's recommended cancer screening age (02:25:47) Liquid biopsies for detecting cancer (02:31:41) CT scans, mammograms and radiation concerns (02:37:25) Menopause - hormonal shifts and health effects (02:42:06) Hormone replacement therapy (HRT) (02:55:50) Perimenopause diagnosis with hormone levels (02:58:57) HRT's impact on dementia, cancer, and heart disease risk (03:01:42) Estrogen's role in bone density (03:04:35) Vitamin D (03:13:17) Testosterone replacement for women's sexual function (03:15:40) HRT safety 10 years post-menopause (03:19:58) Treating low testosterone in men (03:26:46) TRT side effects and risks (03:29:26) Ways to reduce blood pressure (03:36:26) How to measure blood pressure (03:42:23) Peter's longevity optimization routines
@coachsimard8641
9 ай бұрын
Thanks for this Doc! The Norwegian 4x4s - OMG those are brutal, but gooooooood! Cheers!
@angielazaro
8 ай бұрын
I’m fry f
@jaykish4746
6 ай бұрын
Question... I'd a person works outside in the heat do they get heat shock protein benefits?
@Melody-ym4do
5 ай бұрын
@Dr Patrick - you are so brilliant, amazing, smart, and beautiful. Thank you for sharing your knowledge, suggestions, and insights with all of us. Appreciate you and Dr. Attia, Dr. Huberman, Dr. Walker, and the other ones whose names I can't remember off the top of my head. You're all amazing ❤
@ptortland
6 ай бұрын
I’ve been a practicing physician for almost 30 years (Sports Medicine, nonsurgical orthopedics, and Regenerative medicine) Other than the discussion on bio-identical hormones, with which I am well trained and well-versed, this has been one of the most instructional and informative videos that I’ve seen in my entire career.
@fletcher9328
9 ай бұрын
Rhonda Patrick x Peter Attia = LEGENDARY! So excited for this!
@LauraTryUK
9 ай бұрын
I’m with you!!!
@houndofzoltan
9 ай бұрын
I only listen to 4 podcasts, so it's fantastic when there are two of them together and then: it's four hours!! I love the long format. Huge thanks to both Doctors for sharing their passion and knowledge.
@zoranvujovic998
8 ай бұрын
Out of the curiosity, what are the other 2? Because l follow these 2 as well.
@houndofzoltan
8 ай бұрын
@@zoranvujovic998 Sam Harris and Sean Carroll. Not the same area, though Dr Attia and Sam Harris have been on each others' podcasts.
@Activ80
9 ай бұрын
I've watched most of Dr. Attia's videos from way back & read his writings over a long time & not to be too critical but most of the information overload is difficult to follow for the average non medically educated person. I am 81 years of age, physically very fit & still reasonably mentally alert. If I was to worry about all the information Peter expounds I would probably lose my focus on just simply keeping active & eating well which enables me to remain "healthy". I listen to the advice from people like Peter because I am now vitally concened with longevity but in reality the "science" seems to be never ending in comlpexity & still there is no clear cut simple direction.
@godbork
9 ай бұрын
he drops so much biotechnical information to give you the impression he knows what he is talking about. Still, most of what he says about cardiovascular health and the cholesterol-saturated fat myth is sheer nonsense. He spreads the Ancel Keys disinformation and ignores the findings and insights of Joseph Kraft. Watch the interview with Joseph Kraft, the father of the insulin assay (kzitem.info/news/bejne/2GakvGGVnZaJopg), and you will be surprised about the level of nonsense he waffles about...
@laza6141
9 ай бұрын
Just stay very active , don't smoke , don't drink too much , get enough sleep and try to avoid processed foods.
@YourUpstairsNeighbor
9 ай бұрын
Dr. Patrick, you were my gateway into a healthier and more deliberate lifestyle. Thank you! I also bought Dr. Attia's book for my mother and she loves it!
@natalievanhouten8809
8 ай бұрын
I'm that "one" person, 5' 7" 145 lbs (recently gained 20 lbs), sauna and cold plunge 4 x/week. Saw GYN 9/28/23, "normal" pelvic exam, normal PAP, I did c/o overactive bladder and 20 lb weight gain. 12/6/23 diagnosed with stage 4 cancer. Would love to see better screening for ovarian cancer. Also, would be nice if physicians actually listened to your symptom complaints. Just received first chemo tx and down 20 lbs, hoping it's all cancer weight I lost.
@sazennonumber
5 ай бұрын
❤ Wishing you great health.
@CrystallyLavender
5 ай бұрын
I’m sorry, hope you’ll make a full recovery. Is it stage 4 ovarian cancer?
@natalievanhouten8809
5 ай бұрын
@@CrystallyLavender thank you! It is ovarian cancer. I understand a healthy lifestyle doesn't make you immune to disease, I'm just really frustrated my gyn blew off my complaints.
@natalievanhouten8809
5 ай бұрын
@@sazennonumber thank you!
@elizabeth4689
16 сағат бұрын
That’s ridiculous that they missed that. Wishing you a speedy recovery.
@chrisyoung9550
8 ай бұрын
Wow. I can so relate to this. My daughter was born 6 years ago and I'm in my mid 40s. My dad had 5 strokes and a heart attack starting at age 50. As a result I got into exercise at a very young age and even went on to get my degree in exercise physiology. I too am so fascinated by the topic of longevity and I love Dr. Attia. He really inspires me to keep digging though all of this and learning more and training smarter and eating better.
@GiovanniT
9 ай бұрын
Is this the start of the longevity Avengers!? I had to do a triple take on my feed when I saw these two faces side by side. ❤
@AnalyticalSentient
9 ай бұрын
Roundtable with Rhonda Patrick, Peter Attia, Thomas Seyfried, Caldwell Esselstyn, Andrew Huberman, and Thomas Delauer would be good
@NicholasOdinson
9 ай бұрын
I’d add Matt Kaeberlean to the table!
@FoeverDirt
9 ай бұрын
@@AnalyticalSentientmaybe with a side of David Sinclair?
@AnalyticalSentient
9 ай бұрын
@FoeverDirt I mean sure I suppose but I think Huberman, Delauer and Patrick (also perhaps Attia) would probably already have most bases covered from what he might have to add other than something that isn't a low- or no-cost supplement, practice or protocol but yes of course longevity is his specialization no question
@chinchila0hotmama
9 ай бұрын
Real life super hero’s for sure 👏
@sheryl3268
9 ай бұрын
I was wondering when she would have him on her show too, again. He had her on his episode 252, I think. Great to see both of these people discuss health together anytime, anywhere!
@joeyfunk4327
9 ай бұрын
I remember she interviewed him years ago while he was working I’m pretty sure given he was wearing scrubs. Epic to see how far this has came
@cridsy
2 ай бұрын
My two favourite podcasters together, what a treat and as always so informative and educative. I love how you both freely share your learning and knowledge and will happily say when you don't know the answer to something, or outline that you've changed your previous thoughts/position on topics. You are both shining examples. Thank you for continuing to share how we can live longer and healthier lives. Rhonda you should seriously consider writing a book! Peter Attia's book sits on my study desk as a constant reference and the audio version I find very consumable. Thank you Rhonda and Peter.
@thomasstitch1708
9 ай бұрын
I recommend having Dr. Michael Greger on the podcast. His new book "How Not To Age" offers a different view point from Attia, but is well researched and science based. I think your viewers would appreciate his work on the subject of longevity. It would be interesting to hear Rhonda question him on the research he cites in the book.
@stellarblur
9 ай бұрын
Actually Dr. Attia recommends low protein
@stellarblur
9 ай бұрын
Sorry spell fixer
@stellarblur
9 ай бұрын
I believe Dr attia discovered rampamycin
@stellarblur
9 ай бұрын
More importantly mTor
@PedroNord
9 ай бұрын
Actually, Attia recommends 2 grams of protein per kilogram of body weight per day. That’s a very high protein diet.
@quickcinemarecap
8 ай бұрын
00:02 Nearly 50% of first symptoms of coronary artery disease result in sudden death. 02:08 Birth of daughter sparked interest in longevity 06:14 Coronary artery disease is the leading cause of sudden death, with over 50% of first symptoms being sudden death. 08:19 Cholesterol is essential for life and plays a vital role in the body. 12:33 Measuring the concentration of all the apob particles can predict risk. 14:48 Measuring LDL particle number predicts risk better than LDL cholesterol concentration 18:41 ApoB plays a crucial role in lipid recycling and LDL clearance. 20:35 LDL receptor presentation impacts risk factors 24:23 Eliminate causal factors of disease as soon as possible 26:27 Atherosclerosis is a disease that progresses over decades, and apop is a major driver of it. 30:27 LDL plays a major role in reverse cholesterol transport. 32:14 Low levels of APOB and LDL cholesterol are sufficient for normal functioning. 36:04 Four big factors driving ASBD risk 38:00 Lowering triglycerides is key to managing apob levels. 42:05 Dietary choices impact lipid levels 43:52 Nutrition should be used to address energy balance and protein needs, and let lipids fall where they may. 47:23 Genetic control of LDL cholesterol affects ASCVD risk 49:19 PCSK9 gene mutations impact LDL cholesterol and cardiovascular disease 53:05 Early lipid-lowering drug was ineffective and had adverse effects 54:50 Bile acid sequestrants are a class of drugs to lower cholesterol 58:31 Statin can lead to insulin resistance and increased transaminases 1:00:03 Statin's impact on mitochondrial function. 1:04:00 The longer a cell stays in the mitochondrial space, the better it is for ATP production and lactate accumulation. 1:06:11 Metformin may not be a great drug for non-diabetic individuals 1:09:46 Use rate of perceived exertion to exercise in Zone 2. 1:11:32 Heart rate guidance depends on fitness level and daily factors. 1:15:26 Statin use shows neutral to beneficial impact on dementia and Alzheimer's disease. 1:17:26 Statins and diabetes risk 1:21:29 Prefer using alternative tools like aetam, pcsk9 Inhibitors, bidic acid over taking unnecessary risks with Statin, especially for higher risk individuals. 1:23:27 PCSK9 inhibitors are highly effective but expensive. 1:27:15 Desol imbalance can impact health in both positive and negative ways 1:29:08 CT angiogram is a useful tool for assessing plaque accumulation. 1:32:34 Using CTA to determine treatment aggressiveness based on risk factors and test results 1:34:23 Berberine shows potential benefits in lowering LDL cholesterol. 1:37:57 Fasting blood glucose of 100 mg/dL is on the cusp of being too high. 1:39:57 Liver and muscles work as buffer system for glucose 1:44:18 Elevated levels of glucose and insulin can cause damage to small and large blood vessels. 1:46:16 Sleep disruptions significantly reduce insulin sensitivity 1:49:55 Maintaining an average blood glucose level of 100 is better than 115 for overall health. 1:52:03 Training in zone 2 pushes metabolic flexibility and expands mitochondrial capacity. 1:56:07 Optimal cardiorespiratory engine requires balance. 1:57:57 Optimal workout intensity for V2 Max power generation 2:01:18 Understanding the dynamics of a fitness test on a bike for health monitoring. 2:03:00 Respiratory quotient (RQ) indicates fat and glucose oxidation ratio. 2:07:03 High V2 Max reduces all-cause mortality risk significantly. 2:09:03 Smoking is still the number one modifiable risk factor for cancer. 2:12:50 Cancer is still a big black box in terms of understanding its different ways of occurrence. 2:14:49 Early detection reduces cancer burden. 2:18:39 Recommended cancer screenings may not be fully covered by insurance. 2:20:29 Mammography has limitations in cancer detection due to low pre-test probability and personal factors. 2:24:22 Regular screenings are important for early detection 2:26:12 Liquid biopsies can detect cancer using DNA in the blood 2:30:09 Grail test sensitivity is lower for indolent breast cancers 2:32:12 CT scans are not a good way to screen for cancer, except for former or current smokers. 2:36:15 Discussion on the confusion between mammogram and MBI tests. 2:38:01 Menopause causes a rapid decline in important hormones like estrogen, progesterone, and testosterone. 2:41:43 Menopause causes a harsh decline in bone mineral density for women 2:43:46 HRT does not increase the risk of dying of breast cancer 2:48:12 Estrogen did not drive the incidence of breast cancer or mortality associated with breast cancer. 2:50:06 Importance of bioidentical estrogens over synthetic estrogens 2:54:12 Options for taking estrogen and progesterone in hormone therapy. 2:56:03 Measuring hormone levels is key for understanding women's transition to perimenopause. 2:59:50 Initiating HRT at the time of menopause reduces the risk of heart disease and dementia. 3:01:54 Estrogen is crucial for bone density maintenance. 3:05:43 Sunlight-derived vitamin D versus supplementation 3:07:28 Vitamin D levels and toxicity 3:10:48 Importance of measuring vitamin D levels and avoiding deficiency 3:12:22 Estrogen's role in compensating for vitamin D deficiency. 3:15:56 HRT initiation handled on a case-by-case basis 3:17:51 Customized hormone replacement therapy is crucial for individual needs. 3:21:46 Challenges in accurately measuring testosterone levels 3:23:44 Threshold for testosterone levels and TRT initiation 3:27:12 Testosterone replacement therapy does not increase the risk of prostate cancer. 3:29:01 Testosterone may have a slight initial increase in cardiac risk but the effect disappeared over time. 3:32:31 Nutritional supplements and lifestyle changes impact health. 3:34:20 Cocoa flavanols decreased blood pressure 3:37:54 Regular blood pressure checks not valuable for most people. 3:39:53 Limited release of a health program, with positive reception 3:43:20 Dr. Peter Attia emphasizes the importance of sleep for optimal functioning. 3:45:09 Establishing a bedtime routine to optimize sleep quality. 3:48:53 Importance of exercise in maintaining overall health. 3:50:38 Peter Attia's book is a must-read on anti-aging 3:54:04 Dr. Attia and the host plan to continue their conversation in future podcasts due to their shared interests and the abundance of topics to cover.
@TJ700
8 ай бұрын
Thank you for this public service Open.
@shannonsaunders1562
8 ай бұрын
Thank you so much for doing this
@itsjohnib
5 ай бұрын
🙏
@chrisbusby4395
9 ай бұрын
A friend was being tested for MS amongst other things because she couldn’t grip properly etc ,it turned out her vit d levels were extremely low. She was given short term very high doses and after a few weeks everything returned to normal,she was due an MRI scan shortly before one clever doctor suggested to test for vit d.
@f.h.4038
9 ай бұрын
It is normal that MS patients have bursts of symptoms and than pauses in between. She should take real medicine if it is real MS. Vit D is down regulated during disease. Therefore it seems to play a role in many diseases but is only downregulated by default during disease. Measure it when you are not in an active disease state.
@stevenwilson2292
9 ай бұрын
I wish this was a regular thing. Like regular short 30 minute quick dives into topics.
@ortizma13
9 ай бұрын
I don’t say this often enough about certain lecturers on podcasts, but the fact that he hasn’t referred to Notes I’m almost 3 hours into this just shows how smart he is, even though he does still believe in calories and calories out
@Retrosenescent
8 ай бұрын
I don't see any videos on your channel about this topic, so I was wondering if you could do a review of blood pressure and how to lower it with lifestyle intervention. The reason I ask is because I feel like I do everything right, yet my blood pressure readings are always very high. - Gym 3x a week - HIIT 2x a week - Sauna use 3x a week - Diet high in nitrate-rich vegetables - Diet low in sodium, alcohol, and fried foods And I've been doing this for about 10 years now, and my blood pressure is still extremely high.
@davidwhite4547
9 ай бұрын
Go for it Rhonda! Write that book!
@cherieservello4891
9 ай бұрын
Such incredible information What an IMPACTFUL PODCAST!! Thank you!!❤
@FoundMyFitness
9 ай бұрын
Glad you enjoyed it!
@jshan853
8 ай бұрын
One of the most informative, excellent podcasts of them all- thank you, you two are phenomenal!!
@SamShank175
9 ай бұрын
I think Peter is right about so many things. The use of pharmaceuticals over nutrition is one area that I think he's wrong.
@ananavarrete7218
9 ай бұрын
Yes agree and unapologetic about it
@randeepwalia1507
8 ай бұрын
One of you has the data on their side. Besides, I think his position is more accurately characterized as pharmaceuticals AND nutrition
@VanillaAttila
8 ай бұрын
He finally realized metformin was not good for him and stopped taking it. Also takes regenerative food more seriously
@houndofzoltan
8 ай бұрын
Except ... he's doing constant bloodwork to see what's working and I'm assuming you're not. I suspect you're falling for the "natural is better" fallacy.
@SamShank175
8 ай бұрын
@@houndofzoltan Bruce Lipton's book The Biology of Belief tells the history of the study of human biology. Every time we thought we had it figured out and then OOPS. Every time we thought a body part was vestigial, because we didn't understand what it did, only to discover it was actually doing something important. All the diet drugs that have been prescribed by Drs, only to be banned once the bodies started piling up. I think the GLP-1 drugs will be the same, the evidence is just now starting to come to light. Antibiotics? They save lives, right? Oh, except now we have super bugs and we know about the microbiome. Peter himself has changed his mind on various things over the years, any good scientist does.
@djrandlev2864
9 ай бұрын
Fascinating… this is what podcasts are all about. Thank you
@agingdoc
9 ай бұрын
+1
@ryancolson1212
5 ай бұрын
I'm so glad I discovered these legends. So much great content in these four hours. I'll be sure to listen in to the podcasts, very excited
@kend1964
9 ай бұрын
Thanks! Very helpful, thorough discussion.
@eatingcleaner
9 ай бұрын
And I am over 10 year post menopause and still on HRT. And could not feel better.
@wellthi
9 ай бұрын
HRT is not safe (cancer, CVD, stroke) there are more natural approches. Dr Greger have plenty of vid about it on his channel nutritionfacts
@michelle4688
9 ай бұрын
Strong open, Dr P!
@jamesscott1711
9 ай бұрын
Awesome information! Keep up the good work Rhonda and Peter 👍👍👍
@gabyfridman7475
8 ай бұрын
Excellent. Thank You !!!
@marcsantamaria4097
Ай бұрын
So insightful. Thank you both.
@stormwalker321
7 ай бұрын
than ylu both very much...
@kellyfj
9 ай бұрын
Damn I love the "in video" references with the highlights - just amazing!
@alec3972
9 ай бұрын
Totally agree - first symptom was a ‘widow maker’. Life pivot done - eek
@PatrickMC
9 ай бұрын
42:20 love the little shot at Paul Saladino 😉
@missymason2377
5 ай бұрын
Listening from new Zealand 🇳🇿. Totally educational
@saltybaelv
9 ай бұрын
So many unanswered questions around women’s hormones 😭 I’m 29 and am experiencing jawline acne only around my cycle, otherwise my skin is wonderful. I have severe mood swings two days before I start my period (I swing from super angry and irritable one day to literally crying and suicidal the next day). My cycles are regular, meaning in time every month. I can’t sleep at all when I’m ovulating. I took 5mg melatonin, 400mg mag glyc and ashwagandha with rhidiola and doesn’t do shit during ovulation but I tried progesterone cream and that gave me the best night of sleep I’ve ever had AND I didn’t have any mood swings or breast tenderness this last period. What gives?! Aren’t I too young to be having to apply progesterone cream? I don’t want to give myself breast cancer but I can’t keep living like that every single month 😭 also my obgyn says my hormones are fine. This is such BS. Only think blood work says is that I have low vitamin D but I take 5,000IU Vit D + K2 consistently so none of this make sense lol I hate it
@Valoric
9 ай бұрын
Getting enough molecular iodine (not iodide from food and salt) has been shown to be important regarding cyclic mastalgia. Progesterone probably helped because your hormones are dysregulated by insufficient iodine/selenium along with maybe a pathogenic environment/diet/mold exposure. Not gonna say it is 100% this because it's pretty common because of flame retardants like bromide blocking iodine from being used in the body. It's really worth looking into. 400mg of Magnesium Glycinate equals about 60mg of elemental magnesium (RDI is 400mg). It's not much if you actually need it. I take 1g of it morning then 1g night (total 290mg elemental Mg). I was deficient from taking Vitamin D for too long and initially got an ironic excitatory reaction from magnesium at night. I tried metatonin for years. Unless you're old or have some genetic disorder where you can't produce metatonin, it's useless and might actually keep you up at night through a couple different processes. Most melatonin supplements are too much and absorbed too fast. Hormones like that have a very delicate balance and supplements are like a sledgehammer. Only good for changing timezones. We need very little of it. Ashwagandha gave me a hyperthyroid experience (takes a month to fully breakdown ashwagandha). Thyroid is something to think about with that one. IMHO herbal supplements need to be avoided because they can just make it worse since they do way too many things we don't understand and are often contaminated with pesticides and heavy metals. Focus on molecular iodine, your adrenals and thyroid. Which would need to be worked on by mindfulness/acceptance, diet (eat enough fat) and relaxation (only easy exercise). Insomnia is hell and it took me years to realize that the desire for sleep is a catch-22. Unfortunately the more you want it, the less you get. Mindset is half of everything. idk if any of this helps or not. Hope you get some relief soon
@zeusireog
9 ай бұрын
Maybe try eating and exercising according to your cycle. Women have 3 hormones to support during different phases of her cycle. Estrogen, Testosterone, Progestrone. (start count from first day of bleeding) Day 1 - 10 - Estrogen (able to withstand lots of HIIT cardio, Intermittent fasting, low carbs diet, keeping blood sugar levels low) Day 11 - 15 - Testosterone will peak during ovulation (suitable for heavy lifting, resistance training, prolonged water fasts) Day 16 - 18 - Hormones will take a big dip or "crash" transitioning into Progestrone (start to introduce good carbs, needs higher blood sugar levels to prepare to shed your lining) Day 19 - 28 - Progestrone (stop fasting, higher carb diet, taper off cardio and do lighter workouts like pilates, yoga, zone 2, long walks, light weights, keeping cortisol low) Hope that helps!
@llkoolbean4935
9 ай бұрын
Please talk about estrogen positive breast cancer and the hesitation to use hrt in survivors of triple positive BC when they reach menopause. Please.....
@sperizer
9 ай бұрын
Recommend seeing a functional doctor.
@GKerski
8 ай бұрын
You might be interested in the work of Ray Peat PhD to find answers to all those questions.
@josephacolletti
9 ай бұрын
summary of "how ApoB predicts heart disease" section total cholesterol (worst); LDL cholesterol via Friedewald Formula (good): LDL-C = (TC) - (HDL-C) - (TG/5); LDL-C "direct" (better); LDL particles (best) via NMR, or ion motility ApoB (king)
@Outliveathletics
9 ай бұрын
Thank you so much for this episode! You two are awesome 🎉 your work is GREATLY appreciated 😎💯
@pardogg
9 ай бұрын
Dr Attia makes it sound like insulin resistance is a main driver of ApoB formation, and that saturated fat intake is less important - I was under the impression that saturated fat intake is more relevant from what research I've seen. Anyone else have research to show me on this?
@a.Mulligan
4 ай бұрын
Dear Dr The was amazing: so clearThank you so much
@epigeneticnerd4244
9 ай бұрын
With the almost unnatural quantity of protein Peter has now adopted, I fear he’s taken the side of Lane Norton types too much. He’s even admitted it’s difficult to reach his protein goals, which intuitively doesn’t make sense it’s how we optimize health. I love Peter and find him brilliant. But he’s been wrong before too, as we all have.
@roxana262
9 ай бұрын
Good point!!
@juukame
9 ай бұрын
An issue I have regarding protein intake is the units by which I hear it recommended; I've heard people say ~1g per kilogram body weight. I've heard people say ~1g per pound. A huge difference yet I've heard it reported both ways by seemingly credentialed people.
@nichtsistkostenlos6565
9 ай бұрын
Why would we care about what's "natural" or "intuitive"? We care about what's optimal. 99% of our lives as humans right now are unnatural and unintuitive to our predecessors, but we are more healthy and live much longer than we ever did. The purpose of high protein intake combined with strength training is to battle the inevitable onset of sarcopenia. We're not mice in cages, we die frequently at old ages from accidents due to frailty. Also, healthspan is impacted tremendously by muscle mass in old age. People that have strong muscles, joints, and bones live more free and unencumbered lives in old age. Though you may be able to increase your lifespan marginally by lower protein intake (maybe), your healthspan will decrease significantly. Not everything is black and white, it's about trade-offs.
@epigeneticnerd4244
9 ай бұрын
@@nichtsistkostenlos6565 what’s most natural is what drives optimal biology. That’s why your Venus fly trap lasts 2 weeks in your apartment. Excessive protein intake (I.e. forcing intake beyond satiety) is not natural. Our average lifespan is longer due to better infant mortality rates, cleaner water and better hygiene.
@stellarblur
9 ай бұрын
I lean toward Dr Longo take on protein
@alfonso1455
9 ай бұрын
Please, please get into the detail of sauna and HRT patches. Does excessive sweating like a 70 min sauna yoga session nullify the benefits of the patch thereafter?
@suzannestruble
7 ай бұрын
I would also love to please hear more about HRT patches and sauna!! Also, Dr Patrick, do you have an opinion about whether sauna during a cold or flu is contraindicated?
@erwinrogers9470
8 ай бұрын
Great interview👍
@metemad
9 ай бұрын
Great podcast!
@MT0D12Flathead
9 ай бұрын
Can’t wait 🎉
@d2row96
9 ай бұрын
You can't get most doctors to test for insulin resistance so how would you know if the statin is causing insulin resistance.
@porkpie2884
9 ай бұрын
There is no test for insulin resistance
@cindypina4944
9 ай бұрын
There is a test for how much insulin you have. Mine was 14 which is considered high. However my A1C and glucose were good levels.
@porkpie2884
9 ай бұрын
That test for how mush insulin your pancreas is creating doesn't measure insulin resistance though @@cindypina4944
@nichtsistkostenlos6565
9 ай бұрын
@@porkpie2884 There are ways to estimate insulin resistance pretty accurately. HOMA-IR and LP-IR are probably the most practical. To the OP, you can calculate HOMA-IR yourself if you have your fasting glucose and fasting insulin from a basic blood test.
@godbork
9 ай бұрын
@@porkpie2884 have a look at the Kraft test...
@absbi0000
9 ай бұрын
That intro was wild!
@beachnap
9 ай бұрын
I loved this episode, but I'm still left feeling confused honestly. So much advice out there on cholesterol is for the age 50+ crowd. I am a 33 year old woman, healthy height and very physically active (marathon runner as well as surfing, mtn biking, lift weights 3x/wk, etc). I had an ideal lipid profile for years, but after I experienced an unplanned pregnancy followed by a miscarriage I became very anemic. I got two iron infusions which brought my levels back up but the doctor said I need to increase consumption of heme iron, such as red meat and shellfish. Now my cholesterol has skyrocketed shockingly fast and I can't get it to come down. I feel so much better eating more meat but I am considering changing things up and cutting out red meat and most dairy - eating only fish, chicken, tofu, nonfat yogurt, etc. for protein and taking an iron supplement. Should I even be eating eggs? They are recommended for fertility but I worry they will keep my lipids high. I'm trying to conceive again and I'm just so confused as to what I should be eating! I need to support my fertility but I also don't want to go into a pregnancy with dangerously elevated cholesterol.
@bobdec6665
9 ай бұрын
cholesterol myth. Read it
@drironmom6815
6 ай бұрын
It is my understanding that the “progesterone coated IUD’s” actually contain synthetic progestin - with the same risks as oral synthetic progestins.
@Icarianbrother
9 ай бұрын
Dr. Attia stated that a low fat diet lowers blood cholesterol, but thinks that using Statin drugs is a better way to lower blood cholesterol.
@porkpie2884
9 ай бұрын
Attia is a fraud. Lower cholesterol is not good for us, and statins are very toxic, and increase risk of the very diseases it's claimed they reduce
@MrBlaxjax
9 ай бұрын
If I understood right, (and probably I didn’t) he said low fat works to lower cholesterol but it’s probably not a good idea because cutting back on fat can mean increasing intake of(processed) carbs as an energy source. He also said that monounsaturated fats tend to be benign so rule of thumb is cut out saturated fats where you can and add olive oil where you can. Of course all this is made a bit difficult because each person is different. Some people can eat 29 bacon sandwiches a day and be perfectly healthy. For me I found that by cutting down on carbs and especially sugar stuff like triglycerides and overall cholesterol and blood pressure all fell. So my interest is basically should I still aim to eat less saturated fat if my blood test results seem okay with my current diet? Regarding statins it’s not really a fashionable thing to say but it’s probably best to take them if prescribed. Heart disease is a massive killer and statins can help reduce the risk.
@porkpie2884
9 ай бұрын
You have a lot of things the wrong way around. Statins increase risk of heart disease, not decrease it. Saturated fat is not unhealthy. Lowering cholesterol is bad for us. Blood sugar causes heart disease, not sat fat or cholesterol @@MrBlaxjax
@MrBlaxjax
9 ай бұрын
@@porkpie2884 look I agree that blood sugar and also added fructose (which is processed into liver fat and not processed by the insulin system) are public enemy number one as far as metabolic health and heart disease go. But really you are being too dogmatic. Saturated fats and bad cholesterol are usually villains too and yes it’s generally a good idea to take statins if prescribed. Some people possibly me seem to get along okay with a high intake of saturated fat. But not everyone. My inference out of everything I understand (which isn’t a lot) is 1 deal with your added fructose intake. Reduce this to less than 30g/ day ( the uk nhs recommendation) 2 cut back on carbs generally and especially ultra processed food type carbs. For me this seems enough. But for others it won’t be. If you have done all the above and your blood test results are suboptimal then you have to reduce saturated fat and you would just be taking a silly risk by avoiding statins without a very good reason.
@SpindlyScoundrel
9 ай бұрын
@@porkpie2884LOL, 🤡
@bobdec6665
9 ай бұрын
Good job😊
@erwinrogers9470
8 ай бұрын
Love it🔥👏
@KJSvitko
9 ай бұрын
Heart disease is the number one killer of people today and cancer is number two. Being over weight is the number one factor leading to an early death. People who are over weight have higher risks for high blood pressure, heart disease, diabetes and cancer. Even children today have signs of artery disease. Fast foods and sugary drinks have long term consequences. There is an obesity epidemic today where over 60% of the population is overweight or obese. What is common today and "NORMAL" is not healthy. The average person today is not healthy and is taking medications. Heart attacks were once only common in people over 65. Today people in their 40 are having heart attacks. Add more plants and vegetables to your diet and less junk and overly processed foods
@LenkaSaratoga
9 ай бұрын
😆😆😆 Peter Attia advised salt-cured dry meat as a solution.
@agingdoc
9 ай бұрын
True when traditionally categorized by the CDC, WHO etc. - indeed I cited the same statistic in the streaming comments during this premier streaming now. I should have mentioned there though (and do here) that biologic aging is the #1 cause of all of these including cancer and heart disease. Curing cancer has been modeled to only increase lifespan by about 3 years, about 4 for heart disease. If one doesn't get you another (dementia, frailty, respiratory failure etc) will. Thus addressing the biology of aging is potentially more powerful than piecemeal approaches addressing biologic aging. Even in smokers, aging is a greater risk factor than smoking.🚭
@greggbambu411
9 ай бұрын
On excersise hes great. On nutrition not as much. 10 slim jims a day seriously?
@VM-123
8 ай бұрын
The experimental poison cocktails have contributed to sudden heart problems and cancers. Also autoimmune diseases.
@ejboczar
9 ай бұрын
Great update as usual. I have been reading about colchicine and its new therapeutic use in CAD. Any comments?
@gastropodahimsa
7 ай бұрын
In several of your videos over several years you say, and others with you say, eat early and hearty and fast (mostly) as the sun goes down. It sounds good to me and makes sense in the context of the discussions, but I am profoundly unhungry till well after noon and I think I am not alone in that. The fact that so many people are not hungry in the morning is worth noting and explaining, no? Maybe there is a good metabolic reason for it. I'd like your take on that. Thanks
@fabioquirici9218
9 ай бұрын
Niacin ER is great for Lp(a), HDL and ApoB!
@SF_Native
9 ай бұрын
Dr.Patrick is gorgeous as ever!
@zermelo1
7 ай бұрын
1:29:25 CT angiogram for plaque accumulation
@byronquinley1400
6 ай бұрын
A bit surprised to not hear anything on Sulforaphane. Is Dr. Rhonda still bullish on its benefits?
@RobertBurg-o1z
8 ай бұрын
(Not exactly on this week's topic. Hopefully, enough people will ‘like’ this topic that you will consider it.) A disproportionate number of aging athletes seem to have heart electrical problems (bradycardia-tachycardia, sick sinus syndrome, atrioventricular block, atrial fibrillation or flutter (a-fib), etc.). The conventional medical ‘standard of care’ appears to be pacemaker implantation. There seems to be little research into nutritional prevention or reversal. Please update the latest science on causes and prevention, particularly relating to electrolyte deficiencies and/or imbalances (calcium, copper, sodium, potassium, magnesium, etc.).
@marvinmaly
6 ай бұрын
Hello from East Tx=====Marvin
@rossta3949
8 ай бұрын
Attia better make it to 120.
@triluve
8 ай бұрын
2:07:39 veeeeeery smooth Peter
@hcrone
9 ай бұрын
Dr Rhonda Patrick is the original boss!
@TheFarmacySeedsNetwork
9 ай бұрын
Such an excellent podcast! @ foundmyfitness checkout Dr Bryan ..... I can't remember his last name, but he just did a long podcast with someone else on nitric oxide, shouldn't be too hard to KZitem search, excellent insight on nitric oxide as it relates to blood pressure. Pressure. Thank you for everything you do once again!
@TheFarmacySeedsNetwork
9 ай бұрын
I think I need to extend this comment with just a little bit of detail, he talks specifically about not using mouthwash and killing off the bacteria that change nitrate nitrogens into nitric oxide as part of our biome. Very interesting detail that could be easily missed and a huge part. I think, of our epigenetic problems today.
@zermelo1
7 ай бұрын
2:03:12 how VO2 is tested and measured
@williamhenry3337
9 ай бұрын
I am Apoe2 does that impact my health? Please talk about Apoe2 in one of your podcasts.
@intuitivesean443
9 ай бұрын
So I understand that red rice yeast effects cholesterol in a good way can anyone explain also what’s the difference between red rice yeast and bergamot? In what ways do these too supplements effect cholesterol ?
@deissik
9 ай бұрын
Red yeast rice contains a naturally-occurring statin called monacolin K
@shannonsaunders1562
8 ай бұрын
Also, did anyone see if we can download all the studies?
@chestrockwell8328
9 ай бұрын
Why ApoB is a superior predictor of cardiovascular disease, versus CAC scan ?
@porkpie2884
9 ай бұрын
ApoB is not causal of CVD. Attia is wrong and he knows it
@nichtsistkostenlos6565
9 ай бұрын
ApoB is a measurement of the number of ASCVD causing particles in your bloodstream. Which will tell you your risk of developing ASCVD over time. A CAC scan tells you when you already have calcified plaque, indicating you already have ASCVD. They're different tests with slightly different purposes. A CAC scan, for example, would be useless for an average person under the age of about 40.
@leoceoliveira
8 ай бұрын
Indeed.
@heinrichr6902
9 ай бұрын
It is disturbing, when Peter tell us, he knew and are the „Truth“ about Cholesterol. Now i am shure, that the other guys know more. (Feldman, Diamond, Paul Mason)
@carlwatts1230
8 ай бұрын
I posted this comment under an interview with one of the vegan doctors but I wonder what believers in omnivory for human animals to reach optimal health. I think a lion will suffer adverse health conditions when the lion eats little meat and many plants. So also for dogs and cats. Many housecats survive on largely plant-based industrially produced cat food. I don't think that's healthy for them though. I think the cats would be better off eating more meat and less plants. What about humans? Our ancestors at some point seem to have been plant eaters like the other primates. However didn't the human species start hunting a couple of million years ago? Is the human lineage the part of the family of primates that started trying out carnivory? A few million years is enough time to overhaul the digestive system. Lions and cats evolved from other species which weren't necessarily full carnivores. At a certain point enough genetic change accumulates through natural selection to the point where the optimal diet changes. Those who couldn't survive and thrive with the hunting lifestyle (and likely scavenging before that) that pre-human ancestors adopted died off. Gradually the cecum atrophied to the small little thing we call "appendix" now. Stomach acid got more acidic. Intestines changed. Etc. This change in diet and change in anatomy that accompanied likely allowed brains to grow. Less energy towards the digestive system, more available for the brain. Animal fat and meat are very nutrient dense and are more easily assimilated into animal tissue. Hard to know what really happened but I'd put up that story against any that Greger may put forth any day of the week. There's lots of other independent lines of evidence which I could bring in but I'll leave it like this for now. Will probably be c'd anyways like so many of my comments in the YT of recent times. Probably just talking to myself but hey I find it intrinsically enjoyable and worthwhile thinking out loud like this or not quite out loud but people know what I mean I bet
@RosieJ7223
6 ай бұрын
Did he say that women are NOT taking progestin anymore? There are millions of women on progestin-only contraceptives. I listened back and I don’t think I misheard Dr. Attia. Can anyone clarify?
@RickinICT
6 ай бұрын
I thought he said women without a uterus didn't take it, because they don't need to protect the endothelial lining anymore? But I'm not sure, it was a lot to take in.
@Ciskuss
9 ай бұрын
We need a good summary
@agingdoc
9 ай бұрын
Both Rhonda and Peter have shownotes, with the $ supporting them both. I'm in this niche myself and follow the literature - and still worth it with the quality guests they both bring in.
@cmerighe2
9 ай бұрын
The employee: “I finally like this job”
@fionadale8044
9 ай бұрын
Plant Chompers did an interesting review on Dr. Peter Attia's new book, if anyone is interested.
@radmehrabdolahi1346
9 ай бұрын
It was a bit lousy tbh. He cherry picked a bit and was ambiguous about his assessment and gave pretty unspecific criticism at times. I watched it twice by the way!
@fionadale8044
9 ай бұрын
@@radmehrabdolahi1346 I was surprised to learn that animals make LDL and ApoB when Peter claims they don't.
@janinemelnitz2750
9 ай бұрын
His breast cancer screening seems a little too aggressive as well as colon cancer. In someone who has no known risk factors, family history, normal weight etc I cant imagine getting screenined every 6 months.
@nichtsistkostenlos6565
9 ай бұрын
Like he mentioned, this is largely up to you and what you're willing to tolerate. The point is, if you follow that regimen, there is effectively a 100% chance that you will catch any cancer incidence while it's in stage 1. Considering how treatable effectively every cancer is in stage 1, it's a hell of an upside for the downside of the test.
@janinemelnitz2750
9 ай бұрын
@@nichtsistkostenlos6565 but there can be a huge downside. False positives. I know he mentioned this but they are not benign findings…,many unnecessary procedures, follow up, anxiety etc. I’d like to know where he gets his data for this. I’m a physician and have seen this first hand
@Schu2505
4 ай бұрын
Statins increase the odds ratio of a hemorrhagic stoke.
@shannonsaunders1562
8 ай бұрын
what is a E4 vs. E3 woman? did i miss this?
@RickinICT
6 ай бұрын
I believe he was referring to particular gene types that increase the risk of types of breast cancer, but I'm not 100% sure.
@rosepetal9748
9 ай бұрын
❤❤❤
@adamalvarez4190
8 ай бұрын
🔥
@carolr.556
8 ай бұрын
I just don’t see the benefit in statin use if people are already trying to maintain their insulin sensitivity. Aging unfortunately causes a decrease in insulin sensitivity..Also the risk of dementia if your family has a history. Berberine is really great. I am not sure it’s a toxin.. It lowers blood sugar..kills bad bacteria in the gut..
@VTVT1306
6 ай бұрын
I can’t understand the “ safe “ alternatives to statins he talks about around 1:20. Can somebody help?
@VTVT1306
6 ай бұрын
1:22
@VTVT1306
6 ай бұрын
PSK9? It sounds something like that
@undrcroft
9 ай бұрын
Signed up for the email list(annoying to have to do that) to get the BDNF protocol, and now I can't unsubscribe to the mailing list(link doesn't work). This is kinda shady Rhonda
@FoundMyFitness
9 ай бұрын
Hit reply and type "unsubscribe" and we'll make sure you're removed. No idea why it didn't work.
@RosieJ7223
6 ай бұрын
This is fascinating, great podcast. But I laughed out loud at about 33:01 when he talks about how babies in the womb only need a tiny bit of cholesterol for all that growth-- they take it out of their mothers! 😆 Have we tested that? They don’t need as much because the sweet cherubs take it from us while we shrivel in the corner 😆 ’ll gladly keep giving, I’ve had four children and giving life is beautiful…but it’s like the kind of beautiful that’s so intense you sometimes can’t look at it 😉 “What’s that? Johnny needs a kidney? Ok give me ten minutes, I’ve got a pairing knife and of course I won’t miss that kidney at all, darling!”
@crunchy3546
9 ай бұрын
I thought you divided trigs by 2.2 🤔
@DennisNowland
7 ай бұрын
I just can't imagine how my grandmother lived to be 98 without all these pearls of wisdom. Well, actually I do!! BS
@sabby123456789
8 ай бұрын
So to be healthy, avoid: Fruits Grains Beans Potatoes Animal fat (except fish) Dairy fat Coconuts Egg yolks (if you're a sterol hyperabsorber) Eat: Non-starchy vegetables Lean meat Oily fish Egg whites Low-fat dairy Avocados Olives
@luckssj
9 ай бұрын
Question, why do Doctors and some PhD people like to diss food supplements because as a single item they may not work. Food Plant work in synergy, like a good marriage. When will they ever learn?
@johntibaldi9496
9 ай бұрын
You may want to look up clean vs dirty drug.
@relevantbrother8964
4 ай бұрын
My take away from Dr.Attia.over the years wrt exercise is that Zone 2 is the most crucial foundation and element. The cornerstone that enables the other modalities to shine. Its like the bass guitar in a song. You might not notice it but without it the song lacks that vital foundation. Zone 2 enables one to recover better from Zone 5 and weight training as well as improving endurance. In addition to it's own stadnalone beenfits.
@willemvanriet7160
9 ай бұрын
No one messes with my mitochondria with no stinking stattin!
@IP.1
8 ай бұрын
Did you have to mention AG… Since you did, know it’s HIGH in LEAD…
@RJay121
9 ай бұрын
I always listen to KZitem vids at 1.5x playback bc they're too long😮
@agingdoc
9 ай бұрын
But quality. Why rush! I savor them over several sessions!
@dianadavidson7848
6 ай бұрын
Very disappointed that Dr. Attia never returned to discuss risk of statin use as it correlates to Parkinson's. My mother has been on statins for many years and has Parkinson's. She is still taking the statin.
@aa-xn5hc
9 ай бұрын
Not clear at all the explanation of why ApoB100 level already accounts for the smaller lipoproteins that clear very slowly.
@welanduzfullo8496
5 ай бұрын
3:25:17 peter attia forgets that androgen receptors are up and down regulated by circulating free and shbg complex bound testosterone and weakly albumin bound test ...
@SamShank175
9 ай бұрын
We don't need LDL, why would it be there? How many times in history have they said that we didn't need something in the body, only to discover years later that, yes we do need whatever that thing was?
@The_Legend_Himself
9 ай бұрын
This is such a brain dead reductionist statement
@ItspronouncedAaron
9 ай бұрын
I need to master longevity to make it through this episode.
@nathanc777
9 ай бұрын
lol
@anna.m8
9 ай бұрын
😭😭
@hans471
9 ай бұрын
Rip 😢
@SusanaXpeace2u
7 ай бұрын
I know, it'd be a bit sedentary to watch it all! Have you got through it yet? I'm going to watch it at work today, and tomorrow.
@astromob1
5 ай бұрын
At work? How do you have time?
@bartrobinson2103
9 ай бұрын
This guy is too big on drugs!
@nichtsistkostenlos6565
9 ай бұрын
Why? Because he thinks statins might be helpful for some people to avoid dying of heart disease, the literal number one cause of death in the first world?
@wellthi
9 ай бұрын
@@nichtsistkostenlos6565 cause he can just go plant based instead of taking pills
@agingdoc
9 ай бұрын
He is a medical doctor! I like that they both emphasize lifestyle and prevention first. Sometimes, we can do better, but not if we can't or don't have/want to.
@hcrone
9 ай бұрын
40 to 50 grams of protein 4 times per day, Pete? I can't eat 8 cans of sardines in a day. I just cannot. How does anyone do this?
@karlpk3907
9 ай бұрын
Whey protein in a shake
@margomoore4527
9 ай бұрын
Don’t eat any carbs. Eat protein until you aren’t hungry anymore. Does it have to be sardines?
@coachsimard8641
9 ай бұрын
Dbl up on JOCKO MÖLK (2 scoops) blended w/a cup of unsweetened vanilla almond milk! 44grams of protein and a bunch of other good stuff! I keep Molk in the freezer, put the blender jar w/the almond milk in the freezer for 15 mins before blending and it's basically a vanilla milkshake!
@alterego157
9 ай бұрын
There's no need for that much protein. Do some more research on the subject. He's just stuck in some old bs narratives.
@jvm-tv
9 ай бұрын
- Morning shake 40g - Lunch meat + yoghurt 40g - Dinner chicken or fish 40g - A snack during day of nuts + yoghurt + beef jerky 40g
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