I'm joined today by Trevor Lithgow who is the Director of the Centre to Impact AMR strategy in Australia, actually in Victoria, at Monash University in the state of Victoria. And the theme, our theme for today really is going to revolve around, you know, what's going on in Australia. We're very very interested recently and seeing a variety of national initiatives emerge and so I think it's really fun and timely to visit with people in different parts of the world about what's going on so, Trevor, thank you for being here today. Really, really glad we could connect.
Pleasure's all mine, John, thanks.
So I know of you in general as a sort of a molecular microbiologist and some interest in phage therapy but before we go into kind of what you're doing these days, tell me a little bit about you. How did you get interested in antimicrobial resistance? How did you wind up where you are?
Yeah, yeah, it's a sort of long and winding road so I’ll take the short version of it for you but my background is in molecular biology and I’ve always been interested in microbes so they've been the experimental systems of choice in my lab so I did my postdoctoral work at the University of Basel with Gottfried Schatz, looking at how the proteins that generate mitochondria actually get into that organelle and that led me to an interest, when I established my own lab, of starting to work towards understanding how the mitochondrial outer membrane was made. I’ve always been interested in membranes and membrane biology.
And since we know that mitochondria evolved from bacteria, the more we learned about how mitochondrial outer membranes were made, the more we got interested in why it was we didn't know more about how bacterial membranes were made and so, at the time that I moved to Monash University, which is like 12 years ago, I decided to shift the focus of the lab away from the mitochondrial outer membrane and to start working on the bacterial outer membrane. The sort of approaches we take uses structural biology, classic molecular biology, and because we were working with e coli and klebsiella as our bacterial models, a lot of microbiology which I knew from before and was able to bring back into the lab, especially with great colleagues at Monash, so it was a it was a really great move for me personally for the people in my lab and I think also for the science that we've been doing and as soon as we started to work on the outer membranes of gram negative bacteria, it was really made crystal clear to us that the major motivator for understanding these processes in the bacteria was really because of the evolution of antimicrobial resistant phenotypes and the way in which the outer membrane is sort of front and center for how some of those phenotypes develop.
⚕ Who is Trevor Lithgow? - 00:06
⚕ Trevor's Background - 00:44
⚕ Australia and AMR - 6:03
⚕ Centre to Impact AMR - 10:07
⚕ Phage Research at the Centre to Impact AMR - 13:09
⚕ Incentive Structures in Australia - 17:20
⚕ Getting Phage Products to Market - 21:47
⚕ Education on AMR - 24:00
⚕ Australia's Work on Figuring Out the Phage Manufacturing Process - 29:00
Links in video
🔗 Lithgow Lab ► www.monash.edu/discovery-inst...
🔗 Centre to Impact AMR ► www.monash.edu/impact-amr
🔗 Phage Therapy: Working towards providing new treatment options for critically ill Australians ► www.monash.edu/impact-amr/pha...
🔗 Australian Antimicrobial Resistance Network - AAMRNet ► www.mtpconnect.org.au/Categor...
🔗 Mark Blaskovich ► researchers.uq.edu.au/research...
🔗 Interdisciplinary Course on Antibiotics and Resistance (ICARe) ► www.icarecourse.org
🔗 Phage Australia ► phageaustralia.net
Trevor Lithgow's Twitter ► / trevorlithgow
Subscribe ► kzitem.info/rock/99m...
Do you have a question about antibiotics, phage, or antimicrobial resistance? Leave a comment below or tweet Dr. John using #FireExtinguishersOfMedicine!
Twitter ► / johnrex_newabx
Website ► amr.solutions
Supported by the Wellcome Trust ► wellcome.org
John H. Rex, MD | Chief Medical Officer, F2G Ltd. | Operating Partner, Advent Life Sciences. All opinions are my own.
Professor Trevor Lithgow, PhD | Centre to Impact Antimicrobial Resistance. Professor, Microbiology. Professor, Monash Biomedicine Discovery Institute. All opinions are my own.
#AntimicrobialResistance #Phage #Bacteriophage #Antibiotics #AMR #AntibioticResistance #Antimicrobial #AntibioticResearch #AntibioticStewardship #Superbugs
Негізгі бет Ғылым және технология Episode 7 w/ Trevor Lithgow, PhD - AMR Fireside Chat
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