Northwestern University welcomed Dr. Paolo Cravedi for the Division of Nephrology Renal Grand Rounds. Dr. Cravedi is a scientist and physician with a strong interest in organ transplantation. He has been working on both clinical studies to minimize immunosuppression in kidney transplant recipients and mechanistic projects to identify biomarkers of rejection and the immune effects of locally produced complement. In recent years, he has been focusing on the immune-modulating effects of erythropoietin (EPO). The results of his in vitro and murine studies formed the basis for an NIH-funded clinical trial that will test the hypothesis that EPO promotes tolerance in liver transplant recipients by increasing regulatory T cells.
Objectives:
1. To review the immune effects of Erythropoietin (EPO) on effector and regulatory T cells
2. To discuss how EPO prevents and reverts training of murine and human monocytes
3. To review the immunological effects of EPO in mice and humans with autoimmune diseases or transplantation
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Негізгі бет Ғылым және технология Erythropoietin, A Multifaced Hormone That Promotes Immunological Tolerance
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