Neena Gupta was born in Calcutta, India to R. N. Gupta, a LL.B.-graduate and an officer in the State Trading Corporation of India, and Shakuntala Devi Gupta (née Kinra) a former teacher. She grew up in the Karol Bagh area of New Delhi, doing her elementary schooling at the Bal Bharti School and secondary schooling at Vidya Bhawan. She went on to get her Bachelor of Arts from Janki Devi Memorial College, Delhi University. Gupta has made appearances in several international films, such as Gandhi (1982), in which she played the niece of Mahatma Gandhi, and Merchant Ivory films, The Deceivers (1988), Mirza Ghalib (1989), In Custody (1993), and Cotton Mary (1999). She also made an impression in Indian parallel cinema such as Mandi (1983), Rihaee (1988), Drishti (1990) and Suraj Ka Satvan Ghoda (1992). These performances further established her profile in Indian movies alongside her arthouse film contemporaries Rekha, Shabana Azmi, Smita Patil and Dimple Kapadia. she achieved her breakthrough as a newly widowed daughter-in-law in the acclaimed drama Woh Chokri (1994), which won her the National Film Award for Best Supporting Actress.Her big break on television came with Khandaan (1985), Yatra (1986), Gulzar's Mirza Ghalib (1987), a TV miniseries, followed by Shyam Benegal's Bharat Ek Khoj (1988) and later Dard (1994), Gumraah (1995), Shrimaan Shrimati (1995), Saans, Saat Phere: Saloni Ka Safar (2005), Chitthi (2003), Meri Biwi Ka Jawab Nahin (2004). She has also acted in the TV serial, Buniyaad.
She also hosted the Indian version of the TV series The Weakest Link, Kamzor Kadii Kaun and appeared in Jassi Jaissi Koi Nahin which gave her considerable popularity.
She has directed successful TV series, such as Saans (1999), Siski in (2000) and Kyun Hota Hai Pyarrr. She played the role of Shubha, one of the four women main leads in Ladies Special, a daily soap on Sony TV. She is now seen in Dil Se Diya Vachan as a doctor by profession and mother-in-law of the lead character Nandani which airs on Zee TV.
She also ran a theatre production company, 'Sahaj Productions' with actor, Rajendra Gupta, and acted as well as produced the Hindi play Soorya Ki Antim Kiran Se Soorya Ki Paheli Kiran Tak. She has also had some roles in Rishtey which was aired on Zee TV during 1999-2000.
She made an appearance in Amazon Prime's Panchayat as Manju Devi Pradhan. She appeared in season 2 of the same in 2022 as the same character.
She has also been a part of Masaba Masaba, a Netflix show based on her and her daughter Masaba Gupta, who is a designer by profession.
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