In this video we explain the mechanism of action, pharmacokinetics, indications, contraindications and side effects of Furosemide. We use simple explanations and diagrams that are easy to understand, aimed at helping medical students and healthcare professionals of all levels.
Timestamps:
00:37 - Mechanism of action
10:22 - Pharmacokinetics
12:21 - Indications & Contraindications
14:47 - Cautions & adverse effects
17:53 - Summary
Furosemide belongs to a group of medications known as loop diuretics. Loop diuretics cause an increased production of urine by inhibiting the reabsorption of fluid and electrolytes. This is achieved by inhibiting the sodium/potassium/2 chloride co-transporters located on cells within the ascending limb of the loop of henle. Inhibition of these pumps causes fluid and electrolytes to remain in the kidney tubule so they can be excreted in the urine. Furosemide also has vasodilatory effects which contribute to its therapeutic effectiveness. Furosemide is used is oedematous states such as acute pulmonary oedema, peripheral oedema and ascites as well as resistant hypertension. The adverse effects are mainly attributed to the loss of fluid and electrolytes.
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Although this video is designed to provide education, it should not be used to guide clinical practice, treatment or medical decision making. These videos are designed to provide a detailed overview of each topic, and although a lot of research goes into each video errors can occur and medical practice, medical information and protocols may change over time, which is why it is important to follow local and national guidelines. These videos do not constitute medical advice, medical advice should be obtained from an appropriate healthcare provider or senior clinician.
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