Patient presents with a mass anterior to the patella, extending into the quadriceps tendon most consistent with gouty tophus. Gout Tophus are Urate (uric acid) crystals in the joint caused by advanced or unregulated Gout. Here the tophus is in the distal interphalangeal joint. Urate crystals form with the excess of uric acid. This excess comes form a dysfunction of the hypoxanthine-guanine phosphoribosyltransferase enzyme (HGPRT) which convers the precursors of uric acid to other things. A dysfunctional HGPRT means more precursors which lead to more uric acid which leads to crystals, or simply "Gout." This patient had this Tophus removed surgically and was started on Allopurinol. Allopurinol blocks another enzyme (Xanthine Oxidase) which makes uric acid. Hence it prevents buildup of crystals and treats gout.
Негізгі бет Gouty Tophus of Knee
No video
Пікірлер