窒素の脱離能が低い場合、何で先に脱離しないですか? 日本語と英語のwiki説明は違います。どちらが正しいかと迷っています。 日本語のwiki説明(stability of carbanion):ja.wikipedia.org/wiki/%E3%83%9B%E3%83%95%E3%83%9E%E3%83%B3%E8%84%B1%E9%9B%A2 英語のwiki説明(steric effect):en.wikipedia.org/wiki/Hofmann_elimination Hofmann product is preferentially formed due to the steric bulk of the leaving group causing the hydroxide to abstract the more easily accessible hydrogen.
@wk5340
Жыл бұрын
Ammonium group(bulky like tBu) is equatorial subs. It cannot be eliminated with endocyclic hydrogen because of chair conformation.
Пікірлер: 5