If you enjoyed this, you might like my book on the science of aging and longevity, Ageless ageless.link/
There’s a new series on longevity science on Disney+ called Limitless, starring Marvel’s own God of Thunder, Chris Hemsworth. I’m excited to see a big-budget, beautiful documentary about aging biology with a huge name like Thor, I mean Chris, behind it-so I thought I’d make a review of the science behind it.
If you want to help spread the word about aging biology or donate to a charity working on it, there’s more information here: andrewsteele.co.uk/ageless/ho...
This isn’t a sponsored video but the footage of Limitless is courtesy of @disneyplus and @NatGeo. Thanks for letting me use it!
Chapters
00:00 Introduction
01:14 Fasting
05:19 Memory
11:22 Acceptance
13:44 Becoming truly Limitless
Sources and further reading
Calorie restriction
Clive McCay’s classic 1935 paper on calorie restriction in rats pubmed.ncbi.nlm.nih.gov/2520283/
CALERIE results www.thelancet.com/journals/la...
APOE and dementia
First, a quick note: I mention APOE2 at one point in the video without really explaining it! Sorry. This is a different, rarer version of APOE which seems to be protective against dementia. More in the links below…
Chris’s interview with Vanity Fair about receiving his APOE results www.vanityfair.com/hollywood/...
APOE variant Alzheimer’s risks via www.nature.com/articles/s4146...
Read more about APOE and Alzheimer’s disease risk in this ridiculously in-depth overview www.alzforum.org/news/confere...
APOE4 seems to be protective against parasitic infections www.ncbi.nlm.nih.gov/pmc/arti...
APOE4 protects against melanoma www.nature.com/articles/s4159...
But APOE3 seems to be best against covid, APOE4 and APOE2 do worse www.nature.com/articles/s4158...
Base editing: Revolutionary therapy clears girl's incurable cancer www.bbc.com/news/health-63859184
Nature News piece on the state of therapies using base editing more widely www.nature.com/articles/d4157...
The original 2016 paper I show in the video www.nature.com/articles/natur...
Rapamycin, senolytics and aging biology generally
You should check out my book which goes into a lot more detail about these! And it’s got loads of references in the back if you want even more detail ageless.link/
I also did a talk for @TheRoyalInstitution which is (I think) the best overview I’ve done so far • Getting older without ...
Credits
Yeast image by Pilarbini commons.wikimedia.org/wiki/Fi...
C. elegans video by Heiti Paves commons.wikimedia.org/wiki/Fi...
Drosophila picture by Sanjay Acharya commons.wikimedia.org/wiki/Fi...
Lab mouse image by Rama commons.wikimedia.org/wiki/Fi...
Lab rat image by Janet Stephens commons.wikimedia.org/wiki/Fi...
Guppy image by 5snake5 commons.wikimedia.org/wiki/Fi...
Monkeys on dietary restriction image by Jeff Miller/University of Wisconsin-Madison. Canto, on the left, is 27 and calorically restricted, while Owen, on the right, is 29 and was allowed to eat what he liked. news.wisc.edu/newsphotos/monk...
And, once again, thanks to Disney+/National Geographic for the footage from Limitless!
And finally…
Follow me on Twitter / statto
Follow me on Instagram / andrewjsteele
Like my page on Facebook / drandrewsteele
Follow me on Mastodon mas.to/@statto
Read my book, Ageless: The new science of getting older without getting old ageless.link/
Негізгі бет Ғылым және технология How gene editing could save Chris Hemsworth
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