you are, far and away, one of the most effective youtube chemistry channels at teaching.
@totalsynthesis
Жыл бұрын
Wow, thank you!!
@kevinmarrs3372
Жыл бұрын
I can’t say a huge amount about this due to confidentially but the drug at 12:33 (CTP-543) was a project that I worked on during my time in the pharmaceutical industry. It’s still an active project. Ive since moved on to do a PhD but it was certainly an interesting experience to learn about substituting deuterium into drugs to improve their efficacy.
@totalsynthesis
Жыл бұрын
👀 that's awesome!
@clarencechrissmithjr
11 ай бұрын
Sounds positive!
@milsomas9801
Жыл бұрын
As someone who went from a more organic chemistry focus to chemical biology, this video and channel is perfection. Keep the total synthesis videos coming! Your explanations of science concepts is direct and understandable, keep up the good work, subscribed.
@totalsynthesis
Жыл бұрын
Thank you!
@definetlynotacomment1184
Жыл бұрын
Wow didn't expect this to go into process chemistry! Learning about pharmacokinetics is always interesting. This type of video is a blessing. Ist zwar etwas spät, aber: Frohes Neues! :D
@ianbd77
Жыл бұрын
Incredibly impressive video I can't say I understood all of it but it's certainly gave me an insight thank you so much
@totalsynthesis
Жыл бұрын
Awesome man, thanks!!
@thechemist3787
Жыл бұрын
This synthesis clearly shows that process chemist are the best chemist out there ! 👨🔬
@yannikesser3957
Жыл бұрын
Amazing video! Just learned about kinetic isotope effects last semester in Phys Org, interesting to see there are actual uses beyond mechanistic studies.
@jorgejimenez4325
Жыл бұрын
That diazoketone ring forming reaction was cool.
@redwood76
Жыл бұрын
The way you describe chemistry is exquisitely beautiful....
@petevenuti7355
Жыл бұрын
One of the most fascinating of your videos that I have watched so far!
@expiredgoatmeal1666
Жыл бұрын
very interesting video! loving this medchem/investigational style
@cristianionita8359
Жыл бұрын
Here from /sci/; keep it up, fren!
@user-pb4dz6mc6n
Ай бұрын
absolutely stunning video
@totalsynthesis
Ай бұрын
Thanks for the comment, I really appreciate it :)
@espltdm155
Жыл бұрын
really good video covering many areas of chemistry within a single topic
@totalsynthesis
Жыл бұрын
Thanks 💕
@chefboyardab
Жыл бұрын
Aye bro i really like your channel and how you explain things. One of my favorites!
@alexandraschneider5651
Жыл бұрын
Omg I was waiting so long for another video!!🔥🔥🔥
@totalsynthesis
Жыл бұрын
Stay tuned for more videos in the near-future - make sure you're subscribed and enable notifications!
@janrosenboom5852
Жыл бұрын
Nice video! How about one on the total synthesis of Vit. B12? I know it's rather old but the Woodward/Eschenmoser story and the pure scale of the project could be really interesting...
@PotooBurd
11 ай бұрын
Love your work! Comenting for the algorithm 🌻
@kalrbaum
Жыл бұрын
Man, I love some good process chemistry!
@garrysekelli6776
Жыл бұрын
İt's really wierd how a bunch of nazi chemists discovered all this basic science in the 1930s yet they all converted to judaism by 1945.
@johnfox2709
Жыл бұрын
Beautiful discussion of the organic synthesis; though it did bring me some unpleasant flashbacks of undergrad pchem.
@totalsynthesis
Жыл бұрын
Glad I wasnt the only one 🤣
@yourfuneral
Жыл бұрын
Thank you for the nice content. Next time I'll get notified
@AmrendraKumarGupta-xy7ez
7 ай бұрын
nice video. Keep on growing❤❤
@totalsynthesis
7 ай бұрын
Thank you 💖
@chanheosican6636
Жыл бұрын
That very cool i never imagine deterium hydrogen isotope besides potential cancer uses (maybe) for making new drugs. I thought it was only used in nuclear reactors and nuclear bombs.
@totalsynthesis
Жыл бұрын
Thanks for watching!
@romainbonnot87
Жыл бұрын
The mastery of the morph effect in ppt is impressive 😂
@damankharoud5034
Жыл бұрын
HE'S BACK LETS GO!
@totalsynthesis
Жыл бұрын
Back and here to stay 😎
@chadkline4268
11 ай бұрын
I'd like to see some work done on Sanguinarine. If possible.
@thomasferris3750
Жыл бұрын
Duterated DMT for stroke victims, duterated specific spots to help protect it from mono amines oxidase enzymes allowing the drug to have a slightly longer action allowing more time for oxygen to return to the brain helping to prevent long term trauma
@thomasferris3750
Жыл бұрын
There's also research for DMT being used in the recovery process for stroke
@Stonie23
Жыл бұрын
great video and research of the topic... This is so intrereting, and I still lmao about the cylo-proply swag😆
@totalsynthesis
Жыл бұрын
😂😂 thats what I think when I see these molecules which just flex on others
@larryfertel1567
Жыл бұрын
Very interesting. My company makes d-3 MeI in commercial quantities
@MrJman9001
Жыл бұрын
He's back :D
@Christopher.Marshall
Жыл бұрын
01:58 "were carefully prepared using the best purification techniques and temperature controls"... I didn't know Trump was a chemist.
@totalsynthesis
Жыл бұрын
😂 I can imagine him saying "there's no one who's better than me at chemistry" (maybe you know that compliation)
@klauskarpfen9039
Жыл бұрын
Make organic synthesis great again!
@0BRAINS0
Жыл бұрын
Please put the morphine D³ in my I.V. Got a bad habit and I hope the potency doesn't kill me.
@garrysekelli6776
Жыл бұрын
I'm not good at math but H is 1 and D is 2 so 1 cubed would equal 1 but 2 cubed would equal 8.
@garrysekelli6776
Жыл бұрын
Also i think you were saying something or mean to say something about morphine hydrochloride. But instead morphine deuterium chloride.
@klauskarpfen9039
Жыл бұрын
@@garrysekelli6776 Deuterium chloride or hydrogen chloride is in this case irrelevant. What might be more effective though could be the N-trideuteromethyl analogue, but I'd have to look up the metabolic pathway... . As a sidenote, as codeine is a prodrug for m., I'd expect codeine's O-trimethyl congener to be a less effective analgesic.
@mknaomidestiny
Жыл бұрын
>Obamium Subscribed!
@totalsynthesis
Жыл бұрын
🤣
@puo2123
Жыл бұрын
What are the differences between deuterium and tritium in chemical reactions?
@totalsynthesis
Жыл бұрын
Reacts like H or D, but is heavier (one more neutron) and radioactive (beta decay). More used in nuclear physics than organic chemistry except for labeling
@puo2123
Жыл бұрын
@@totalsynthesis but does it change the reaction rate? Ive done chemistry with tritium but never measured reaction rates
@totalsynthesis
Жыл бұрын
@@puo2123 yes, increased isotope effect due to even higher mass
@elementbr
Жыл бұрын
Amide. With an e. Not amid, like the American scientists pronounce.
@rredding
Жыл бұрын
Deuterium instead of Protium (the ordinary hydrogen isotope) in your body... Do we know how that works out, e.g. in your mitochondria? Nope, we don't 👐🏻 Not in my body!🙅🏻
@totalsynthesis
Жыл бұрын
If you consider that Deuterium is occuring in nature in 1 out of 6500 normal hydrogens, and your body is processing billions upon billions of molecules... we are probably fine with having some hundred milligrams of drugs with deuterium in us :)
@rredding
Жыл бұрын
@@totalsynthesis Well, I don't like the drugs that interfere with processes in our body, and often only mask symptoms. Now follows a bit too long rant.. I don't like the fact that most pharmaceutical companies have a financial model that prospers when customers (me, "the patient") are life long prescribed their "medicines". Examples are plenty: statins, blockers, NSAID, antacids and e.g. stuff that helps you with athlete's food. Chemotherapy, Fentanyl, Oxycodone. But also the 'innocent' Acetaminophen is dangerous, due to its interaction with other drugs. They usually don't cure but "manage" your disease process. I don't believe that we'll be honestly informed about threats that Deuterium may form for us. I see more in healthier living, staying away from packaged food, all the sugars and refined carbs, and not to forget the vegetable oils. These cause the metabolic diseases that make the pharmaceutical companies flourish, up to trillions of dollars per year. Perhaps it's interesting to see the wheels behind our modern society.. You know them probably. The big investors and their owned big three (pharma, food, media). A lot of writing that goes way beyond Deuterium, I admit. I see more in food, minerals, vitamins. And yes, when really necessary may use "allopathic" drugs.
@totalsynthesis
Жыл бұрын
@@rredding I understand your sentiment, and also agree the value of healthier lifestyle is underappreciated - however, unfortunately there are people who try their best and still get for example cancer or inflammatory disease. Maybe we will get them at some point in our life despite our best efforts to prevent them? I'm certain I would be happy about having something that gives me the chance for disease remission. Are drugs perfect? No - but are they of value? Absolutely. That includes drugs that manage symptoms/ progression as well as drugs that have a high likelihood of actually curing the disease - they do exist, and they are priced even higher. Whether those prices are fair, and if it's ok for the pharmaceutical industry to have one of the highest margins across industries - that's another point...
@victordonchenko4837
Жыл бұрын
@@rredding All drugs interfere with the processes in your body. That's how they work. They are for when processes in your body aren't doing what is good for you, like with autoimmune diseases. And also we do know what deuterium drugs do in your body -- as we do with every drug that is released to the public. According to studies you can replace as much as 20% of your daily water intake with heavy water (en.m.wikipedia.org/wiki/Heavy_water#Toxicity_in_humans), with nothing happening to you. That's way past what most drugs will kill you at. Additionally the deuterium in drugs is often attached to a C rather than an O preventing proton exchange with ambient water in your body (it stays in the drug).
@knivesnico8775
Жыл бұрын
hi
@totalsynthesis
Жыл бұрын
Hello friend
@theoyassa8515
Жыл бұрын
deuturmom
@gaurav.raj.mishra
Жыл бұрын
/sci/ bro
@archivariouss
8 ай бұрын
Putting the D into Drugs got me laughing af what is wrong with me...
@totalsynthesis
8 ай бұрын
😂😂😂 fine sense of humor
@archivariouss
8 ай бұрын
@@totalsynthesis ❤️♿️❤️
@THECRANKE
Жыл бұрын
Nile red is a horrible example of chemist or something close
@totalsynthesis
Жыл бұрын
:(
@TheRealFreznoBob
Жыл бұрын
Hola TS, you speak of neutrons but I posit to you that no such thing exists. Your so-called neutron will very shortly turn into a proton and an electron. It would be stupid to assume that this electron and proton were created in some kind of atomic fissioning event, instead it would be prudent to assume that the proton and electron were in some intimately paired situation. In fact when you assume that one of the electrons has moved to the interior of the atomic structure then you can do away with one of your fundamental forces and simply assume protons are held together because of this inner electron. Less fundamental forces equals a more believable model of reality. I don't know if you'll get anything from this text, most people can barely function within their current paradigms let alone envision another. Don't hate, just relate.
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