𝐒𝐮𝐛𝐬𝐜𝐫𝐢𝐛𝐞 𝗙𝐨𝐫 𝗠𝐨𝐫𝐞 𝗜𝐧𝐟𝐨𝐫𝐦𝐚𝐭𝐢𝐨𝐧 𝐨𝐧 𝗛𝐞𝐚𝐥𝐭𝐡 👩⚕ 𝐚𝐧𝐝 𝗠𝐞𝐝𝐢𝐜𝐢𝐧𝐞💉🩺💊
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Intracellular Accumulations -
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Intracellular accumulations refer to the build-up of various substances within cells due to abnormal metabolism, defective protein folding or transport, enzyme deficiencies, or exposure to indigestible materials. These accumulations can be of endogenous origin, such as lipids, proteins, glycogen, and pigments, or exogenous substances like minerals and infectious agents. Common examples include fatty change (steatosis) in the liver due to alcohol abuse or obesity, accumulation of misfolded proteins in neurodegenerative disorders like Alzheimer's disease, and accumulation of glycogen in glycogen storage diseases. Additionally, pigments like hemosiderin (iron) and lipofuscin (wear-and-tear pigment) can accumulate in cells due to chronic injury or aging. These substances can be harmless or lead to cellular dysfunction, depending on their type, amount, and persistence. For instance, excess lipid accumulation can disrupt cell membrane integrity, while excessive iron can catalyze free radical formation, causing cellular damage. Understanding the mechanisms behind intracellular accumulations is essential for diagnosing and managing various pathological conditions. 🧬🔍⚖️
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Негізгі бет Intracellular Accumulations: Pathology Hindi Lecture
Пікірлер: 3