This lecture serves as an introduction to the world of cross-coupling reactions. It offers insights into the historical evolution of this research domain and acquaints you with the key cross-coupling reactions that will be explored throughout this series of lectures. The main topics covered in the lecture are: definition of cross-coupling reactions; overview of the mechanism of cross-couplings; popularity of cross-couplings in medicinal chemistry and related disciplines; the Nobel Prize in Chemistry 2010; the main periods of the development of cross-coupling chemistry; cross-couplings mediated by transition metals; the first catalytic and selective cross-couplings; the discovery of palladium (Pd) and the first catalysts on it; Heck coupling - the first Pd-catalyzed cross-coupling; Sonogashira coupling; introduction of less reactive organometallics; Negishi coupling; introduction of stable organometallics; Stille coupling; Suzuki-Miyaura coupling; what makes the Suzuki-Miyaura coupling special?; Hiyama coupling; Buchwald-Hartwig amination. The lecture is largely inspired from the review article by V. Snieckus, Angew. Chem. Int. Ed. 2012, 51, 5062-5085.
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