Get a 7% discount on your next purchase from laboratoriumdiscounter.com with the secret code "THYLABS2023" (this is the new code the old one is outdated).
@unknown_official3
6 ай бұрын
video: dont try this at home me: im gonna do this it looks fun
@risingpyro1354
2 жыл бұрын
Cooler Kanal, mach weiter so. Gucke mir deine Videos gerne an. Den Code habe ich gerade verwendet, hoffe du bekommst dadurch weiteren Support 👍
@garycard1456
2 жыл бұрын
Another idea (on the theme of alkaloid extraction from plant material): extraction of solanine from green potatoes (to make potatoes turn green and accumulate solanine, simply leave potatoes exposed to sunlight for a few weeks). As with nicotine, care is advised: solanine is poisonous. Another idea: extraction of morphine from poppies.
@THYZOID
2 жыл бұрын
Forget about the morphine one. I already planned to get tropanol from datura though
@oitthegroit1297
2 жыл бұрын
@@THYZOID You should try extracting atropine, hyocyamine, and scopolamine from Atropa Belladonna, aka deadly nightshade.
@THYZOID
2 жыл бұрын
I’ll do this with datura because I have kilos worth of seeds
@WarlordEnthusiast
Жыл бұрын
@@THYZOID Just be careful with that Datura, Datura is a horrific drug known as a "Deliriant", it's like being in a living nightmare.
@THYZOID
Жыл бұрын
@@WarlordEnthusiast i am perfectly aware of that. nobody should underestimate datura
@ingorichter649
Ай бұрын
A hot water extract of tobacco is a very good treatment against harmful insects to protect plants.
@PoorMansChemist
2 жыл бұрын
Nice work!!! Your videos are always kick ass. 🙂
@Sniperboy5551
Жыл бұрын
I like the shirt from your profile picture 😎
@pelegsap
2 жыл бұрын
Nice! Maybe using a Soxhlet extractor could be more efficient, although using Soxhlet with water is rather annoying.
@kid_missive
Жыл бұрын
Soxhlet followed by steam distillation maybe, as soxhlet is exhaustive and you would get a very messy mixture from it.
@jackmclane1826
Жыл бұрын
Nicotine should be soluble in pretty much every organic solvent either. So... go for it.
@Zenzicubic
2 жыл бұрын
Cool! Never seen this before. Maybe you could try extraction of quinine from cinchona?
@bromisovalum8417
Жыл бұрын
Cotinine, the oxidation product of nicotine with H2O2, is much less toxic than nicotine, whilst still retaining similar pharmacological properties. It's a nootropic, and at one point cotinine fumarate was considered to be marketed as antidepressant by the pharma industry. I wouldn't be comfortable to handle pure nicotine, however apparently you can spray tobacco leaves with 1-3% H2O2, and the bulk (~80% of nicotine will be converted to cotinine). Could be to interest to those who grow their own tobacco.
@garycard1456
2 жыл бұрын
In plants, alkaloids are secondary metabolites. They are synthesised by the plants via enzymes. The biosynthetic pathways are quite complex and multi-step.
2 жыл бұрын
You handled the 4g of nicotine way too casually. It's enough to kill dozens of people. Always double bag your gloves, and for the love of god get good nitrile gloves if you wanna do stuff like this. The low yield might come from the solution not actually penetrating through the tobacco properly, usually this extraction is carried out with mechanical stirring. In our procedure (from 1962) they add oxalic acid to the 1.5L distillate and concentrate, take up with KOH and extract. This always yielded very clean Nicotine in our student labs.
@contomo5710
2 жыл бұрын
yeah was about to mention, acid base it, as usual with plant stuff
@GigsVT
2 жыл бұрын
Nicotine toxicity was far overestimated for many years. Apparently it is far more toxic to lab animals than humans. Once vaping became a thing we had real world data on overdose fatality rates and they revised the LS50 up by an order of magnitude, as people were commonly surviving quite large doses. It is still of course toxic in large doses and dangerous to leave around children, but it is not as bad as people thought.
@midwestchem368
2 жыл бұрын
I've spilled 10% nicotine on my arms high enough to get it inside my gloves on my arm also. I immediately washed up and cleaned with alcohol afterwards just in case. I was fine and had probably a few grams of nicotine in propylene glycol on my skin. Not even a nicotine rush happened I actually still craved nicotine at that point lol It's dangerous but I think it's been exaggerated over time.
@user255
2 жыл бұрын
Nicotine absorb quite slowly through intact skin.
@user255
2 жыл бұрын
@@GigsVT The real LD50 value is likely still only somewhat higher, than for cyanide salts. The high values are from cases where people have drank nicotine, vomited and then hospitalized. IE the real absorbed dose is much lower and the survival required hospital care. Not quite the same as measuring LD50 values with rats.
@RhoGamingYT
2 жыл бұрын
So that community post is this. Why I did think you would redo the nicotine extraction.
@EdwardTriesToScience
2 жыл бұрын
a proper steam distillation isnt too difficult to set up, all you need is a flask to boil water and some plastic tubing, a thermometer adapter and a glass tube, stick the glass tube in the thermometer adapter to the bottom of the distilling flask and connect the plastic tube to the flask to boil water, or alternatively use a chromatography bulb packed with the material
@shitfuckmcgee8611
2 жыл бұрын
3:38 Now I feel a whole lot better about the time I swirled around my reaction mix and lost a stopper after it popped out.
@talesfromthelab
2 жыл бұрын
The very first time I can actually use a rabat code froma youtube video :) Next time I order I'll think of it. Awesome videos!
@user255
2 жыл бұрын
Challenges: - Persin from avocado seeds. - Ergine from morning glory seeds. - Mimosine from mimosa pudica seeds.
@shitfuckmcgee8611
2 жыл бұрын
I'd be interested to see ergine although it my be controlled in his country. As far as I can tell ergot alkaloids aren't very concentrated in morning glories and you need to do column chromatography to separate them from the other gunk.
@user255
2 жыл бұрын
@@shitfuckmcgee8611 Damn laws... Some source says alkaloids 0.0029% to 0.0059% by weight.
@TheBackyardChemist
2 жыл бұрын
I think a heavy-return Dean-Stark setup with some ether prefilled into the DS trap could have also worked nicely!
@ehhmehh5070
2 жыл бұрын
Glaucine from glaucium flavum it's a obscure hallucinogen
@jackmclane1826
Жыл бұрын
Could you make a video about removing peroxides from ethers?
@dimaminiailo3723
2 жыл бұрын
It is much better to carry out a water liquid extraction before steam distillation. I read topic about in an old book where it is described in all details. Oxalic acid uses for the concentration of the distillate, for example
@halimali8132
2 жыл бұрын
Share books
@dimaminiailo3723
2 жыл бұрын
@@halimali8132 This is Russian encyclopedia called Энциклопедический словарь Брокгауза и Ефрона. You can translate a page on Wikisource which contain the article about nicotine
@derenjoy3r
2 жыл бұрын
Btw, what about the Barbituric Acid project ?
@funnyfails1275
Жыл бұрын
Sehr gutes Video und toller Kanal👍
@tracybowling1156
2 жыл бұрын
This was an excellent video. You are very funny and make me laugh. A lot of people who do chemistry are VERY SERIOUS all the time! It's nice to see. I wanted to know if any nicotine was added to this tobacco before you acquired it or was it 100% natural? Thank you! ☺️
@THYZOID
2 жыл бұрын
It was 100% natural
@graystone2802
Жыл бұрын
I also enjoy this guys enthusiasm, but be aware that chemistry like this needs to be taken very seriously. One slip up can put you in the emergency room, even with the correct precautions. For reference, at the end he is holding enough substance in his fingertips to kill 30+ men. Not to be taken lightly
@tracybowling1156
Жыл бұрын
@@graystone2802 It is a really good thing that I would have no clue how to even start a chemistry project. 😆
@iscuit
2 жыл бұрын
Nice vid
@generalingwer4341
Жыл бұрын
Thanks for video.
@patricksweetman3285
Жыл бұрын
The reactions with Cu^2+ and Co^2+ are easily explained by the fact that freebase nicotine is strongly basic. You got Cu(OH)2 and Co(OH)2 precipitates.
@talamoreb
2 ай бұрын
Hi, just wondering, if you dry the leaves after can they still be used for smoking let’s say
@garycard1456
2 жыл бұрын
Galantamine from the flower bulbs of species in the Galanthus botanical family. Such as snowdrop (buy the bulbs from a garden center).
@Iz0pen
4 күн бұрын
Smoking a clean tobacco sans adulterants has many health benefits
@THYZOID
4 күн бұрын
💀
@thegrandlevel313
10 ай бұрын
You ever wonder why so many new manly soaps and candles have tobacco flavor? Cause more tobacco is used for this extraction process and that’s what’s sitting on top over there… the essential oils of the tobacco.
@tomh2628
2 жыл бұрын
Would adding sodium hydroxide to the flask before distilling to freebase the nicotine maybe give higher yield? I'm wondering if maybe it was in its salt form and some of it didn't come over. Also great job with the video, I really enjoyed it!
@THYZOID
2 жыл бұрын
more hydroxide might help
@fazalhadi7262
5 ай бұрын
Could someone tell me that how are nicotine commercially extracted from tobacco etc…………. ?😊
@uncle_thulhu
Жыл бұрын
If you want to store the nicotine, make a 10mg/100ml solution in propylene glycol and keep in a freezer to stop the nicotine from degrading.
@THYZOID
Жыл бұрын
It will also not degrade if stored in a dark bottle under argon. no need to dilute it
@uncle_thulhu
Жыл бұрын
@@THYZOID oh, I know, I just figured it would be safer diluted. Plus that's usually the concentration you'd add to e-juice in countries like mine (Australia) where you can't get it premixed. Also, and I know this might come as a shock, not all of us have access to pure argon. Or welding equipment. Or oxyacetaline, for that matter. Personally, I live in a one-bedroom, upstairs apartment with no balcony. I ain't doing no home chem here, much as I'd like to.
@THYZOID
Жыл бұрын
@@uncle_thulhu As long as theres no oxygen it should be fine. Even flushing with something like butane would do the job.
@brandin8r550
Жыл бұрын
love the channel but you have to fix your audio. Make it louder :)
@lashajakeli
Жыл бұрын
It is interesting how you make nicotine gum from tobacco (A-Z), maybe you wanna try that next time
@afshinshaloo2489
Жыл бұрын
It was a very beautiful and informative video. I have some questions Please add the required materials in writing to the description I did not understand the composition time and the amount of sodium chloride, please explain What happens if sodium chloride is not used? Please guide me, thank you very much So far, my nicotine preparation has failed 5 times All I got was a small amount of thick brown oil
@THYZOID
Жыл бұрын
I literally put all the information required into the video. The reason you use sodium chloride in water is to remove some additional water from the organic layer the exact amount does not matter. To get a high purity compound you should consider a fractional distillation at the end. My product is still slightly contaminated.
@garystinten9339
Жыл бұрын
This is about to kick off in Australia.
@peterlin5145
2 жыл бұрын
very cool!
@vxbrxnt
2 жыл бұрын
I have an interesting idea. What if you took liquid hydrogen chloride and mixed it with distilled water inside a high pressure container? That way you'll force more HCl than it's typically possible. You would have >38% conc. HCl. Same thing can be done with CO2. Perhaps you can make some super-carbonated water and give it a taste test.
@THYZOID
2 жыл бұрын
I don´t have LN2 right now so no liquid HCl for now
@yourfuneral
2 жыл бұрын
keep it up!
@Sniperboy5551
Жыл бұрын
I subbed just for using Nicotiana rustica.
@afshinshaloo2489
Жыл бұрын
You have made a very beautiful and complete video. When adding potassium hydroxide to tobacco, do we also pour solvent into the flask? Did I understand correctly?
@THYZOID
Жыл бұрын
Yes. The solvent is water. You can also add a solution of KOH or NaOH instead of adding solid KOH first and then water
@gemominerals
Ай бұрын
How much water is used and how much koh used in it@@THYZOID
@ericmoeller3634
Жыл бұрын
im smoking a cigarette while im finishing this video
@Linguae_Music
Жыл бұрын
Next you should do cebil seeds and bufotenin. >:D
@afshinshaloo2489
Жыл бұрын
I have a question, what other liquid can be used instead of MTBE? Can chloroform (CHCL3) be used?
@THYZOID
Жыл бұрын
any non polar solvent can be used. chloroform works, diethyl ether and DCM also work
@coalesce3333
Жыл бұрын
If the tobacco is smokes or cures does that make it carcinogenic?
@tibejanssens9616
9 ай бұрын
Hi man, i do my end project about nicotine and was looking for a method to extract it. On 1:15 you added some liquid but I don't know if its just water or some other liquid?
@THYZOID
9 ай бұрын
water
@kallah4999
2 жыл бұрын
I was wondering about Laboratorium Discounter. Guess they`re good then, thanks for discount code.
@StanlyLu
11 ай бұрын
HI sir nice video! learn alot. I like to ask u a question that if u don't mind. Which Is "What are both sodiun chloride solution and molecular sieves used for? Separate the H2O from the Ether layer?"
@THYZOID
11 ай бұрын
Sodium chloride solution is first used to remove most of the dissolved water in the ether. With molecular sieves you remove the tiny bit of moisture that remains.
@StanlyLu
11 ай бұрын
@@THYZOID got it. appreciate. LOL
@yasserotb1454
2 жыл бұрын
As I said before I fully agree for the highest quantity of substance but my budget says otherwise
@maraz666
2 жыл бұрын
Next, try extracting the beta-carbolines.
@procactus9109
2 жыл бұрын
Excellent, now I need a source of bulk tobacco lol
@marianocenteno4603
2 жыл бұрын
what about extracting serotonin, histamine or acetylcholine from stinging nettle or other plants that sting, i dont really know which one has the best concentrations, and btw really good video
@THYZOID
2 жыл бұрын
I won´t extract histamine but I might be able to make some
@6alecapristrudel
2 жыл бұрын
@@THYZOID Histidine decarboxylation?
@SuperAngelofglory
2 жыл бұрын
Beware with that stuff, pure base nicotine is deadly
@THYZOID
2 жыл бұрын
I know
@paulflur4519
5 ай бұрын
I think angel trumpets are the strongest plant containing nicotine, but not because of the nicotine content.
@THYZOID
5 ай бұрын
they do not contain nicotine at all
@paulflur4519
5 ай бұрын
@@THYZOID that’s odd, as even potatoes have 15 micrograms/gram
@THYZOID
5 ай бұрын
@@paulflur4519 but not barely as much as tobacco
@vat8367
Жыл бұрын
would ethyl acetate work the same way the ether does?
@karolus28
2 жыл бұрын
Cool
@opportunityexamchannel
Жыл бұрын
Can we extract nicotin from simple way like, Tobacco leaf was soaked in water for 24 hour and the dilute nikotin in water and then boil . The vapour should be condensed and that's nicotine. Is it possible
@THYZOID
Жыл бұрын
no
@mortezashafei-ss1lk
2 ай бұрын
5:24 5:36 5:37
@michaelharned8741
Жыл бұрын
Maybe you can extract coniine from poison hemlock
@pritishnilendu9006
5 ай бұрын
Can you please tell how to make nicotine powder?
@THYZOID
5 ай бұрын
pure nicotine is a liquid. you can only get pure nicotine powder by freezing it but it will liquify again once at room temp
@pritishnilendu9006
5 ай бұрын
So, if one wants to get nicotine powder, how will one get?
@THYZOID
5 ай бұрын
@@pritishnilendu9006 it does not exist
@tghftg6899
10 ай бұрын
how Much temperature did take to do distillation ?
@THYZOID
10 ай бұрын
I just turned up the heating mantle. The vapour has a temperature slightly lower than that of water vapour due to the azeotrope with nic
@oneofthechannelsofalltime
Жыл бұрын
Can you move the nitrogen one carbon to the right please? Thanks.
@THYZOID
Жыл бұрын
the molecule on thumbnail is correct so i won´t
@plyaskinLab
Жыл бұрын
A drop of nicotine kills a horse, and a hamster is torn to pieces.
@KdEAG1112
Жыл бұрын
where did u get the tabacco from? As far as i know it is not legal?
@THYZOID
Жыл бұрын
of course it is legal. i can legally grow 100 Plants of this every year
@dolcefarniente________86
Жыл бұрын
Heets of Iqos? Do you reccomend? Or the new entry of iqoS Terea? Thank u
@THYZOID
Жыл бұрын
i do not recommend smoking at all but heating tobacco instead of burning it should be healthier than smoking.
@dolcefarniente________86
Жыл бұрын
@@THYZOID thanx for u r advice,better for me looking herbal tobacco
@tmxboom
6 ай бұрын
Soooooooo, in theory IF I get my hands on an pretty clean freebase nicotine (made for vapes ofc) and I mix it with the proper amount of benzoic acid (that is also pretty clean), I would get Nicotine Benzoate that I can smoke? Or just don't try to make it cheaper and pay the ungodly amount of tax in a vape shop (all of this in theory ofc). Just curious lmao
@THYZOID
6 ай бұрын
well regarding the taxation it would be illegal for you to do so but in theory this would work exactly like you described it
@tmxboom
6 ай бұрын
@@THYZOID I DEFINITELY won't evade taxes because I'm a GOOD AND PROPER citizen :33 *wink wink* But thank you for your help regarding this!!!
@robertk9307
2 жыл бұрын
For your poison collection how about racine from castor beans
@THYZOID
2 жыл бұрын
sadly illegal
@robertk9307
2 жыл бұрын
Perhaps something more realistic. You have a pool how about testing your water without commercialy avialable test strips. Testing for free chlorine,alkalinity,TDS, combined chlorine etc..
@R-Tex.
Жыл бұрын
Why not NaOH?
@drasiella
Жыл бұрын
_smokes happily_
@pritishnilendu9006
5 ай бұрын
Is it a vaccum distillation process sir?
@THYZOID
5 ай бұрын
no
@pritishnilendu9006
5 ай бұрын
@@THYZOID We are also manufacturing nicotine by almost the same process that u did.I Want to connect with you on e-mail. Can you please give me your e-mail, so that i can connect u.
@THYZOID
5 ай бұрын
you can contact me via instagram or reddit. link in the video description
@svt9068
Жыл бұрын
With all respect you some like a knowledgeable and well practiced chemist, but the way you handle some of the glassware makes me think your high.
@Melsik_Pogosian
4 ай бұрын
Hello! Can you make nicotine 99.9% pure? Medical quality?
@THYZOID
4 ай бұрын
nah. just buy it tbh. it is dirt cheap
@gemominerals
Ай бұрын
Meaning what i can't understand @@THYZOID
@Appophust
5 ай бұрын
Is that makhorka tobacco?
@THYZOID
5 ай бұрын
yes
@Appophust
5 ай бұрын
@@THYZOID I thought it was the same as N. Rustica. Thank you very much for your reply. 😁
@praspurgh
2 жыл бұрын
nicotine benzoate is oil? wouldn't it be a salt therefore solid?
@THYZOID
2 жыл бұрын
idk. for some reason it isn´t. even with some bought nicotine it turned into an oil
@user255
2 жыл бұрын
@@THYZOID Mix of choline and urea is oil like DES. Maybe there is something similar going on.
@lithiumferrate6960
2 жыл бұрын
Couldn't you use a really strong acid and freebase it later on from the soluble salts?
@THYZOID
2 жыл бұрын
If i did that directly with the tobacco sud there would be a lot of impurities
@posko7374
Жыл бұрын
@@THYZOID that's exactly what i did.. my mistake i did a/b extraction and i was left with a wax but with nicotine inside now do you think there is a way to to purify it? i have try to basify all and distill it over but the wax evaporated too and i still got this wax, any solution? thank you
@posko7374
Жыл бұрын
I was thinking to use 95 % ethanol and perform a colder distillation or use zeolite to filter the ethanol from the wax, thank you
@fburton8
2 жыл бұрын
Does the ether you used smell the same as diethyl ether?
@THYZOID
2 жыл бұрын
No it smells vastly different
@fburton8
2 жыл бұрын
@@THYZOID Ooh! You know what my next question is going to be... :) When I was young, I discovered how much of a fire hazard ether (diethyl) is when it climbed out of the open bottle on my work bench and wafted its way towards a bunsen flame. No explosion, just a whoosh of bright blue flame over the surface of the bench which burnt itself out in a couple of seconds. I learned a lesson from that mistake. Amazingly, I also managed to survive a few other 'close calls' in my hands-on pursuit of chemical and electrical knowledge.
@Josezwitterion
2 жыл бұрын
My friend you are very funny when you smoke green plant have insterenting 💡
@midwestchem368
2 жыл бұрын
Isn't the main oxidation product nicotine n-oxide? I wonder if there is a good way to convert it back because I have 100ml of bad nicotine lol
@THYZOID
2 жыл бұрын
I am sure there is a way to convert it back to nicotine but I don’t know how
@midwestchem368
2 жыл бұрын
@@THYZOID maybe I can make a video trying it but it's an n-o bond I'd imagine it might be similar to breaking an n-oh bond.
@tasteslikepennies2549
8 ай бұрын
Okay. I think I'm catching on. So he said potassium hydroxide so that's obviously going to break down the bonds I believe. And then he's going to attempt to contain the salads in some sort of wacky solvent I'm going to guess right now there's going to be a triple wash🎉🎉🎉🎉
@tasteslikepennies2549
8 ай бұрын
There's not that many syllables in aluminum
@mohammedaibani2384
Жыл бұрын
Does any of you know how to isolate nicotine from tobacco leaves?
@THYZOID
Жыл бұрын
The tobacco from this video was just dried and blended into a smaller size. It once was home grown tobacco.
@p1ai162
Жыл бұрын
Why did you need the ether?
@THYZOID
Жыл бұрын
to extract the nicotine from the aqueous phase
@p1ai162
Жыл бұрын
@@THYZOID why didn't you evaporate the water?
@THYZOID
Жыл бұрын
@@p1ai162 water forms an azeotrope (lower boiling mixture) with nicotine. you boil the water = you also boil off all the nicotine
@p1ai162
Жыл бұрын
@@THYZOID you don't boil, you just evaporate, in vacuum maybe
@Salt_and_Peroxide
8 ай бұрын
hm
@markmiguel2143
2 жыл бұрын
that is not what i though you looked like lmao
@YeeModz
Жыл бұрын
bester deutscher mann
@ЛпепепПнмпмемемепе
Ай бұрын
Germany boy
@p1ai162
Жыл бұрын
Tabako*!
@THYZOID
Жыл бұрын
no.
@bishalscreation
Жыл бұрын
👌👌👌
@Edik0704
2 жыл бұрын
probier mal lol
@DerDrako
2 жыл бұрын
👍
@MadScientist267
2 жыл бұрын
This bastard chemical lol... Must... Quit...
@noodlelynoodle.
2 жыл бұрын
You can do it! I just quit again a few weeks ago and miss the stimulant but not needing it is so nice
@illmnts
Жыл бұрын
Dokha (a type of uncured tobacco popular in the Middle East) is likely stronger. It's been known to make people fall over (50mg/g)
@THYZOID
Жыл бұрын
yup. read about it and always wanted to try it once. i don´t smoke but i really wanna try that stuff
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