Tuberculosis is the second leading cause of death by infectious disease in the world right now. Number one has only existed for a year and a half.
While much more is known about the former, including effective treatments, the world still struggles to alleviate its burden. Part of the problem is how new technology, such as IGRA and NAAT, made pathways more complex, even if more effective.
In this video, I’ll review the evidence and try to clear up everything you need to know about latent TB: as a practitioner or a student. In my years of practice in Brazil, and even in the United States, I often saw people with suspicion for latent or active TB. Distilling the main concepts and relevant evidence for it will hopefully make it easier for you as well.
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References:
-Theme song: In the Hall of the Mountain King - Edvard Grieg
-tb deaths www.who.int/hiv/mediacentre/n...
-UK guidelines, world incidence map www.bmj.com/content/352/bmj.h...
-latent TB to active risk ‘82 study www.ncbi.nlm.nih.gov/pmc/arti...
-latent tb cdc www.cdc.gov/tb/publications/f...
-tst image from cdc commons.wikimedia.org/w/index...
-tst induration commons.wikimedia.org/wiki/Fi...
-isoniazide hepatitis risk pubmed.ncbi.nlm.nih.gov/10086...
-discontinue TB precautions cdc.gov/mmwr/preview/mmwrhtml/rr5417a1.htm
-IGRA principles www.ncbi.nlm.nih.gov/pmc/arti...
-dx latent TB adults www.uptodate.com/contents/app...
-WHO 2014 dx TB in children apps.who.int/iris/bitstream/h...
-WHO 2006 dx TB children www.ingentaconnect.com/conten...
-study rifampin isoniazide academic.oup.com/cid/article/...
-study rifapentine isoniazide www.nejm.org/doi/10.1056/NEJM...
-study rifampin solo www.nejm.org/doi/10.1056/NEJM...
childhood exposure, risk of invasive TB pubmed.ncbi.nlm.nih.gov/15141...
-WHO latent TB infection apps.who.int/iris/bitstream/h...
-TST cutoffs paper www.ncbi.nlm.nih.gov/pmc/arti...
-simplify gif imgur.com/gallery/kHzlD/comme...
-GIF indecisive drivingcoursereviews.com/wp-c...
-GIF its a lot giphy.com/gifs/thebachelorett...
-GIF mix n match / 119838040063832277
-eradication smallpox www.cdc.gov/smallpox/history/...
-eradication polio www.thestar.com/news/insight/...
-kid thumbs up gif giphy.com/gifs/retro-thumbs-u...
-boo gif media.giphy.com/media/8caqKmP...
Негізгі бет Latent TB: what's new, what's outdated
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