This is the 22nd lecture from the course Chem 51C Organic Chemistry taught by David Van Vranken at UC Irvine in Spring 2020. At the beginning of the lecture I talk about phenethylamines and the Henry reaction in Shulgin's book PiHKAL and on the EROWID web site. I review methods for the synthesis of amines: reduction of nitroarenes to anilines and lithium aluminum hydride reduction of amides and nitriles to amines. I introduce a new method called reductive amination using the reagent sodium cyanoborohydride. I start talking about amines as bases and the varying ionization states of amine functional groups.
Course Coverage: Organic Chemistry 5th Ed., J. Gorzynski-Smith
Chapter 18: Electrophilic Aromatic Substitution
Chapter 19: Carboxylic Acids and the Acidity of the O-H Bond
Chapter 20: Introduction to Carbonyl Chemistry; Organometallic Reagents; Oxidation and Reduction
Chapter 21: Aldehydes and Ketones--Nucleophilic Addition
Chapter 22: Carboxylic Acids and Their Derivatives--Nucleophilic Acyl Substitution
Chapter 23: Substitution Reactions of Carbonyl Compounds at the α Carbon
Chapter 24: Carbonyl Condensation Reactions
Chapter 25: Amines
Негізгі бет Lec 22 Amine Synthesis
Пікірлер: 94