I am an OBGYN resident, and I am making this video to highlight the ACOG recommendations for administering low-dose aspirin during pregnancy to reduce/delay the onset of preeclampsia. This video is intended for OBGYN residents and medical students.
Mechanism of Action: Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting an enzyme called cyclooxygenase (COX). By doing so, it reduces the production of prostaglandins, which are hormone-like substances involved in inflammation and blood clotting. Low-dose aspirin refers to a daily dose of 81 mg, which is lower than the typical adult dose used for pain relief (325 mg).
Timing of Administration: The American College of Obstetricians and Gynecologists (ACOG) and other medical guidelines recommend starting low-dose aspirin between 12 and 28 weeks of gestation in women who are at high risk of preeclampsia. The specific timing may vary based on individual risk factors and healthcare provider recommendations.
High-Risk Criteria: Women who are considered at high risk of developing preeclampsia may include those with a history of preeclampsia in a previous pregnancy, chronic hypertension, diabetes, kidney disease, autoimmune disorders, multiple pregnancies (twins, triplets), or advanced maternal age.
Benefits: Several studies have shown that the use of low-dose aspirin in high-risk pregnant women can significantly reduce the incidence of preeclampsia, along with its associated complications such as preterm birth, fetal growth restriction, and placental abruption. By lowering the risk of preeclampsia, the well-being of both the mother and the baby can be improved.
Негізгі бет Low-Dose Aspirin in Pregnancy
Пікірлер