Finally it's here!! For full transparency, during one part of the project my SD card corrupted, causing me to lose some footage. Since I couldn't go back and redo it, I had to record staged footage and reuse older footage. So from 19:45 to 20:58 and 21:40 to 22:17 you see me re-enact what it looked like as closely as possible but without the product actually being there. Then from 20:59 to 21:39 I am reusing footage from before. Also, the structure of m-chloroperbenzoic acid at 17:44 is drawn wrong, it should be the meta isomer, not para. And I realized 'cyclisize' is not a word, I will use the excuse of not being a native speaker. Enjoy this 11 step synthesis!!
@ihateyou1379
Жыл бұрын
New minion movie looking good lol. great work very impressive
@adrianpip2000
Жыл бұрын
Extremely cool multi-step synthesis! Not to mention that you did some high quality practical synthesis here. Also pretty cool that you're sending off samples to supporters. Would just like to add that it'd be nice to have some small text in the corner of the video when it's a re-enactement. Cheers!
@shiftgood
Жыл бұрын
1ml of this sells for $360....
@joshuaosterhout
Жыл бұрын
This content was super interesting, but it comes at you like a bullet train (no pauses). It can be a little disconcerting when you speed through 5 solid minutes of chemical names with no break in between.
@cas8891
Жыл бұрын
Are you by any chance dutch? I noticed a little bit after way too long but i did pick out a couple of pronunciations when i started to focus on it, and now you saying youre not a native speaker... That would be really cool! Anyways loved the video im glad i got it in my recommended im definately gonna binge you
@kiro9291
Жыл бұрын
there's nothing quite like finding a new chemistry channel to binge
@oldboyneverrichagain1113
Жыл бұрын
rightt
@shebahammy
Жыл бұрын
When Nile red is taking too long
@jc4359
Жыл бұрын
This is my first video of his too, I'm 45 seconds in or so lmao. Already know I'm gonna be watching more.
@spyingpro4563
Жыл бұрын
@@shebahammy haha yes 😂😂
@udittlamba
Жыл бұрын
I just found this channel and I concur!
@pezboy715
Жыл бұрын
17:03 you know you’re not feeling great about your yield when you suddenly feel the need to add a decimal
@joaogabrielaguiar3761
Жыл бұрын
In the beginning of 2020, a large chunk of Rio de Janeiro's water supply was contaminated with geosmin due to an cyanobacteria* bloom in the Guandu river, from which most of Rio's water is pumped. There was nothing wrong with the water, it is obviously treated, but they couldn't remove all the geosmin, and since we can detect it in such small quantities, everyone's water tasted and smelled like dirt for some months. It still happens from time to time, but it usually lasts a few days, nothing compared to the almost three months (iirc) in 2020. * Although Brazilian media just called it an algea bloom, cyanobacteria aren't algea.
@abacaixi
Жыл бұрын
Todo mundo gosta de água do filtro de barro, mas quando a água fica com gosto de barro todo mundo NOOOOOSA
@ygdbll
Жыл бұрын
@@abacaixi pior
@aline11904
Жыл бұрын
hmm delicia agua com cheirinho de terra
@2ndPortal
Жыл бұрын
You're telling me instead of synthesizing it we xan just get some algae to do it for us? Lol
@LukaFanNo8
Жыл бұрын
was there ever a paper published about the type of algae??
@EddieTheH
Жыл бұрын
"after 100 years, it has all filtered through" We're all familiar with that! I do enjoy that anhydrous humour.
@autisticguitar666
Жыл бұрын
Interesting last name Eddie
@EpicManaphyDude
Жыл бұрын
anhydrous humor 😂
@EddieTheH
Жыл бұрын
@@autisticguitar666 Give it a Google, you might laugh.
@_Solaris
Жыл бұрын
Clever.
@jixpuzzle
Жыл бұрын
"Anhydrous humour" nice one lol. Only chemistry students will get it haha.
@ianrocks2112
Жыл бұрын
As our Aussie friend always says, yellow chemistry is evil lol
@schr4nz
Жыл бұрын
And our Canadian friend says "I love urine chemistry!"
@crabcrab2024
Жыл бұрын
To be honest, I am really sick and tired of this. Yellow is just as good as the other colours of the rainbow.
@_thisnameistaken
Жыл бұрын
@@crabcrab2024 yellow is a bad color🥶🥶🥶🥶🥶
@jaymzx0
Жыл бұрын
Tar!
@crabcrab2024
Жыл бұрын
@@jaymzx0 Tar is dark-brown or black, not yellow)))
@leek5682
Жыл бұрын
Can’t get over how complicated this process is. In my college organic chemistry labs I’d manage to mess up a 3 step process, so seeing someone carry this out so perfectly is super impressive.
@zachliveris2881
Жыл бұрын
Yeah but the chemistry has been done before. A 3 step novel synthetic route can be far more challenging vs repeating known procedures
@naumen6508
8 ай бұрын
@zachliveris2881 you think they did novel synthetic routes in college ?
@oitthegroit1297
Жыл бұрын
That's my favourite smell, along with the smell of pine trees and cool, brisk, fresh winter air, as well as burning wood. Just writing this brings back so many memories, it's surreal.
@jackass6257
Жыл бұрын
I feel like the morning summer air of the suburbs with all the pine bushes and trees, but here in Cali winter is the best if you have a clear nose cuz everything is blooming after rain
@garycard1456
Жыл бұрын
I wonder why the air on a crisp frosty winter morning has its own characteristic smell? What could the chemical composition be?
@oitthegroit1297
Жыл бұрын
@@garycard1456 The chemical composition is 78.08% nitrogen, 20.95% oxygen, 0.93% argon, 0.04% carbon dioxide, small amounts of other gases, and 100% cold lol.
@ghislainedidntkillherself
Жыл бұрын
@@oitthegroit1297 sounds about right. checks out👍🏼👍🏼👍🏼
@MrCh0o
Жыл бұрын
@@garycard1456 I always thought it was just the nose getting instantly runny causing the "smell", since it doesn't seem likely that there's anything special in the air during winter
@isocle
Жыл бұрын
"In the end, I am left with.. YELLOW???" What a plot twist haha! Tom really did the chem community right with starting this trend
@T3sl4
Жыл бұрын
Chemtubers all watch each other and I am here for it
@hashimhassan4970
Жыл бұрын
Wait can you explain the yellow trend and where it started?
@T3sl4
Жыл бұрын
@@hashimhassan4970 Extractions and Ire
@isocle
Жыл бұрын
@@hashimhassan4970 Tom from explosions and fire (and his secondary channel, extractions and ire) has a running gag of yellow = bad after having a terrible experience trying to make S4N4, pretty sure. Since then it's kind of picked up because most of the time something going yellow is a bad sign that something is degrading and tar is coming your way :)
@oufannamedbrandon6715
Жыл бұрын
@@isocle also Grimace isn't yellow.. Don't forget about Grimace now! The ol' goofy purple bastard!
@craoun6116
Жыл бұрын
As a preparative organic chemist I have to say, that is some quality work right here. Congrats to you my friend, I usually mess things up big time when trying to reproduce a paper for the first time :)
@defenestrated23
Жыл бұрын
As a (former) synthetic chemist and longtime chemistry hobbyist, I concur! This is great work.
@antares8826
Жыл бұрын
Videos like this always make me appreciate the rotary evaporator we have in our lab.
@ghislainedidntkillherself
Жыл бұрын
you got any broken out-of-service units? asking for… a friend of course
@zachliveris2881
Жыл бұрын
@@AndyU96 they both accomplish the same thing except the vacuum distillation setup in the vid applies heat which can be bad if your compounds are sensitive to heat. But mostly cause it takes way less time to use a rotovap vs using vacuum distillation
@2bleubird
9 ай бұрын
@@AndyU96rotovap is faster and easier to get going.
@pelegsap
Жыл бұрын
Regarding 13:23 - I'm sure you already know it, but for anyone who wonders: many organic stuff are yellow because they have a lot of conjugated bonds in them (in the case of the imine here the bezene ring is conjugated to the nitrogen via its free electron pairs). This causes the electronic excitation energy to drop, bringing it from the close UV range into the visible range, i.e. the molecule absorbs deep-blue/violet photons, and we're left with a yellowish-looking product. For green we would need to absorb in the visible range both blue and red, which is not very likely.
@T3sl4
Жыл бұрын
In addition, the aldol step at 15:45 tends to produce anything from yellow to orange, red, brown and tar -- at least on less, specific shall we say, substrates? Example, a similar reaction done with acetone leads to condensation products ranging from diacetone alcohol to mesitylene and relatives, and onward including indeterminate polymers. Fortunately, the molecule here reacts preferentially with itself in good yield.
@waterunderthebridge7950
Жыл бұрын
A substance doesn’t really need to absorb the entire excess spectrum to produce a certain color as human vision cannot discern accurately between spectral colours and mixed colours. Instead, it’s more a complementary color thing where the absorption of a certain (narrow) spectrum makes you perceive the substance as the complementary color due to the absorbed spectrum being effectively subtracted from white (for the purposes of human vision at least). For green, you’d “only” need to absorb in the red spectrum just like how most green plants do. The remaining “excess” blue and yellow adds up to green.
@pelegsap
Жыл бұрын
@@waterunderthebridge7950 good point
@Kenionatus
Жыл бұрын
@@T3sl4 tar 🎉
@drasiella
11 ай бұрын
You misspelled C U R S E D
@I_XuMuK_I
Жыл бұрын
Oh yes, yellow chemistry at its finest.
@clayton8or
Жыл бұрын
Yellow chemistry :( Geosmin :) This was a fantastic video, the subtle humorous acknowledgment of frustrations among the otherwise professional depiction made me actually physically laugh during a chemistry video, bravo.
@variouselite
Жыл бұрын
Wow. The patience. The dedication. Not to mention the skill. Mad respect brother.
@ninjarobotmonk3y
Жыл бұрын
I love that there are smart people who are happy to share how smart they are, so I can look at all the squiggly diagrams and fancy equipment and feel like I got a tiny little bit smarter. Thanks for taking the time to create, edit, and share.
@RhoGamingYT
Жыл бұрын
This video is more emotional to me for some reason
@TheGayestPersononYouTube
Жыл бұрын
This is such a weird coincidence, this morning while getting ready for work I saw I had a sample of 1% geosmin in triethyl citrate sitting on my shelf from years ago and decided to smell it only for you to post this later in the day. It’s a wonderful smell, but you’re right it can get overpowering very quickly. Great video!
@mightybing
6 ай бұрын
With a synthesis of so many steps and ever decreasing yields I'd be getting anxiety about having to repeat the whole process just to have enough material for the final steps. Amazing work!
@potumnn
Жыл бұрын
I don't know if you did an QaA about this but I was curious about the way you keep up with the things you do in your life and the passion about chemistry? Do you work as an chemist or you keep up another type of work and you make these wonderful videos on your free time? How much did you spent from the start to this day on home chemistry? When and how did you study chemistry (i imagine moreover the school education)? Did someone inspired you? Did someone has incentivated you to pursue this passion at home? Did you received or do you ask for chemistry or practical help from someone? What do your friends or parents think about your passion? Whould you ever incentivate someone to follow this beautiful path which is chemistry and sperimental home chemistry? And do you consider yourself happy? I hope you would answer these questions and remember that we're really happy to be your followers and that your's is one of the best chemistry channels here on the platform!!
@tiger12506
Жыл бұрын
Like NileRed, but with a 10x harder product and difficult process. Really interesting to watch, I had never heard of that chromotographic separation process before. I don't know how the closed captions work, but there were many inconsistencies between what was said and what was in the captions. Also, I caught at least one situation where your video text said 1% HCl and you said out loud 10% HCl. This is absolutely insane, and I would have loved to to get my hands on that and smell it.... spread it around the house... lol.
@someguy8375
Жыл бұрын
I see explosions and fire is not alone in his opinions regarding yellow chemistry
@Osmone_Everony
Жыл бұрын
What always amazes me is how mother nature creates the most complex molecules with ease (apparently). Just think of all the fruit flavors for example. And here, she just let's it rain on soil and voila... Petrichor. This makes me wonder if scientists have found out how this all is achieved (especially flavors) naturally.
@joda7697
Жыл бұрын
if we knew everything, chemistry and biology as sciences wouldn't exist anymore
@durshurrikun150
Жыл бұрын
Fruit flavors are not that complex
@Ziggyzaggy300
Жыл бұрын
"Oh wow, seems to be going good, glad he did it first tr-" "I ADDED BROMINE"
@vianocorentin4296
Жыл бұрын
So sad there is no more sample, I've almost touched by the tip of my fingers one of my dreams,. This fragrance is like smelling life, its really therapeutic for me, just few breathes of it and it's like a big calm ocean with blue clear sky, take place all over my inner self. No more knots in my guts. only feather-light state instead. This a definition of a really peacefull sent. Thank you and bravo to you dear Chemiolis.
@julienescudero2361
Жыл бұрын
As an organic chemist I can tell you that this is some very nice work. Very impressive. Congrats!
@xxluggixx2559
Жыл бұрын
Pure Geosmin solutions are a part of many sensory kits! At the food company I once worked at they did taste tests of some water samples. The testers were trained by drinking highly diluted chemicals such as Geosmin or DMS.
@hussaintalwara6452
Жыл бұрын
I am physics lover but now I can see my mind going in arms of chemistry.
@atescoshorse8399
Жыл бұрын
Best chemistry youtuber on the platform, love all of your videos, always excited when a new one comes out. Keep up the great work
@xerolad4086
Жыл бұрын
Ah now I get the smell referrence!
@perry4809
Жыл бұрын
Yes, make rain smell science man
@ajax3017
Жыл бұрын
I have no clue what's happening or what he is doing but it's satisfying to see all that chemical work turn into something
@ugarit5404
Жыл бұрын
One of your best videos,outstanding reactions and an unusual compound. Very nice of giving samples of product too!
@scrotiemcboogerballs1981
Жыл бұрын
I love the smell of rain right before it starts pouring down lol thanks for sharing
@paprika1716
Жыл бұрын
Short path vacuum destilation and yellow. Thats all I understand but I think thats the essence of this video.
@Sinnistering
Жыл бұрын
This was an awesome video!! Thank you. I loved the chemistry, I loved the humor, just an all around perfect video.
@edoardobandieri2688
Жыл бұрын
Your videos are always amazing, but this one is probably the best. Very well done! Keep it up :)
@chemistryofquestionablequa6252
Жыл бұрын
I LOVE the smell of petrichor! Gonna have to make it!
@DylanoTheWizard
Жыл бұрын
hell yeah this is my type of 2 am content
@dyatlov3466
Жыл бұрын
This is not a video about chemist. This a journey through the most deep sentiment of science.
@palamalama
Жыл бұрын
Love laid back style of your commentary dude, makes this very enjoyable and approachable 😀
@raneman7415
Жыл бұрын
Can we just appreciate how mother nature just does this naturally and so quickly. Thats insane!
@PonteBata
Жыл бұрын
I always wanted to make that compound. Thanks for sharing
@TheMRPadders
Жыл бұрын
I always thought it was the lack of smells that made the rain smell. You learn something new every day
@f4ckmyl1fe
Жыл бұрын
Love u
@nigeljohnson9820
Жыл бұрын
There is nothing like a simple straight forward synthesis, and this is nothing like a simple straight forward synthesis.
@Z6D4C4
Жыл бұрын
As a NileRed enjoyer, this channel is such a great discovery!
@experimental_chemistry
Жыл бұрын
So complicated that I lost track this time. 😵💫 It's a miracle that so much product could be obtained at all in the end. Sending smell samples was invented by labcoatz - a good idea to profitably compensate for the missing sensory impression. How about the sent of wet dog next time? 😉
@soleil_127
Жыл бұрын
i’m taking organic chemistry right now and learned the general forms of a bunch of these reactions last week ! i love it when i can start to understand what’s going on in long syntheses
@mihirsanghvi9876
Жыл бұрын
And thats one heck of a long synthesis
@cyansorcerer6491
Жыл бұрын
truly an underrated channel. Watching you make this was so interesting
@gravity3268
Жыл бұрын
I was always told the smell of rain was from O3 (rather than the regular O2 we breathe) but I never really looked into it! Thanks for the video
@BierBart12
Жыл бұрын
You DO smell ozone when there's a lot of static electricity, or very strongly directly after a lightning struck
@Purin1023
11 ай бұрын
Man I love the smell of ozone. Its like spicy air
@ianrocks2112
Жыл бұрын
You’re hilarious in this video
@bs-qu1vq
Жыл бұрын
That was a very technical and laborious process, and you crushed it! Good job
@josepmcomajoncoses5118
11 ай бұрын
What an amazing synthesis. Congrats!! I cannot imagine the time all those steps took. Truly impressive.
@bdnugget
Жыл бұрын
I think another good reason to add athylene glycol during the bromination is to disfavour deprotection of the ketal, since that will also yield ethylene glycol (le Chatelier principle). Oh yeah the deprotected one is probably a pretty strong lachrymator too lmao
@sibazonumpurum188
Жыл бұрын
A long time a holy grail of fragrance molecules for me! But never had the balls to go all nuts and make it from scratch... Also: MgSO4 tends to "complexate" with ketoesters and diketones, which can partially explain low yields in some of the steps. I've gotten into this pitfall a few times in my practice in the lab...
@JamesTDG
Жыл бұрын
Yay, found something to fill in my void of NileRed content
@goranjosic
Жыл бұрын
I like to watch your videos when I'm tired and want to take a short nap in the armchair. I'm not a chemist, nor am I too interested in chemistry, but I enjoy listening and watching a bit of video until I fall asleep for a short time. 😃❤️ And of course Im always awake at the end to see the result!
@DeathMetalDerf
Жыл бұрын
I really wish I had picked o-chem instead of cybersecurity...
@MrCh0o
Жыл бұрын
How many people who were interested in chemistry but ended up choosing IT over it can we gather, I wonder
@BroversXproductions
Жыл бұрын
Oh, a nice smell :). We all thought you were going to make some cursed tellurium compound or something lol
@idrisali8608
Жыл бұрын
my friend your videos are only getting better and better, very enjoyable
@brycethoreson9216
Жыл бұрын
My favorite smell. So cool someone recreated it
@pelegsap
Жыл бұрын
Damn, that's impressive and awesome. You deserve to get a rotovap.
@pelegsap
Жыл бұрын
I mean, you also deserve an NMR and GCMS machines, but one step at a time ;)
@maqabayker
Жыл бұрын
It was not a good idea to watch this before my report deadline. Now my brain doesn't even work. Man, those were a lot of steps there lol. The videos are getting more complex day by day. I can't imagine how complex videos will be in a year from now.
@IbnBahtuta
Жыл бұрын
So, it's a raining down to earth upload. Thanks, I really needed this, honest. ;-)
@theisgunvald4219
Жыл бұрын
The most impressive thing about Geosmin if you ask me, is the fact that we humans can detect it at as low as 5 parts per trillion. That’s about equivalent to a bloodhound’s ability to track prey. We know that dogs have been reported to track scents at distances of 20-150km away, sometimes even longer depending on weather conditions. This goes to show how deeply engrained agriculture is in our biology.
@ejkozan
Жыл бұрын
Beautiful synthesis! I really see Chemiolis perfume line a thing XD Maybe just not in carbon tet XD I understand so well yellow... yellows and oranges, most hated colours Keep good work!
@synapsomorphy
Жыл бұрын
I love your style of humor. Nothing against explosions and fire, but I can't really get into it because there's so much screen shaking and gags. You have the perfect amount of funny stuff timed just right along with 95% actual chemistry.
@MrCh0o
Жыл бұрын
Yeah, while I'm usually up for memery, this video was refreshingly chill after watching other chemistry youtubers
@moonshifter0
Жыл бұрын
This is so satisfying
@erich.5326
Жыл бұрын
Say it with me now "Yellow chem bad"
@Fireworker2K
Жыл бұрын
I wonder if it'd work as a perfume
@stephenkwas3280
Жыл бұрын
Awesome video as always! I was wondering, though, why does the enamine form a more substituted alkene? I was always taught that it prefers to form a less substituted alkene because of sterics. Perhaps it has something to do with the fact that the nitrogen is only monoalkylated, not dialkylated? Thanks!
@Chemiolis
Жыл бұрын
Yes that's right, normally the steric effects on a secondary amine will cause repulsion by the lone pair of the nitrogen and the methyl group, and it will favor the alkene on the less substituted position. Since this is a primary amine there is no such steric effect and it will favor the most stable position, which is the most substituted alkene.
@knurlgnar24
Жыл бұрын
Of all the excellent KZitem chemistry creators including Nile Lab, Nurd Red, and Cody's Rage, Chemiolis is one of them.
@atakoranodonbrachiosaurus1209
Жыл бұрын
it's the best scent when one heads out- weird how one molecule (though likely a group) can bring such calm and clarity to the mind
@KittenRaptor
9 ай бұрын
Processes like this are why I had to quit chemistry. This level of focused complexity and crippling ADHD do not mix. I'm writing this about halfway through the video and I already forgot what you're making. IIRC you're turning rubber gloves into McDonalds Special Sauce?
@dmmax18
Жыл бұрын
Is there a proper scientific explanation why it is always yellow and not some other goddamn color? 😅
@Chemiolis
Жыл бұрын
I think it's because side reactions often form small conjugated systems, which are yellow because of the wavelengths these typically absorb. Since larger systems aren't formed and other colors usually require a more exotic structure, it will just make yellow :(
@Kampftroll
Жыл бұрын
This looked like so much work, thank you for doing it, love the video!
@Nicker000
Жыл бұрын
Love the idea of giving back to the community, supported
@djillusii7333
Жыл бұрын
I always thought the rain smell was something unique to my area. Because we have creosote bushes everywhere it makes a unique rainy smell when it rains lol. People always say that rain here doesn't smell like anywhere else in a good way, so I always thought.
@dipankarbanerjee1130
Жыл бұрын
Chemistry lovers are legends
@dennisdecoene
Жыл бұрын
Now that my dear friend was an enormous amount of work. Well done
@user-hj5yn2ti2s
Жыл бұрын
this is type of content that I wanted. I love smell of rain so much.
@SeattlePioneer
Жыл бұрын
Everybody needs a hobby. After listening for a while, I jumped to the end for the dramatic conclusion!
@puffdaddy69
Жыл бұрын
God really doesn’t want us smelling grass artificially
@lucxrio6956
Жыл бұрын
i have no idea why i watched this video the entire way through without understanding a thing. There is just something very satisfying about it. Hope it helps me in my chem final a few days from now.
@env0x
Жыл бұрын
this is so cool, petrichor is my favorite smell ever and i used to have a bottle of ESO that had geosmin in it and the company that sold it ran out of business and i've never been able to find anything quite like it since.
@David.C.Velasquez
Жыл бұрын
Holy shit! This synthesis is epic in the literal sense... Bravo Sir.
@jozefnovak7750
Жыл бұрын
Super! Thank you very much!
@IrishRepoMan
Жыл бұрын
Rain be like: "You do all that, and I'll just fall on some dirt, k?"
@PepekBezlepek
Жыл бұрын
man you are an absolute legend for making this ♥ this has to be the best "amateur" orgsyn channel on youtube and I am so happy somebody is still making content like this. So many steps, great videography, narration, YELLOW memes, smell commentary. made me super happy to watch ☺ you've guaranteed a Patreon supporter as soon as I land a job. one note - audio could be louder. was hard to understand on full phone volume while showering 😆 don't judge me, that's when I got to it 😆
@BritishBeachcomber
Жыл бұрын
Petrichor, one of the loveliest scents on this beautiful planet of ours...
@gameboygeorge1
Жыл бұрын
this video is awesome, such a cool idea.
@northwestalternativemedia2125
Жыл бұрын
I really enjoyed this extraction. 😊
@splash4485
Жыл бұрын
i randomly got this recommendation altough my youtube page is almost only gaming and I dont regret clicking on this! thank you for this fascinating video
@TheZombieSaints
Жыл бұрын
Wow what commitment! Bloody amazing stuff mate 👍
@Pixelgon404
Жыл бұрын
I’m learning about these in college nowww so very exciting and helpful applications of knowledge thanks
@doctorbolsen
Жыл бұрын
Finally, more chemistry content
@technoman9000
Жыл бұрын
OK, I just watched this and couldn't resist. The smell of rain is one of my favorite things so I subscribed. Hope I get a sample!
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