MAO Inhibitors. How Do These Antidepressants Work and How To Use Them Safely
The MAO Inhibitors are thought to be more effective than other antidepressants for depressions characterized by excessive sleeping, increased appetite (often with carbohydrate craving), feelings of heaviness in the body, and high sensitivity to perceived rejection or insult.
“MAO” stands for monoamine oxidase. MAO is an enzyme that breaks down the monoamine neurotransmitters. The classic monoamine neurotransmitters are: epinephrine, norepinephrine, dopamine, and serotonin. By inhibiting their breakdown, the MAO inhibitors can boost levels of all these neurotransmitters.
But there are side effects and risks to this strategy. And many clinicians don’t prescribe MAO inhibitors because of lack of experience with these medications or because of concern about potential risks.
This lecture explains how the MAO inhibitors work, and the mechanisms behind the potential risks. It discusses the therapeutic benefits of these medications, and how to use them safely.
This lecture was given at the July 1, 2020 meeting of the SZconsult learning community. Check out SZconsult.org for more information.
SZconsult is a free consultation + education service offered by Northeast Ohio Medical University. It’s open to any clinician who wants to learn more about schizophrenia-spectrum illness, or who wants to tap into the collective wisdom of the learning community to find answers to clinical problems.
⌛ Video Chapters ⌛
00:00 Introduction
00:39 Monoamine Oxidase Inhibitors (MAOI)
01:37 MAO Enzymes
03:14 MAOI
05:37 MAOI Interactions
09:49 MAOI Food Interactions
12:44 Efficacy Meta-analysis
16:14 Selegiline Efficacy
17:53 Common Adverse Effects
18:43 New Interest in MAOIs
21:54 Summary
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