excellent video, as per your usual! Thank you for this!
@beckyjohnson8012
3 жыл бұрын
Thanks for breaking the evidence down for us so succinctly Dr Beaber! I'm encouraged that this could be a possibility for those of us over 60 with progressive disease. I just hope it's available soon! Otherwise I may have to go to the vet and bark like a pup! Lol!
@buffalobob870
3 жыл бұрын
Nice to see therapies that show hope for progressive forms of MS. Would be nice to have the "right to try" philosophy extended to other conditions such as MS; especially those who have advanced to EDSS 5+. Great video!
@DrBrandonBeaber
3 жыл бұрын
I am definitely encouraged to see more research for people with progressive MS. Masitinib is truly unique in the field of MS.
@cedricfayolle9382
3 жыл бұрын
I'm not a specialist, only a shareholder from France but your explanation was clear and well organized, thanks for this nice video. Hope for sick people that Masitinib will be authorized soon everywhere in the world
@DrBrandonBeaber
3 жыл бұрын
Thanks.
@relledom
3 жыл бұрын
Thanks for the great video, giving pwMS again some hope! Best regards from Germany!
@DrBrandonBeaber
3 жыл бұрын
I'm glad you got something out of it relledom
@carlacampillo8256
3 жыл бұрын
Thank you doctor for another cool and interesting video! Is the mechanism of masitinib the same as that of evobrutinib (in this case studied for RRMS)? I think this kind of research based on the innate response of the immune system is very promising. Thank you very much for making the results understandable for us!
@MrKoshnica
3 жыл бұрын
Again, great video, and thanks!
@desiredecove5815
3 жыл бұрын
Thank you - sharing ❤️✌🏻
@Jesusleal10
3 жыл бұрын
Hi Dr. Beaber. Do we know the cognitive benefits of taking BTK inhibitors? We know that disability-wise is awesome, but do we have data on Cognition and Brain Volume? Thanks.
@DrBrandonBeaber
3 жыл бұрын
I'm not aware of any specific data on this right now.
@paul6150
3 жыл бұрын
Ok, let's combine this with ocrelizumab and let's start tomorrow. Not trying to be funny, but 2 year trial starting from?? Plus some insurance company BS probably. I might be at EDSS 7 by then. Question: Is there a reason you can think of why this might not go along with other DMT? Combining stuff might be the only hope for progressive patients. Well maybe I am not in my most positive mood today.
@DrBrandonBeaber
3 жыл бұрын
In theory, this could be used with other disease modifying therapies. The culture of MS doctors is that we tend to use single agents. In rheumatology, combinations of immunosuppressives are commonly used. The one study on combination therapy (the COMBIRx study of copaxone + Avonex) didn't show any benefit of the combination.
@ghost8726
3 жыл бұрын
@@DrBrandonBeaber would you he interested in doing a study with the combination of ocrevus and this drug? If so, count me in😭
@aditya50499
3 жыл бұрын
@@ghost8726 I emailed companies investigating BTKIs requesting them to provide me access to their investigational agents for compassionate use, but none of them acceded to my request. I read in one article on Masitinib one German doctor suggesting that the combination of Masitinib and some anti CD therapy would be more effective than Masitinib as a standalone treatment.
@Teslakoils
3 жыл бұрын
Thank you for sharing sir. I was wondering what your personal opinion is on Mavenclad.
@DrBrandonBeaber
3 жыл бұрын
I think it is definitely one of the high-efficacy disease modifying therapies. It is probably more deleterious than b-cell depleters, but this is difficult to judge.
@Teslakoils
3 жыл бұрын
@@DrBrandonBeaber thank you for your quick response. Mavenclad is likely my next choice if my current DMT stops working, but I’m gathering as many opinions and as much information as I can.
@dombullet6714
3 жыл бұрын
Great video hope FDA will allowed soon
@RSsboy90
3 жыл бұрын
Hey Brandon. Would you care to elaborate on what p-value means in the context of medical articles?
@DrBrandonBeaber
3 жыл бұрын
the p-value is the probability that the observed result would occur by chance if the treatment has no effect.
@Lukashumungus
3 жыл бұрын
Hello Dr. Brandon Beaber So if it works how long wold it take to be available from now?
@dombullet6714
3 жыл бұрын
depend the pressure than patients can put on FDA and EMA
@DrBrandonBeaber
3 жыл бұрын
2 phase III trials are needed to get FDA/EMA approval and then another year to get approved, so probably at least 3 years.
@Lukashumungus
3 жыл бұрын
@@DrBrandonBeaber thank you very much for you answer and for your great work ! your channel is very important!!!!
@Petra44YT
3 жыл бұрын
But ... it is available. For dogs. Just find a vet. :-)
@Lukashumungus
3 жыл бұрын
@@Petra44YT sadly im a cat :(
@rawsomehappy
3 жыл бұрын
Nice when treatments aren’t pigeon holed for singular conditions and show promise across the human playing field. I saw a promising study using proprionic acid Your thoughts?
@DrBrandonBeaber
3 жыл бұрын
I think so far there are just basic science articles like this one: pubmed.ncbi.nlm.nih.gov/32160527/ Is there an actual clinical trial you were referring to Myrna?
@rawsomehappy
3 жыл бұрын
@@DrBrandonBeaber Alexander Duscha et al.: Propionic acid shapes multiple sclerosis disease course by immunomodulatory mechanism, in: Cell, 2020, DOI: 10.1016/j.cell.2020.02.03t5i Know of a patient prescribed propionic acid with promising results
@aditya50499
3 жыл бұрын
Sir, as I see, there are some BTK inhibitors that are already being used to treat certain cancers in humans and this one, Masitinib, has been approved to treat mast cell tumours in dogs. It seems the company, AB Science is now trying to repurpose the same drug to treat MS.
@DrBrandonBeaber
3 жыл бұрын
You are correct.
@VisionsOfBulgaria
3 жыл бұрын
Dr. Beaber, please study the IVM (Ivermectin) drug, which deals with P2X4 receptor and has very promising remyelination properties.
@DrBrandonBeaber
3 жыл бұрын
I can look into this. Do you have a link to the relevant study?
@beckyjohnson8012
3 жыл бұрын
I'd be interested in this research too!
@roberture5903
3 жыл бұрын
Would this medication be in pill form if approved ? My therapy now tysabri infusions. Thankyou for another informative video.
@dombullet6714
3 жыл бұрын
pill
@DrBrandonBeaber
3 жыл бұрын
This would be an oral medication (Masivet for Dogs mast cell tumors is a tablet): images.squarespace-cdn.com/content/v1/595bda4abebafb281989df79/1500126835900-QOZBUH7LC6ZNLRNXZ582/ke17ZwdGBToddI8pDm48kKGpjsq0ebHzrvZ8Fuam4KFZw-zPPgdn4jUwVcJE1ZvWEtT5uBSRWt4vQZAgTJucoTqqXjS3CfNDSuuf31e0tVFKUKjGrbFhgGOpWeL1fAjzGzdzlj3ZHBEFKD3ZOTSZDN1lH3P2bFZvTItROhWrBJ0/image-asset.png
@roberture5903
3 жыл бұрын
@@DrBrandonBeaber Thankyou Brandon, much appreciated sir.
@Petra44YT
3 жыл бұрын
@@DrBrandonBeaber Cool! ... Why not just take the dog tablets? They are just 55 pounds per package.
@ghost8726
3 жыл бұрын
Seeing as though the target of this drug is completely different than that of an ocrevus or the other popular ms drugs & we see results as good as those, I would love to see a combined treatment study using this & ocrevus. Ocrevus seems to be the most effective with least side effects and risks, also reduce brain atrophy ( something which ( might be wrong ) only lemtrada and hsct show ) & has amazing 6 year results.
@bidulou0417
3 жыл бұрын
bonjour ce n'est pas possible d'avoir la traduction.... tout le monde n'a pas la chance de parler anglais merci
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