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MECHANISM OF AEROBIC RESPIRATION: Aerobic respiration takes place in mitochondria aerobic respiration leads to complete oxidation of glucose molecule to Co_2 and water in the presence of oxygen. It involves 4 major steps.1 Glycolytic break down of glucose to pyruvic acid. 2 Oxidative decarboxylation of pyruic acid to acetyl co A. 3 Kerb's cycle.4 Terminal oxidation and phosphorylation in respiratory chain. 1 Glycolysis:-The conversion of 1 glucose molecule into 2 molecules of pyruic acid is called glycolysis. The reactions are described in anaerobic respiration.Oxidative decarboxylation of pyruic acid to acetyl coA: The pyruic acid, generated in the glycolysis can not enter into kreb's cycle unless it forms Acetyl coA. Pyruvic acid enters mitochondrial matrix and undergoes complete biological oxidation and is converted into Acetyl coA.The formation of Acetyl coA from pyruvic acid involves removal of Co_2and hydrogen and so it is known as oxidative decarboxylation.Pyruvic acid reacts with thiamine pyrophosphate to form acetaldehyde. TPP complex and Co_2 is released. The complex reacts with co- factor;lipoic acid in the oxydised state to form acetyl lipoic acid complex, releasing TPP. The Acetyl lipoic acid complex reacts with coenzyme- A to form Acetyl co- A and reduced lipoic acid. The reduced lipoic acid is re- oxidized by NAD forming NADH + H+. Formation of Acetyl co. A is the connecting link between glycolysis and kreb's cycle. Kreb's cycle: Acetyl co A formed from pyrucvic acid is the feel of kreb's cycle which includes a series of oxidation reactions. The sequence of reactions in this cycle are described by sir Hans krebs in 1937. In 1953, krebs was awarded Nobel prize, and the cycle is frequently refered to as krebs cycle in his honour.The first formed substance in this cycle is citric acid, hence it is also known as citric acid cycle.
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