1:40 Oxidative stress
2:00 High energy phosphate depletion
3:40 Uncoupling of oxidative phosphorylation
6:15 Mechanism of Mitochondrial swelling / rupture
6:55 Fluid Volume hydrostatic pressure relationship
7:50 Membrane tension (Laplace law)
9:50 Why outer mitochondrial membrane rupture first
11:08 Compliance
12:30 Cyt C
13:45 MPT - Ca vicious cycle
Mitochodria picture - Nevit Dilmen - Mitochondria - Own work (From Wikimedia Commons)
Kroemer G, Galluzzi L, Brenner C. Mitochondrial membrane permeabilization in cell death. Physiol Rev. 2007 Jan;87(1):99-163. doi: 10.1152/physrev.00013.2006. PMID: 17237344.
Bonora M, Pinton P. The mitochondrial permeability transition pore and cancer: molecular mechanisms involved in cell death. Front Oncol. 2014;4:302. Published 2014 Nov 17. doi:10.3389/fonc.2014.00302
Bernardi P, Rasola A, Forte M, Lippe G. The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology. Physiol Rev. 2015 Oct;95(4):1111-55. doi: 10.1152/physrev.00001.2015. PMID: 26269524; PMCID: PMC4600949. journals.physi...
Tao J, Sun SX. Active Biochemical Regulation of Cell Volume and a Simple Model of Cell Tension Response. Biophys J. 2015;109(8):1541-1550. doi:10.1016/j.bpj.2015.08.025
Delpire E, Gagnon KB. Water Homeostasis and Cell Volume Maintenance and Regulation. Curr Top Membr. 2018;81:3-52. doi:10.1016/bs.ctm.2018.08.001
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Негізгі бет Mechanism of Mitochondrial permeability transition (MPT).
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