An alternative explanation for the diabetes study is that people with mild diabetes (non insulin dependent) often only take metformin but have regular doctor appointments, while the general population does not have the same level of medical care. What this study can mean is that regular doctors visits increase health and longevity, which sounds like a a very reasonable conclusion.
@TonyHightower
2 жыл бұрын
I hope (and expect) that this will be a factor in the next round of studies.
@SanthoshMooga
2 жыл бұрын
She said people who take other medicine for diabetes are still dying early. So may be u r wrong too. But regular doctor visits and checkups are good for everyone though
@chrismarinohardin9929
2 жыл бұрын
This is a reasonable possibility. However, we also know that Metformin affects cell metabolism. If metformin slows cell metabolism it’s quite possible it legitimately does just cause cells to accumulate damage at a slower rate. We know that fasting also seems to dramatically increase longevity. Mice forced to fast live a decent percentage longer than their peers consistently.
@josephk87171
2 жыл бұрын
But then how would that explain the worse outcomes for diabetics on other drugs than the baseline
@GreatStuff2Watch
2 жыл бұрын
That doesn't explain the results. People who are type 2 diabetics and metformin have reached a point of weight gain and other issues that would indicate them dying years earlier than a standard group of people without type 2.
@patrycjapudeko6688
2 жыл бұрын
The problem is if researchers confirm that this drug is "anti-aging" it would immediately be much more expensive, and at the same time less available for the people with diabetes, who desperately need it... Let's not forget about that!
@jcd-k2s
Жыл бұрын
But I desperately need to live longer
@Daniel-Davies-Gonstead-Student
Жыл бұрын
@@jcd-k2s Do you? Think about what you're saying.
@lazyhominid
Жыл бұрын
In the US, sure. But not elsewhere, since the patents are expired.
@jcd-k2s
Жыл бұрын
@@Daniel-Davies-Gonstead-Student I don't see the problem, yes I do
@CatboyChemicalSociety
Жыл бұрын
@@jcd-k2sgo hoard some then like buy 10kg supply and resell later
@jgalindoj
2 жыл бұрын
At first, I was scared of the way this video would talk about taking a drug without prescription. I found you did it very responsibly. Thanks you.
@AznDudeIsOn
2 жыл бұрын
This drug is OTC in many countries
@TheIgdrasil1
2 жыл бұрын
@@AznDudeIsOn Unfortunately in Europe its only with prescription.
@Competitive_Antagonist
2 жыл бұрын
With 5 extra years, I'd be able to watch even more KZitem videos.
@joseramirezgarcia232
2 жыл бұрын
Cleo is awesomely responsible. Trust her.
@FacePlant1324
2 жыл бұрын
I wouldn't be able to take that if it increased my heart rate. I already take meds fhat increase my heart rste
@salpirwani
2 жыл бұрын
My Dads been taking Metformin for the past 30+ years for Diabetes. Fought serious Covid, Heart attack, Broken Hip and still goes to work at the age of 70! Maybe on to something here...
@LarryWhite-kw5mj
10 ай бұрын
I take 2,1000 daily,rather than insulan,10 years,am 67,still alive
@Viv8ldi
3 ай бұрын
Metformin fought covid?…
@kubbybear5458
24 күн бұрын
@@Viv8ldi I keep trying to write a response to you, but it has disappeared twice now! In short, yes, there have been studies that metformin usage supported less severe covid cases (although i cannot attest to the truth of them, even with my own metformin vs covid experience that sways in that direction) There's articles out there you could probably look up. It's been a while since I've seen one though.
@MedlifeCrisis
2 жыл бұрын
Great job explaining a complex topic fairly and succinctly. Btw one of the experts in your clips there, Andrew Steele, is a friend of mine. I’ll let him know he makes a cameo!
@Geroscientist
2 жыл бұрын
please consider doing a video with Andrew Steele on aging biology research!
@ashmac4732
2 жыл бұрын
shes not going to let you smash bro.
@lordtanatos84kmkn59
Жыл бұрын
When ever I like a video there is a comment from you, there is a very strong correlation.
@krishp1104
Жыл бұрын
@@ashmac4732 dang
@saddish2816
Жыл бұрын
@@ashmac4732 LMFAOO
@martinebon4333
2 жыл бұрын
As someone who works in the field of research, we have already been using Metformin as one of the trial arms for prostate cancer due to observed anti cancer effects. This trial is still ongoing and results will probably be published in 5years.
@b3tth0l3
Жыл бұрын
4 years left, fingers crossed
@RobBrulinski
Жыл бұрын
Remind us in 4 years!
@user-bw6cd2bt1t
7 ай бұрын
I dont have time on my hand so I would take the plunge considering metformin pretty safe throughout its 60 year use in treating patients.
@marian.9026
6 ай бұрын
I was diagnosed with stage 1 endometrial cancer this past August. I almost lost my mind all the doctors kept trying to push a hysterectomy on me but I haven't had children yet. I started fertility sparing hormone therapy. I stayed up for 2 months trying to learn as much as possible about my condition. I came across a couple of studies where merformin was used in conjunction with the hormone therapy and had excellent results. I had my doctor prescribe it. 3 months after starting my therapy my first biopsy came back absolutely completely normal.
@joebidenw4385
Ай бұрын
3 yrs left @@b3tth0l3
@sakshamjoshi9950
2 жыл бұрын
I'm so looking forward to see this channel become HUGE one day. Fine job Cleo. Keep up the good work👍
@kevinkwon3608
2 жыл бұрын
Huge, if true
@kiidkif2009
9 ай бұрын
@@kevinkwon3608shit u beat me to it...a yr ago too dammit
@shanaybhem5783
2 жыл бұрын
This is a masterclass for anyone that wants an example of brilliantly presented, informative, and responsible journalism. Beautifully edited, and just plainly honest and heartfelt. 12/10
@v1d300
2 жыл бұрын
I like this format. One topic, not too deep, not too shallow, just enough to educate us enough for more research if interested. Great going Cleo! Good luck and keep growing!
@camilavalero5006
2 жыл бұрын
Hi Cleo! I don’t know about aging but I’m a not diabetic woman taking metformin because a side effect of it is controlling polycystic ovaries (PCOS) syndrome. It blew my mind when, several years ago, my gyno prescripted to me because of that side effect scientists found about. Love your videos! Huge fan from Argentina 💘🇦🇷
@deo3367
Жыл бұрын
This sounds weird. But I am so jealous you’re on metformin. I have PCOS and my doctors say “just lose weight. It will cure it” (I physically can’t lose weight because of PCOS.) EVERY woman tells me to get on metformin. So I ask my PCP, and they ALL refuse to give me metformin because I’m not diabetic. It’s so frustrating
@rosequartzjewelryllc
Жыл бұрын
@@deo3367that is so frustrating! I also have pcos and could not lose weight because my energy levels were so low and my insulin was high. If you cannot get ahold of metformin I highly suggest you try inositol. I found some at a vitamin store like gmc no prescription needed.
@Roswell33
11 ай бұрын
PCOS and insulin resistance go hand in hand which is why Metformin works
@rosequartzjewelryllc
11 ай бұрын
@@Roswell33 the way a friend explained it explained it well for me. “ you can’t lose weight because you’re always tired and hungry, and you’re always tired and hungry because the food you do eat isn’t being converted into enough energy because of insulin resistance “ this mindset was a game changer and ultimately the kick I needed to go to a specialist. It also took some of the shame and guilt out of my weight gain. My energy and even vision are back!! I no longer go home and just nap. I now go home have energy to feed myself properly with a more thought out meal and have the energy to exercise or do stuff around the house! I’m so much better off! The weight is gradually going down and I don’t have to starve myself. If you’re suffering from pcos do yourself a favor and get professional help, it’s not your fault but it is your responsibility to to what is best for you.
@kiidkif2009
9 ай бұрын
Never have i heard about someone taking a drug because of the side effect thts interesting to me
@HundredMillionViews
2 жыл бұрын
Cleo, I'm a diabetes researcher building an artificial pancreas for controlling people's blood sugar in intensive care units. Blood sugar is actually _enormously_ important for mortality in critically ill patients, and people with diabetes who are just under general hospital care. You can reduce mortality by 30% _across the board_ by controlling blood sugar well (and 300% in COVID patients), making well controlled blood sugar in hospitals one of the most widely applicable technologies since the invention of penicillin, or the polio vaccine! Let me know if you want to talk about the wide world of glucose control some time, would be happy to share!
@jakebruce11
2 жыл бұрын
What does it mean to reduce mortality by 300%?
@therealsunnyk
2 жыл бұрын
Hey I was watching this thing about a group of Vegans who have a massive caloric deficit (like 1200 calories a day), and one thing they were talking about was blood sugar control and its impact on lifetime (also limiting cell damage overall). Could just being a vegan with a caloric deficit help you as much as this pill?
@jk-gb4et
2 жыл бұрын
@@jakebruce11 1/3rd as much ? i dont know
@jk-gb4et
2 жыл бұрын
@@jakebruce11 But i do not think you can decrease something by more than 100% or else you get into negatives or something, so they probably worded it wrong
@HundredMillionViews
2 жыл бұрын
Hi! Appreciate the comment :) This is a colloquialism to mean it's 3x smaller, so if you want a stricter more mathematically correct term, you might say: COVID patients with good glucose control have a mortality rate that is 1/3 of the mortality rate of patients with poor glucose control. In other words, if you have COVID and don't have good glucose control, you're 3 times more likely to die. It's pretty serious stuff!
@hermant3593
2 жыл бұрын
Oh my GODDD!! Your journalism - ugh it’s so good!! Such a responsible take on a potentially life-changing technology. No hype, no clickbait, no jumping to conclusions - just strong reminders of how complex this world is and how difficult it is to acquire information and weigh the risks. This was a LOVELY breath of fresh air journalism. Oh my gosh thank you so much. 😊
@krishna7404
2 жыл бұрын
So if Metformin is hypothesized to counter ageing by reducing the amount of blood sugar flowing in our cardiovascular system, would switching to restrictive sugar diet achieve similar effect?
@ak4good
2 жыл бұрын
Yes that is indeed a viable strategy, check out episode 2 of this series: kzitem.info/rock/wD5YYkbYmN2iFHON9FyDXg
@ernststravoblofeld
2 жыл бұрын
Yes. Cutting sugar has many benefits, and one is decreased all cause mortality. There may be some causation/correlation issues though. People who are willing to cut sugar for health (or take a pill that makes you shit funny) are probably doing other health related things that the general population isn't doing as much.
@kjkj4725
2 жыл бұрын
Yep, keto and low carb has quite a bit of good studies when it comes to diabetes and PCOS
@9DeadDingo
2 жыл бұрын
Yes thast why doctors talk about fasting causing you to age less
@Hansulf
2 жыл бұрын
Basicly yes. The thing is that high sufar levels in our Blood cause a ton of problems. But fats too. We better get rid of them by locking them somewhere else.
@gurtejsingh2596
2 жыл бұрын
This is slowly becoming my favourite channel on KZitem, it's well researched, and really has an optimistic and personal side to it that i feel is really lacking in general these days. Looking forward to seeing more of this for sure!
@charlesloeffler333
2 жыл бұрын
I was on metformin, but was taken off of it because (I believe) it was hard on one of my major organs. I think it was either the liver or kidneys. People should check out side effects before self medication
@keithdutton1246
Жыл бұрын
Bad drug. Kills kidneys. It’s the poison they give pour diabetics. 😢
@azmi3333
10 ай бұрын
When I took it, it was hard on my butt hole. 😢
@fw1421
8 ай бұрын
I’ve been taking Metformin for 10+ years. I haven’t seen any anti-aging properties.
@diinhmd
2 жыл бұрын
I happened to read about Metformin being used as an anti-aging drug some time ago and I've always wanted to learn more. This is a great video 👍
@claudiasolorzano3524
2 жыл бұрын
I was prescribed Metformin and I was taking it for about a year. I have PCOS which means I have some insulin resistance, but I am not diabetic. I lost weight and had trouble putting on muscle. For someone that was already underweight, this became a big issue for me. I was excited to read about possible longevity effects of Metformin and made me more inclined to continue taking it, but I quit a lot of medications in order to try conceiving. I don't believe I will take Metformin again unless my Endocrinologist thinks I should go on it again. I felt fine taking it, I feel better off of it. Excited to see what these studies find, always wanted to learn more.
@alexfall862
2 жыл бұрын
One of the strengths of this channel so far appears to be general video production value and finding interesting topics. One of the clear weaknesses is the lack of due-diligence with research. The arguments in favor of the videos' attention grabbing premises are backed by expert interviews (from people very close to the industry), while any objections are from Cleo's voice instead of a contrary expert interview. That framing elevates experts with vested interests in their particular niche, and devalues the more sober views of other experts filtered or omitted through Cleo. So far it's just two videos, but I'm suspecting it'll be a pattern in future videos. "Is fracking actually ok?"=talk to expert engineer in fracking, "Drug makes you live longer?"=talk to professor promoting and likely looking for continued funding on his own work with the drug. What would have taken this video up to the next level would be finding an expert in the field who objected to the conclusions offered by the experts. Have someone on to talk about the likely causes of the reduction in all-cause mortality that aren't related to metformin. Perhaps, people with diagnosed diabetes are generally more aware of their day-to-day health and make more frequent doctors visits, and would have better outcomes in regards to preventative health practices. Or perhaps Metformin may have specific knock-on benefits in reducing heart disease. While it would have been a damper on the more positive interpretation of the premise (which I understand is the channel's mission) I think it would have added a lot of depth. Great video series so far though, and I look forward to more videos!
@chrismarinohardin9929
2 жыл бұрын
I liked the video but I agree that this is a valid criticsm, constructively delivered!
@lordbuxton8135
2 жыл бұрын
Except in this particular video we are still waiting for any conclusions. So to argue another side would be inconclusive at this point. Hopefully she follows up down the road on some topics. Because your right a journalist should present both sides of a debate.
@curtismmichaels
Жыл бұрын
Your journalistic ethic is a rare and honorable thing to witness. Sharing your personal, and vulnerable perspective really brings the information home and places our responsibilities on ourselves. Brava!!!
@tracephoto1823
2 жыл бұрын
1. I really love reporting like this. Taking existing conclusions accepted by the public and saying “wait, let’s really look at this”. Allowing the search for truth to cut though. Awesome. 2. The Doc reminds me of Paul Simon. Just saying. 3. If it turns out that Metformin actually works in some appreciable way, you can bet the drug companies will find a way to produce it (or a more ‘stylish’ version) for far more $$$$ per pill than it goes for now. 4. By stock in Metformin.
@jojak8066
2 жыл бұрын
Yup
@chrismarinohardin9929
2 жыл бұрын
I mean, does the price have to go up to make it insanely profitable? If every single person in the world has to pay $5/mo for the pills, that’s literally close to half a trillion dollars a year.
@tracephoto1823
2 жыл бұрын
@@chrismarinohardin9929 yeah, but ya know what’s better than half a trillion?…..a trillion. Profit leads the greedy by the nose. My daughters all have Cystic Fibrosis. Among other meds, they all have to take enzymes (Creon 20) in order to digest food. Years ago I was between jobs (so no insurance) and needed to pick up a 100 count bottle of Creon pills. That’s enough for about 20 meals. The cost without insurance? $800. Trust me, if there’s a way for greedy humans to make money on a common drug, they will find a way.
@heysciencesam
2 жыл бұрын
Thanks for this story. Love your work and the way you storytell - you’re awesome. Metformin has been studied by the stem cell community for a while and while it’s promising, it also seems to have some potential effects on stem cells (our collaborators saw this in the brain in mice and it’s in trials too). So I’d add that uncertainty to the potential risk (and benefit!) calculation. I also worry how the affordability and availability might change if there’s more demand (particularly among wealthy Americans) and hope it remains accessible for those with diabetes.
@Babihrse
Жыл бұрын
It's not accessible for those with diabetes. Ireland my da can't get it anymore because of worldwide shortages. The drug they put him on to substitute caused an allergic reaction and he had to be jabbed with an epi pen by paramedics. All I can think of is the lyrics to red hot chilli peppers californication. Sicker than the rest there is no test to break the spell of aging. The song alludes to people with money can just pay to get whatever they want
@barnone1086
2 жыл бұрын
The side effects can be horrible. As someone that was put on metformin when I was younger as it was suggested for PCOS sufferers, it's not something I would recommend unless you need it as in have pre existing conditions. But everyone's different. Great video though, really interesting topic
@-nomi.-
2 жыл бұрын
was prescribed it to counteract increased appetite from antidepressants and yep, it was worse than it sounds
@DinosaurMermaidArt
2 жыл бұрын
Same here. Not just a little diarrhea and not just the first week. Do not recommend.
@zhazhagab0r
2 жыл бұрын
It definitely hits different people differently. I have periodic diarrhea, but the appetite control is 100% worth it to me, especially after I quit birth control. I've seen a lot of other folks with PCOS find the side effects too much vs. the benefits, though.
@robertstancliffsr9575
2 жыл бұрын
I a have been taking metformin for type 2 diabetes for over 25 years, 1X2mgs daily. No side effects no liver or kidney damage and no low B12 level. Works great for me. Also,, I'm 78 now and hoping that longevity thing proves to be true.........
@barnone1086
2 жыл бұрын
@@robertstancliffsr9575 That's awesome. Sadly not everyone has the same response. As with any medication it people can have varying reactions. It also doesn't help that up until recently clinical trials were primarily done on Men and not women. Our bodies are different and can respond in different ways
@deltonadoug
Ай бұрын
As a person who is diabetic and who has also had a kidney transplant, I urge you look into the affects of metforman on the kidneys.
@Leggir
2 жыл бұрын
My grandmother lived to 95, but Dimentia took her mind at the age of 72. Besides her ability to run around the nursing home, she was incapable of speech or recognizing anything. I'm not sure I'd want to live longer than that what age your mind goes.
@GnosticAtheist
Жыл бұрын
Depends. If I am no longer self-aware or no longer have an identity, I'm probably not going to care. Also, I would be interested in the process of losing my sanity and memory. While it will be horrific, at seems highly interesting. I need to complete a memory map before it happens so I can trace what goes first and how it affects identity.
@msjkramey
Жыл бұрын
@GnosticAtheist you say you wouldn't care but my granddad has been suffering with alzheimers for years. He is very distraught and confused most of the time. He's quick to sadness and anger and has acted out violently towards nursing home staff. He used to be the most gentle man. He may not remember the net suffering but most days are really hard on him. The one silver lining is that he doesn't remember that my Grammy died, so he's not heart broken by that
@Daniel-Davies-Gonstead-Student
Жыл бұрын
@@msjkramey Why let him suffer? This is going to seem crude, but if you care about him, follow this. Most people don't let a pet suffer. Why let him suffer? I'm not looking for an answer, I'm just hope you think about it.
@msjkramey
Жыл бұрын
@@Daniel-Davies-Gonstead-Student what are you suggesting? That we murder him?
@googiegress
Жыл бұрын
@@msjkramey Wow, it's very interesting what people are willing to write to strangers online. As a fellow human, I'll apologize to you for that guy. I wish you luck through a very tough time.
@muskan-op7rm
2 жыл бұрын
its soo exicting to watch such informative videos with unique topics. u are doing great job, thanks Cleo! we love u:)
@carllofgren5599
Жыл бұрын
I am diabetic since then years. As a factoryworker I handle the same weight of things with my hands everyday and when I was put on medication with metformin I lost musclepower significantly. Metformin maybe be a good medicin, but not for me.
@samgray49
Жыл бұрын
My mom was put on Metformin way back in the day before I was born and dropped some 42 pounds. We both have PCOS, and it's kind of annoying that people are using off-label to try and live longer, and that people are using it - abusing it - for weight loss. While I feel bad for people who struggle with weight loss, it is hurting those who rely on it.
@googiegress
Жыл бұрын
Is it hurting people who need it, though? Meaning: do you go into the pharmacy and discover that they can't fill your prescription this month because they ran out? For Metformin, I doubt it. And if someone else is using the drug to lose weight, arguing that you think that isn't medically necessary or as important as your case is a bit like them coming into your life and arguing that their use is more important than yours. Both arguments fail because neither of you knows what's actually going on with the other one. You can construct some perfect "abuser" to argue against but that's just moving the goalposts so you can win against your strawman.
@strawberry338
8 ай бұрын
It’s not in short supply, your comment is redundant
@chrisanderson2797
2 жыл бұрын
This is my favorite series on KZitem right now. Candid coverage of important topics.
@Thebreakdownshow1
2 жыл бұрын
JOey Rogan talked about it must be legit. lol. Love the video keep up the good work.
@lostfan5054
8 күн бұрын
Thanks for not making a clickbait title or thumbnail :) Love this ethical channel!!!
@RetroRecipes
2 жыл бұрын
Nice video. May I ask what you use for the animations? Re Metformin, I feel the mechanism is fairly clear. Higher blood glucose is a bio marker that correlates with faster ageing. Reducing this even in those with no diabetes slows the inflammation that higher blood glucose causes. Less inflammation = slower aging. 🤞
@paradise_valley
2 жыл бұрын
Yeah it’s common knowledge that most people who have access to decent healthcare who are in their 60s/70s can choose to take this, regardless of whether they have conditions like diabetes or not. Right?
2 жыл бұрын
She edits in Premiere Pro so likely After Effects
@ok373737
2 жыл бұрын
Glucose lowering is not the entire story. Metformin inhibits mTOR, which is one of the 3 main aging pathways.
@TonyHanation
2 жыл бұрын
End credit at @8:14 shows Whitney Theis does both the design and animation in this episode (and probably more!)
@tcctech3211
2 ай бұрын
I know you have millions of subs, but I hope you see this message, You are a true GEM among the masses, your approach to science is one of a kind, you take science and show people how to see if from a human everyday perspective. Thank you for the time and care you take with all your videos and your ability to put so much humanity into them. God Bless you and your loved ones.
@nemanjaivanovic5973
2 жыл бұрын
The video is well done and nicely presented. I am personally always skeptical about things that seem overstated. Especially when it is the ultimate easy way out - a pill. Plenty of existing studies clearly show a correlation between exercise, healthy plant based diet, occasionally being uncomfortably cold or hot, etc. and a longer healthier lifespan. Seems like we can all benefit from such a lifestyle improvement rather than taking a pill that we hope works.
@chamuuemura5314
Жыл бұрын
I’m hearing you but every study on plant based diets I’ve ever read failed to account for the fact that the average vegan is simply more conscious of diet choices than the average non-vegan. A Wholefoods vegan will in general be healthier than someone eating 5 BigMacs a day, but factor in similar deit profiles but one person includes milk while the other has potatoes friend in Omega-6 loaded vegetable oil, and the milk drinker will likely be better off.
@Roswell33
11 ай бұрын
@@chamuuemura5314plant based doesn't mean vegan
@paloma4090
Жыл бұрын
I wouldn't take metformin, but I do take nmn and it's been amazing! I've experienced an increase in strength and my skin is looking much better
@spaznicholson374
2 жыл бұрын
The book Lifespan by David Sinclair is a really good read that talks about metformin and other drugs and non-drug activities that are at least correlated with being healthy for longer and some of which they have isolated the cellular effects that are actually causing the improvements.
@handlemonium
2 жыл бұрын
YES! Derek from Veritasium sums up Sinclair's findings: to slow or even temporarily stop aging or the shortening of telomeres (while actual cell renewal studies play out) anyone can integrate 4 lifestyle habits: 1. Eat 10-20% less meat 2. High Intensity Workouts 3. Intermittent fasting 4. Spend periods of time in temperatures that are a little too hot or a little too cold for comfort.
@tesladrew2608
Жыл бұрын
@@handlemonium it's probably not meat, but carbs and vegetable oils(linoleic acid).
@handlemonium
Жыл бұрын
@@tesladrew2608 that too. He did say less protein.
@tesladrew2608
Жыл бұрын
@@handlemonium doesn't mean he's right
@TheInfectous
Жыл бұрын
@@tesladrew2608 It's useless to say whether he's right or wrong without knowing the baseline. If you eat meat once a week you might need more, if you eat it twice or 3 times a day certainly less, there's also a difference between red and white meat as well as your individual body. That's the problem that's never talked about when people bring up studies, nobody is an average, a fat person is different than a fat active person is different than a fat active person who eats well is different from a fat active person who eats well and is stressed is different from a fat active person who eats well, is stressed and has unlucky genetics... and so on and so forth, there are countless compounding factors that make it extremely difficult to nail down what you can expect the data to do for you. In terms of meat, some people may need more meat, some people might be better with none at all, completely depends how your body is processing it; if you're overweight, taking some vitamins and fasting until you're a healthy weight would probably be better than anything you could eat... being obese is almost as bad for you as smoking a pack of cigarettes a day... and that's just cancer risk.
@pgplaysvidya
2 жыл бұрын
the problem is that a cheap thing on the market could easily balloon in cost. If you look at, what was it, quinoa? it used to be a cheap staple food that was eaten because more expensive staple foods were exported. However, once we (westerners) found out about it, it ballooned the cost of quinoa and now peruvians can't eat it as staple food now i'm not talking about people who farm quinoa making more money because of increase in demand, because it no longer applies to this situation. it's more that "if people even thought this cheap drug would help them live longer, they will throw money at it" and suddenly you can't treat diabetes using this drug because it's being used for people afraid of dying.
@pgplaysvidya
2 жыл бұрын
the other thing is, wait, you get to live for FIVE YEARS extra, and that's a MAYBE? Just exercise and eat properly. don't smoke or do anything that unnecessarily adds variables to why you might die early.
@AGuiFr
2 жыл бұрын
Considering all the issues with climate change, biodiversity loss and our society reliance on non-renewable resources, I have trouble being enthusiastic about the prospects of humans living longer. It will already be difficult for everyone to live a decent life with 11 billion people by 2100. If we find ways to extend human life by several decades, a new kind of demographic transition will start with a new equilibrium much higher. While it is difficult to argue that at an individual scale it would be awesome, I am very concerned of the consequences of such discoveries at a global scale.
@dmlbs
2 жыл бұрын
💯 Death is the natural ending, if we eliminate these types deaths what would replace them?
@Dicyroller
2 жыл бұрын
I am 51 and my husband is four years older than I am. I have started to see hearing loss, graying, height loss, and other little bits of age in him. (don't get me wrong I am aging as well) I get so afraid I will lose him. I am afraid that my time with him is too short. I can not imagine living without him. He is my rock, my love, my heart. If I could give him something that would make him live longer I would.
@24barron
2 жыл бұрын
You are doing awesome work. Really appreciate the time you put in and the palatability of your approach to complex topics.
@barepilot1954
2 жыл бұрын
I've taken Metformin for decades. My daughter recently pulled pictures of me over the past 10 years and said. Dad you just don't look older. What's going on? I'm 67.
@NK-ju6el
2 жыл бұрын
I'm 23(about to turn 24 soon), I've been taking metformin for maybe over 5 years. I don't have diabetes, I was prescribed it because I was overweight, didn't have period and have insulin resistance. I am very familiar with how metformin affects my body. I'm willing to become a subject of the study but I live in Eastern Europe. I'm very interested in this cuz I'm trying to get off the pill cuz I heard it leads to cancer, and i also lost a lot of weight and have regular period now.
@nesq4104
2 жыл бұрын
This shit is horrible. It robs b vitamins. Switch to alkaline diet. Problems solved.
@lyvsix
Жыл бұрын
The pill (in particular nowadays) does not lead to cancer... it in fact makes it less kikely to have some cancers in our reproductive organs. I would not get off the pill for such a reason. I absoluteely love it and Im dreading the day I will be too old to take it....
@marcusswift7969
2 жыл бұрын
As I’m watching this I can’t help but think “but wouldn’t regular exercise produce similar benefits, have less side effects and it has the added benefit of making your muscles bigger”. And a walk is free.
@ashwanisingh6759
2 жыл бұрын
I guess the conclusion is, wait for a solid research before taking any decision regarding that.
@dcterr1
Жыл бұрын
"If I could save time in a bottle, the first thing that I'd like to do is to save every day 'til eternity passes away just to spend them with you." - Jim Croce
@simrangarg2132
2 жыл бұрын
Love your research and the delivery girl!! Keep going!! I love the offbeat topics you pick. Would love to see more tech debunks from you.
@brianedwards7142
2 жыл бұрын
I was my late mother's carer. Among other things she took Metformin. Her death at only 86 truly was a blessed release as she had lost her mind and mobility.
@ResidualSelfImage
7 ай бұрын
metformin (Glucophage) delays the processing of glucose but does not prevent the consequence of excessive glucose dietary intake. Extending life span without side effects of metformin can be done with fasting OR time restricted eating, OR low carb diet OR caloric restriction... which on the average can extend lifespan by about 20 percent... no drug is needed. Metformin will not stop the thymus gland from aging
@IndigoIndustrial
Жыл бұрын
I'm a medical researcher and my gut feeling is that soon there will be high confidence in a 3 times a week pill composed of low doses of fairly generic things - aspirin, metformin etc to extend middle age (looking/feeling ~40-something) until your late 70s. This pill will only work if you have a good diet, regular exercise, sleep, low stress and no smoking/excessive drinking/UV exposure/occupational hazards/sugar etc. Living well is the basis but a constant, low dose, biochemical nudge might push all of the diseases of aging back a few decades for people who do the right thing.
@jordanmcglotten3499
2 жыл бұрын
Hey Cleo! Great job :)
@arobatiteewebrechtefeld4889
Жыл бұрын
Beautiful presentation. I'm from the small pacific island nation of Kiribati where people have a small life expectancy with men at 52 and women at a little above that. My dad is now pushing 84 years old this coming November 25th, 2023 and he has been diabetic since he was 30 years old, so basically he has been on Metformin since then which has been 54 years now and he is amazingly healthy given his age, and being from Kiribati he has a good memory and good eye sights. His doctor told him 54 years ago that he will be diabetic for the rest of his life and must get on metformin for the rest of his life as well, he been on it ever since (54 years ago). His children, 6 in all still alive with the oldest being 62 years old (also diabetic) and myself 49 yrs old non-diabetic. I'm not surprised he might outlive most of us as he has outlived most people in his generation in our village and probably in our island nation given the smallest life expectancy here. I now believe that metformin did this to him and I will be taking metformin myself to live as long. Thank you so much.
@hueypautonoman
2 жыл бұрын
I think we need to re-examine how we treat aging people for this to be effective. Assuming it’s not just the rich taking this, we need to take care of elderly longer so that they’re not dying of starvation, freezing, heat stroke or any of the things poor elderly often die from. A universal income for life would be a good step. Universal healthcare would be huge.
@Shuttterbugg
11 ай бұрын
I took it for Wright loss and it worked amazingly
@nobbie01
2 жыл бұрын
Hopefully the demand for its antiaging use won't affect the supply for people who need it for diabetes...
@katherinexu5554
2 жыл бұрын
It’s very cheap and easy to manufacture, so I doubt the supply would run out.
@danielclv97
2 ай бұрын
Correlation is definetly a huge thing in this study. People that have diabetees might eat more healthy (less sugars an processed food), might generally take more care of their health (they already have a rough diagnostic which might wake up a lot of people to take more care of their health), might be more prone to take their medications for other diseases (it's a small difference from taking 1 pill a day vs 3 or 5 per day, but huge difference between taking no pills and 1 pill), might get more medical attention (trough more appointments, blood tests, screening in general), might get more attention from their loved ones (who might get increasingly affraid that they will loose the said person sooner rather then later), might pray more (I'm not saying that here is a divine intervention, but praying in general I feel like it's some kind of medidative practice), might listen to their body more on what it hurts and how they feel, might be more gratefull for their lives. Probably there isn't a person who benefits from all, but given how many hidden variables there are, it's easy to see the benefits when taking a big number of persons. I think if you really want to live longer, you know what to do, eat healthy, exercise, be happy, gratefull, see and hug people, get regular check-ups and listen to your body.
@robinandersson862
2 жыл бұрын
I can't help but think of how this drug, if its anti-aging effects were to be confirmed, would impact the balance between global births and deaths and the ensuing impact on global environmental, economic, and social sustainability.
@ernststravoblofeld
2 жыл бұрын
Putting off death for a couple years, if that, wouldn't have and real effect. Everyone still dies.
@Aptonica
2 жыл бұрын
@@ernststravoblofeld i wouldn’t be so sure, the balance is still very much changed for however many years and could have very large, not so positive consequences
@brandib3990
2 жыл бұрын
My question is, does taking metformin increase your chances of muscle atrophy in the long term? Based on what Dr. B mentioned about your muscles not getting “bigger” with exercise
@jamesfrankel7827
Жыл бұрын
Dr. Sinclair and the metformin without diabetes group suggest not taking metformin on days you workout. It's that simple
@redflamesundur
2 жыл бұрын
Thanks for making these videos, with great experts and graphics. I hope you're not afraid to go into detail with these extremely knowledgeable people, for example - how does metformin reduce blood sugar (what's the interaction on a cellular level)? Another small note about the scaling of the disease-risk graph: it seems to me that to preserve the proper shape of the curve, you should have stretched the x axis, instead of compressing the y axis. Of course, this will also lower the rates of disease for a given age, so for illustrative purposes I don't think it matters much. Just trying to keep you sharp ;)
@XenoTravis
6 күн бұрын
That ending was a train of sadness and yet hope.
@maxslater6991
2 жыл бұрын
Very interesting, loved the video! The biggest thought I had through this was simply - if people stop dying because they can live longer but keep reproducing at what point does the world become overpopulated and what issues does that cause?
@DrAndrewSteele
2 жыл бұрын
Great question, and one I’ve thought about a lot! There’s actually a video on my channel about exactly this if you want to find out more-and, spoiler alert, the amount of difference it would make to population is surprisingly small!
@christophv.3274
2 жыл бұрын
I doubt that people would be living "that" much longer. Maybe a few years but not decades. It would be a way to small factor in terms of overpopulation. Education, wealth and political stability are way more impact full
@jk-gb4et
2 жыл бұрын
A related thing is with life expectancies having grown significantly in the past 50 years or so. An example that comes to mind is Japan, with a huge elderly population that can not work, which forces the younger people to work more and pay more taxes to pay for social services, etc. It is not exactly related to overpopulation (Japan's is decreasing now), but it still makes you think about the effect of growing long life expectancies
@jk-gb4et
2 жыл бұрын
Essentially, I am saying it might cause depopulation instead, which may be an equally problematic issue
@ygreq
2 жыл бұрын
Societies where people live longer healthier lives tend to have less children. Look at Japan. Or just think of the difference between Europe and Africa.
@schumzy
2 жыл бұрын
So there's this strange drug, that does ALL that, reduces damage, etc etc. The crazy part it's free. I think it's called exercisecillin. it's pretty revolutionary.
@BiodegradableYTP
2 жыл бұрын
For the longest time I've always followed the simple medical advice that if you do not have the illness/disease/etc that a form of medication treats, then you should *NOT* take it or you may suffer horrible side-effects. I'm not convinced taking some cheap meds for diabetics is the key to living longer and I laugh at the rich, bored idiots who think it is. Cool video, Cleo!
@DrAndrewSteele
2 жыл бұрын
4:29 haha it’s me! Wasn’t expecting this tiny cameo! Great video and the same conclusion I came to as an ageing biology nerd…given that Nir and TAME will hopefully tell us one way or the other in the next few years, I’m happy to watch and wait too. :)
@CleoAbram
2 жыл бұрын
hahah hello! I watched your whole interview and it helped during my research, so thank you!
@DrAndrewSteele
2 жыл бұрын
@@CleoAbram Glad to be of service! There are definitely a few more ideas in aging biology which would be Huge if True so do hit me up if you want to chat!
@Jermont86
2 жыл бұрын
But if we decrease aging, would the current system still work? The population will increase drastically and how will that affect the environment?
@thatsawesome2060
Жыл бұрын
I have diabetes and taking metformin with insulin, my sugar level actually very well managed for decades already, what interested me is wten i meet my class mate they often say i am look young.
@Soniaganhi
2 жыл бұрын
Mrs Charlotte's is legit and her method works like magic I keep on earning every single week with her new strategy
@Springsteen002
2 жыл бұрын
Sometimes I wonder if she's used magic power trade
@Springsteen002
2 жыл бұрын
I've never heard or seen any of her clients complain of Lost....I think she's just too perfect
@fargorealtors
2 жыл бұрын
A lot I mean a lot of people have borderline high sugar levels as they age. They may not officially have diabetes but sitting on the border is very dangerous health wise. So potentially taking a lower dose of slow release Metformin may have huge benefits. Ask your doctor, that's just a closer thought.
@AEVMU
Жыл бұрын
Far more important is to eat well, sleep well, be thin, and keep your heart healthy. If you are none of those things, you will probably die early anyway, drug or not.
@rmp3499
Жыл бұрын
I have been taking metformin for more than 10 years now as I have pre diabetes. It does seam to keep me from developing full blown diabetes. It did reduce appetite by about 1/3. Unfortunately not my weight. Still 190 pounds at 5"11'' I am now 70 years old but still look the same as I did at 60. My brother is 2 years younger than me yet looks 10 years older than I do. Maybe there is something to this anti-aging thing. At least the appearance of it.
@roberthermosillo5727
Жыл бұрын
Great video! Neuroscience researcher here. It's important to qualify HOW metformin provides "anti-aging" benefits. In stem cell cultures, metformin induces stem cells to become "fated" (i.e. cellular differentiation). They are no longer pluripotent. This means that metformin is causing increased cellular turnover. Outwardly, this appears as "slower aging". However, it's been shown that stem cells have a limited number of time that they can replicate. So, from another perspective, one could interpret metformin's effects as actually "accelerated aging."
@David5467
Жыл бұрын
One thing that concerns me is when the doctor said that the mussel wouldn't be as big, don't forget your heart is a mussel too. I wouldn't want my heart getting smaller.
@SamAmiri
8 ай бұрын
0:37 doctor here, understand that if you have kidney issues, you should NOT take it, regardless of what you think.
@fluxequinox
Жыл бұрын
Make a drug that takes me back to the time when my grandma was alive, so that i can tell how how much i loved her after which i would transfer all my life energy to her and finally cease to exist
@Woodsmasher
5 күн бұрын
Min.02:36 There should have been a fourth group: people with no diabetes taking the pill...
@Whathefleck
Жыл бұрын
I just started this drug about 3 weeks ago for Type 2 diab. The diarrea thing hasn't been that bad for me. Only twice in three weeks. Still haven't seen my blood sugar go down yet. Apparently it takes upwards of two months before it actually starts working.
@kinfilmdiaries
2 жыл бұрын
Proud to be apart of the pre-100k subscribers Cleo gang!
@paradox_1729
2 жыл бұрын
The background music from 4:40 is really not necessary. makes it very hard to hear what is being talked about.
@leonswift
2 жыл бұрын
Alternative approach: We could simply address the main causes of our most common diseases (heart disease, diabetes, certain forms of cancer) The causalities among those are well researched and meta studies are being published internationally with some of the leading universities and research facilities. Hint: Nutrition and exercise are key factors.
@JackClose
2 жыл бұрын
This is such an incredible balance between comprehensive journalism and personal reflection/emotion. Thank you for this!
@geraldstiling3735
Жыл бұрын
I have type 2 diabetes,and so the side effects are not an issue. Living longer is a bonus!
@nektariosmusic
Жыл бұрын
I've been taking Metformin for fifteen years. Now I feel better! 😀
@blacksmith67
Жыл бұрын
First time your channel pops up in my recommendations and I am impressed by your presentation, honesty, knowledge, frankness, and the warmth that you brought with the generations of your family. You have a sub, and I hope that you gain a great viewership… you deserve it.
@rikvanderbruggen988
2 жыл бұрын
The true question is "how far do we wanna take this?" Do we want to stop people from dieing alltogether? What would that mean for humanity? Would having children be illegal? What happens if someone dies from an exident? Or violence? Who gets to have a baby to replace this dead person? Besides all that, the renewal of people (so to say) gives new and intersting insights on the world from generation to generation, which moves humanity forward. I personally dont think we should have the desire to stop that.
@tearsintherain6311
2 жыл бұрын
That’s the problem with humans, we always want more, but even when we get there it still is never enough
@timeliebe
23 күн бұрын
When I saw your article said "Metformin", I knew I had to watch it because I take it every day for my diabetes! I can tell you, I think 1500 mg a day, and I sure don't feel any younger.
@Danielle_1234
Жыл бұрын
The leading theory right now is Metformin increases autophagy. Autophagy breaks down old cells and replaces them with stem cells increasing ones lifespan. Autophagy happens when one fasts, so this life extension can be had without a pill. It's hot topic being studied right now since the 2016 Nobel Price was given for discovering the mechanisms of autophagy.
@donnadrwal1987
9 ай бұрын
I have been on Metformin for decades now. Many people have said I don’t look my age. I am working on a weight loss journey using Noom. I find the more weight I lose, the better (as in younger) I feel. I wonder if there is really something to this Metformin theory.
@renato360a
2 жыл бұрын
I fully expected this video to not be so thoroughly and frankly informative... I'm astounded.
@valentinivanov3389
Жыл бұрын
I have taken metformin for years, starting and stoping. Never had a single case of stomach upset. Was able to put on a significant amount of muscle on it. Quite a lot of my friends have taken it for anti aging, and non of them had any issues with diarrhea. Side effects are overblown
@ericvanvlandren8987
Жыл бұрын
Philosophical, and controversial, question for you Cleo: Is dying bad? Is it something which should be delayed? Why? To have more time? Why not change the way we use our time now? Is quality of life, perhaps, more important than length of life? Human lifespan has indeed grown over time, but very gradually. And even now there are some serious societal implications for having lots and lots of old people. If that were suddenly magnified by, say, a 20% life extension … what then? Pretty hard to know, but easy to see some huge challenges. And … why? OK, maybe that was more than one question.
@farabihussain8518
Жыл бұрын
Longevity without quality of life is also something to consider. Decrease calories also improves longevity and will like reduce the complications arising from obesity and poor nutritional intake.
@AliyevRashid
Ай бұрын
I am 2nd type diabetic, and us met forming about 5 year, ns not feel becoming young. What I only feel, is my sugar and blood pressure become normal.
@oootkarsh
Жыл бұрын
Once you have diabetes, you start consciously thinking about what you eat. And you tend to adopt healthy habits on average. That's what makes you lives longer.
@nikitashutkov1804
2 жыл бұрын
Thank you for showing how good journalism can be. I deeply respect and appreciate people who do this.
@LauraTryUK
11 ай бұрын
What a FANTASTIC video!!!! What a gift you have and you are sharing it with the world 🌟
@john-wiggains
Жыл бұрын
We already know anti aging medicines. They’re called diet, exercise, and meditation. Additional medicines on top would be quite interesting for sure!
@AceChampElite
2 жыл бұрын
Living=Aging Aging=Dying Therefore Living=Dying Living is the leading cause of Death. 💀
@Ghennesph
Жыл бұрын
Or maybe it just lowers bloodsugar levels which puts the body into ketosis... It's like using a drug to treat the negative symptoms of smoking, rather than questioning whether or not you should be smoking.
@Lornicopia
Жыл бұрын
I have been on Metformin since I was 40. I never had any of the side effects. I am 54 and people ballpark my age at 40. I don't have grey hair. I am very agile and have the stamina of a 20 year old. I also don't have heavy wrinkling or sagging,puffy skin etc. I think perhaps because I use reading glasses,that classifies me in the 40 age range in people's minds. However,younger people who I work with and have known since they were teens and even children,often remark that I don't age. Also my peers remark on this. Part of it is genetic and another part of it is Metformin,eating tumeric,taking aspirin every morning,,using alpha hydroxy 4 times a year on my skin,and being a waiter where I am not sedentary,and lift,bend and stretch all day long. I also do yard work when I am off. I do take naps any time I can. I usually get 7 to 7 and a half hours of sleep. I drink water all day long. I have 6 to 8 beers a night,Miller lite,and I smoke. So,something is working out pretty well. I cut out caffeine at 35,and I count my carbs and my sodium intake every day and try to stay in a healthy ballpark of stable intake. I walk about 14 miles a day at work.
@bill9989
Жыл бұрын
I'm coming up on 2 years on metformin. I'm lucky, I never had negative side effects.
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