April 3, 2024
Discussion forum: community.cancerpatientlab.org/c/pancreatic-cancer/
Full transcript: docs.google.co...
Recent advances in pancreatic cancer treatment. 00:00:06
Personalized cancer medicine for pancreas cancer. 00:01:31
Targeting KRAS mutations in pancreatic cancer. 00:06:47
Pancreatic cancer treatment and new approaches. 00:12:36
Using cryotherapy for cancer treatment. 00:17:50
Liquid biopsies for pancreatic cancer diagnosis and treatment. 00:27:01
Pancreatic cancer treatment and genetic mutations. 00:33:49
Early detection of pancreatic cancer through blood tests.00:38:25
Radioligands for pancreatic cancer treatment. 00:43:29
Cancer treatment resistance and empowering patients. 00:50:12
KRAS mutations and resistance in cancer treatment. 00:53:56
“Precision cancer medicine for pancreas cancer is finally becoming real for the clinic.
“I'm particularly optimistic about our new approaches to target KRAS, which could open up a whole range of new therapies for patients with pancreas cancer outside of traditional cytotoxic chemotherapy, which nobody likes.
“We can learn a lot from people who are willing to stray from outside of the norm or convention because with pancreas cancer, that convention is just not acceptable. As I'm sure Roger [Royse] will tell you, the long term outcomes with the standard of care for pancreas cancer are unacceptably poor. We need paradigm shifts in order to move the needle with this very difficult-to-treat disease.” - John Strickler
Meeting Summary
Patients who are diagnosed with pancreatic cancer and do an online search for their prospects are confronted with a poor prognosis and dire statistics. The overall five-year survival rate is 7.2%. Looking only at pancreatic cancers that have not spread beyond the pancreas (“localized” cancers), the survival rate is 27.1%. For cancers that have spread, but only to nearby areas (“regional” cancers), the survival rate is 10.7%.
Metastatic (Stage IV) pancreatic cancer has a five-year survival rate of 1 %.
If they then search for standard treatment options, they find:
Pancreatic cancer treatment may involve surgery, chemotherapy, radiation therapy, vaccination, pain management, immunotherapy and dietary changes.
Surgery remains the gold standard of treatment, but can be achieved only in a small number of patients whose cancer is caught early and is localized. The main surgical approach ("Whipple" procedure) involves removing the head of the pancreas, which is connected to the top part of the small intestine. Those who undergo a successful Whipple procedure may boost their 5-year survival rate up to 25%.
Despite the grim survival statistics and poor prognosis associated with this disease, improvements in supportive care, chemotherapy, and molecular diagnostics are enabling some patients to live longer and better. Key among these developments are drugs which target a mutation (e.g., KRAS). If you have this mutation, you have a new treatment option to consider.
John Strickler, MD, Associate Professor of Medicine in the Division of Medical Oncology at Duke University and co-leader of the Molecular Tumor Board and Precision Cancer Medicine and Investigational Therapeutics Research Program, is uniquely qualified to discuss advances in pancreatic cancer care. Dr. Strickler specializes in the treatment of esophageal, gastric, pancreatic, and colorectal cancers. with a focus on clinical trials. Clinical trial patients usually come to him looking for an alternative therapy once standard treatments have not been effective. He recently published results on a study of pancreatic cancer patients with a specific mutation (KRAS G12C).
The seesion includes a discussion of:
What are the improvements in treatments for pancreatic cancer coming online today?
- Personalized medicine
- Genetic testing and molecular profiling
- Early detection
What are future improvements to keep an eye on?
- Testing advances
- Liquid biopsies (blood draws)
- Cancer vaccines
- Cryotherapy
- Radioligands
- Drug repurposing
What are the challenges in finding additional future treatments for pancreatic cancer?
- Heterogeneity of resistance
- Finding a treatment for a target
- Adverse selection for trials
- Merging diagnostics with bioinformatics
- Finding signal in the blood
- Test accuracy
- Treatment proliferation
What can you do?
- Get genetic testing
- Learn
- Engage
The information and opinions expressed on this website or platform, or during discussions and presentations (both verbal and written) are not intended as health care recommendations or medical advice by Cancer Patient Lab, its principals, presenters, participants, or representatives for any medical treatment, product, or course of action. You should always consult a doctor about your specific situation before pursuing any health care program, treatment, product or other course of action that might affect your health.
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