Very underrated channel! You're amazing as a tutor and content creator ❤️
@sciencewithtal
Жыл бұрын
Thank you very much! I am happy that you found the videos useful!
@auhontussh
Жыл бұрын
@@sciencewithtal can i have any contact with you?
@auhontussh
Жыл бұрын
@@sciencewithtal would you help me understand fiber theory model? My exam is in 2 days :'(
@sciencewithtal
Жыл бұрын
@@auhontussh Send me an email to sciencewithtal@gmail.com with your questions. I will try my best to help you out!
@auhontussh
Жыл бұрын
@@sciencewithtal please check your email
@nithuran2432
Жыл бұрын
Super Helpful! Thank you so much! I hope you continue to make more neurophysiology videos!
@sciencewithtal
Жыл бұрын
Thank you very much for the feedback. I should have a new neurophysiology video coming up soon, so stay tuned for that!
@avigailkoppel3266
Жыл бұрын
Thank you! It was explained very well.
@sciencewithtal
Жыл бұрын
Glad it was helpful! Thank you for the feedback.
@yasminfrid
Жыл бұрын
Thank you so much! you create amazing videos and excellent explains the topic. Very helpful!
@sciencewithtal
Жыл бұрын
Thank you, I am glad it was helpful!
@joshuaolorocisimo7611
10 ай бұрын
Great animation and clear explanation!
@sciencewithtal
10 ай бұрын
Thank you !!
@drueckeberger1751
Күн бұрын
Hey, thank you for recording a video regarding this topic. This might be a stupid question, but I'm pretty new to the subject. How can "positive" current injected by an electrode lead to depolarisation of the cell when there're potassium cations leaving by means of the resistors. Shouldn't the voltage become more negative due to positive charge leaving the cell ? In addition to that, I was wondering how the capacitor normally behaves when there're depolarisations and hyperpolarisations (not imposed artificially). Thank you in advance😅.
@Muck-qy2oo
Жыл бұрын
I recently found out that the reason why high frequency currents don't stimulate neurons as much as low frequencies is the fact that the main parameter determining the stimulus strength is the charge transfered to the neuron, within a specific amount of time (time constant of the cell). At higher frequencies the charge transfered by every halfwave becomes smaller with increasing frequency. My experiments showed me that for both large and small contact areas there is no significant stimulus with macroshock if the charge Q is below approximately 0.3 to 0.8 µC. So at 250 kHz 400 mA of current should have the same stimulating effect like 0.5 mA at 50 Hz.
@sciencewithtal
Жыл бұрын
Very interesting to think about. Thanks for sharing that!
@Muck-qy2oo
11 ай бұрын
@@sciencewithtal Yes. But of course the relationship is mostly nonlinear for low frequencies and seems to get more and more linear with frequencies above 3 kHz.
@cleganshotaway3332
Жыл бұрын
Thank you for this video, it is very helpful.. I have a question please, why is the relationship between tau and RL (the resistance through leaky channels) directly proportional? In my understanding, the smaller this resistance is, the easier it is to lose the injected positive charge, which in itself impedes the charging of the capacitor, thus making tau long. Thanks!
@sciencewithtal
Жыл бұрын
Thank you for the feedback! The relationship "Tau = RL x Cm" is found purely by definition because it allows to 1) simplify the equation (as it replaces 2 variables with 1) and 2) it introduces Tau, which has units of seconds and gives us an idea about the time to charge/discharge the circuit. I don't really have an alternate explanation for how this relationship came about. For a given value of membrane capacitance, let's say 5, if the resistance through the leaky channels decreases (goes from let's say 4 to 2), Tau will become smaller since its value is found by the product of Cm and RL (5 x 4 > 5 x 2). Hence, a smaller value of resistance makes the charge and discharge of the capacitor smaller (since Tau decreases). The way I see it is that a smaller resistance means the channels are more open and that causes the charges that make up the given capacitance to enter and leave faster, which would explain the smaller Tau. Inversely, a higher resistance would mean the channels are more closed and that would impede on the charging of the circuit since its harder for the positive charges to enter and leave. Let me know if that answer clarifies your question !!
@cleganshotaway3332
Жыл бұрын
@@sciencewithtal Thank you, I think I understand it now... :)
@KALDI9
7 ай бұрын
Hi I just wanna ask how the neuron will deal in case of the people who has asperger's syndrome ? What difference would be ?
@sciencewithtal
7 ай бұрын
Good question! Unfortunately, I do not think this is something that has been figured out properly. From what I learned, Asperger's syndrome (AS) and most other autism-related conditions are typically studied at the level of neuronal connections (brain circuits) rather than the individual neurons themselves. I did find this article (pubmed.ncbi.nlm.nih.gov/37179554/) that mentions that a protein called RIM, which is important for neurotransmission, is abnormally expressed in AS. Yet, when it comes to receptor expression and how the neurons in AS conduct signals differently from neurotypical people I am not sure this has been advanced. Sorry that I wasn't able to say much more about this.
@KALDI9
7 ай бұрын
@@sciencewithtal they say that the people who have asperger's syndrome they are smart and their brains works faster , they scan and then react faster , so if we want to project that on this , what are the values those would get changed in the circuit so we can have have different curves different results ?
@sciencewithtal
7 ай бұрын
@@KALDI9 The RC circuit response is mostly relevant for excitatory and inhibitory postsynaptic potentials (EPSP/IPSP) which are electrical activities sub-threshold (do not trigger an action potential until they sufficiently summate to do so). The speed of conduction for a signal in a neuron is mostly limited to the action potential because it happens way faster than the postsynaptic potentials. From my understanding, I do not think that information is stored the individual neuron but more so across all the connections it makes. As such, I think its more plausible that Asperger's Syndrome is caused because there are more connections and thus information can be found faster rather than because the individual neurons communicate faster. Nonetheless, at 11:50 I discuss what happens when the time constants are increased or decreased.
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