Siddhartha Mukherjee, M.D., D.Phil., is an author and an oncologist at the Columbia University Medical Center. His 2010 book, The Emperor of All Maladies: A Biography of Cancer, won numerous awards, including the 2011 Pulitzer Prize for General Non-fiction and the Guardian First Book Award. His most recent book, The Gene: An Intimate History, was published in 2016 and appeared at #1 on the New York Times Bestseller list, receiving a number of accolades, including being nominated for the Wellcome Trust Prize.
Dr. Mukherjee grew up in India before coming to the United States as an undergraduate to study biology at Stanford University under Nobel Laureate Paul Berg. He completed his graduate studies (D.Phil.) at the University of Oxford on a Rhodes Scholarship. After that he earned his M.D. from Harvard University in 2000. In 2009, Dr. Mukherjee joined the faculty at Columbia University Medical Center’s Department of Medicine, in the Hematology/Oncology Division. In this interview he recounts his undergraduate experience in the lab of Paul Berg, his time at Oxford, and his work as an oncologist. Dr. Mukherjee also tells us what motivated him to become a writer, as well as his thoughts on the Human Genome Project. An expert science communicator, he provides invaluable insights into how he approaches important issues in bioethics such as genetic determinism and gene-editing.
The National Human Genome Research Institute’s (NHGRI) Oral History Collection features discussions with influential figures in the field of genomics and the history of institute. Intended for researchers and scholars, each oral history contains extensive conversation about science and medicine, biographical details and insights into the inner workings of institutions and initiatives. For more information, visit NHGRI’s History of Genomics Program at: www.genome.gov/leadership-ini...
Credits:
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Executive Producer/Interviewer/Historian: Christopher Donohue, Ph.D.
Assistant Producers: Kris Wetterstrand, M.S., Mukul Nerurkar
Producer/Videographer/Editor: Alvaro Encinas
Voiceover (Interview Questions): Zachary Utz, M.A.
Chapters:
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00:00 - Introduction
00:31 - Who were some important mentors early in your career?
09:18 - When did you first hear of the Human Genome Project? What were your initial thoughts?
12:53 - Tell us how you came to write The Emperor of All Maladies
18:08 - For you, what makes cancer such a fascinating subject?
19:50 - Why do you think our progress combatting cancer has been so “sobering”?
26:18 - How have efforts like The Cancer Genome Atlas (TCGA) changed the fight against cancer?
33:02 - Do you think of the HGP and TCGA as question-generating enterprises? How are they distinct from other types of scientific inquiry?
40:23 - How do you define the “public” and effectively communicate scientific inquiry to that “public”?
44:25 - What role do you think scientists should fill within the pubic discourse?
46:02 - How did you decide to write “The Gene: An Intimate History?”
47:49 - Why is genetic information an important topic for you?
51:07 - How does the HGP figure into debates over genetic determinism?
53:02 - How should scientists approach ethical concerns over determinism arising from social genomics?
56:02 - How can science communicators help us avoid deterministic frameworks?
56:57 - What most excites you about the future of genomic medicine?
01:00:58 - How can scientists effectively navigate, and communicate, these complex ethical issues?
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