Link for free download of John's two text books, 159.69.48.3/
Campbell's Pathophysiology Notes, Amazon orders for the UK, www.amazon.co.uk/dp/B012HWC8S...
Campbell's Physiology Notes
www.amazon.co.uk/dp/095537972...
Omicron, clinical picture (7th December)
Dr Angelique Coetzee, South African Medical Association
First to raise alarm about the new omicron
• Omicron symptoms "tota...
Totally different symptoms
Can be easily missed
Body aches and pains
Muscle pains
Headache
Tiredness (1 to 2 days)
Slight sore throat
No severe cough
No runny nose
Decrease in patients coming to doctors
South Africa vaccines
Pfizer
J and J
Hospitalizations, 99% unvaccinated
Symptoms more intense in unvaccinated
More intense but not severe
Body aches and pains
Muscle pains
Headache
Lateral flow testing and Omicron
Becomes positive after 24 hours up to 5 days
Very accurate
Omicron prevalence in SA
www.nicd.ac.za
Ref for graphics (3rd December data)
www.nicd.ac.za/wp-content/upl...
SGTF has increased from 0.9% in October to 96.3% for November.
Children under the age of 12 years accounted for 7.9% of the SGTF positives,
and those 13 - 18 years old for 6.1%.
For week 47,
Hospital data from SA
www.nicd.ac.za/wp-content/upl...
Live data, hospital patients who have tested positive
www.nicd.ac.za/diseases-a-z-i...
Omicron and common cold
osf.io/f7txy/
Omicron has insertion mutation ins214EPE
(From the common cold, HCoV-229E coronavirus)
Could have been acquired by switching
Involving the genomes of other viruses that infect the same host cells as SARS-CoV-2
It is plausible that the Omicron insertion
could have evolved in a co-infected individual
PFIZER AND BIONTECH PROVIDE UPDATE ON OMICRON VARIANT
www.pfizer.com/news/press-rel...
Preliminary laboratory studies demonstrate that three doses of the Pfizer-BioNTech COVID-19 Vaccine neutralize the Omicron variant (B.1.1.529 lineage),
while two doses show significantly reduced neutralization titers
Data indicate that a third dose of BNT162b2 increases the neutralizing antibody titers by 25-fold compared to two doses against the Omicron variant;
titers after the booster dose are comparable to titers observed after two doses against the wild-type virus which are associated with high levels of protection
As 80% of epitopes in the spike protein recognized by CD8+ T cells are not affected by the mutations in the Omicron variant, two doses may still induce protection against severe disease
The companies continue to advance the development of a variant-specific vaccine for Omicron and expect to have it available by March
in the event that an adaption is needed to further increase the level and duration of protection - with no change expected to the companies’ four billion dose capacity for 2022
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