The Nishiyama Group is studying the synthesis of natural organic compounds using electrical energy. The aim is to synthesize compounds that are useful in medicine and other fields, and to enable environmentally friendly organic synthesis.
Q: Our aim is to actually synthesize biologically active organic compounds that occur in nature. There are a wide variety of such compounds, ranging from quite complex to very simple. In particular, a feature of our research is that were using electrochemistry, or electrolysis, for environmentally friendly organic synthesis.
Chemical synthesis using electrochemistry and electrolysis can be used to induce only the reactions needed, without producing toxic substances. Consequently, it is currently topical as a means of environmentally friendly chemical synthesis. The Nishiyama Group is breaking new ground internationally, through original organic electrolysis reactions using phenols.
QOne current environmental problem is waste products that are organic halogen compounds. As these contain halogens such as chlorine or bromine, they are toxic, and they dont naturally decompose. But electrolysis can be used to remove the halogens.A feature of our research is that we synthesize organic compounds based on phenols. Benzene is easy to polymerize. But if you combine just two benzene rings,please clarify part about ether, or link benzene rings directly, then those compounds can be used, for example, to synthesize a chain of amino acids, which is strongly biologically active. So were doing quite original research on phenol chemistry, using electrochemistry for synthesis, as I mentioned earlier.
For pharmaceuticals manufactured by organic synthesis, safety testing is extremely important. It can take over a decade to produce a single drug. Organic electrolysis reactions, which do not use toxic substances, are expected to be very safe, and to enable much faster development. For such research, the Nishiyama Group uses a special system to develop man-made biologically active substances that are more effective than natural organic compounds.
QIn our study meetings, we have one team that makes the target substances using electrochemistry, and another team that makes complex compounds using standard chemical synthesis. The two teams can complement each other by bringing together their new discoveries and new technologies. For example, weve had several cases where standard chemical synthesis alone doesnt work, but electrochemistry can be used to find a more effective reaction at once. In that sense, we aim to achieve complete syntheses through both teams helping each other.
Негізгі бет Ғылым және технология Organic Electrolytic Synthesis
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